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The map label for this gene is yeiA [H]

Identifier: 225851829

GI number: 225851829

Start: 311134

End: 312444

Strand: Reverse

Name: yeiA [H]

Synonym: BMEA_A0316

Alternate gene names: 225851829

Gene position: 312444-311134 (Counterclockwise)

Preceding gene: 225851830

Following gene: 225851827

Centisome position: 14.7

GC content: 60.64

Gene sequence:

>1311_bases
ATGGCTGATCTTTCAACGAATTTCCTCGGCATCAAATCACCCAATCCGTTCTGGCTCGCCTCGGCCCCGCCGACCGACAA
GGCCTATAATGTCGAGCGCGCTTTCAAGGCAAGCTGGGGCGGCGTAGTCTGGAAAACGCTCGGCGCGGAAGGCCCGCCGG
TGGTCAACGTAAACGGCCCGCGCTATGGCGCGATCCACGGCGCGGACCGGCGGCTTCTCGGCCTCAACAATATAGAACTC
ATCACCGACCGGCCGCTGGAGATAAACCTGCGCGAGATGAAAGAGGTGAAAATGCGCTGGCCGGACCGCGCATTGATCGC
CTCGATCATGGTGCCCTGCGAGGAGGAGGCATGGAAGGCGATCCTGCCGCTGGTGGAGGAAACCGGCGCGGACGGGATCG
AACTCAATTTCGGCTGCCCGCACGGCATGAGCGAGCGCGGCATGGGGGCAGCGGTTGGTCAGGTGCCGGAATATGTCGGC
ATGGTCGTCAAATGGTGCAAGCAATACAGCCGTATGCCGGTTATCACCAAGCTGACGCCCAATATCACCGATATCCGCAA
GCCTGCCCGTGCGGCTTTTGCCAATGGCACGGATGCTTTGTCACTCATCAATACGATCAATTCCATCGTGTCTGTCGATC
TCGACACGATGTCGCCCGTGCCTTCCATCGACGGGCGCGGCAGCCATGGCGGCTATTGCGGCCCGGCGGTCAAGCCGATT
GCGCTCAACATGGTGGCGGAGATTGCCCGCGACGCGGAAACGGCGGGTCTGCCGATTTCAGGCATTGGCGGCATCACCAC
CTGGCAGGATGCGGCTGAGTTTATCGCGCTTGGCTGCGGCACGGTGCAGGTCTGCACCGCCGCGATGACCTATGGCTTCA
AGGTCGTGCAGGAGATGATCGACGGTCTTTCCGACTGGATGGACAGCAAGGGCTATCAGACACTCGACGACTTCCAGGGC
TGCGCCGTTTCCCATGTGACCGACTGGCAATATCTCAACCTCAACTATGTCACCAAGGCCCGCATCAATCAGGACCTCTG
CATCCAATGCGGCCGCTGCCACATTGCCTGTGAGGACACCTCGCATCAGGCCATCACGGCCATGGTGAATGGCGCGCGTC
ATTTCGAGGTGATCGACGAGGAATGCGTCGGCTGCAATCTCTGTGTCAATGTCTGCCCGGTGGAGAACTGCATCACCATG
GAGCAGATTTCCGGCGTAGACCCGCGCACGAAGGCGCCCATCATGCCCGCTTACGCCAACTGGACCACGCATCCGAACAA
TCCGGCGGCCATGAAGGAGGCCGCCGAATAA

Upstream 100 bases:

>100_bases
CGAAGCCGTTCTTTCCGGTGCCGCGCATCATGCGCCCGCAGCGCCATCCCGTCACGCAACCGTTCAACCTGGCAGCGAAC
AGGGTTTGGGAGATTGAAAA

Downstream 100 bases:

>100_bases
AAGACTTTCGCAATAGAGCATTTCCAAAAAAGTGCGAAGCGCGTTCAGGCAAACCGTGCCTGAATGGCCTGCGACAGAAG
GGCGACAGGCCGCGTGGTGT

Product: dihydropyrimidine dehydrogenase

Products: uracil; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKASWGGVVWKTLGAEGPPVVNVNGPRYGAIHGADRRLLGLNNIEL
ITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVG
MVVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQG
CAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITM
EQISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE

Sequences:

>Translated_436_residues
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKASWGGVVWKTLGAEGPPVVNVNGPRYGAIHGADRRLLGLNNIEL
ITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVG
MVVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQG
CAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITM
EQISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE
>Mature_435_residues
ADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKASWGGVVWKTLGAEGPPVVNVNGPRYGAIHGADRRLLGLNNIELI
TDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGM
VVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPIA
LNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQGC
AVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITME
QISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=334, Percent_Identity=36.5269461077844, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI87082059, Length=412, Percent_Identity=40.5339805825243, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI71984108, Length=513, Percent_Identity=30.7992202729045, Blast_Score=225, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=26.9113149847095, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640763, Length=315, Percent_Identity=38.4126984126984, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI18858217, Length=315, Percent_Identity=38.4126984126984, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: 1.3.1.2

Molecular weight: Translated: 47234; Mature: 47102

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00198 4FE4S_FERREDOXIN ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKASWGGVVWKTLGAEGPPVVNVNGP
CCCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIHGADRRLLGLNNIELITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKA
CEEEEECCCCEEECCCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGMVVKWCKQYSRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMI
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DGLSDWMDSKGYQTLDDFQGCAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDT
HHHHHHHHCCCCCCHHHHCCCEEEECCCEEEEEEEEEEHHHCCCCHHEECCCEEEEECCC
SHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITMEQISGVDPRTKAPIMPAYAN
CCHHHHHHHCCCHHHEEHHHHHCCCEEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCCC
WTTHPNNPAAMKEAAE
CCCCCCCCHHHHHCCC
>Mature Secondary Structure 
ADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKASWGGVVWKTLGAEGPPVVNVNGP
CCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIHGADRRLLGLNNIELITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKA
CEEEEECCCCEEECCCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGMVVKWCKQYSRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAFANGTDALSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDAETAGLPISGIGGITTWQDAAEFIALGCGTVQVCTAAMTYGFKVVQEMI
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DGLSDWMDSKGYQTLDDFQGCAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDT
HHHHHHHHCCCCCCHHHHCCCEEEECCCEEEEEEEEEEHHHCCCCHHEECCCEEEEECCC
SHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITMEQISGVDPRTKAPIMPAYAN
CCHHHHHHHCCCHHHEEHHHHHCCCEEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCCC
WTTHPNNPAAMKEAAE
CCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; NADP+

Specific reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]