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The map label for this gene is tdcB [H]

Identifier: 222527415

GI number: 222527415

Start: 5214105

End: 5215340

Strand: Direct

Name: tdcB [H]

Synonym: Chy400_4206

Alternate gene names: 222527415

Gene position: 5214105-5215340 (Clockwise)

Preceding gene: 222527414

Following gene: 222527416

Centisome position: 98.96

GC content: 58.41

Gene sequence:

>1236_bases
ATGAGCCGATTCGCAATTGAACTGGCCGATATTCAGTCTGCACGGCGGGCGTTGCGGGATATTATCCTACCCACGCCAGT
ATTGCCGGCAACCCGCCTGAGTGCTGAACTGGGTGGGTCAATTTTTTACAAGGCTGAAAATACCCAGCAGAGTGGTTCGT
TCAAAATTCGTGGTGCTTACAACACGATCATTCATCTGTCACCTGAAGAGAAACAACGCGGCGTGATTGCACCGTCTGCC
GGGAATCACGCTCAGGGTGTCGCGCAGGCAGCCCAGTTATTGGGGGTAAAAGCAACAATTGTGATGCCTGAGCGCGCTCC
ATTGACCAAAGTGGTGGCAACCCGCCGGTTGGGCGCCGAGGTCATTCTGCACGGCGCCACCTTCGATGATGCGATGGCCT
ACGCACACGCTCTCAAAGAAGAACGTGGCTTAACCTACGTCCATGCCTTCGATCATCCACGGGTGATTGCAGGTCAGGGA
ACGATTGGCCTGGAACTGGTTGAAGCCCTGCCCGATTTAAACCAACTGGTCGTACCAATCGGCGGTGGTGGCCTGATCAG
CGGGATTGCCCTGGCCGTGAAGACATTGTTGCCGCACGTGCGTATCATCGGTGTGCAGGCTGCCGGCTGTGCGCCGGTGC
CGGCCTCGCTCGCCGCCGGTCATCCGGTGACGGCACCGACTGCGCATACGATTGCAGATGGTATTGCCGTGAAGCGTCCC
GGCGAACTCACCCTGCCGATGATCCAGGCCCTGGTTGATGACGTTGTCACCGTTGATGACGAAGAGATTGTGATGGCAAT
CGCGCACGTGTTGCAATACAGTCGTCTGGTGGTCGAGGGAGCCGGCGCCGCAGGTGTTGCTGCCCTGCTCAGTGGTAAGG
TGCCGGTACAACCACACCAGGTGACGGCGACGATCCTTTGCGGTGGGAATATCGATGCGAATCTGCTGATGCGGGTGATT
GAGTATGCCCTGGTTCGCCAGGGACGCTACCTCTTGCTCCGCACCAGCGTCGATGATCGTCCGGGCGGCCTGGCCGGCCT
GGTCAATCACGTTGCCTCGACCGGTGCCAGCGTCATGGATCTCTTCCATCGCCGTGGGATGTGGCGAGTGCCAATCGACC
GTGCCGGCGTTGAACTCATCCTCGAAGTCCGTGATGAAGAACACGCTCAGATGGTCATCAATTCTCTCGAACAGGCCGGC
TACCATTGCGAGCGCGAACCGAACTGGCCGATATAA

Upstream 100 bases:

>100_bases
TTTCCGCATCCTGGCTGCCCGTGCCGCCAATGCCCAGGAACTTATCACCGGGGAAGATTAGGCCAATGCAGGCCATTAGT
CCAGGGAGCAATGACGTTCC

Downstream 100 bases:

>100_bases
TACGCACTGCTTTATCTGGAACAGTGCGTCTGGTGTGCTCTGTAATCCACATCCTGCATTGCCTGAAGTGCGGAAGCTGT
GCTTTCGCACTTCATGGCGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSRFAIELADIQSARRALRDIILPTPVLPATRLSAELGGSIFYKAENTQQSGSFKIRGAYNTIIHLSPEEKQRGVIAPSA
GNHAQGVAQAAQLLGVKATIVMPERAPLTKVVATRRLGAEVILHGATFDDAMAYAHALKEERGLTYVHAFDHPRVIAGQG
TIGLELVEALPDLNQLVVPIGGGGLISGIALAVKTLLPHVRIIGVQAAGCAPVPASLAAGHPVTAPTAHTIADGIAVKRP
GELTLPMIQALVDDVVTVDDEEIVMAIAHVLQYSRLVVEGAGAAGVAALLSGKVPVQPHQVTATILCGGNIDANLLMRVI
EYALVRQGRYLLLRTSVDDRPGGLAGLVNHVASTGASVMDLFHRRGMWRVPIDRAGVELILEVRDEEHAQMVINSLEQAG
YHCEREPNWPI

Sequences:

>Translated_411_residues
MSRFAIELADIQSARRALRDIILPTPVLPATRLSAELGGSIFYKAENTQQSGSFKIRGAYNTIIHLSPEEKQRGVIAPSA
GNHAQGVAQAAQLLGVKATIVMPERAPLTKVVATRRLGAEVILHGATFDDAMAYAHALKEERGLTYVHAFDHPRVIAGQG
TIGLELVEALPDLNQLVVPIGGGGLISGIALAVKTLLPHVRIIGVQAAGCAPVPASLAAGHPVTAPTAHTIADGIAVKRP
GELTLPMIQALVDDVVTVDDEEIVMAIAHVLQYSRLVVEGAGAAGVAALLSGKVPVQPHQVTATILCGGNIDANLLMRVI
EYALVRQGRYLLLRTSVDDRPGGLAGLVNHVASTGASVMDLFHRRGMWRVPIDRAGVELILEVRDEEHAQMVINSLEQAG
YHCEREPNWPI
>Mature_410_residues
SRFAIELADIQSARRALRDIILPTPVLPATRLSAELGGSIFYKAENTQQSGSFKIRGAYNTIIHLSPEEKQRGVIAPSAG
NHAQGVAQAAQLLGVKATIVMPERAPLTKVVATRRLGAEVILHGATFDDAMAYAHALKEERGLTYVHAFDHPRVIAGQGT
IGLELVEALPDLNQLVVPIGGGGLISGIALAVKTLLPHVRIIGVQAAGCAPVPASLAAGHPVTAPTAHTIADGIAVKRPG
ELTLPMIQALVDDVVTVDDEEIVMAIAHVLQYSRLVVEGAGAAGVAALLSGKVPVQPHQVTATILCGGNIDANLLMRVIE
YALVRQGRYLLLRTSVDDRPGGLAGLVNHVASTGASVMDLFHRRGMWRVPIDRAGVELILEVRDEEHAQMVINSLEQAGY
HCEREPNWPI

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=37.7358490566038, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI19923959, Length=299, Percent_Identity=34.1137123745819, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI33469958, Length=315, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=45.6310679611651, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1790207, Length=381, Percent_Identity=38.8451443569554, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71991565, Length=393, Percent_Identity=39.9491094147583, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17537387, Length=406, Percent_Identity=36.2068965517241, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=29.153605015674, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320930, Length=341, Percent_Identity=39.0029325513196, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=41.5841584158416, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=265, Percent_Identity=27.9245283018868, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355833, Length=393, Percent_Identity=37.6590330788804, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=38.3838383838384, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43637; Mature: 43506

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFAIELADIQSARRALRDIILPTPVLPATRLSAELGGSIFYKAENTQQSGSFKIRGAY
CCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEEE
NTIIHLSPEEKQRGVIAPSAGNHAQGVAQAAQLLGVKATIVMPERAPLTKVVATRRLGAE
EEEEEECCCHHHCCEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCE
VILHGATFDDAMAYAHALKEERGLTYVHAFDHPRVIAGQGTIGLELVEALPDLNQLVVPI
EEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCCEEEEEE
GGGGLISGIALAVKTLLPHVRIIGVQAAGCAPVPASLAAGHPVTAPTAHTIADGIAVKRP
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCHHHHHCCCEECCC
GELTLPMIQALVDDVVTVDDEEIVMAIAHVLQYSRLVVEGAGAAGVAALLSGKVPVQPHQ
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCCE
VTATILCGGNIDANLLMRVIEYALVRQGRYLLLRTSVDDRPGGLAGLVNHVASTGASVMD
EEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHH
LFHRRGMWRVPIDRAGVELILEVRDEEHAQMVINSLEQAGYHCEREPNWPI
HHHHCCCEECCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRFAIELADIQSARRALRDIILPTPVLPATRLSAELGGSIFYKAENTQQSGSFKIRGAY
CCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEEE
NTIIHLSPEEKQRGVIAPSAGNHAQGVAQAAQLLGVKATIVMPERAPLTKVVATRRLGAE
EEEEEECCCHHHCCEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCE
VILHGATFDDAMAYAHALKEERGLTYVHAFDHPRVIAGQGTIGLELVEALPDLNQLVVPI
EEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCCEEEEEE
GGGGLISGIALAVKTLLPHVRIIGVQAAGCAPVPASLAAGHPVTAPTAHTIADGIAVKRP
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCHHHHHCCCEECCC
GELTLPMIQALVDDVVTVDDEEIVMAIAHVLQYSRLVVEGAGAAGVAALLSGKVPVQPHQ
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCCE
VTATILCGGNIDANLLMRVIEYALVRQGRYLLLRTSVDDRPGGLAGLVNHVASTGASVMD
EEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHH
LFHRRGMWRVPIDRAGVELILEVRDEEHAQMVINSLEQAGYHCEREPNWPI
HHHHCCCEECCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA