| Definition | Chloroflexus sp. Y-400-fl chromosome, complete genome. |
|---|---|
| Accession | NC_012032 |
| Length | 5,268,950 |
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The map label for this gene is liaS [H]
Identifier: 222526913
GI number: 222526913
Start: 4602161
End: 4604536
Strand: Direct
Name: liaS [H]
Synonym: Chy400_3691
Alternate gene names: 222526913
Gene position: 4602161-4604536 (Clockwise)
Preceding gene: 222526912
Following gene: 222526914
Centisome position: 87.34
GC content: 57.32
Gene sequence:
>2376_bases ATGGATCGGATCGAGACGGTTATGCGGTGGGTGCGCCGGGTGTCGCGCGTGCTCGTCGTGGTGACAGCGCTACTCCTGAT GGTGATGGGAGTACGTGAACTGCTGGCAGGTGATGCGGTGTTTGGGACGGCGTTGATCATGCTAGGCGTTGCCGGTATCC CCGCTGCCAACCCGTTTCGCTCGCCGTCTGCGGGGAGAGCAGACGGATTAGCAGGGCAATCAAGCCGTGAGCAATTTACC AGTCTGGTCACGCAACTGATCGCAGCCGGTTTCGGGCTGGTTGCCATCATTGCCACCCTGCTGATCATCTTCGGCCCGCG TGCGCTCAGCGACCTCGGCTGGACGGAATATGCCCTGCACTACACCGCCCTGGGTGTGGTGGTGGTGGTTGGCATGGTGT TTCTAAGCATCCTGATGCTCATGCGACGCCTGATCCTGCCGCGGTTGCAACAGGAGATTGAGGAGCGAGCACAACAACTC AGTGAGCGGCAATCGCTCTTGCTGGCCCAACTGCGCGAGGCGGCAGCGCAAGAGGAGCGGAACCGGCTGGCGCGTGATCT GCACGATACGATCAAGCAGCAATTATTCAGCATCAATATCGCTGCGGCAACCGCTCAAAGTCTGTATGAGCGCGATCCGG TTGGTGCTGCCCAGCATATTCAACACGTGCGTGACCTGTCTCAGGCGGCGATGGCCGAGATGAAAGCATTGCTTACCCAA CTGCGCCCGCAACCCCTGGCAACCATTGGCCTGATCGAGGCAATTCGCGAACAGCTTGAAGCACTCCATTTTCGGGCAGA GGTCAGCACCGCATTGCACCACGATGGCTTCCCGGATGAAGCGTTGCTGCTCCCCGGTACTCAGGAGACGGTATTTCGGG TTATTCAGGAGGCACTCTCGAACGTGGCCCGTCACGCCCGTGCCCGTCATGTGCAGGTCTCATTTGGGCAAGAGATGGTT GCCGGCAGATCATGGCTGACGGTGACCGTTGCCGATGATGGGCGGGGCTTCGATCCGGCAACCAGTACATTGGGGATGGG AATGACCAATATGCGTGCCCGAATTGAAGCGCTCGGTGGCGAGCTGGCAGTGCGCTCAGCGCCACATGCCGGAACGACAA TCCAGTTTCGGATTCCGCTTGCCGAACAGGAGAGTCAACACGAGAAGGAGGTACGTATGCGCGAGGAGCGTTTCCAGCAC ATCTTCACCATCAGTGGTCTGACTTCCTTGACCGGTATAGCATTCGTTATCGGTGGGCTATCATTGACGCTAGCACTCCA GAACGCACCGCTGTACTTTGCAGGTATCGGTATTCTTGGTGTGCTGATCGGTGTTGGGCTGTTGCCGGTGATGATGAACC GGCGGCGGCGGGCACGTCCCTGGGCAACGCATTCGATCTGGCAAACGTTGCTGCGCTTCTACGACCTATTGACGGTGGGT TTCTTGCTGTCGATCATTGCCTGGGTGACATTCTCCATAAAGGCGTTTGCGCTCACGTTTCTGCTCGGAGTCGGGATTGT CGGTGTAGCAATTGCACTCATCCGCACACACCGCATCCTCAACGACCGCATCACAGAATGGGCAACGCAATCTACGTTGC GCACGCAGGTTCGGGAAAGCTGGTTCTTTCTGGGATTTGTGATCGGTTTTCAAGTGCTGGTCTACAGCGGGTTGTTCGGC TCGATGCAGGCAGTGTACCTGTTCCACGATACGCTTGATCGAAGCTGGTTTGTGTCGCTCCTGGCGATTGGTTATCCGCT GGTGATGATTCCGTACAGTGTTATCGGTCTGGTTATCAGTTATCACCACCTCCGCCGGTTAACAGCACTTGAAGGTAAGT CGTCTGTGGCTGAACCGGTGGTGGATAGCGGATTGCGCCGTCTGCGTCGTACAGCCATCCTACTCACACTGGCCTACCAC ATCCTGTGCATCAGCGTCGGGGTACTGATCGAATTCCAGGTGCCATTCGGCGGCGTAGCGGCGCTTGTTGCGCTGGTGAT ACTGGTCGGCAAGTGGTGGATCGAACGTTCACTGACCGCACGAATTGCCGAATGGTCATCTCGCTATAGTCAGTTGTCGG CATTGACAATGTACGGTACGTTTCTCTTCACCTACATCTTTAGCTTCCTGGGGTTGCTGATAGGTGCGGCGATTGCGATG AGCCAGGGCGGGATTGACGCATCGATCCAGGATGCTGTGATCGATAGTTCACTTGCCGCCCTGCCAACCGCAGCGCCGTG GATGATCGTCGGTTTTGGCACCTGGTGGCTGGGAGTCTTCCCGTACCTGTTGCTCCAGACCATCAACACCTTGCGTCGTT TGCAGATCGTAGCGCGAGAGCAAGCGGACACGGCACAATCACTGTCAGATGGATAA
Upstream 100 bases:
>100_bases GGGCGGCATTGATAATGCTAGGCGCTGCCGTTATCCCCGCTGCCAACCCGTTTCGCTCGCCGTCGAACGATGGTGAAGGT AGGGGAACGGAGTGAGCGCT
Downstream 100 bases:
>100_bases CGAGATGTGGATATGGATGCGGAAGCTTTGCTTCTGCATCCACATATCGCAGATCGGGTTTTGTGGGAGGGCAACGCTCT CTTCATCTGGTTCGTCACAT
Product: integral membrane sensor signal transduction histidine kinase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 791; Mature: 791
Protein sequence:
>791_residues MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFRSPSAGRADGLAGQSSREQFT SLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALHYTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQL SERQSLLLAQLREAAAQEERNRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQ LRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALSNVARHARARHVQVSFGQEMV AGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGGELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQH IFTISGLTSLTGIAFVIGGLSLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVG FLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRESWFFLGFVIGFQVLVYSGLFG SMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVISYHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYH ILCISVGVLIEFQVPFGGVAALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAM SQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVAREQADTAQSLSDG
Sequences:
>Translated_791_residues MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFRSPSAGRADGLAGQSSREQFT SLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALHYTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQL SERQSLLLAQLREAAAQEERNRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQ LRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALSNVARHARARHVQVSFGQEMV AGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGGELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQH IFTISGLTSLTGIAFVIGGLSLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVG FLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRESWFFLGFVIGFQVLVYSGLFG SMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVISYHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYH ILCISVGVLIEFQVPFGGVAALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAM SQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVAREQADTAQSLSDG >Mature_791_residues MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFRSPSAGRADGLAGQSSREQFT SLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALHYTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQL SERQSLLLAQLREAAAQEERNRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQ LRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALSNVARHARARHVQVSFGQEMV AGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGGELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQH IFTISGLTSLTGIAFVIGGLSLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVG FLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRESWFFLGFVIGFQVLVYSGLFG SMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVISYHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYH ILCISVGVLIEFQVPFGGVAALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAM SQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVAREQADTAQSLSDG
Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also
COG id: COG4585
COG function: function code T; Signal transduction histidine kinase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 histidine kinase domain [H]
Homologues:
Organism=Escherichia coli, GI87082311, Length=231, Percent_Identity=32.9004329004329, Blast_Score=80, Evalue=4e-16, Organism=Escherichia coli, GI1787474, Length=199, Percent_Identity=29.1457286432161, Blast_Score=67, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR003660 - InterPro: IPR011712 - InterPro: IPR005467 - InterPro: IPR017202 [H]
Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]
EC number: =2.7.13.3 [H]
Molecular weight: Translated: 87136; Mature: 87136
Theoretical pI: Translated: 9.74; Mature: 9.74
Prosite motif: PS50109 HIS_KIN ; PS00165 DEHYDRATASE_SER_THR
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFR CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC SPSAGRADGLAGQSSREQFTSLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALH CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHH YTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQLSERQSLLLAQLREAAAQEER HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQ HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALS HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHH NVARHARARHVQVSFGQEMVAGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGG HHHHHHHHCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHCC ELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQHIFTISGLTSLTGIAFVIGGL HHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVG HHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHH FLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRES HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH WFFLGFVIGFQVLVYSGLFGSMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVIS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH YHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYHILCISVGVLIEFQVPFGGVA HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHH ALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAM HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVARE HCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QADTAQSLSDG HHHHHHHCCCC >Mature Secondary Structure MDRIETVMRWVRRVSRVLVVVTALLLMVMGVRELLAGDAVFGTALIMLGVAGIPAANPFR CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC SPSAGRADGLAGQSSREQFTSLVTQLIAAGFGLVAIIATLLIIFGPRALSDLGWTEYALH CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHH YTALGVVVVVGMVFLSILMLMRRLILPRLQQEIEERAQQLSERQSLLLAQLREAAAQEER HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NRLARDLHDTIKQQLFSINIAAATAQSLYERDPVGAAQHIQHVRDLSQAAMAEMKALLTQ HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LRPQPLATIGLIEAIREQLEALHFRAEVSTALHHDGFPDEALLLPGTQETVFRVIQEALS HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHH NVARHARARHVQVSFGQEMVAGRSWLTVTVADDGRGFDPATSTLGMGMTNMRARIEALGG HHHHHHHHCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHHCC ELAVRSAPHAGTTIQFRIPLAEQESQHEKEVRMREERFQHIFTISGLTSLTGIAFVIGGL HHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SLTLALQNAPLYFAGIGILGVLIGVGLLPVMMNRRRRARPWATHSIWQTLLRFYDLLTVG HHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHH FLLSIIAWVTFSIKAFALTFLLGVGIVGVAIALIRTHRILNDRITEWATQSTLRTQVRES HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH WFFLGFVIGFQVLVYSGLFGSMQAVYLFHDTLDRSWFVSLLAIGYPLVMIPYSVIGLVIS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH YHHLRRLTALEGKSSVAEPVVDSGLRRLRRTAILLTLAYHILCISVGVLIEFQVPFGGVA HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHH ALVALVILVGKWWIERSLTARIAEWSSRYSQLSALTMYGTFLFTYIFSFLGLLIGAAIAM HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH SQGGIDASIQDAVIDSSLAALPTAAPWMIVGFGTWWLGVFPYLLLQTINTLRRLQIVARE HCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QADTAQSLSDG HHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]