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The map label for this gene is nadC [H]

Identifier: 222524249

GI number: 222524249

Start: 1239565

End: 1240410

Strand: Reverse

Name: nadC [H]

Synonym: Chy400_0971

Alternate gene names: 222524249

Gene position: 1240410-1239565 (Counterclockwise)

Preceding gene: 222524250

Following gene: 222524247

Centisome position: 23.54

GC content: 60.99

Gene sequence:

>846_bases
ATGGAACTTCCCCGTCATATCGTTGACGCCGTGGTCGCGCAGGCGCTGGCCGAAGATGTTGGTGGTGGCGATCTGACCAC
CTTGACCGCTATTCCGGCGACAGTGCAGAGTTCCGCGCAGGTTGTGGTGCGTGAGGCCGGTGTGGTAGCCGGGCTGCCGG
TCGTGATTGCCGTTTTTCGCCAGCTTGATCCTGGCGTCGCCGTGCAATGCCATGTGGCTGAAGGGGCGGCTGTTTCTGCT
GGTACGACCCTGGCAACGATTACCGGTTCGGCGCGTAGTATTCTCACCGGTGAACGGGTGGCGCTCAATCTGTTGCAGCG
GCTGAGCGGGATTGCCACGCTGACTGCGCAGTACGTTGCCGCAATAGCCGGCACGCAGGCGAAGATTCTCGATACCCGGA
AGACAACGCCTGGGCTGCGTGCCCTGGAGAAATACGCTGTACGGGTAGGTGGTGGCTACAATCATCGGTTTGGCCTGTAC
GATGGGGTGATGTTGAAAGACAACCATCTGGCGATCCTGGCTGCCCAGGGGATCGATCTGGCCGGGGCGATCAGGCACGT
GCGCCGGCAGCTTGGGCCAATGGTGCGGCTTGAAGTTGAAGTCGAGAGTGTGGCGGCAGCAATCGTTGCTGCCGAAGCCG
GGGCCGATCTGATCTTGCTCGATAACATGCCGCCTGATCAGTTGCGGCTGGCAGTACAGGCTGTTGCTGGGCGCGCCAAA
ACGGAAGCCAGTGGTGGCGTGACGTTGCAGACCGTGCGCGCGATTGCCGAAACCGGTGTTGATTATATCTCGGTTGGCGC
GCTGACCCATTCGGTGCGTGCGCTCGACATCGGTCTCGATATTTGA

Upstream 100 bases:

>100_bases
AGTACCTTGGATTACATAATGCGCCGCTAATCACACGGCGCGATGACTATCATCGGATACAATACCGTCGGAGGATCGGG
TTGTAGTAAAGGATGTCATA

Downstream 100 bases:

>100_bases
TTTATGGCACACCCAGCAGGGCGACAGCGTCGATCTCGCTCCAGCTTCCATCACGCTGATCGATGGTGATACGCGCACTG
ACAATTCGGGTCAGGGTTTG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFRQLDPGVAVQCHVAEGAAVSA
GTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYVAAIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLY
DGVMLKDNHLAILAAQGIDLAGAIRHVRRQLGPMVRLEVEVESVAAAIVAAEAGADLILLDNMPPDQLRLAVQAVAGRAK
TEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGLDI

Sequences:

>Translated_281_residues
MELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFRQLDPGVAVQCHVAEGAAVSA
GTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYVAAIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLY
DGVMLKDNHLAILAAQGIDLAGAIRHVRRQLGPMVRLEVEVESVAAAIVAAEAGADLILLDNMPPDQLRLAVQAVAGRAK
TEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGLDI
>Mature_281_residues
MELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFRQLDPGVAVQCHVAEGAAVSA
GTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYVAAIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLY
DGVMLKDNHLAILAAQGIDLAGAIRHVRRQLGPMVRLEVEVESVAAAIVAAEAGADLILLDNMPPDQLRLAVQAVAGRAK
TEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGLDI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=284, Percent_Identity=38.3802816901408, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=45.2898550724638, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321162, Length=284, Percent_Identity=33.8028169014084, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 28937; Mature: 28937

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFR
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCHHHHHHHCCCCCCHHHHHHHHH
QLDPGVAVQCHVAEGAAVSAGTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYVA
HCCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
AIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLYDGVMLKDNHLAILAAQGIDL
HHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEEEECCCCH
AGAIRHVRRQLGPMVRLEVEVESVAAAIVAAEAGADLILLDNMPPDQLRLAVQAVAGRAK
HHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCC
TEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGLDI
CCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEEEEECCC
>Mature Secondary Structure
MELPRHIVDAVVAQALAEDVGGGDLTTLTAIPATVQSSAQVVVREAGVVAGLPVVIAVFR
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHCCHHHHHHHCCCCCCHHHHHHHHH
QLDPGVAVQCHVAEGAAVSAGTTLATITGSARSILTGERVALNLLQRLSGIATLTAQYVA
HCCCCCEEEEEECCCCEEECCCEEEEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
AIAGTQAKILDTRKTTPGLRALEKYAVRVGGGYNHRFGLYDGVMLKDNHLAILAAQGIDL
HHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEEEECCCCH
AGAIRHVRRQLGPMVRLEVEVESVAAAIVAAEAGADLILLDNMPPDQLRLAVQAVAGRAK
HHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCC
TEASGGVTLQTVRAIAETGVDYISVGALTHSVRALDIGLDI
CCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]