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The map label for this gene is pdxH

Identifier: 225851952

GI number: 225851952

Start: 441921

End: 442532

Strand: Reverse

Name: pdxH

Synonym: BMEA_A0447

Alternate gene names: 225851952

Gene position: 442532-441921 (Counterclockwise)

Preceding gene: 225851954

Following gene: 225851950

Centisome position: 20.82

GC content: 60.13

Gene sequence:

>612_bases
ATGACAAATTCCAGCGACGATTTCACCCAAAGCGCCGAACCGTTCAAGCTCTTCGCCGAATGGCTGGCCGATGCCGCCAA
GAGCGAACCTAACGATCCCAATGCGGTGGCGCTTGCGACCGTAGACCCTGATGGCCTGCCCAATGTACGCATGGTGCTTC
TGAAGGATTTCGACGAGACGGGCTTTGTCTTCTACACCAATTATGAGAGCAAGAAGGGACAGGAAATCCTTTCCGCCGAA
AAGGCCGCCATGTGCTTCCACTGGAAGTCGCTGCGCCGTCAGGTGCGCGTGCGCGGGCCGGTGGAAAAGGTGAGCGATGC
CGAGGCCGATGCCTATTATGCCTCGCGCCCACGCGGCAGCCGCATCGGGGCCTGGGCCTCGAAACAGTCGCGCCCGCTGG
AAAGCCGCTTTGCACTGGAAAAGGCGGTCGCCGAATATACCGCCAAATATGCCATTGGCGATATTCCCCGCCCGCCTTAC
TGGTCGGGTTTCCGCATCCGTCCGGTGTCAATCGAGTTCTGGCACGACCGGCCCTTCCGCCTGCATGACCGTGTGCTTTT
CACGCGGCCAACGCCGGAAGGCGACTGGAACAAGGACAGGCTTTATCCCTGA

Upstream 100 bases:

>100_bases
GGCATGGACAAAATATTGGATATGGACGAAGGTCGCTCCACCCTCGCGCCAAACCATAAGTTAACTCGTCACTACAGCCT
AGCCTTTGGAACCAGTAAAA

Downstream 100 bases:

>100_bases
TCTAACAACGCAAAGGCCACCCGAAACGGTGGCCTTCCTTCATACAAGCGGCTTTACCGCAACCCAGAGGGTTCCGAATA
CAAGCCCAAGAAAGATCAGC

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MTNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDETGFVFYTNYESKKGQEILSAE
KAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGSRIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPY
WSGFRIRPVSIEFWHDRPFRLHDRVLFTRPTPEGDWNKDRLYP

Sequences:

>Translated_203_residues
MTNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDETGFVFYTNYESKKGQEILSAE
KAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGSRIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPY
WSGFRIRPVSIEFWHDRPFRLHDRVLFTRPTPEGDWNKDRLYP
>Mature_202_residues
TNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDETGFVFYTNYESKKGQEILSAEK
AAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGSRIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPYW
SGFRIRPVSIEFWHDRPFRLHDRVLFTRPTPEGDWNKDRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=186, Percent_Identity=43.5483870967742, Blast_Score=160, Evalue=5e-40,
Organism=Escherichia coli, GI1787926, Length=193, Percent_Identity=45.0777202072539, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17553712, Length=199, Percent_Identity=41.2060301507538, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319509, Length=196, Percent_Identity=40.8163265306122, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45551845, Length=186, Percent_Identity=42.4731182795699, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24644901, Length=186, Percent_Identity=42.4731182795699, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=25.5952380952381, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_BRUA2 (Q2YMD1)

Other databases:

- EMBL:   AM040264
- RefSeq:   YP_413904.1
- ProteinModelPortal:   Q2YMD1
- SMR:   Q2YMD1
- STRING:   Q2YMD1
- GeneID:   3788842
- GenomeReviews:   AM040264_GR
- KEGG:   bmf:BAB1_0444
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   PRK05679
- BioCyc:   BMEL359391:BAB1_0444-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 23281; Mature: 23150

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 55-55 BINDING 58-58 BINDING 60-60 BINDING 77-77 BINDING 117-117 BINDING 121-121 BINDING 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDET
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCC
GFVFYTNYESKKGQEILSAEKAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEECCCCCCC
RIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPYWSGFRIRPVSIEFWHDRPFR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCE
LHDRVLFTRPTPEGDWNKDRLYP
EECEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDET
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCC
GFVFYTNYESKKGQEILSAEKAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEECCCCCCC
RIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPYWSGFRIRPVSIEFWHDRPFR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCE
LHDRVLFTRPTPEGDWNKDRLYP
EECEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA