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The map label for this gene is mutY [H]

Identifier: 225852029

GI number: 225852029

Start: 512423

End: 513499

Strand: Reverse

Name: mutY [H]

Synonym: BMEA_A0530

Alternate gene names: 225852029

Gene position: 513499-512423 (Counterclockwise)

Preceding gene: 225852035

Following gene: 225852028

Centisome position: 24.16

GC content: 61.19

Gene sequence:

>1077_bases
ATGGATCCCACGACTTTTCTTCTGCGCTGGTATGACCGTCATCATCGCGTCCTGCCGTGGCGCGTGACGCCTGTTGACGC
GGCCAAAGGAGACGTCGCCGATCCCTATCGTGTATGGCTGTCGGAAATCATGCTGCAACAGACAACCGTTGAAGCCGTGA
AATCCTATTTCTTGCGCTTTATCGAGCGATGGCCGACGGTCCGGGCCATGGCGAAGGCGAGCGAGGATGATATTCTTCGC
GCTTGGGCAGGGCTTGGCTATTATTCCCGCGCGCGCAATCTCAAGAAATGCGCCGATATCGTCGTCGCCGAACATGGCGG
AGAATTTCCGAAAAGTGCGGCCGGCCTCAAGGAATTGCCTGGCATCGGCGATTATACCTCGGCGGCAATCGCTGCCATCG
CCTTTGGCGAGCAGGTCGCCGTGGTGGATGGCAATGTCGAGCGCGTGATCTCGCGCCTTTATGCTATCGACACCCCCCTC
CCCGTCGCAAAGGCGCAGATTCGCGCGCTCATGGGGCAGATGACGCCACCTGACCGCCCCGGCGATTTTGCACAGGCCAT
GATGGATCTGGGCGCGACGATCTGCACGCCGCGCCGCCCGGCCTGCGCGCTCTGCCCGCTCAATAAGGGATGCATCGCGC
TGTGCGAACGCGACCCGGAAGACTTTCCGGTAAAAGCGCCCAAAGCGGAAAAGCCGGTGCGCACAGGCGCGGCCTTCATT
GCCATTGCGGGTGACGGCTCCGTCTATCTGCGCAAGCGCAAGGGCGAAGGCTTGCTGGCGGGCATGACGGAAGTGCCGGG
CAGCGGCTGGACCGCGCGCATCGACGGTGACGCAACGGTGAATGCAGCGCCCTTTTCGGCAGCCTGGACACCATCCGGCA
CCATCACGCACGTCTTCACGCATTTCGAGTTGCGGCTGTCGGTTTATCGTGCCAGCAATGTGCGGAAACAAGCGGCGAAT
GAAGGATGGTGGTCAACGCCCGAGGAGCTTTGCGGCGAGGCCCTGCCAACGGTTATGAAAAAAGCCATTGCCGCCGCTAT
TCCAGACGCTTTCAAACGGGGGAGGAAAAGCCGTTGA

Upstream 100 bases:

>100_bases
ACCGACAAAGGCGACACACGCACGAGCAAAAGTGCGTTCGACCTCTATTATGAAAGCCATTCTTTTAACGAATCCGCATG
GATACGCATCAAGCAGGCCC

Downstream 100 bases:

>100_bases
ACAGTAGCCCGGTCAAACATGTCGTTTTCGATATCGGCAAGGTGCTCATTCACTATGATCCGGAACTTGCCTTTCTGGAT
ATCATTCCTGATGCTGGCGA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MDPTTFLLRWYDRHHRVLPWRVTPVDAAKGDVADPYRVWLSEIMLQQTTVEAVKSYFLRFIERWPTVRAMAKASEDDILR
AWAGLGYYSRARNLKKCADIVVAEHGGEFPKSAAGLKELPGIGDYTSAAIAAIAFGEQVAVVDGNVERVISRLYAIDTPL
PVAKAQIRALMGQMTPPDRPGDFAQAMMDLGATICTPRRPACALCPLNKGCIALCERDPEDFPVKAPKAEKPVRTGAAFI
AIAGDGSVYLRKRKGEGLLAGMTEVPGSGWTARIDGDATVNAAPFSAAWTPSGTITHVFTHFELRLSVYRASNVRKQAAN
EGWWSTPEELCGEALPTVMKKAIAAAIPDAFKRGRKSR

Sequences:

>Translated_358_residues
MDPTTFLLRWYDRHHRVLPWRVTPVDAAKGDVADPYRVWLSEIMLQQTTVEAVKSYFLRFIERWPTVRAMAKASEDDILR
AWAGLGYYSRARNLKKCADIVVAEHGGEFPKSAAGLKELPGIGDYTSAAIAAIAFGEQVAVVDGNVERVISRLYAIDTPL
PVAKAQIRALMGQMTPPDRPGDFAQAMMDLGATICTPRRPACALCPLNKGCIALCERDPEDFPVKAPKAEKPVRTGAAFI
AIAGDGSVYLRKRKGEGLLAGMTEVPGSGWTARIDGDATVNAAPFSAAWTPSGTITHVFTHFELRLSVYRASNVRKQAAN
EGWWSTPEELCGEALPTVMKKAIAAAIPDAFKRGRKSR
>Mature_358_residues
MDPTTFLLRWYDRHHRVLPWRVTPVDAAKGDVADPYRVWLSEIMLQQTTVEAVKSYFLRFIERWPTVRAMAKASEDDILR
AWAGLGYYSRARNLKKCADIVVAEHGGEFPKSAAGLKELPGIGDYTSAAIAAIAFGEQVAVVDGNVERVISRLYAIDTPL
PVAKAQIRALMGQMTPPDRPGDFAQAMMDLGATICTPRRPACALCPLNKGCIALCERDPEDFPVKAPKAEKPVRTGAAFI
AIAGDGSVYLRKRKGEGLLAGMTEVPGSGWTARIDGDATVNAAPFSAAWTPSGTITHVFTHFELRLSVYRASNVRKQAAN
EGWWSTPEELCGEALPTVMKKAIAAAIPDAFKRGRKSR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI115298650, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI115298654, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI115298652, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI190358497, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI6912520, Length=398, Percent_Identity=35.929648241206, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789331, Length=311, Percent_Identity=39.871382636656, Blast_Score=211, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39100; Mature: 39100

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPTTFLLRWYDRHHRVLPWRVTPVDAAKGDVADPYRVWLSEIMLQQTTVEAVKSYFLRF
CCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IERWPTVRAMAKASEDDILRAWAGLGYYSRARNLKKCADIVVAEHGGEFPKSAAGLKELP
HHHCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHCC
GIGDYTSAAIAAIAFGEQVAVVDGNVERVISRLYAIDTPLPVAKAQIRALMGQMTPPDRP
CCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
GDFAQAMMDLGATICTPRRPACALCPLNKGCIALCERDPEDFPVKAPKAEKPVRTGAAFI
CHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEE
AIAGDGSVYLRKRKGEGLLAGMTEVPGSGWTARIDGDATVNAAPFSAAWTPSGTITHVFT
EEECCCEEEEEEECCCCEEEEHHHCCCCCCEEEECCCCEECCCCCCCCCCCCCCHHHEEH
HFELRLSVYRASNVRKQAANEGWWSTPEELCGEALPTVMKKAIAAAIPDAFKRGRKSR
HHEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCC
>Mature Secondary Structure
MDPTTFLLRWYDRHHRVLPWRVTPVDAAKGDVADPYRVWLSEIMLQQTTVEAVKSYFLRF
CCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IERWPTVRAMAKASEDDILRAWAGLGYYSRARNLKKCADIVVAEHGGEFPKSAAGLKELP
HHHCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHCC
GIGDYTSAAIAAIAFGEQVAVVDGNVERVISRLYAIDTPLPVAKAQIRALMGQMTPPDRP
CCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
GDFAQAMMDLGATICTPRRPACALCPLNKGCIALCERDPEDFPVKAPKAEKPVRTGAAFI
CHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEE
AIAGDGSVYLRKRKGEGLLAGMTEVPGSGWTARIDGDATVNAAPFSAAWTPSGTITHVFT
EEECCCEEEEEEECCCCEEEEHHHCCCCCCEEEECCCCEECCCCCCCCCCCCCCHHHEEH
HFELRLSVYRASNVRKQAANEGWWSTPEELCGEALPTVMKKAIAAAIPDAFKRGRKSR
HHEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]