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The map label for this gene is bioD [C]

Identifier: 222527447

GI number: 222527447

Start: 5257567

End: 5258637

Strand: Direct

Name: bioD [C]

Synonym: Chy400_4238

Alternate gene names: 222527447

Gene position: 5257567-5258637 (Clockwise)

Preceding gene: 222527446

Following gene: 222527448

Centisome position: 99.78

GC content: 55.74

Gene sequence:

>1071_bases
ATGGCAACACTGTATGTCGCCTCAACCGAAACCTACGTCGGCAAAAGTGCGGTGTGTGTGGGATTGCTGCGGCGGATGCA
GCAAGATGGCTTTCGCGTCGGGTATATGAAGCCGGTGAGCGTTTCGGTAACGCACACACCTGATGCGGTTCTCGATGAAG
ATGCTGCCTTTATCCGCCAAACCATTGGCCTGGATGCGCCGATGGAGCAGGTGGCGCCGGTGTTGATTACACCGGGAGTG
ATCGAGTCCATTTTACGTGGACAACCACACTCATTTGCCAAAACGCTGCGCGATGCTTACCTGGCCGTGTCGCGTCAGAA
AGATATTGTTGTCCTCGAAGGGACAAACACCTGGGCCGAGGGAGCATTGGTCGATCTGACCGCCGATCAGGTTACTGATA
TGCTCCAGGCTCCTGGTCTGCTCGTCTGTCGTTACACCTCAACCCTGTCGGTTGATACCATTCTGAGCGTGCAGCGTTAT
GTTGGGGATCGCCTGCTTGGGGTGTTGATCAATCAGGTCGAAGAACCGCACCGCGAGTTTGTGCGTAATCGGGTCACCCC
ATTCCTGGAGGGGCGTGGGATTCCGGTGCTGGGTATTCTGCCACGTGACCGCTTGCTCTCCGGGGTAACGGTGAACGAGC
TGGCTCAACATCTTGGCGGTCAGCTCATTGGGCGCCCAGAATGGGGTGAAAAGATGCTCGATTCGTTGATGATCGGGGCA
ATGGGCGCTGAGGCAAGCCTCTCATTCTTCCGTCGCCGGGCCAATAAGGCGGTGATTACCGGCGGCGACCGTAGCGATCT
ACAGTTGATCGCGTTGCAAACCAGTACCAATGCCCTGGTATTGACCGGTAATATCCGGCCAACGATGCAGGTGATGGATC
GGGCTGCCGAATTGGAAGTGCCGATTATCCTGGTTGCCGATGACACGCTGAGCACCGTTGATCGCGCTGAACGGTTGTTT
GGCAGAGTTCGGTTCCACCAGGAAGCGAAACTGCGCCGCTTTACCGAATTGCTTGATACGCATTTCGATTTTGATCGACT
GTATCGCCTGTTGGGGTTGCAAATCCATTAG

Upstream 100 bases:

>100_bases
AAATTGTCGAGATGGATATCAATCCACTCGTCGTCCATCATGAAGGTGAGGGCGCAGTCGTCCTCGATGCCCGGATCATC
CTCAACTAATGGAGGCAATG

Downstream 100 bases:

>100_bases
GAAGTGTTATGACGACCGATCCGTTGCCCGAAAATGCCGAGGTGATCGGCCCATTGATCTTCGTGCCCAATCCTGACTAT
CCCTATCCGTTTCCGGTTGC

Product: DRTGG domain-containing protein

Products: ADP; Dethiobiotin; H+; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MATLYVASTETYVGKSAVCVGLLRRMQQDGFRVGYMKPVSVSVTHTPDAVLDEDAAFIRQTIGLDAPMEQVAPVLITPGV
IESILRGQPHSFAKTLRDAYLAVSRQKDIVVLEGTNTWAEGALVDLTADQVTDMLQAPGLLVCRYTSTLSVDTILSVQRY
VGDRLLGVLINQVEEPHREFVRNRVTPFLEGRGIPVLGILPRDRLLSGVTVNELAQHLGGQLIGRPEWGEKMLDSLMIGA
MGAEASLSFFRRRANKAVITGGDRSDLQLIALQTSTNALVLTGNIRPTMQVMDRAAELEVPIILVADDTLSTVDRAERLF
GRVRFHQEAKLRRFTELLDTHFDFDRLYRLLGLQIH

Sequences:

>Translated_356_residues
MATLYVASTETYVGKSAVCVGLLRRMQQDGFRVGYMKPVSVSVTHTPDAVLDEDAAFIRQTIGLDAPMEQVAPVLITPGV
IESILRGQPHSFAKTLRDAYLAVSRQKDIVVLEGTNTWAEGALVDLTADQVTDMLQAPGLLVCRYTSTLSVDTILSVQRY
VGDRLLGVLINQVEEPHREFVRNRVTPFLEGRGIPVLGILPRDRLLSGVTVNELAQHLGGQLIGRPEWGEKMLDSLMIGA
MGAEASLSFFRRRANKAVITGGDRSDLQLIALQTSTNALVLTGNIRPTMQVMDRAAELEVPIILVADDTLSTVDRAERLF
GRVRFHQEAKLRRFTELLDTHFDFDRLYRLLGLQIH
>Mature_355_residues
ATLYVASTETYVGKSAVCVGLLRRMQQDGFRVGYMKPVSVSVTHTPDAVLDEDAAFIRQTIGLDAPMEQVAPVLITPGVI
ESILRGQPHSFAKTLRDAYLAVSRQKDIVVLEGTNTWAEGALVDLTADQVTDMLQAPGLLVCRYTSTLSVDTILSVQRYV
GDRLLGVLINQVEEPHREFVRNRVTPFLEGRGIPVLGILPRDRLLSGVTVNELAQHLGGQLIGRPEWGEKMLDSLMIGAM
GAEASLSFFRRRANKAVITGGDRSDLQLIALQTSTNALVLTGNIRPTMQVMDRAAELEVPIILVADDTLSTVDRAERLFG
RVRFHQEAKLRRFTELLDTHFDFDRLYRLLGLQIH

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0857

COG function: function code R; BioD-like N-terminal domain of phosphotransacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To A.fulgidus AF1212 [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR010766 [H]

Pfam domain/function: PF01656 CbiA; PF07085 DRTGG [H]

EC number: 6.3.3.3 [C]

Molecular weight: Translated: 39418; Mature: 39287

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLYVASTETYVGKSAVCVGLLRRMQQDGFRVGYMKPVSVSVTHTPDAVLDEDAAFIRQ
CEEEEEECCCHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCHHHCHHHHHHHH
TIGLDAPMEQVAPVLITPGVIESILRGQPHSFAKTLRDAYLAVSRQKDIVVLEGTNTWAE
HHCCCCCHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GALVDLTADQVTDMLQAPGLLVCRYTSTLSVDTILSVQRYVGDRLLGVLINQVEEPHREF
CEEEEECHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNRVTPFLEGRGIPVLGILPRDRLLSGVTVNELAQHLGGQLIGRPEWGEKMLDSLMIGA
HHHCCCHHHCCCCCCEEEECCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MGAEASLSFFRRRANKAVITGGDRSDLQLIALQTSTNALVLTGNIRPTMQVMDRAAELEV
CCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
PIILVADDTLSTVDRAERLFGRVRFHQEAKLRRFTELLDTHFDFDRLYRLLGLQIH
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
ATLYVASTETYVGKSAVCVGLLRRMQQDGFRVGYMKPVSVSVTHTPDAVLDEDAAFIRQ
EEEEEECCCHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCHHHCHHHHHHHH
TIGLDAPMEQVAPVLITPGVIESILRGQPHSFAKTLRDAYLAVSRQKDIVVLEGTNTWAE
HHCCCCCHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GALVDLTADQVTDMLQAPGLLVCRYTSTLSVDTILSVQRYVGDRLLGVLINQVEEPHREF
CEEEEECHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRNRVTPFLEGRGIPVLGILPRDRLLSGVTVNELAQHLGGQLIGRPEWGEKMLDSLMIGA
HHHCCCHHHCCCCCCEEEECCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MGAEASLSFFRRRANKAVITGGDRSDLQLIALQTSTNALVLTGNIRPTMQVMDRAAELEV
CCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
PIILVADDTLSTVDRAERLFGRVRFHQEAKLRRFTELLDTHFDFDRLYRLLGLQIH
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 10 {HCO3-}} 40 {MgCl2}} 0.045 {7,8-diaminononanoate}} 0.42 {ATP}} [C]

Substrates: ATP; CO2; 7,8-Diaminononanoate [C]

Specific reaction: ATP + CO2 + 7,8-Diaminononanoate <==> ADP + Dethiobiotin + (3) H+ + Phosphate [C]

General reaction: Carboxylation; Heteroatomic ring closure [C]

Inhibitor: Ag+; Cd2+; Co2+; Cu2+; Hg2+; Ni2+ [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]