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The map label for this gene is pyrE [H]

Identifier: 222527452

GI number: 222527452

Start: 5261288

End: 5261947

Strand: Direct

Name: pyrE [H]

Synonym: Chy400_4243

Alternate gene names: 222527452

Gene position: 5261288-5261947 (Clockwise)

Preceding gene: 222527451

Following gene: 222527453

Centisome position: 99.85

GC content: 58.79

Gene sequence:

>660_bases
ATGACCGAGGCGAATCTCTTAACCATCCTTCAGGAATTAGGAGCAATTGTCACCAACGACCATATCGTGTACACCTCTGG
GCGCCACGGCAGTAGTTATGTCAACAAAGACGCACTCTACCCACACACGGCTGCGGCCAGCATGGTGGGGGCTGCTCTGG
CTGGACACTTTGCCACCGCCGGGGTCGAGACCGTTGCCGGGCCAACCATTGGTGGAGTCATTATGGCACAATGGACGGCT
CATCACCTGTCGCAGATCTGCGGACGTGAAGTGCTGGCCGTGTATGCCGAAGAAGAGCAGCATGACACCGGCAAGCGACG
GGTCTTCCGGCGCGGCTACGATGCCCATATTGCCGGAAAGCGCGTTCTGGTGGTCGAGGATGTGATAACGACTGGTGGTT
CAGTCCGCCTGGTGGTGGAAGCGGTAACCGCTGCCGGCGGAGTTGTCGTCGGCGTTGGTGCATTGTGCAATCGCGGCGGC
ATCAGCGCTGCCGATCTCGGTATTCCGCAACTAGTTGCGCTGACCGAATTGCCGCTGGAAAGCTATCCGGCGGAAACCTG
CCCTCTCTGTGCTGCCGGTGTGCCTGTCAACACCCGGCTGGGCAAAGGCGCAGCGTATGTTCGTAACCTGACAACAAACC
CATCATCACCAACGTCATAA

Upstream 100 bases:

>100_bases
CATCGGACGACCAATTACTGCGCCACCGGCAATCATCGGCGATCCGGTCACCGCAGTCGCACGGATTCTTGCAGAATTGG
AACAGGAATGATAGAAGCTT

Downstream 100 bases:

>100_bases
CAGCACTGGTGTGAACAACGGCAGGCGTTACGAACAGCCCACGTTGTGGGGAATAACAGATAGCGGTAAACCAGGCTGAC
ACACAAACACGCGCAACGTA

Product: phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATAGVETVAGPTIGGVIMAQWTA
HHLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGKRVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGG
ISAADLGIPQLVALTELPLESYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS

Sequences:

>Translated_219_residues
MTEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATAGVETVAGPTIGGVIMAQWTA
HHLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGKRVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGG
ISAADLGIPQLVALTELPLESYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS
>Mature_218_residues
TEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATAGVETVAGPTIGGVIMAQWTAH
HLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGKRVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGGI
SAADLGIPQLVALTELPLESYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22625; Mature: 22494

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATA
CCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GVETVAGPTIGGVIMAQWTAHHLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGK
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEHECCCHHCCHHHHHHHHCCCCCEECCC
RVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGGISAADLGIPQLVALTELPLE
EEEEEEHHHHCCCCEEEEEEEHHHCCCCEEEHHHHHCCCCCCHHHCCCHHHHHHHHCCHH
SYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS
HCCCCCCCCEECCCCCCCCCCCCHHHHEECCCCCCCCCC
>Mature Secondary Structure 
TEANLLTILQELGAIVTNDHIVYTSGRHGSSYVNKDALYPHTAAASMVGAALAGHFATA
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GVETVAGPTIGGVIMAQWTAHHLSQICGREVLAVYAEEEQHDTGKRRVFRRGYDAHIAGK
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEHECCCHHCCHHHHHHHHCCCCCEECCC
RVLVVEDVITTGGSVRLVVEAVTAAGGVVVGVGALCNRGGISAADLGIPQLVALTELPLE
EEEEEEHHHHCCCCEEEEEEEHHHCCCCEEEHHHHHCCCCCCHHHCCCHHHHHHHHCCHH
SYPAETCPLCAAGVPVNTRLGKGAAYVRNLTTNPSSPTS
HCCCCCCCCEECCCCCCCCCCCCHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]