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The map label for this gene is gdhA [H]

Identifier: 225851754

GI number: 225851754

Start: 238589

End: 239854

Strand: Reverse

Name: gdhA [H]

Synonym: BMEA_A0235

Alternate gene names: 225851754

Gene position: 239854-238589 (Counterclockwise)

Preceding gene: 225851760

Following gene: 225851753

Centisome position: 11.28

GC content: 60.9

Gene sequence:

>1266_bases
GTGACCACGGAAAATCTGCTCGAAAGTGCACTCGTCCGGCTGGACGAAGCGGCAAGCCACATAAACATCGATGCGGATGT
CATCGAAAAGCTGAAGTTTGCGCGTGAGACCATGAAAGTGCGGTTGATGATCCGCATGGACGACGGTTCGCGCAAGTCCT
TTATTGCGTGGCGCTGCCGCTATGACGACACTCGCGGACCGACCAAGGGCGGCATCCGCTACCATCCCGATTCAACGGTG
GAAGAAGTCGAGACGCCCGCCTTCTGGATGACCTTCAAATGCGCCGTGATGAACCTGCCTTATGGCGGCGGCAAGGGCGC
GATCCAGGTCGATCCGCGCCAGCTCTCCAAGGCTGAACTGGAGCGCCTTTCGCGCGCCTATATCCAGGCTTTCTCCGGCA
TCATCGGCCCGGACCGCGACATTCCGGCCCCGGACGTCTATACGAATTCCATGATCATGGGCTGGATGGCTGACGAATAC
TCCCAGATCGTCGGCCAGTCCTCTCCCGCCGTCATTACCGGCAAGCCCATCGCACTTGGTGGCTCGCTCGGACGCAATGA
CGCGACCGCACGCGGCGGCTTCTACCTCGTTCGCCACCTCTCGCACGATCTGGGCCTCGCTTCGGTTCTGCGCGTCGCCA
TCCAGGGTTTTGGCAATGCCGGACAGTTCATGGCCAAGCTGATGGCGGGCGACGGCCACAAGATCGTCGCCGTGTCGGAT
TCCGCAGGGGCGGTCTATTGCGCGGATGGCCTTGACGTCGACCTGCTTCTGGCCGCCAAGGCTGATGGCAAGTCCGTCAT
TTCAACCGCCGGTCACAAGGGCCACGAGGCGATCAGCGCCGACGAACTCGTCGCCGCCGATTGTGACGTGCTGGTGCCAA
GCGCCATGGAAAACATGATCCATGCCGGTAATGCAGCTTCCATTCGCGCCAAGCTTATCGTGGAACTGGCCAACGGCCCG
GTCACGGGGGACGCTGACAAGATCCTCGCCGAAAAGGGCGTGATGGTCCTGCCGGACATTCTTGCCAATGCTGGCGGCGT
GACGGTTTCCTATTTTGAATGGGTGCAGAACCGTCAGGGTTATTACTGGACGCTTGAAGAAATCCATGAACGCCTGAAGA
CGATCATGGAACGCGAAGGCCGCGCCATCTGGAACCATGCCCGCGAACGCGGTGTGACCCTGCGCACGGCTGCCTATGTG
CATGCGCTGGAGCGCCTTGCACAAGCGATCGAGGCCCACGGCACGCAAAACGACTTCGCGGCCTGA

Upstream 100 bases:

>100_bases
ACACTATTGTCCTTTTTGCTTTCCTTTTGTTGCGCAAAGGCGTAGTCAGAAATACGCAAAATCGCATTTTTAAAAACATA
CACGCAAGAAAGGTGATTTC

Downstream 100 bases:

>100_bases
TTCACTCTACGAACGTTACCCTCCTGTCGGATTACCGGCGGGAGGGGACAAAAAGCGGTTTCTTTTTCCGCCCGCACGAC
AATCTTGAGCTGCTGGCGCC

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTTENLLESALVRLDEAASHINIDADVIEKLKFARETMKVRLMIRMDDGSRKSFIAWRCRYDDTRGPTKGGIRYHPDSTV
EEVETPAFWMTFKCAVMNLPYGGGKGAIQVDPRQLSKAELERLSRAYIQAFSGIIGPDRDIPAPDVYTNSMIMGWMADEY
SQIVGQSSPAVITGKPIALGGSLGRNDATARGGFYLVRHLSHDLGLASVLRVAIQGFGNAGQFMAKLMAGDGHKIVAVSD
SAGAVYCADGLDVDLLLAAKADGKSVISTAGHKGHEAISADELVAADCDVLVPSAMENMIHAGNAASIRAKLIVELANGP
VTGDADKILAEKGVMVLPDILANAGGVTVSYFEWVQNRQGYYWTLEEIHERLKTIMEREGRAIWNHARERGVTLRTAAYV
HALERLAQAIEAHGTQNDFAA

Sequences:

>Translated_421_residues
MTTENLLESALVRLDEAASHINIDADVIEKLKFARETMKVRLMIRMDDGSRKSFIAWRCRYDDTRGPTKGGIRYHPDSTV
EEVETPAFWMTFKCAVMNLPYGGGKGAIQVDPRQLSKAELERLSRAYIQAFSGIIGPDRDIPAPDVYTNSMIMGWMADEY
SQIVGQSSPAVITGKPIALGGSLGRNDATARGGFYLVRHLSHDLGLASVLRVAIQGFGNAGQFMAKLMAGDGHKIVAVSD
SAGAVYCADGLDVDLLLAAKADGKSVISTAGHKGHEAISADELVAADCDVLVPSAMENMIHAGNAASIRAKLIVELANGP
VTGDADKILAEKGVMVLPDILANAGGVTVSYFEWVQNRQGYYWTLEEIHERLKTIMEREGRAIWNHARERGVTLRTAAYV
HALERLAQAIEAHGTQNDFAA
>Mature_420_residues
TTENLLESALVRLDEAASHINIDADVIEKLKFARETMKVRLMIRMDDGSRKSFIAWRCRYDDTRGPTKGGIRYHPDSTVE
EVETPAFWMTFKCAVMNLPYGGGKGAIQVDPRQLSKAELERLSRAYIQAFSGIIGPDRDIPAPDVYTNSMIMGWMADEYS
QIVGQSSPAVITGKPIALGGSLGRNDATARGGFYLVRHLSHDLGLASVLRVAIQGFGNAGQFMAKLMAGDGHKIVAVSDS
AGAVYCADGLDVDLLLAAKADGKSVISTAGHKGHEAISADELVAADCDVLVPSAMENMIHAGNAASIRAKLIVELANGPV
TGDADKILAEKGVMVLPDILANAGGVTVSYFEWVQNRQGYYWTLEEIHERLKTIMEREGRAIWNHARERGVTLRTAAYVH
ALERLAQAIEAHGTQNDFAA

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI4885281, Length=454, Percent_Identity=34.1409691629956, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI31377775, Length=454, Percent_Identity=33.7004405286344, Blast_Score=255, Evalue=6e-68,
Organism=Escherichia coli, GI1788059, Length=360, Percent_Identity=30.2777777777778, Blast_Score=158, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17544676, Length=476, Percent_Identity=32.7731092436975, Blast_Score=247, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6319256, Length=413, Percent_Identity=28.3292978208232, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324951, Length=366, Percent_Identity=28.1420765027322, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45553475, Length=435, Percent_Identity=32.183908045977, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI45549226, Length=448, Percent_Identity=30.8035714285714, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24649283, Length=480, Percent_Identity=32.0833333333333, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24649460, Length=396, Percent_Identity=31.3131313131313, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 45614; Mature: 45482

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTENLLESALVRLDEAASHINIDADVIEKLKFARETMKVRLMIRMDDGSRKSFIAWRCR
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEEEEEE
YDDTRGPTKGGIRYHPDSTVEEVETPAFWMTFKCAVMNLPYGGGKGAIQVDPRQLSKAEL
CCCCCCCCCCCEEECCCCHHHHHCCCEEEEEEEEEEEECCCCCCCCCEEECHHHHHHHHH
ERLSRAYIQAFSGIIGPDRDIPAPDVYTNSMIMGWMADEYSQIVGQSSPAVITGKPIALG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEECCCEEEC
GSLGRNDATARGGFYLVRHLSHDLGLASVLRVAIQGFGNAGQFMAKLMAGDGHKIVAVSD
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEC
SAGAVYCADGLDVDLLLAAKADGKSVISTAGHKGHEAISADELVAADCDVLVPSAMENMI
CCCEEEEECCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHCCCCEECHHHHHHHH
HAGNAASIRAKLIVELANGPVTGDADKILAEKGVMVLPDILANAGGVTVSYFEWVQNRQG
HCCCCHHEEEEEEEEECCCCCCCCHHHHHHHCCCEEEHHHHCCCCCCCHHHHHHHHCCCC
YYWTLEEIHERLKTIMEREGRAIWNHARERGVTLRTAAYVHALERLAQAIEAHGTQNDFA
EEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
A
C
>Mature Secondary Structure 
TTENLLESALVRLDEAASHINIDADVIEKLKFARETMKVRLMIRMDDGSRKSFIAWRCR
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEEEEEE
YDDTRGPTKGGIRYHPDSTVEEVETPAFWMTFKCAVMNLPYGGGKGAIQVDPRQLSKAEL
CCCCCCCCCCCEEECCCCHHHHHCCCEEEEEEEEEEEECCCCCCCCCEEECHHHHHHHHH
ERLSRAYIQAFSGIIGPDRDIPAPDVYTNSMIMGWMADEYSQIVGQSSPAVITGKPIALG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEECCCEEEC
GSLGRNDATARGGFYLVRHLSHDLGLASVLRVAIQGFGNAGQFMAKLMAGDGHKIVAVSD
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEC
SAGAVYCADGLDVDLLLAAKADGKSVISTAGHKGHEAISADELVAADCDVLVPSAMENMI
CCCEEEEECCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHCCCCEECHHHHHHHH
HAGNAASIRAKLIVELANGPVTGDADKILAEKGVMVLPDILANAGGVTVSYFEWVQNRQG
HCCCCHHEEEEEEEEECCCCCCCCHHHHHHHCCCEEEHHHHCCCCCCCHHHHHHHHCCCC
YYWTLEEIHERLKTIMEREGRAIWNHARERGVTLRTAAYVHALERLAQAIEAHGTQNDFA
EEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7787182; 8590279; 8905231 [H]