Click here to switch to the map view.

The map label for this gene is mvk [H]

Identifier: 222524233

GI number: 222524233

Start: 1220455

End: 1221390

Strand: Reverse

Name: mvk [H]

Synonym: Chy400_0955

Alternate gene names: 222524233

Gene position: 1221390-1220455 (Counterclockwise)

Preceding gene: 222524234

Following gene: 222524232

Centisome position: 23.18

GC content: 60.9

Gene sequence:

>936_bases
ATGGCAACGGCACCGGCGAAACTCATCCTCTGTGGCGAGCACGCCGTCGTCTACGGTCGTCCGGCGATTGCTCTGCCACT
GGCCGATATTCGCGCCACGGCTACCGTAGCGCCATCTCCTGCCGGGAGTGGGCCGATGATCCATGCCCCTGATCTCGGTG
GCAGGTGGCGCGTGGCCGAACAGCCGACCGATCCACTCAGCAGGCTGGTCACCACTGTCGTCGAACGTTTCGGGCTGCCG
GCTGATGTCGAGATCACAATTCGCTCTGCCATCCCAATTGCCAGTGGGATGGGCAGTGGCGCCGCAATTGCCACGGCAAT
TGTGCGAGAGCTGTTGGCCTACGGCGGTCAAACTCTGCCACCGGCAGAGATTTCTGCCATCGTCTACGAGAGTGAACGTG
CGTATCACGGCACACCGAGCGGCATTGACAATACCGTTGTTGCGTTTGAACAGCCTATCTGGTTTCAACGCCGTCCTGAT
CAACCACCACTCATCGAGCCGATTGTCATTGGCACTCCCCTGACTCTGGTGGTCGGTGATACCGGTGTGCGTAGCCCCAC
ACGCTTACCGGTTGGTGCTGTGCGCGAGCGCTGGCAAGCCGATCCTGCTCGCTATGAAGCACTGTTCGACCAGGTAGCAA
CGCTGGTCGTTGCTGCACGAACTGCCCTTGCCGAAGGGGATGTGGTGACGTTGGGAACGCTACTCAACACCAATCACGAA
TTGCTCCGCGACATTGGCGTGTCATCGGCAGAACTTGATTGCCTGACCACCGCTGCCCGTTCAGCCGGCGCTCTGGGTGC
CAAACTGGCCGGTGCCGGTTGGGGTGGGGTGATGCTGGCACTCACTACCCCCGATCAGGCACCGGTTATTGCGGCGGCAT
TACAGGCCGCGGGTGCAACAAATACCCTCGTGACCACAATTGCAGCCACCGGCTGA

Upstream 100 bases:

>100_bases
TCCCGACCGCACCCTTCTCGACGAGACACTGGCGAAGATTCGCAAGAAGATCATTTCCAGTCTCGAACGGGAACTGGGTG
CTACAATCCGCAGCTAAGCG

Downstream 100 bases:

>100_bases
AACCTCTCAGAAATGCCCTCACCCCCGGCCCTTCTTCCGCTACGCGGGAGAGGGGTGACTGGGGTTTGCGCTAGTGCTTC
CTGATGCGGCCAAATTTGCG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MATAPAKLILCGEHAVVYGRPAIALPLADIRATATVAPSPAGSGPMIHAPDLGGRWRVAEQPTDPLSRLVTTVVERFGLP
ADVEITIRSAIPIASGMGSGAAIATAIVRELLAYGGQTLPPAEISAIVYESERAYHGTPSGIDNTVVAFEQPIWFQRRPD
QPPLIEPIVIGTPLTLVVGDTGVRSPTRLPVGAVRERWQADPARYEALFDQVATLVVAARTALAEGDVVTLGTLLNTNHE
LLRDIGVSSAELDCLTTAARSAGALGAKLAGAGWGGVMLALTTPDQAPVIAAALQAAGATNTLVTTIAATG

Sequences:

>Translated_311_residues
MATAPAKLILCGEHAVVYGRPAIALPLADIRATATVAPSPAGSGPMIHAPDLGGRWRVAEQPTDPLSRLVTTVVERFGLP
ADVEITIRSAIPIASGMGSGAAIATAIVRELLAYGGQTLPPAEISAIVYESERAYHGTPSGIDNTVVAFEQPIWFQRRPD
QPPLIEPIVIGTPLTLVVGDTGVRSPTRLPVGAVRERWQADPARYEALFDQVATLVVAARTALAEGDVVTLGTLLNTNHE
LLRDIGVSSAELDCLTTAARSAGALGAKLAGAGWGGVMLALTTPDQAPVIAAALQAAGATNTLVTTIAATG
>Mature_310_residues
ATAPAKLILCGEHAVVYGRPAIALPLADIRATATVAPSPAGSGPMIHAPDLGGRWRVAEQPTDPLSRLVTTVVERFGLPA
DVEITIRSAIPIASGMGSGAAIATAIVRELLAYGGQTLPPAEISAIVYESERAYHGTPSGIDNTVVAFEQPIWFQRRPDQ
PPLIEPIVIGTPLTLVVGDTGVRSPTRLPVGAVRERWQADPARYEALFDQVATLVVAARTALAEGDVVTLGTLLNTNHEL
LRDIGVSSAELDCLTTAARSAGALGAKLAGAGWGGVMLALTTPDQAPVIAAALQAAGATNTLVTTIAATG

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=378, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557769, Length=378, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323864, Length=399, Percent_Identity=23.3082706766917, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707210, Length=347, Percent_Identity=28.5302593659942, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32004; Mature: 31873

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAPAKLILCGEHAVVYGRPAIALPLADIRATATVAPSPAGSGPMIHAPDLGGRWRVAE
CCCCCCEEEEECCCEEEECCCEEEEEHHHHCEEEEECCCCCCCCCEEECCCCCCEEEECC
QPTDPLSRLVTTVVERFGLPADVEITIRSAIPIASGMGSGAAIATAIVRELLAYGGQTLP
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PAEISAIVYESERAYHGTPSGIDNTVVAFEQPIWFQRRPDQPPLIEPIVIGTPLTLVVGD
HHHEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEECC
TGVRSPTRLPVGAVRERWQADPARYEALFDQVATLVVAARTALAEGDVVTLGTLLNTNHE
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHH
LLRDIGVSSAELDCLTTAARSAGALGAKLAGAGWGGVMLALTTPDQAPVIAAALQAAGAT
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
NTLVTTIAATG
CCEEEEEEECC
>Mature Secondary Structure 
ATAPAKLILCGEHAVVYGRPAIALPLADIRATATVAPSPAGSGPMIHAPDLGGRWRVAE
CCCCCEEEEECCCEEEECCCEEEEEHHHHCEEEEECCCCCCCCCEEECCCCCCEEEECC
QPTDPLSRLVTTVVERFGLPADVEITIRSAIPIASGMGSGAAIATAIVRELLAYGGQTLP
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PAEISAIVYESERAYHGTPSGIDNTVVAFEQPIWFQRRPDQPPLIEPIVIGTPLTLVVGD
HHHEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEECC
TGVRSPTRLPVGAVRERWQADPARYEALFDQVATLVVAARTALAEGDVVTLGTLLNTNHE
CCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHH
LLRDIGVSSAELDCLTTAARSAGALGAKLAGAGWGGVMLALTTPDQAPVIAAALQAAGAT
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
NTLVTTIAATG
CCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA