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The map label for this gene is gabT [H]

Identifier: 222526848

GI number: 222526848

Start: 4507358

End: 4508701

Strand: Direct

Name: gabT [H]

Synonym: Chy400_3624

Alternate gene names: 222526848

Gene position: 4507358-4508701 (Clockwise)

Preceding gene: 222526847

Following gene: 222526849

Centisome position: 85.55

GC content: 58.56

Gene sequence:

>1344_bases
ATGACTGCGCCTGCTGTGCGCCACATTCGTCTTGTCACTGAAATACCCGGCCCGCGTTCGCGCGCATTACTGGCGCGGCG
TGATGCGGCGGTGGTTGCCGGTTTGGGGCGGGCAACGCCGATAGCGATTGCCTCCGGCCAGGGTGCGCTGGTGACCGATG
TTGATGGCAATACCCTGATCGATTTTGTTAGTGGGATTGGGACGCTCGCCGTCGGCCACTGTCCTCCTGAAGTGGTTCAG
GCGATTCAGGCTCAGGCCGAACAGTTGATCCATCTTTCGGCGTTAGTTGGCACCTACGAACCGTATGTCGCCCTCTGCGA
GCGGTTAAATGCGCTGGCACCCATCAGCGAGCCGTGCAAGACGTTGCTATCGAATTCGGGCGCCGAAGGGGTGGAAAATG
CGATCAAATTTGCCCGCGCTGCGACCGGTCGTCCGGCCATTATCGTGTTCGATGGCGCGTACCACGGGCGAACGCTGCTT
ACGCTTTCGCTCACGTCCCGCACCTACTTCAAAAAGAAATTCGGCCCCTTTGCCCCAGAGATTTACCGCGCACCTTTTCC
TTACGCTTATCGGATGGGCATGAGTGAAGCGGAGGCAGTTGAGCAGTGCTGGGCCGCATTTGAACGCATGCAGATTGCCG
GTGTCGATCCCGAAACGGTGGCTGCGGTCTTGATTGAACCGGTGCAGGGTGAAGGTGGCTTTATCCCGGTGCCGGTCGAA
TTTATGCGGCGCTTACGCGAATTCTGCACGCGCAACGGCTCACTGTTGATTGTCGATGAAGTGCAGAGTGGTTTTGGCCG
TACCGGTACGCTCTTCGCGATTGAGCAGTTTGGGGTTGAACCCGACATCATTGTAGCGGCCAAGAGTATTGCTGCCGGTA
TGCCACTGGCTGCCACAATTGGTCGTGCCCGCATTATGGATTGCGCCCACTACGGCGGTGTCGGTGGTACCTACGGCGGC
AATCCGCTCGCCTGTGTCGCAGCGCTGGCCACTATCGATCTGATTGAACGCGAGCGCTTGCTGGAACGGGCAAAGGTGAT
CGGCCAACAGATTCGGGCCAGATTTGAACCATTACTGACCGATGATTCACTCGATCCACTGGTTGGTGATGTTCGTGGTC
TGGGGGCAATGATCGGGATCGAGCTGGTCAAGGATCGCCGCAAACGCACGCCAGCCGCCGCCGAAGAGGTGCTGGCGATC
CTGGGGCGTGCGCTTGAACGTGGTGTGCTGGCGATGCGGGCCGGTCTGTATGTGAACTGTATCCGCTTGCTGGTACCACT
TGTTATCACCGATGATCAGCTCGATGAAGGGTTAGAGGTGCTGATAGGGGCAATGCGCCACTGA

Upstream 100 bases:

>100_bases
GAATGCGTTCTCCTGTTTCCCCTGTTCGCCAACCATCAGCATTTCGTATTATAATGACCGGTATCAGTTGTGGCAGCAAA
TACACAAAGGAGTGACCATC

Downstream 100 bases:

>100_bases
AGAGCATTGAGGCAGCCGTGAAGGGTGAGCGTGCAGGAACCCTGTGCGCTCGCTGTGATCACGTGCTGCCTTATTCCAAA
GGAGAATATCTCATGACTAT

Product: class III aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTAPAVRHIRLVTEIPGPRSRALLARRDAAVVAGLGRATPIAIASGQGALVTDVDGNTLIDFVSGIGTLAVGHCPPEVVQ
AIQAQAEQLIHLSALVGTYEPYVALCERLNALAPISEPCKTLLSNSGAEGVENAIKFARAATGRPAIIVFDGAYHGRTLL
TLSLTSRTYFKKKFGPFAPEIYRAPFPYAYRMGMSEAEAVEQCWAAFERMQIAGVDPETVAAVLIEPVQGEGGFIPVPVE
FMRRLREFCTRNGSLLIVDEVQSGFGRTGTLFAIEQFGVEPDIIVAAKSIAAGMPLAATIGRARIMDCAHYGGVGGTYGG
NPLACVAALATIDLIERERLLERAKVIGQQIRARFEPLLTDDSLDPLVGDVRGLGAMIGIELVKDRRKRTPAAAEEVLAI
LGRALERGVLAMRAGLYVNCIRLLVPLVITDDQLDEGLEVLIGAMRH

Sequences:

>Translated_447_residues
MTAPAVRHIRLVTEIPGPRSRALLARRDAAVVAGLGRATPIAIASGQGALVTDVDGNTLIDFVSGIGTLAVGHCPPEVVQ
AIQAQAEQLIHLSALVGTYEPYVALCERLNALAPISEPCKTLLSNSGAEGVENAIKFARAATGRPAIIVFDGAYHGRTLL
TLSLTSRTYFKKKFGPFAPEIYRAPFPYAYRMGMSEAEAVEQCWAAFERMQIAGVDPETVAAVLIEPVQGEGGFIPVPVE
FMRRLREFCTRNGSLLIVDEVQSGFGRTGTLFAIEQFGVEPDIIVAAKSIAAGMPLAATIGRARIMDCAHYGGVGGTYGG
NPLACVAALATIDLIERERLLERAKVIGQQIRARFEPLLTDDSLDPLVGDVRGLGAMIGIELVKDRRKRTPAAAEEVLAI
LGRALERGVLAMRAGLYVNCIRLLVPLVITDDQLDEGLEVLIGAMRH
>Mature_446_residues
TAPAVRHIRLVTEIPGPRSRALLARRDAAVVAGLGRATPIAIASGQGALVTDVDGNTLIDFVSGIGTLAVGHCPPEVVQA
IQAQAEQLIHLSALVGTYEPYVALCERLNALAPISEPCKTLLSNSGAEGVENAIKFARAATGRPAIIVFDGAYHGRTLLT
LSLTSRTYFKKKFGPFAPEIYRAPFPYAYRMGMSEAEAVEQCWAAFERMQIAGVDPETVAAVLIEPVQGEGGFIPVPVEF
MRRLREFCTRNGSLLIVDEVQSGFGRTGTLFAIEQFGVEPDIIVAAKSIAAGMPLAATIGRARIMDCAHYGGVGGTYGGN
PLACVAALATIDLIERERLLERAKVIGQQIRARFEPLLTDDSLDPLVGDVRGLGAMIGIELVKDRRKRTPAAAEEVLAIL
GRALERGVLAMRAGLYVNCIRLLVPLVITDDQLDEGLEVLIGAMRH

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=432, Percent_Identity=32.6388888888889, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=29.9319727891156, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=34.1025641025641, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=32.6241134751773, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI24119277, Length=402, Percent_Identity=31.0945273631841, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI284507298, Length=326, Percent_Identity=31.2883435582822, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI188536080, Length=418, Percent_Identity=27.511961722488, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI38679950, Length=418, Percent_Identity=27.511961722488, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI38679946, Length=418, Percent_Identity=27.511961722488, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=45.8628841607565, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=42.5178147268409, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=36.318407960199, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1788044, Length=414, Percent_Identity=32.1256038647343, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI145693181, Length=365, Percent_Identity=35.8904109589041, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786991, Length=405, Percent_Identity=31.6049382716049, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=32.0916905444126, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=31.5420560747664, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI25144271, Length=420, Percent_Identity=28.0952380952381, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.8095238095238, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=28.7625418060201, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=385, Percent_Identity=26.7532467532467, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=160, Percent_Identity=27.5, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=29.81220657277, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=29.951690821256, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=453, Percent_Identity=26.0485651214128, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161085790, Length=434, Percent_Identity=31.3364055299539, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574759, Length=418, Percent_Identity=32.0574162679426, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21357415, Length=444, Percent_Identity=29.7297297297297, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=32.4644549763033, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI281366494, Length=415, Percent_Identity=26.9879518072289, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24667139, Length=415, Percent_Identity=26.9879518072289, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24667143, Length=415, Percent_Identity=26.9879518072289, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 47787; Mature: 47656

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPAVRHIRLVTEIPGPRSRALLARRDAAVVAGLGRATPIAIASGQGALVTDVDGNTLI
CCCCHHHHEEEEECCCCCCHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEECCCCHHH
DFVSGIGTLAVGHCPPEVVQAIQAQAEQLIHLSALVGTYEPYVALCERLNALAPISEPCK
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHH
TLLSNSGAEGVENAIKFARAATGRPAIIVFDGAYHGRTLLTLSLTSRTYFKKKFGPFAPE
HHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHHCCCCCHH
IYRAPFPYAYRMGMSEAEAVEQCWAAFERMQIAGVDPETVAAVLIEPVQGEGGFIPVPVE
HHCCCCCHHHHCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHEECCCCCCCEECCCHH
FMRRLREFCTRNGSLLIVDEVQSGFGRTGTLFAIEQFGVEPDIIVAAKSIAAGMPLAATI
HHHHHHHHHCCCCCEEEEECHHCCCCCCCEEEEHHHHCCCCCCEEEHHHHHCCCCHHHHH
GRARIMDCAHYGGVGGTYGGNPLACVAALATIDLIERERLLERAKVIGQQIRARFEPLLT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDSLDPLVGDVRGLGAMIGIELVKDRRKRTPAAAEEVLAILGRALERGVLAMRAGLYVNC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLLVPLVITDDQLDEGLEVLIGAMRH
HHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAPAVRHIRLVTEIPGPRSRALLARRDAAVVAGLGRATPIAIASGQGALVTDVDGNTLI
CCCHHHHEEEEECCCCCCHHHHHHHCCHHHHHCCCCCCCEEEECCCCCEEEECCCCHHH
DFVSGIGTLAVGHCPPEVVQAIQAQAEQLIHLSALVGTYEPYVALCERLNALAPISEPCK
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHH
TLLSNSGAEGVENAIKFARAATGRPAIIVFDGAYHGRTLLTLSLTSRTYFKKKFGPFAPE
HHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHHCCCCCHH
IYRAPFPYAYRMGMSEAEAVEQCWAAFERMQIAGVDPETVAAVLIEPVQGEGGFIPVPVE
HHCCCCCHHHHCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHEECCCCCCCEECCCHH
FMRRLREFCTRNGSLLIVDEVQSGFGRTGTLFAIEQFGVEPDIIVAAKSIAAGMPLAATI
HHHHHHHHHCCCCCEEEEECHHCCCCCCCEEEEHHHHCCCCCCEEEHHHHHCCCCHHHHH
GRARIMDCAHYGGVGGTYGGNPLACVAALATIDLIERERLLERAKVIGQQIRARFEPLLT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDSLDPLVGDVRGLGAMIGIELVKDRRKRTPAAAEEVLAILGRALERGVLAMRAGLYVNC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLLVPLVITDDQLDEGLEVLIGAMRH
HHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]