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The map label for this gene is thrA [H]

Identifier: 222526825

GI number: 222526825

Start: 4480639

End: 4481703

Strand: Reverse

Name: thrA [H]

Synonym: Chy400_3600

Alternate gene names: 222526825

Gene position: 4481703-4480639 (Counterclockwise)

Preceding gene: 222526827

Following gene: 222526824

Centisome position: 85.06

GC content: 59.44

Gene sequence:

>1065_bases
ATGACACCGATTATTCAACTTGGTCTTGGTGGTGTTGGTCGGGCACTTGTCCGTCAGATGCTGGCTGTGGCACCGACCAT
TCGCCGACGCTATGGCATCGACTTGCGCTACACAGCCCTGGTGGACAGCCGTGGCGCACTGGCCGGCGATCCGGCACTCA
CCGATGATCAGATTCAGACTGTGCTTACCGCCAAAGCGGCGGGTCATCATATTGATAGTCTTGCCCACGCTATTACTGAT
CGACACTGGCTGGAACTCTTACCGGCAACGATGGCTATCGTGGTTGACGTCACGGCGGCGGGGAGTCACGCGGCACCGCT
TGCTGCTGCTATCTCTGCCGGACACCGGGTGGTGCTGGCCAACAAACGACCGTTGTGTGAGAGTTATGAACTCTTTGCCG
CGCTGACTGAACGTGGCGCGACCCGCTACGAAGCAACCGTCGGCGCAGGCTTACCGGTGATTGGTGTGCTGCAAAGCCTG
ATCGATAGCGGCGACGAGGTACGCGCCATTGAAGCGGCCTTGAGTGGAACCCTCGGCTTTCTCATGAGTGAGCTTGAACG
TGGGGTTGGCTTCGCCGATGCAGTACGCACGGCCCACCAGCTCGGTTACACCGAACCCGATCCTCGCGACGATCTGAGCG
GTGCGGATGTCGCCCGTAAAGCGCTCATTCTGGCCCGTACCTGTGGCATGCATCTGCCGCCTGATGCTGTAATCGCCGAG
CCACTCTTCCCGGCGACCCTGAAAGAGATCAGCGTCACCGAATTTCTCCAACGGCTTGAGGAAGCAGAACACGAGGTGAT
GAACCGTTTGCAGGTGGCCAGTGCTAACGGGAAGGTGTTGCGCTACATCACCCGCATCAGTCCTGACAATGGGGTCGAGG
TTGGCCTGCGCGAATTGCCCACCGATCATCCGCTCGCCAGTCTGCGCGGCCCAGATAATATGATCAGTTTCACGACGAAT
CGCTACGCTGATCGCCCGCTTGTCGTCCGTGGCCCCGGCGCCGGCGTAGAAGTGACCGCAGCCGGTGTGTTGAGCGATAT
TATTGCCACCGCACGAGAGTTATGA

Upstream 100 bases:

>100_bases
GCGCGGCAGACCGTCAAATCCGTGCAACCGATCAGGCTGCCAGACAGCAACACACCCTGTGGTACAATAGCCGCACATTG
GACGGAGACCAGGGGAAGCT

Downstream 100 bases:

>100_bases
CCCTGCAAGCACAAGCTGACACAGCTCCCATAGCCCGTGATGTGCCATTGATCGACTTGCATCGCCATCTCGATGGCAAT
GTGCGGCTCACCACTATCCT

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTPIIQLGLGGVGRALVRQMLAVAPTIRRRYGIDLRYTALVDSRGALAGDPALTDDQIQTVLTAKAAGHHIDSLAHAITD
RHWLELLPATMAIVVDVTAAGSHAAPLAAAISAGHRVVLANKRPLCESYELFAALTERGATRYEATVGAGLPVIGVLQSL
IDSGDEVRAIEAALSGTLGFLMSELERGVGFADAVRTAHQLGYTEPDPRDDLSGADVARKALILARTCGMHLPPDAVIAE
PLFPATLKEISVTEFLQRLEEAEHEVMNRLQVASANGKVLRYITRISPDNGVEVGLRELPTDHPLASLRGPDNMISFTTN
RYADRPLVVRGPGAGVEVTAAGVLSDIIATAREL

Sequences:

>Translated_354_residues
MTPIIQLGLGGVGRALVRQMLAVAPTIRRRYGIDLRYTALVDSRGALAGDPALTDDQIQTVLTAKAAGHHIDSLAHAITD
RHWLELLPATMAIVVDVTAAGSHAAPLAAAISAGHRVVLANKRPLCESYELFAALTERGATRYEATVGAGLPVIGVLQSL
IDSGDEVRAIEAALSGTLGFLMSELERGVGFADAVRTAHQLGYTEPDPRDDLSGADVARKALILARTCGMHLPPDAVIAE
PLFPATLKEISVTEFLQRLEEAEHEVMNRLQVASANGKVLRYITRISPDNGVEVGLRELPTDHPLASLRGPDNMISFTTN
RYADRPLVVRGPGAGVEVTAAGVLSDIIATAREL
>Mature_353_residues
TPIIQLGLGGVGRALVRQMLAVAPTIRRRYGIDLRYTALVDSRGALAGDPALTDDQIQTVLTAKAAGHHIDSLAHAITDR
HWLELLPATMAIVVDVTAAGSHAAPLAAAISAGHRVVLANKRPLCESYELFAALTERGATRYEATVGAGLPVIGVLQSLI
DSGDEVRAIEAALSGTLGFLMSELERGVGFADAVRTAHQLGYTEPDPRDDLSGADVARKALILARTCGMHLPPDAVIAEP
LFPATLKEISVTEFLQRLEEAEHEVMNRLQVASANGKVLRYITRISPDNGVEVGLRELPTDHPLASLRGPDNMISFTTNR
YADRPLVVRGPGAGVEVTAAGVLSDIIATAREL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=349, Percent_Identity=35.8166189111748, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786183, Length=342, Percent_Identity=34.7953216374269, Blast_Score=191, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6322599, Length=363, Percent_Identity=36.0881542699724, Blast_Score=170, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 37584; Mature: 37452

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIIQLGLGGVGRALVRQMLAVAPTIRRRYGIDLRYTALVDSRGALAGDPALTDDQIQT
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHH
VLTAKAAGHHIDSLAHAITDRHWLELLPATMAIVVDVTAAGSHAAPLAAAISAGHRVVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEE
NKRPLCESYELFAALTERGATRYEATVGAGLPVIGVLQSLIDSGDEVRAIEAALSGTLGF
CCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LMSELERGVGFADAVRTAHQLGYTEPDPRDDLSGADVARKALILARTCGMHLPPDAVIAE
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
PLFPATLKEISVTEFLQRLEEAEHEVMNRLQVASANGKVLRYITRISPDNGVEVGLRELP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHCC
TDHPLASLRGPDNMISFTTNRYADRPLVVRGPGAGVEVTAAGVLSDIIATAREL
CCCCHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPIIQLGLGGVGRALVRQMLAVAPTIRRRYGIDLRYTALVDSRGALAGDPALTDDQIQT
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHH
VLTAKAAGHHIDSLAHAITDRHWLELLPATMAIVVDVTAAGSHAAPLAAAISAGHRVVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEE
NKRPLCESYELFAALTERGATRYEATVGAGLPVIGVLQSLIDSGDEVRAIEAALSGTLGF
CCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LMSELERGVGFADAVRTAHQLGYTEPDPRDDLSGADVARKALILARTCGMHLPPDAVIAE
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHC
PLFPATLKEISVTEFLQRLEEAEHEVMNRLQVASANGKVLRYITRISPDNGVEVGLRELP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHCC
TDHPLASLRGPDNMISFTTNRYADRPLVVRGPGAGVEVTAAGVLSDIIATAREL
CCCCHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]