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The map label for this gene is gmhB [H]

Identifier: 222527268

GI number: 222527268

Start: 5005999

End: 5006604

Strand: Direct

Name: gmhB [H]

Synonym: Chy400_4052

Alternate gene names: 222527268

Gene position: 5005999-5006604 (Clockwise)

Preceding gene: 222527264

Following gene: 222527269

Centisome position: 95.01

GC content: 57.43

Gene sequence:

>606_bases
ATGCGCGCTGTCTTTCTCGACCGTGACGGGGTTATTAATCACAACCGCCCTGATCACGTCAAAAATCTGGCCGAGTTTCA
GTTCCTACCGGGTGCGCTGACCGCGTTGCGTCTGCTAACCAGTGCCGGGTTTCGCATCTTTGTTATCACCAACCAGGCAG
CGGTTGGGCGTGGGTTGATGACGGTAGAGGCGCTGGAAGAAATTCATGCCCACTTGCGCGCGATTGCCCGTTATCACGGG
GCAACTATTGACGATATCCGATACTGTCCTCACACCCCGGAAGAGCGTTGCGGGTGCCGGAAGCCGCAACCCGGTATGAT
CCAGGAGCTGGCAGCCCGGCACCAGATTGATTGTCGAGCGACATTCCTGATTGGCGATGCGCTCACCGATATTGCTGCCG
GTCAGCGGATGGGATGCCAGACGATTCTGGTCAAGAGTGGGAGAGGCAGTGCAGAATTGCAGAAACCGGAATTACGGCGC
TATCAACCAACCCACATCGCCGACGATCTGCTGGCGGCAACGCGATGGTTGCTGCAAGAGGAACTCAGGCCGGTATCGGT
GACCACGCAACCACTAACCGGTGTACTGACCACCGTACCACAGTAG

Upstream 100 bases:

>100_bases
GCAGATCGTCAGCAAGAGCGTGTACTGTAACACTGTCGCCGCAGCCTACCGTCTTCACCACGTGGAATCGTCTTGCATGC
AGCGCCAGGGGAGGGGTCTT

Downstream 100 bases:

>100_bases
TACAGGGAATGCTATGGAAGACCGTCTACAGCGTGTTGTTCGGCATATCCTGATGATCACTCTCCTGGTCGGGTTGAGTG
GGTGCAGCATCAGCAGCCTG

Product: histidinol-phosphate phosphatase family protein

Products: L-histidinol; phosphate

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRAVFLDRDGVINHNRPDHVKNLAEFQFLPGALTALRLLTSAGFRIFVITNQAAVGRGLMTVEALEEIHAHLRAIARYHG
ATIDDIRYCPHTPEERCGCRKPQPGMIQELAARHQIDCRATFLIGDALTDIAAGQRMGCQTILVKSGRGSAELQKPELRR
YQPTHIADDLLAATRWLLQEELRPVSVTTQPLTGVLTTVPQ

Sequences:

>Translated_201_residues
MRAVFLDRDGVINHNRPDHVKNLAEFQFLPGALTALRLLTSAGFRIFVITNQAAVGRGLMTVEALEEIHAHLRAIARYHG
ATIDDIRYCPHTPEERCGCRKPQPGMIQELAARHQIDCRATFLIGDALTDIAAGQRMGCQTILVKSGRGSAELQKPELRR
YQPTHIADDLLAATRWLLQEELRPVSVTTQPLTGVLTTVPQ
>Mature_201_residues
MRAVFLDRDGVINHNRPDHVKNLAEFQFLPGALTALRLLTSAGFRIFVITNQAAVGRGLMTVEALEEIHAHLRAIARYHG
ATIDDIRYCPHTPEERCGCRKPQPGMIQELAARHQIDCRATFLIGDALTDIAAGQRMGCQTILVKSGRGSAELQKPELRR
YQPTHIADDLLAATRWLLQEELRPVSVTTQPLTGVLTTVPQ

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=156, Percent_Identity=35.8974358974359, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082027, Length=139, Percent_Identity=30.2158273381295, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: 3.1.3.15

Molecular weight: Translated: 22321; Mature: 22321

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVFLDRDGVINHNRPDHVKNLAEFQFLPGALTALRLLTSAGFRIFVITNQAAVGRGLM
CCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCHHHCCCHH
TVEALEEIHAHLRAIARYHGATIDDIRYCPHTPEERCGCRKPQPGMIQELAARHQIDCRA
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCEE
TFLIGDALTDIAAGQRMGCQTILVKSGRGSAELQKPELRRYQPTHIADDLLAATRWLLQE
EEEEHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
ELRPVSVTTQPLTGVLTTVPQ
HCCCCEEECCCHHHHHHCCCC
>Mature Secondary Structure
MRAVFLDRDGVINHNRPDHVKNLAEFQFLPGALTALRLLTSAGFRIFVITNQAAVGRGLM
CCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCHHHCCCHH
TVEALEEIHAHLRAIARYHGATIDDIRYCPHTPEERCGCRKPQPGMIQELAARHQIDCRA
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCEE
TFLIGDALTDIAAGQRMGCQTILVKSGRGSAELQKPELRRYQPTHIADDLLAATRWLLQE
EEEEHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
ELRPVSVTTQPLTGVLTTVPQ
HCCCCEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; H2O

Specific reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919; 12101286 [H]