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The map label for this gene is folD

Identifier: 222526767

GI number: 222526767

Start: 4410885

End: 4411742

Strand: Direct

Name: folD

Synonym: Chy400_3541

Alternate gene names: 222526767

Gene position: 4410885-4411742 (Clockwise)

Preceding gene: 222526766

Following gene: 222526768

Centisome position: 83.71

GC content: 59.67

Gene sequence:

>858_bases
ATGAGCGCACGCATCCTCGATGGTAAGGCACTGGCGCAAGAGCTACGGGCCGAAGCCGCAGCCCAGATTGCTGAATTGCG
CACTCAGATTGATCGTCCACCTACAATCGCCGTGGTGCAGGTCGGTGATGATCCGGCGGCAACCCGCTATGTGCGGAGCA
TTGACCGCCTGTGTCAGTCGTTGGGAGCTGCCTGCCGGGCAATTGCACTTCCGGCAGAAACGGCGCAGGCCGACCTGGAA
GCGACCGTGGCGACGCTGAGTGCAGATGATCGGATTGACGGTATCTTACTGCAATTACCGTTACCGGCGGGTTTAACCCT
CGATGGTGTGCTAAGCCGGCTTGCCCCGGAAAAGGATCTCGATGGTATTCACCCGATCAACGCCGGCTTGCTGGCGCAGG
GGCGGCCAACCCTCACACCCAACACCCCGGCTGGTGGCATTGAACTCATGCGGCGTTATGGTATCGACATTCGCGGGCGG
CGTGCCGCAGTGGTTGGCCGCTCGGCAATTGTTGGTCGACCTATGGCCCTCCTGCTACTACAAGCCGATGCGACAGTGAC
AATCTGTCATTCCCGGACACCCGATCTCGGTGCAGTTTTGCGCGAGTGCGATATTATCGCTGCGGCTGCCGGTCGTCCTG
GTCTGATCACTGCCGATATGGTCAAACCCGGTGCAACCGTAATCGACTTCGGTACCAATGTGTTAGCCGATGGAAGTATG
GTTGGCGATGTCGATTTTGCTGCCGTGGCCGAGGTGGCCGGGGCAATTACGCCGGTACCCGGTGGTACCGGGCCGGTGAC
CAACATCATGTTGATGCGGAATCTGATCACGGCAACGCGCACTCGTCTCGGCATCTAA

Upstream 100 bases:

>100_bases
TGTTCGTGCGCGAGACACGGGCGCAGTTGCAAGACCTGCTGATCGGACTTGGTGATGAAGTTGATGGTATCGTCACCATT
GTTCGGGGAAGGATGGCGGG

Downstream 100 bases:

>100_bases
CCACCTGTAGCTACTCACGAGCAAGGACGAGACATATAGGTTGGCGTGCGAGGTGACAATCTCGCACGTAACAAATCACT
CTGGCCGTCAGGTGTTACCA

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQSLGAACRAIALPAETAQADLE
ATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDLDGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGR
RAAVVGRSAIVGRPMALLLLQADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSM
VGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI

Sequences:

>Translated_285_residues
MSARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQSLGAACRAIALPAETAQADLE
ATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDLDGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGR
RAAVVGRSAIVGRPMALLLLQADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSM
VGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI
>Mature_284_residues
SARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQSLGAACRAIALPAETAQADLEA
TVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDLDGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGRR
AAVVGRSAIVGRPMALLLLQADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSMV
GDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=292, Percent_Identity=38.3561643835616, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI94721354, Length=297, Percent_Identity=39.7306397306397, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI222418558, Length=294, Percent_Identity=40.1360544217687, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI36796743, Length=206, Percent_Identity=27.1844660194175, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786741, Length=278, Percent_Identity=46.0431654676259, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17568735, Length=296, Percent_Identity=40.5405405405405, Blast_Score=193, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6321643, Length=300, Percent_Identity=38.3333333333333, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319558, Length=288, Percent_Identity=39.5833333333333, Blast_Score=201, Evalue=9e-53,
Organism=Drosophila melanogaster, GI17136816, Length=296, Percent_Identity=42.9054054054054, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17136818, Length=296, Percent_Identity=42.9054054054054, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI62472483, Length=284, Percent_Identity=39.7887323943662, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551871, Length=284, Percent_Identity=39.7887323943662, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24645718, Length=284, Percent_Identity=39.7887323943662, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17137370, Length=284, Percent_Identity=39.7887323943662, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_CHLAA (A9WJ10)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636858.1
- ProteinModelPortal:   A9WJ10
- SMR:   A9WJ10
- GeneID:   5825083
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_3281
- HOGENOM:   HBG328751
- OMA:   CLMMLRD
- ProtClustDB:   CLSK975315
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 29479; Mature: 29347

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LGAACRAIALPAETAQADLEATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
DGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGRRAAVVGRSAIVGRPMALLLL
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHCCCCEEEEE
QADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSM
ECCCEEEEECCCCCCHHHHHHHHHEEEECCCCCCEEEHHCCCCCCEEEECCCCEEECCCE
VGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI
ECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LGAACRAIALPAETAQADLEATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
DGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGRRAAVVGRSAIVGRPMALLLL
CCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHCCCCEEEEE
QADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSM
ECCCEEEEECCCCCCHHHHHHHHHEEEECCCCCCEEEHHCCCCCCEEEECCCCEEECCCE
VGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI
ECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA