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The map label for this gene is zraS [H]

Identifier: 225851823

GI number: 225851823

Start: 300703

End: 302328

Strand: Reverse

Name: zraS [H]

Synonym: BMEA_A0308

Alternate gene names: 225851823

Gene position: 302328-300703 (Counterclockwise)

Preceding gene: 225851826

Following gene: 225851814

Centisome position: 14.22

GC content: 58.61

Gene sequence:

>1626_bases
TTGCATGCCAAAGCCGGACCGCACCGGGCACGAGGGCCTGCCTGCGGACGACTCACCGATTTGGAACCTGACATGGCGGT
TGCTGACAAAACCATCGATACAAGCGGCACTTCCCCTCAAGCCGCTTCACCTGCCGCCGCTGACGACAGAACGTCCTCAA
CGCAATTCACCCGGCTGCGCTGGCGCAACCGGCTGTCCAACAAGCTTTTGCTTCTGACGGCGCTGGCCGTTCTCATTGCT
GAAGTGCTGATTTTCGTGCCTTCCATCGCCAATATGCGGGTGCGCTGGATGAATTCACGCCTCGATACGGTCGGCGCGGT
GAGCGAGGTTCTGGCCTCCAGCGACAGTATGGAAGTGCCGCGCGACATTCAGGACAAGGTGCTTCTGGCGACCGGCACCA
AGGCCATTGCCCTTCGCGAAGCGGGGGCATCGCGTCTTCTGGCCCTGACCGAGATGCCGCGCAAGATCGATAAGGTTATC
GATCTGGACAATATCAGTGAAGCGGGCGCCATATGGGATACTTTTGACACGCTGTTCAATGGCGGCAACCGCACCTTGCG
CATTTACGGCACTGTTTCGCCATCGACATCGCCGGGGCGAATCATCGAAATCGTCACTTCCGACGCACCGTTGCGCCATG
CCATGCTGGTTTATGCGCGCAATGTGGCGCTTATCTCGCTCATCATTTCAGTGATCGCTGCAAGCCTTGTCTATCTCATC
ATCCATGAGATGCTGTTGCGGCCTGTGCGCATCATGCATCGCAACATGATCGATTTTGCCACCACGCCCGACAATCCGGC
GCTCATACTCGTACCGGAAAATCGTAAGGACGAGTTCGGCGTCGCGCAACGCCAGATCGCCCATATTCAAAGCGACCTGC
AACGCACGCTAAAAGAGCAAAAACATCTGGCCGATCTCGGCCTTGCCGTCTCCAAGATCAATCACGACATGCGCAACATT
CTTGCTTCCGCCCAGCTCATGTCCGACCGTCTGGCCGATACGAACGATCCCATGGTGCAGCGTTTTGCGCCAAAACTCAT
CCGCACGCTCAGCCGCGCCATCAGCTATTCGGAAAGCGTGATCGCCTATGGCCGCTCGCAGGAAGAACCGCCGAAACCTC
GTCGTGTGCTTCTGCACGCCATCATCACCGATGTGCAGAACACGCTCAATCTCAGCGCCGAATCCGGGATCGAGTTCCAG
AATCTGGTGCCCGAAAATTTCGAGCTGGATGTCGATTCGGAACAGCTCTTCCGCGTGCTCAGCAATCTGTGCCGCAATTC
CGTGCAGGCCATGGAGCGCGACCAGAGCAGCGATGCTGCAACGATCAAGCGACTGACGATTTCCGCCGGGCGTATCGGCA
CGACGGCGATCATCGGGGTCGAGGATACGGGGCCCGGCCTGCCGCAAAAGGCCCGTGACAATCTTTTCACCGCCTTCAAA
GGCTCAACGCGCAGCGACGGCACCGGGCTCGGCCTTGCCATCGCACAGGAATTGATCCGGGCACATGGCGGGACAATCGA
ATTGCGGGAAGACCGGCCCATCGGCGCGCATTTCGAGATTCGCCTGCCTGATTTGCCGATGCAGCGTGACACTCGCAACA
ATCAGCAGGCAGAGGAGAGTGCCTGA

Upstream 100 bases:

>100_bases
AATGCATCAATACGCCTCGGTCGCGCACGGTTTTTAACCCCGTCGGCAAAGGGCGTTGGAATTATGCTGCGACAGCATAT
ATAGGAAGCTACATTTATTC

Downstream 100 bases:

>100_bases
AGCAATCTTCACGGCCTGCATGGGAGGATAAAAAGCCGGGAAAGCGGGCATCTGCAAGAAATCTTCACATAAGCGCATTT
TTTTCTCAGAAGACGCTTGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MHAKAGPHRARGPACGRLTDLEPDMAVADKTIDTSGTSPQAASPAAADDRTSSTQFTRLRWRNRLSNKLLLLTALAVLIA
EVLIFVPSIANMRVRWMNSRLDTVGAVSEVLASSDSMEVPRDIQDKVLLATGTKAIALREAGASRLLALTEMPRKIDKVI
DLDNISEAGAIWDTFDTLFNGGNRTLRIYGTVSPSTSPGRIIEIVTSDAPLRHAMLVYARNVALISLIISVIAASLVYLI
IHEMLLRPVRIMHRNMIDFATTPDNPALILVPENRKDEFGVAQRQIAHIQSDLQRTLKEQKHLADLGLAVSKINHDMRNI
LASAQLMSDRLADTNDPMVQRFAPKLIRTLSRAISYSESVIAYGRSQEEPPKPRRVLLHAIITDVQNTLNLSAESGIEFQ
NLVPENFELDVDSEQLFRVLSNLCRNSVQAMERDQSSDAATIKRLTISAGRIGTTAIIGVEDTGPGLPQKARDNLFTAFK
GSTRSDGTGLGLAIAQELIRAHGGTIELREDRPIGAHFEIRLPDLPMQRDTRNNQQAEESA

Sequences:

>Translated_541_residues
MHAKAGPHRARGPACGRLTDLEPDMAVADKTIDTSGTSPQAASPAAADDRTSSTQFTRLRWRNRLSNKLLLLTALAVLIA
EVLIFVPSIANMRVRWMNSRLDTVGAVSEVLASSDSMEVPRDIQDKVLLATGTKAIALREAGASRLLALTEMPRKIDKVI
DLDNISEAGAIWDTFDTLFNGGNRTLRIYGTVSPSTSPGRIIEIVTSDAPLRHAMLVYARNVALISLIISVIAASLVYLI
IHEMLLRPVRIMHRNMIDFATTPDNPALILVPENRKDEFGVAQRQIAHIQSDLQRTLKEQKHLADLGLAVSKINHDMRNI
LASAQLMSDRLADTNDPMVQRFAPKLIRTLSRAISYSESVIAYGRSQEEPPKPRRVLLHAIITDVQNTLNLSAESGIEFQ
NLVPENFELDVDSEQLFRVLSNLCRNSVQAMERDQSSDAATIKRLTISAGRIGTTAIIGVEDTGPGLPQKARDNLFTAFK
GSTRSDGTGLGLAIAQELIRAHGGTIELREDRPIGAHFEIRLPDLPMQRDTRNNQQAEESA
>Mature_541_residues
MHAKAGPHRARGPACGRLTDLEPDMAVADKTIDTSGTSPQAASPAAADDRTSSTQFTRLRWRNRLSNKLLLLTALAVLIA
EVLIFVPSIANMRVRWMNSRLDTVGAVSEVLASSDSMEVPRDIQDKVLLATGTKAIALREAGASRLLALTEMPRKIDKVI
DLDNISEAGAIWDTFDTLFNGGNRTLRIYGTVSPSTSPGRIIEIVTSDAPLRHAMLVYARNVALISLIISVIAASLVYLI
IHEMLLRPVRIMHRNMIDFATTPDNPALILVPENRKDEFGVAQRQIAHIQSDLQRTLKEQKHLADLGLAVSKINHDMRNI
LASAQLMSDRLADTNDPMVQRFAPKLIRTLSRAISYSESVIAYGRSQEEPPKPRRVLLHAIITDVQNTLNLSAESGIEFQ
NLVPENFELDVDSEQLFRVLSNLCRNSVQAMERDQSSDAATIKRLTISAGRIGTTAIIGVEDTGPGLPQKARDNLFTAFK
GSTRSDGTGLGLAIAQELIRAHGGTIELREDRPIGAHFEIRLPDLPMQRDTRNNQQAEESA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=25.6302521008403, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=27.0161290322581, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790300, Length=119, Percent_Identity=39.4957983193277, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=25.938566552901, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59438; Mature: 59438

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAKAGPHRARGPACGRLTDLEPDMAVADKTIDTSGTSPQAASPAAADDRTSSTQFTRLR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
WRNRLSNKLLLLTALAVLIAEVLIFVPSIANMRVRWMNSRLDTVGAVSEVLASSDSMEVP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RDIQDKVLLATGTKAIALREAGASRLLALTEMPRKIDKVIDLDNISEAGAIWDTFDTLFN
CCHHCCEEEEECCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GGNRTLRIYGTVSPSTSPGRIIEIVTSDAPLRHAMLVYARNVALISLIISVIAASLVYLI
CCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHEMLLRPVRIMHRNMIDFATTPDNPALILVPENRKDEFGVAQRQIAHIQSDLQRTLKEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KHLADLGLAVSKINHDMRNILASAQLMSDRLADTNDPMVQRFAPKLIRTLSRAISYSESV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
IAYGRSQEEPPKPRRVLLHAIITDVQNTLNLSAESGIEFQNLVPENFELDVDSEQLFRVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHCCCCCCEECCCHHHHHHHH
SNLCRNSVQAMERDQSSDAATIKRLTISAGRIGTTAIIGVEDTGPGLPQKARDNLFTAFK
HHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCEEEEEECCCCCCCCHHHHHCEEEHCC
GSTRSDGTGLGLAIAQELIRAHGGTIELREDRPIGAHFEIRLPDLPMQRDTRNNQQAEES
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHCC
A
C
>Mature Secondary Structure
MHAKAGPHRARGPACGRLTDLEPDMAVADKTIDTSGTSPQAASPAAADDRTSSTQFTRLR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
WRNRLSNKLLLLTALAVLIAEVLIFVPSIANMRVRWMNSRLDTVGAVSEVLASSDSMEVP
HHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RDIQDKVLLATGTKAIALREAGASRLLALTEMPRKIDKVIDLDNISEAGAIWDTFDTLFN
CCHHCCEEEEECCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GGNRTLRIYGTVSPSTSPGRIIEIVTSDAPLRHAMLVYARNVALISLIISVIAASLVYLI
CCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHEMLLRPVRIMHRNMIDFATTPDNPALILVPENRKDEFGVAQRQIAHIQSDLQRTLKEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KHLADLGLAVSKINHDMRNILASAQLMSDRLADTNDPMVQRFAPKLIRTLSRAISYSESV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
IAYGRSQEEPPKPRRVLLHAIITDVQNTLNLSAESGIEFQNLVPENFELDVDSEQLFRVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHCCCCCCEECCCHHHHHHHH
SNLCRNSVQAMERDQSSDAATIKRLTISAGRIGTTAIIGVEDTGPGLPQKARDNLFTAFK
HHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCEEEEEECCCCCCCCHHHHHCEEEHCC
GSTRSDGTGLGLAIAQELIRAHGGTIELREDRPIGAHFEIRLPDLPMQRDTRNNQQAEES
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]