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The map label for this gene is rsbRA [H]

Identifier: 222527398

GI number: 222527398

Start: 5192411

End: 5193979

Strand: Direct

Name: rsbRA [H]

Synonym: Chy400_4189

Alternate gene names: 222527398

Gene position: 5192411-5193979 (Clockwise)

Preceding gene: 222527395

Following gene: 222527400

Centisome position: 98.55

GC content: 52.2

Gene sequence:

>1569_bases
ATGAATCTCAACGACAACTCAACAGACAGCCTGCTTGCTGAGTGTATAGCACAACGTGATCGTTTACGACGCATTATCGA
AACGACCAATCTTCTGGTAGTAGAAATAGATGCCGGCGGGCGAATCACCTACATCAATCCGGCCTGTCAGCGATACTTTG
GGGTGACTCCTGAAGAGTGTCTTCAGCAAATTGCCTGGACATTCATTCACCCTGAAGAGCAAGATCAGGCAAGAGAGCAC
TTTCGTGCGTTGATCGCTCAACAACAACCCTCTGACACATTTGAAAGCCGACTTCTCCTCCGCGATGGTTCTATCCTGCA
TTTGCGCTGGACCATTGCCATTCACTACACCGACAACGGTCAGTTCTCATCACTCACTGCCATTGCTCACGATATCGACC
AGCTTCATCACATGCGCACAAGGCAGCAACTGCAAGAAGAAGAACTACAAACCTTTAAACTCCTGGTCGAACTTGCCCCT
GATGGTATTGCCATCGCCGATACGCAATTGCGTATGACATATACCAACCAGGCTTTTTGCACCATGCTTGGCTACGAGTC
ACTGATTGGAAAAACTGTCGTTGACATCACCTATCCCGATGATCACCAGCAACTGGCAGACATCGCCAAAACATTGCAGC
AGGGGCAGACCGTTCACACAACGATTCGCTATGTGCGTAGCGATGGATCACTCATAACGGTACAGGCTTCCGCACTTGGC
TTGTACAACCGTGACGGTCAACTGACCGGCTTTGCGTCAATTAACCGCGATGTGACGGCTCAGATAGAGGCTGAAGAAGA
ACTGCGACAAAGCGAACAGCGAAACCGGACACTACTGGCTGCCATGCCCGATCTCATGTTCTTGCTCAGCAGCGATGGTG
TCTTCCTCAATTACAAGCCTGATCCTACCGGTCGCCTGCTGGTACCCCCTGAAATGTTCCTCAACCGCCATGTGACTGAG
GTGCTGCCACCTGAACTCGCCACACAAATCCTGCAGCGAATCGACGCCCTCAAGCGTAGTGGCGAGATGCAGACGTTCGA
GTACCAGATTGAGATTGACAACCAGGTTGAGGTGTACGAAGCCCGCATGGTCTTGCTGCAAGATAACGTCATGGTGCTTT
CCCGCAATATTACTGCCCAACGTCAGGCCGAACGCGAACGAGCAGCCATGCAAGAGCAGATAATTCAGGCGCAACAGGCC
ACGTTGCGCGAACTGAGTACGCCGCTCATGCCAATTGCTGACGGTGTGGTGGCGATGCCGCTGATTGGAGCCATCGACTC
AGCACGGGCCCAACAAATTATGGAAAGTTTGCTGTACGGCGTGGCCGAATACAAGGCACGGGTCGCCATTATTGATATTA
CCGGCGTGAAAGTCGTTGATACGCAGGTTGCCGGAGCGTTGATTCGCGCGGCGCAGGCGGCCAGAATGCTGGGTGCTAAA
GTGGTCTTAACCGGAATTAGTCCTGAAATTGCTCAGACGTTGGTGCATATCGGCGCTGACTTAGGTGCGATGAAGACAAA
GGCTACCCTGCAAGAAGGTATTCGCTACGCATTGGCGGGCAAGCAATGA

Upstream 100 bases:

>100_bases
AGACAATATTCTCTACACCCAGTCTTATCTGGTTTAAACACAATAGAGATGGTATAGTAGATATGGGCTTTATAATGAAA
GGCAGCCAGGAAAACACGCT

Downstream 100 bases:

>100_bases
GCGGCAGATTGCTACTCTGCCGCTCGTGAAAGCCATTGCGGTGCTGCTCAACGGCGGGGAAGGAGTGCCAGGCGTAATCG
GTAGATTGGCAGGGAACGAC

Product: putative PAS/PAC sensor protein

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MNLNDNSTDSLLAECIAQRDRLRRIIETTNLLVVEIDAGGRITYINPACQRYFGVTPEECLQQIAWTFIHPEEQDQAREH
FRALIAQQQPSDTFESRLLLRDGSILHLRWTIAIHYTDNGQFSSLTAIAHDIDQLHHMRTRQQLQEEELQTFKLLVELAP
DGIAIADTQLRMTYTNQAFCTMLGYESLIGKTVVDITYPDDHQQLADIAKTLQQGQTVHTTIRYVRSDGSLITVQASALG
LYNRDGQLTGFASINRDVTAQIEAEEELRQSEQRNRTLLAAMPDLMFLLSSDGVFLNYKPDPTGRLLVPPEMFLNRHVTE
VLPPELATQILQRIDALKRSGEMQTFEYQIEIDNQVEVYEARMVLLQDNVMVLSRNITAQRQAERERAAMQEQIIQAQQA
TLRELSTPLMPIADGVVAMPLIGAIDSARAQQIMESLLYGVAEYKARVAIIDITGVKVVDTQVAGALIRAAQAARMLGAK
VVLTGISPEIAQTLVHIGADLGAMKTKATLQEGIRYALAGKQ

Sequences:

>Translated_522_residues
MNLNDNSTDSLLAECIAQRDRLRRIIETTNLLVVEIDAGGRITYINPACQRYFGVTPEECLQQIAWTFIHPEEQDQAREH
FRALIAQQQPSDTFESRLLLRDGSILHLRWTIAIHYTDNGQFSSLTAIAHDIDQLHHMRTRQQLQEEELQTFKLLVELAP
DGIAIADTQLRMTYTNQAFCTMLGYESLIGKTVVDITYPDDHQQLADIAKTLQQGQTVHTTIRYVRSDGSLITVQASALG
LYNRDGQLTGFASINRDVTAQIEAEEELRQSEQRNRTLLAAMPDLMFLLSSDGVFLNYKPDPTGRLLVPPEMFLNRHVTE
VLPPELATQILQRIDALKRSGEMQTFEYQIEIDNQVEVYEARMVLLQDNVMVLSRNITAQRQAERERAAMQEQIIQAQQA
TLRELSTPLMPIADGVVAMPLIGAIDSARAQQIMESLLYGVAEYKARVAIIDITGVKVVDTQVAGALIRAAQAARMLGAK
VVLTGISPEIAQTLVHIGADLGAMKTKATLQEGIRYALAGKQ
>Mature_522_residues
MNLNDNSTDSLLAECIAQRDRLRRIIETTNLLVVEIDAGGRITYINPACQRYFGVTPEECLQQIAWTFIHPEEQDQAREH
FRALIAQQQPSDTFESRLLLRDGSILHLRWTIAIHYTDNGQFSSLTAIAHDIDQLHHMRTRQQLQEEELQTFKLLVELAP
DGIAIADTQLRMTYTNQAFCTMLGYESLIGKTVVDITYPDDHQQLADIAKTLQQGQTVHTTIRYVRSDGSLITVQASALG
LYNRDGQLTGFASINRDVTAQIEAEEELRQSEQRNRTLLAAMPDLMFLLSSDGVFLNYKPDPTGRLLVPPEMFLNRHVTE
VLPPELATQILQRIDALKRSGEMQTFEYQIEIDNQVEVYEARMVLLQDNVMVLSRNITAQRQAERERAAMQEQIIQAQQA
TLRELSTPLMPIADGVVAMPLIGAIDSARAQQIMESLLYGVAEYKARVAIIDITGVKVVDTQVAGALIRAAQAARMLGAK
VVLTGISPEIAQTLVHIGADLGAMKTKATLQEGIRYALAGKQ

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 58405; Mature: 58405

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNDNSTDSLLAECIAQRDRLRRIIETTNLLVVEIDAGGRITYINPACQRYFGVTPEEC
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECHHHHHHCCCCHHHH
LQQIAWTFIHPEEQDQAREHFRALIAQQQPSDTFESRLLLRDGSILHLRWTIAIHYTDNG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEECCCEEEEEEEEEEEEECCC
QFSSLTAIAHDIDQLHHMRTRQQLQEEELQTFKLLVELAPDGIAIADTQLRMTYTNQAFC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHH
TMLGYESLIGKTVVDITYPDDHQQLADIAKTLQQGQTVHTTIRYVRSDGSLITVQASALG
HHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEEHHHHHEECCCCEEEEEEHEEE
LYNRDGQLTGFASINRDVTAQIEAEEELRQSEQRNRTLLAAMPDLMFLLSSDGVFLNYKP
EECCCCCEEEEEECCCCEEEEEECHHHHHHHHHHCCEEEHHHHHHHHHHCCCCEEEEECC
DPTGRLLVPPEMFLNRHVTEVLPPELATQILQRIDALKRSGEMQTFEYQIEIDNQVEVYE
CCCCEEEECHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEH
ARMVLLQDNVMVLSRNITAQRQAERERAAMQEQIIQAQQATLRELSTPLMPIADGVVAMP
HEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
LIGAIDSARAQQIMESLLYGVAEYKARVAIIDITGVKVVDTQVAGALIRAAQAARMLGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCCE
VVLTGISPEIAQTLVHIGADLGAMKTKATLQEGIRYALAGKQ
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHCCCCC
>Mature Secondary Structure
MNLNDNSTDSLLAECIAQRDRLRRIIETTNLLVVEIDAGGRITYINPACQRYFGVTPEEC
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECHHHHHHCCCCHHHH
LQQIAWTFIHPEEQDQAREHFRALIAQQQPSDTFESRLLLRDGSILHLRWTIAIHYTDNG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEECCCEEEEEEEEEEEEECCC
QFSSLTAIAHDIDQLHHMRTRQQLQEEELQTFKLLVELAPDGIAIADTQLRMTYTNQAFC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHH
TMLGYESLIGKTVVDITYPDDHQQLADIAKTLQQGQTVHTTIRYVRSDGSLITVQASALG
HHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEEHHHHHEECCCCEEEEEEHEEE
LYNRDGQLTGFASINRDVTAQIEAEEELRQSEQRNRTLLAAMPDLMFLLSSDGVFLNYKP
EECCCCCEEEEEECCCCEEEEEECHHHHHHHHHHCCEEEHHHHHHHHHHCCCCEEEEECC
DPTGRLLVPPEMFLNRHVTEVLPPELATQILQRIDALKRSGEMQTFEYQIEIDNQVEVYE
CCCCEEEECHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEH
ARMVLLQDNVMVLSRNITAQRQAERERAAMQEQIIQAQQATLRELSTPLMPIADGVVAMP
HEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
LIGAIDSARAQQIMESLLYGVAEYKARVAIIDITGVKVVDTQVAGALIRAAQAARMLGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCCE
VVLTGISPEIAQTLVHIGADLGAMKTKATLQEGIRYALAGKQ
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]