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The map label for this gene is hydA [H]

Identifier: 225851826

GI number: 225851826

Start: 307033

End: 308502

Strand: Reverse

Name: hydA [H]

Synonym: BMEA_A0312

Alternate gene names: 225851826

Gene position: 308502-307033 (Counterclockwise)

Preceding gene: 225851827

Following gene: 225851823

Centisome position: 14.51

GC content: 59.66

Gene sequence:

>1470_bases
ATGGCCAAGACCGGGGCAAGCAAAGTCATCAAGGGCGGCACCGTCATCACGGCTGACCGCACGTTCAGGGCAGATATTCT
TATCGAAGACGACAAGATCGCCGCCATTGGCGATAGCCTTGAAGGCGATGAGGTCATCGACGCATCCGGCTGCTATGTCA
TGCCGGGCGGCATCGACCCGCACACCCACCTGCAAATGCCCTTCATGGGCACATATTCCTCCGACGATTTCGACACGGGC
ACGGCGGCAGCACTTGCCGGCGGCACGACGATGGTGGTCGATTTCGTCCTGCCGGATTCCGAGGGCAATCTTCTGGATGC
GCTTCAGGAATGGTTTCAGAAGGCGGGCAAGGCGCGCACCGATTATTCGTTCCACATAGCGATCACCGGCTGGAACGAGC
GCACTTTCAACGAAATGGTCGAAGTGGTGAAGCGCGGCATCAACACGTTCAAGCATTTCATGGCCTATAAGGGCGCGCTG
ATGGTGAATGACGATGAGATGTTCGCCTCGTTCCAGCGTTGTGCGGAACTGGGTGCCATGCCGCTCGTCCATGCGGAAAA
CGGCGATATCGTCGCGCAATTGCAGGCGAAACTCATGGCCGAAGGCAATGACGGGCCGGAAGCCCATGCCTATTCCCGCC
CGCCGGAAGTGGAAGGAGAAGCCACCAATCGCGCCATCATGATCGCCGATCAGGCGGGCGTACCGCTTTATGTGGTGCAT
GTCTCCTGCGAGCAAAGCCATGAAGCAATCCGCCGCGCGCGCCAGAAGGGTATACGTGTTTTCGGCGAGCCGCTGATCCA
GCATCTGACGCTCGATGAAAGCGAATATCACAATCGCGACTGGGACTATGCCGCGCGGCGCGTGATGTCGCCGCCGTTCC
GCGACAAGCTCAATCAGGACAGCCTCTGGGCGGGCCTTGCGGCTGGAAGCCTGCAATGCGTGGCGACCGATCATTGCGCC
TTCACCACCGAGCAGAAACGCTATGGCATCGGCAATTTCACCAAGATTCCGAACGGCACCGGCGGGCTGGAGGAACGTAT
GCCGGTTCTGTGGACGCGCGGCGTGCGAACGGGCCGCCTGACACCTAATGAGTTCGTGGCCGTCACTTCCACGAACATCG
CGAAAATCCTCAACATCTATCCGCAGAAAGGTGCCGTGGTGCCAGGCGCGGACGCCGATCTTGTTATATGGGATCCGGAG
GCGACCAAGAAGATTTCCGCCAAGACGCAGCATTCCTCCATCGATTACAACGTGTTCGAGGGTTTCGAGCTGAAGGGGCT
GCCGATCATGACGCTGTCGCGCGGGCGGATCGCCTTCGACAAGGGACAGGTGACAGCAAAACCGGGCGACGGGCGCTTCA
TCGAGCGTGAGCCGAATGGCGCGGTCAATCGCGCGCTATCGCAATGGAAGGAAATTGTCGCGCCGCGCAAGGTGGAGCGC
AGTGCCGAACATATGCCGATAGGAGTCTGA

Upstream 100 bases:

>100_bases
CGACGTGCTTCTGCATGCTGTATTGGAGACTGCTGAAATTGTAAGCTGAACTTCCCAATACCGCTGTTCGCAACAAAACC
AACAAGGGGAACGACGAACA

Downstream 100 bases:

>100_bases
TGCGATGACCATGGCTCAGCTTCGGGAAGTGCATATGATGAACGTCAATAGCATGGCCCCGGAGCGGGGCCCGAAAGCAG
ACGGGAAGCGTGCTTCCGGG

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MAKTGASKVIKGGTVITADRTFRADILIEDDKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTG
TAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHIAITGWNERTFNEMVEVVKRGINTFKHFMAYKGAL
MVNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
VSCEQSHEAIRRARQKGIRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCA
FTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPE
ATKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
SAEHMPIGV

Sequences:

>Translated_489_residues
MAKTGASKVIKGGTVITADRTFRADILIEDDKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTG
TAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHIAITGWNERTFNEMVEVVKRGINTFKHFMAYKGAL
MVNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
VSCEQSHEAIRRARQKGIRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCA
FTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPE
ATKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
SAEHMPIGV
>Mature_488_residues
AKTGASKVIKGGTVITADRTFRADILIEDDKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTGT
AAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHIAITGWNERTFNEMVEVVKRGINTFKHFMAYKGALM
VNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHV
SCEQSHEAIRRARQKGIRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCAF
TTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPEA
TKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVERS
AEHMPIGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=484, Percent_Identity=46.0743801652893, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI4503379, Length=456, Percent_Identity=47.1491228070175, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI190194363, Length=455, Percent_Identity=47.6923076923077, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=46.4912280701754, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=44.8351648351648, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=44.8351648351648, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI19923821, Length=480, Percent_Identity=43.125, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=26.3285024154589, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=40.4814004376368, Blast_Score=334, Evalue=9e-93,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=31.5789473684211, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=47.4120082815735, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71989490, Length=482, Percent_Identity=45.643153526971, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI86575075, Length=457, Percent_Identity=32.6039387308534, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI193204318, Length=438, Percent_Identity=25.7990867579909, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=410, Percent_Identity=26.3414634146341, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=46.5934065934066, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=46.1368653421634, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24644287, Length=308, Percent_Identity=44.1558441558442, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24644289, Length=229, Percent_Identity=46.7248908296943, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24642586, Length=408, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI18859883, Length=463, Percent_Identity=22.2462203023758, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53632; Mature: 53501

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTGASKVIKGGTVITADRTFRADILIEDDKIAAIGDSLEGDEVIDASGCYVMPGGIDP
CCCCCCCCEECCCEEEEECCCEEEEEEEECCCEEEECCCCCCCCEEECCCCEEECCCCCC
HTHLQMPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKART
CCEEECCEEECCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
DYSFHIAITGWNERTFNEMVEVVKRGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAM
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCC
PLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
CEEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
VSCEQSHEAIRRARQKGIRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQD
ECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHCCCC
SLWAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRL
HHHHHHCCCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCC
TPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPEATKKISAKTQHSSIDYNVFE
CCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCCCCCCCEEEEC
GFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
CCEECCCEEEEECCCEEEEECCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHH
SAEHMPIGV
CCCCCCCCC
>Mature Secondary Structure 
AKTGASKVIKGGTVITADRTFRADILIEDDKIAAIGDSLEGDEVIDASGCYVMPGGIDP
CCCCCCCEECCCEEEEECCCEEEEEEEECCCEEEECCCCCCCCEEECCCCEEECCCCCC
HTHLQMPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKART
CCEEECCEEECCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
DYSFHIAITGWNERTFNEMVEVVKRGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAM
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCC
PLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
CEEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
VSCEQSHEAIRRARQKGIRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQD
ECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHCCCC
SLWAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRL
HHHHHHCCCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCC
TPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPEATKKISAKTQHSSIDYNVFE
CCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHCCCCCCCCCCEEEEC
GFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
CCEECCCEEEEECCCEEEEECCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHH
SAEHMPIGV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]