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The map label for this gene is mutT [C]

Identifier: 222526692

GI number: 222526692

Start: 4317893

End: 4318366

Strand: Reverse

Name: mutT [C]

Synonym: Chy400_3462

Alternate gene names: 222526692

Gene position: 4318366-4317893 (Counterclockwise)

Preceding gene: 222526693

Following gene: 222526690

Centisome position: 81.96

GC content: 57.38

Gene sequence:

>474_bases
ATGACGGTCAAATATACGCGCTGGCTGCGTAGTTACGTCGGTCATCAGCGAATTTTACAGGTACGGGCAAGTGGTTTTGT
GCGCAATGAAGCCGGCCAGATTCTGCTCTGTCGGCGGGCGGATGTGATGCTCTGGGATGTGCCGGGTGGTACGATTAACC
TCGATGAGTCGCCGGCCCAGGGCCTGGTACGGGAGGTGCGCGAGGAGACCGGTCTGCTGTTGCGACCCGAAAAGCTGATT
GGCATCTACAGTGGCCCCGATTTTGCCTGGAGCTACCCCAACGGTGATCAGTCACAAATCCTGGCGATCTTTTTTGCCGC
CCGTATTGTCGGCGGTGAACTCCAACAGGCCGGGCACGAAAATGTGAATGTGGGTTTCTTTGATCCCAATCATCTGCCAC
CACTGCTCACCCGCACCCGCCGAATGCTGGCCGATGCGTTCGCAAACCGGCCAGAGGCGGCTTTTGACTTTTAG

Upstream 100 bases:

>100_bases
CTGGTCAGTTAACGTGCGGCGCAACCTTGTCATCCCATTCCGCACCTGCTGCTACGCAGTTCTGCTATAATAGCCGGCAA
TTCGAGCAAAGGAGCGGGCT

Downstream 100 bases:

>100_bases
AACATACTGTCAGGCGGGTTATCTGCCCCGTGCGTAGTAGAGCGGGGCTACCTGCCGCACCAATCCTTTCAACTCTAACA
AAGCCAGTGCTGCTGCTGTC

Product: NUDIX hydrolase

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MTVKYTRWLRSYVGHQRILQVRASGFVRNEAGQILLCRRADVMLWDVPGGTINLDESPAQGLVREVREETGLLLRPEKLI
GIYSGPDFAWSYPNGDQSQILAIFFAARIVGGELQQAGHENVNVGFFDPNHLPPLLTRTRRMLADAFANRPEAAFDF

Sequences:

>Translated_157_residues
MTVKYTRWLRSYVGHQRILQVRASGFVRNEAGQILLCRRADVMLWDVPGGTINLDESPAQGLVREVREETGLLLRPEKLI
GIYSGPDFAWSYPNGDQSQILAIFFAARIVGGELQQAGHENVNVGFFDPNHLPPLLTRTRRMLADAFANRPEAAFDF
>Mature_156_residues
TVKYTRWLRSYVGHQRILQVRASGFVRNEAGQILLCRRADVMLWDVPGGTINLDESPAQGLVREVREETGLLLRPEKLIG
IYSGPDFAWSYPNGDQSQILAIFFAARIVGGELQQAGHENVNVGFFDPNHLPPLLTRTRRMLADAFANRPEAAFDF

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006357
- InterPro:   IPR023215
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00702 Hydrolase; PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17684; Mature: 17553

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKYTRWLRSYVGHQRILQVRASGFVRNEAGQILLCRRADVMLWDVPGGTINLDESPAQ
CCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEECCCEEEEECCCCEEECCCCHHH
GLVREVREETGLLLRPEKLIGIYSGPDFAWSYPNGDQSQILAIFFAARIVGGELQQAGHE
HHHHHHHHHCCCEECHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHCCCC
NVNVGFFDPNHLPPLLTRTRRMLADAFANRPEAAFDF
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TVKYTRWLRSYVGHQRILQVRASGFVRNEAGQILLCRRADVMLWDVPGGTINLDESPAQ
CCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEECCCEEEEECCCCEEECCCCHHH
GLVREVREETGLLLRPEKLIGIYSGPDFAWSYPNGDQSQILAIFFAARIVGGELQQAGHE
HHHHHHHHHCCCEECHHHHEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHCCCC
NVNVGFFDPNHLPPLLTRTRRMLADAFANRPEAAFDF
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631946 [H]