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The map label for this gene is argH

Identifier: 222526835

GI number: 222526835

Start: 4492220

End: 4493605

Strand: Reverse

Name: argH

Synonym: Chy400_3610

Alternate gene names: 222526835

Gene position: 4493605-4492220 (Counterclockwise)

Preceding gene: 222526836

Following gene: 222526834

Centisome position: 85.28

GC content: 58.66

Gene sequence:

>1386_bases
ATGGAACACCGGCTTTGGGGTGGACGTTTCAGTGAACCGACAGCGGCGGAGATGCGTCGCTTCAACGACTCCTTCCATTT
TGATGTCCGTTTGGCCGAGGTCGATATTGCCGGCAGTATCGCCTGGGCCGGTGCCCTATTGCAGGCCGGTCTGATTAATG
AAACCGAACACGCCGACCTCGTGCGCGGGCTGGAACTGGTGCGGGCCGAATTCGCGAACGGGAGCTTCGTGGCCGCAGCG
GGTGACGAAGACATTCATACCGCTGTTGAGCGGCGCCTGCGCGAGTTAATCGGCGATGCGGCGCTCAAGCTACACACCGG
GCGCTCACGCAACGATCAGGTGGCAACCGATATGCGCCTCTACACTATCGGGATTGCGCGCCAGCTTGATCGGCGTCTGC
GCGATCTGCAACTTGCTCTGCTGGCCCAGGCCGAACAACACACTGCCACGGTGATGCCGGGTTATACCCATCTTCAGCGT
GCGCAACCGATCACCTTTGGGCATTGGTGTCTGGCGTATGTTGAGATGTTTGCCCGTGACCGGAGTCGTCTGAACGATGC
CATCCGCCGGATGCGTGTACTGCCTCTCGGTGCCGGTGCGTTGGCCGGTAATTCACTCGGCGTCGAACGCGAGCGCCTGA
CCGAGTTGCTCGATGAATTTGATGAGCTGTCCGCCAACTCACTCGATGCAGTCAGTGATCGTGATTTTGTTGCCGAAGTG
CTCTTTGCCTGTGCCTTAATCGGTGTCCACCTGAGCCGATTGGCCGAAGATGTGATCCTCTACGCCAGTGCTGAATTTGG
CTTTCTCGAACTGGCTGATGCCTACAGTACCGGCTCAAGTCTGATGCCACAAAAGAAGAATCCCGATAGTATGGAATTGC
TGCGCGGCAAAAGTGGTCGCCTGCTGGGCAACCTTGTCGCCTTGCTGACGGTCCTGAAAGGGTTGCCGCTGACCTACAAC
AAAGACATGCAAGAGGACAAAGAACCGCTCTTTGACAGTTTTGATACGCTCGATCTGGGTTTGCAGGTAGCCGCAGCGGC
CATTGCGACCATGACAGTACGGCCTGAGCGCATGGCAGCAGCGCTCGACGATGCCATGCTGGCCACCGATCTGGCCGACG
AGCTGGTGCGGCGTGGCGTACCGTTCCGCGTTGCCCACAGCAAGGTTGGTCAACTGGTACAGCGCGCACTGACCCGTGGG
GTAAGCCTGCGGCAGCTTCCCCTTGCGGATTACCAGGCCGTCGAGCCATCGCTCGATGCGAGCATTTATGATGTGTTCGA
CATGCAGCGCAGCGTCGCGCAAAAAGCCAGTTACGGCGGGACTGCACCACAGCGGGTTCGCGAACAGTGTGCTCGCTGGC
GTGACAGTTTGTTGAATGATGAATAG

Upstream 100 bases:

>100_bases
CGGCAACTACTGGCAATTGCTGATACGTTGTGGTCTGAATATCGAACATCATCAGACGGCGGCCAGTGCACCGTTGTCAT
TGCGATAGAGGAGTAGAGAG

Downstream 100 bases:

>100_bases
TCGTTCGGCATCAGCATTTTGTATCATTGAAGAGGAAAACAGCACAGCTATGACCAGTCCACTCTACGCACCGCCGGTAA
GCCTGCCGGTCCTTCACATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MEHRLWGGRFSEPTAAEMRRFNDSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADLVRGLELVRAEFANGSFVAAA
GDEDIHTAVERRLRELIGDAALKLHTGRSRNDQVATDMRLYTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQR
AQPITFGHWCLAYVEMFARDRSRLNDAIRRMRVLPLGAGALAGNSLGVERERLTELLDEFDELSANSLDAVSDRDFVAEV
LFACALIGVHLSRLAEDVILYASAEFGFLELADAYSTGSSLMPQKKNPDSMELLRGKSGRLLGNLVALLTVLKGLPLTYN
KDMQEDKEPLFDSFDTLDLGLQVAAAAIATMTVRPERMAAALDDAMLATDLADELVRRGVPFRVAHSKVGQLVQRALTRG
VSLRQLPLADYQAVEPSLDASIYDVFDMQRSVAQKASYGGTAPQRVREQCARWRDSLLNDE

Sequences:

>Translated_461_residues
MEHRLWGGRFSEPTAAEMRRFNDSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADLVRGLELVRAEFANGSFVAAA
GDEDIHTAVERRLRELIGDAALKLHTGRSRNDQVATDMRLYTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQR
AQPITFGHWCLAYVEMFARDRSRLNDAIRRMRVLPLGAGALAGNSLGVERERLTELLDEFDELSANSLDAVSDRDFVAEV
LFACALIGVHLSRLAEDVILYASAEFGFLELADAYSTGSSLMPQKKNPDSMELLRGKSGRLLGNLVALLTVLKGLPLTYN
KDMQEDKEPLFDSFDTLDLGLQVAAAAIATMTVRPERMAAALDDAMLATDLADELVRRGVPFRVAHSKVGQLVQRALTRG
VSLRQLPLADYQAVEPSLDASIYDVFDMQRSVAQKASYGGTAPQRVREQCARWRDSLLNDE
>Mature_461_residues
MEHRLWGGRFSEPTAAEMRRFNDSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADLVRGLELVRAEFANGSFVAAA
GDEDIHTAVERRLRELIGDAALKLHTGRSRNDQVATDMRLYTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQR
AQPITFGHWCLAYVEMFARDRSRLNDAIRRMRVLPLGAGALAGNSLGVERERLTELLDEFDELSANSLDAVSDRDFVAEV
LFACALIGVHLSRLAEDVILYASAEFGFLELADAYSTGSSLMPQKKNPDSMELLRGKSGRLLGNLVALLTVLKGLPLTYN
KDMQEDKEPLFDSFDTLDLGLQVAAAAIATMTVRPERMAAALDDAMLATDLADELVRRGVPFRVAHSKVGQLVQRALTRG
VSLRQLPLADYQAVEPSLDASIYDVFDMQRSVAQKASYGGTAPQRVREQCARWRDSLLNDE

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=446, Percent_Identity=50.8968609865471, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI68303542, Length=446, Percent_Identity=50.8968609865471, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI68303549, Length=446, Percent_Identity=48.6547085201794, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI68303547, Length=446, Percent_Identity=47.9820627802691, Blast_Score=396, Evalue=1e-110,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=49.2204899777283, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17553882, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32565146, Length=214, Percent_Identity=28.0373831775701, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=48.471615720524, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221473854, Length=456, Percent_Identity=46.7105263157895, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI78706858, Length=456, Percent_Identity=46.7105263157895, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24640179, Length=218, Percent_Identity=28.8990825688073, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640177, Length=218, Percent_Identity=28.8990825688073, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78710009, Length=253, Percent_Identity=26.4822134387352, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CHLAA (A9WJR8)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636923.1
- ProteinModelPortal:   A9WJR8
- SMR:   A9WJR8
- GeneID:   5825150
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_3348
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51006; Mature: 51006

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRLWGGRFSEPTAAEMRRFNDSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADL
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHHHHCCCCCHHHHHH
VRGLELVRAEFANGSFVAAAGDEDIHTAVERRLRELIGDAALKLHTGRSRNDQVATDMRL
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHH
YTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQRAQPITFGHWCLAYVEMFARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
RSRLNDAIRRMRVLPLGAGALAGNSLGVERERLTELLDEFDELSANSLDAVSDRDFVAEV
HHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LFACALIGVHLSRLAEDVILYASAEFGFLELADAYSTGSSLMPQKKNPDSMELLRGKSGR
HHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCH
LLGNLVALLTVLKGLPLTYNKDMQEDKEPLFDSFDTLDLGLQVAAAAIATMTVRPERMAA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHH
ALDDAMLATDLADELVRRGVPFRVAHSKVGQLVQRALTRGVSLRQLPLADYQAVEPSLDA
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCH
SIYDVFDMQRSVAQKASYGGTAPQRVREQCARWRDSLLNDE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEHRLWGGRFSEPTAAEMRRFNDSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADL
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHHHHCCCCCHHHHHH
VRGLELVRAEFANGSFVAAAGDEDIHTAVERRLRELIGDAALKLHTGRSRNDQVATDMRL
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHH
YTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQRAQPITFGHWCLAYVEMFARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
RSRLNDAIRRMRVLPLGAGALAGNSLGVERERLTELLDEFDELSANSLDAVSDRDFVAEV
HHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LFACALIGVHLSRLAEDVILYASAEFGFLELADAYSTGSSLMPQKKNPDSMELLRGKSGR
HHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCH
LLGNLVALLTVLKGLPLTYNKDMQEDKEPLFDSFDTLDLGLQVAAAAIATMTVRPERMAA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHH
ALDDAMLATDLADELVRRGVPFRVAHSKVGQLVQRALTRGVSLRQLPLADYQAVEPSLDA
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCH
SIYDVFDMQRSVAQKASYGGTAPQRVREQCARWRDSLLNDE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA