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The map label for this gene is metC [H]

Identifier: 225852257

GI number: 225852257

Start: 744247

End: 745416

Strand: Reverse

Name: metC [H]

Synonym: BMEA_A0779

Alternate gene names: 225852257

Gene position: 745416-744247 (Counterclockwise)

Preceding gene: 225852263

Following gene: 225852256

Centisome position: 35.07

GC content: 56.15

Gene sequence:

>1170_bases
GTGGCTAAGCAGCAGTTGAAGACAGAGAAGTTGGGCATAAACACGCGGCTTGCTCATGACGGTTATTGCCCCGGCGACTA
TCACGGCTTTGTCAACCCGCCCGTCGTGCGCGCATCGACCGTGCTTTTTCCCGATGCAGAAACCATGGCAAGCAACGGCC
AGAAATATACCTATGGCACACGCGGCACGCCCACAAGCGAAGCGCTTTGCAAAGCCATCGACGCGCTGGAGGGCTCTGCG
GGAACGGTTTGCGTTCCATCGGGGCTAGCGGCCATAACCGTTCCGCTGCTGGGATTTCTTTCACCCGGCGATCATGCGCT
TCTTGTCGATTCGATTTATTACCCGACCCGCCACTTCGCCAATACGATCCTGAAACGCATGGGTGTGGACGTCGAATATT
ACGATCCGGAAATCGGTGCGGACATTGCAAAGCTGATGCGCCCGAACACCAAGGTCGTGTTTACGGAATCACCCGCCTCC
AACACATTCGAGATACAGGATATTCCTGCCATCGCTGAAGCCGCCCACAAGGGCAATGCCATCGTCATGATGGACAATAC
CTGGGCGACACCGCTTTATTTCCGGGCGCTCGATTTCGGCGTGGACATCAGCATTCACGCAGCAACCAAATATCCCTCCG
GCCATTCCGACATTCTTTTCGGCACCATTTCGACCAATGAGAAATGCTGGCCGCAATTGCTGGAAACACACGGCACGATG
GGCCTTTGTGCCGGGCCTGACGACACCTACCAGATCTTGCGCAGACTGCGCACCATGGGCATCCGGCTGGAACATCATCG
CAAAAGCGCACTGGAGATTGCCCGCTGGCTGGAAAATCATCCAATGGTGGAACGCGTTCTGCATCCAGCCCTCGAAAGCC
ATCCCGGCCATGAAATCTGGAAACGCGATTTTTCCGGTTCGTCCGGCATTTTCTCCTTTGTTCTGGCAAAGGGCGAACAT
GCGCAAGCGAGCGCCTTCCTCAACGCGCTGGAGATTTTCGGCCTCGGCTATTCGTGGGGTGGCTATCAAAGCCTTGCGCT
TGAAGTGAAGCTTGGCGACCGCACCGTTTCGAAGAACGATTATGCCGGGGCGGTCATCCGCCTTCAGATCGGTCTGGAAG
ACGTGCCCGACCTCATCGCCGATCTCGAAAGAGGTTTTGCTGCAATCTGA

Upstream 100 bases:

>100_bases
CGAAGCTCTTTTTGCCGAAGCCAATCTTGTACCCAGCCGGCAGAATCACGTCTTTCGAGAATCTGTGGAACAGCACGCAA
CATGGTCTGGAGGCATTTTC

Downstream 100 bases:

>100_bases
TTACTTAGGGCAGTTCCTGTTTAATTCAGGCAACCGCGCCATAAGGAAGATCATGATGACTTGGGTATTCATAATACAGG
GCGTTATGGCGATCGGCCTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSA
GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPAS
NTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
GLCAGPDDTYQILRRLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGEH
AQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGAVIRLQIGLEDVPDLIADLERGFAAI

Sequences:

>Translated_389_residues
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSA
GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPAS
NTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
GLCAGPDDTYQILRRLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGEH
AQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGAVIRLQIGLEDVPDLIADLERGFAAI
>Mature_388_residues
AKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAG
TVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASN
TFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMG
LCAGPDDTYQILRRLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGEHA
QASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGAVIRLQIGLEDVPDLIADLERGFAAI

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=33.972602739726, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=30.958904109589, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI25453487, Length=348, Percent_Identity=30.4597701149425, Blast_Score=151, Evalue=9e-37,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=46.4102564102564, Blast_Score=347, Evalue=6e-97,
Organism=Escherichia coli, GI1790375, Length=370, Percent_Identity=30.8108108108108, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17560056, Length=330, Percent_Identity=36.3636363636364, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71980708, Length=396, Percent_Identity=32.3232323232323, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17538055, Length=320, Percent_Identity=35.3125, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=46.2462462462462, Blast_Score=315, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6319307, Length=377, Percent_Identity=30.7692307692308, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6323333, Length=385, Percent_Identity=25.7142857142857, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321904, Length=368, Percent_Identity=26.6304347826087, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321254, Length=388, Percent_Identity=25.2577319587629, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922554, Length=384, Percent_Identity=36.1979166666667, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42516; Mature: 42385

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGT
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCC
RGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFA
CCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEECHHCCHHHHH
NTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNA
HHHHHHHCCCEEEECCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCCE
IVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
EEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCE
GLCAGPDDTYQILRRLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIW
EEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KRDFSGSSGIFSFVLAKGEHAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKND
HHCCCCCCCCEEHEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEECCCC
YAGAVIRLQIGLEDVPDLIADLERGFAAI
CCCEEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGT
CHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCC
RGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFA
CCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEECHHCCHHHHH
NTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNA
HHHHHHHCCCEEEECCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCCE
IVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
EEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCE
GLCAGPDDTYQILRRLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIW
EEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KRDFSGSSGIFSFVLAKGEHAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKND
HHCCCCCCCCEEHEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEECCCC
YAGAVIRLQIGLEDVPDLIADLERGFAAI
CCCEEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]