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The map label for this gene is hemB [H]

Identifier: 225852274

GI number: 225852274

Start: 765841

End: 766878

Strand: Reverse

Name: hemB [H]

Synonym: BMEA_A0797

Alternate gene names: 225852274

Gene position: 766878-765841 (Counterclockwise)

Preceding gene: 225852278

Following gene: 225852273

Centisome position: 36.08

GC content: 59.25

Gene sequence:

>1038_bases
ATGACCGATCGTCAGTCCAAATATCTGCCAGCCAATATCAGCCAGCACGTCGATGACGTAACGGGCAGCCGCCGCCTGCG
CCGCATGCGCAAGGCCGACTGGTCGCGCAGGCTGGTGCAGGAAAACCACCTGACGGTGAACGACCTCATTCTTTCCTTCT
TCCTGACCTATGGCTCCGGCGTGAGCGAGCCGGTGGAAGCAATGCCCGGCGTGGAACGTTATTCGGTGGATATGGCCGTG
CGCATGGCTGAAAAAGCCGCCAGGCTTGGCATTCCAGCCATCGCCCCCTTCCCGCGCGAAAAGCCGGAAGTGAAAACCGA
CGACGGCTCCTTCGTCGCAAACCCGGATAACCTCATCAACCGTGCGGTACGCGCCATCAAGAAAGAAGTGCCGGAAATCG
GCATCATCACCGATGCCGCGCTGGACCCCTTCACCACACATGGCCATGACGGCATTTTGCGCGACGGAGAAATTCTCAAC
GACGAATCGGTCGCCATGGTGGTGCGCGGCGCGCTTTCCCAGGCCGAGGCCGGTGCAGACATCATCGCCCCGTCCGACAT
GATGGATGGCCGTGTGGGCGCTGTCCGCCAGGCACTGGACGAGCACGGCTTCAGCCATGTGCCGATCATGTCCTATGCGA
CCAAGTTTGCCTCTGCCTTTTACGGCCCCTATCGCGGCGCCATCGGCACGCAAGGCCTGCTGAAAGGCGACAAGAAAACC
TATTACATCGATCCGGCCAACCCTGAAGAAGCTGTTCGCGAAGCCGAACAGGACATTGCCGAGGGCGCCGACATGCTGAT
GGTGAAACCGGGCCTGCCCTATCTCGATATCATCCACCGTCTGAAGGACGAATTCCGCCTGCCGACCTTCGCCTATCAGG
TATCCGGCGAATATGCGATGATAAAGGCTGCCGGGATCAATGGCTGGATCGACGAGGAAAAGGTGATGATGGAAAGCCTG
CTCGCCTTCAAGCGCGCAGGCTGTGACGGAATTCTGACCTATTTCGCAATGGAAGTGGCTGAAAAGCTCAAGGCCTGA

Upstream 100 bases:

>100_bases
TGTTCTTGGTTTCATCGCTTTTCCCATGATAAACGGATGCCCATCCGATGCCAGCCTTGGGGCTTCACATTCCAAGGCGT
CACTTCTCGGGAACAGTTCC

Downstream 100 bases:

>100_bases
TCGGGCTATTCCATTTCGGCACGTTAAACCCGTTTCCTTGAAATAGCCGGTTTCCGTTACCATGTTGGGCGTTGTTGCGC
TAAGATTGCGGAACAGCGCC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTDRQSKYLPANISQHVDDVTGSRRLRRMRKADWSRRLVQENHLTVNDLILSFFLTYGSGVSEPVEAMPGVERYSVDMAV
RMAEKAARLGIPAIAPFPREKPEVKTDDGSFVANPDNLINRAVRAIKKEVPEIGIITDAALDPFTTHGHDGILRDGEILN
DESVAMVVRGALSQAEAGADIIAPSDMMDGRVGAVRQALDEHGFSHVPIMSYATKFASAFYGPYRGAIGTQGLLKGDKKT
YYIDPANPEEAVREAEQDIAEGADMLMVKPGLPYLDIIHRLKDEFRLPTFAYQVSGEYAMIKAAGINGWIDEEKVMMESL
LAFKRAGCDGILTYFAMEVAEKLKA

Sequences:

>Translated_345_residues
MTDRQSKYLPANISQHVDDVTGSRRLRRMRKADWSRRLVQENHLTVNDLILSFFLTYGSGVSEPVEAMPGVERYSVDMAV
RMAEKAARLGIPAIAPFPREKPEVKTDDGSFVANPDNLINRAVRAIKKEVPEIGIITDAALDPFTTHGHDGILRDGEILN
DESVAMVVRGALSQAEAGADIIAPSDMMDGRVGAVRQALDEHGFSHVPIMSYATKFASAFYGPYRGAIGTQGLLKGDKKT
YYIDPANPEEAVREAEQDIAEGADMLMVKPGLPYLDIIHRLKDEFRLPTFAYQVSGEYAMIKAAGINGWIDEEKVMMESL
LAFKRAGCDGILTYFAMEVAEKLKA
>Mature_344_residues
TDRQSKYLPANISQHVDDVTGSRRLRRMRKADWSRRLVQENHLTVNDLILSFFLTYGSGVSEPVEAMPGVERYSVDMAVR
MAEKAARLGIPAIAPFPREKPEVKTDDGSFVANPDNLINRAVRAIKKEVPEIGIITDAALDPFTTHGHDGILRDGEILND
ESVAMVVRGALSQAEAGADIIAPSDMMDGRVGAVRQALDEHGFSHVPIMSYATKFASAFYGPYRGAIGTQGLLKGDKKTY
YIDPANPEEAVREAEQDIAEGADMLMVKPGLPYLDIIHRLKDEFRLPTFAYQVSGEYAMIKAAGINGWIDEEKVMMESLL
AFKRAGCDGILTYFAMEVAEKLKA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=38.2352941176471, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=46.7084639498433, Blast_Score=259, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=35.1097178683386, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358291, Length=314, Percent_Identity=34.3949044585987, Blast_Score=198, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38055; Mature: 37924

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRQSKYLPANISQHVDDVTGSRRLRRMRKADWSRRLVQENHLTVNDLILSFFLTYGSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VSEPVEAMPGVERYSVDMAVRMAEKAARLGIPAIAPFPREKPEVKTDDGSFVANPDNLIN
CCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHH
RAVRAIKKEVPEIGIITDAALDPFTTHGHDGILRDGEILNDESVAMVVRGALSQAEAGAD
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
IIAPSDMMDGRVGAVRQALDEHGFSHVPIMSYATKFASAFYGPYRGAIGTQGLLKGDKKT
EECCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEE
YYIDPANPEEAVREAEQDIAEGADMLMVKPGLPYLDIIHRLKDEFRLPTFAYQVSGEYAM
EEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCEEE
IKAAGINGWIDEEKVMMESLLAFKRAGCDGILTYFAMEVAEKLKA
EEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDRQSKYLPANISQHVDDVTGSRRLRRMRKADWSRRLVQENHLTVNDLILSFFLTYGSG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
VSEPVEAMPGVERYSVDMAVRMAEKAARLGIPAIAPFPREKPEVKTDDGSFVANPDNLIN
CCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHH
RAVRAIKKEVPEIGIITDAALDPFTTHGHDGILRDGEILNDESVAMVVRGALSQAEAGAD
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
IIAPSDMMDGRVGAVRQALDEHGFSHVPIMSYATKFASAFYGPYRGAIGTQGLLKGDKKT
EECCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEE
YYIDPANPEEAVREAEQDIAEGADMLMVKPGLPYLDIIHRLKDEFRLPTFAYQVSGEYAM
EEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCEEE
IKAAGINGWIDEEKVMMESLLAFKRAGCDGILTYFAMEVAEKLKA
EEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]