Click here to switch to the map view.

The map label for this gene is frzE [H]

Identifier: 222524203

GI number: 222524203

Start: 1166501

End: 1168762

Strand: Reverse

Name: frzE [H]

Synonym: Chy400_0924

Alternate gene names: 222524203

Gene position: 1168762-1166501 (Counterclockwise)

Preceding gene: 222524204

Following gene: 222524202

Centisome position: 22.18

GC content: 54.95

Gene sequence:

>2262_bases
ATGCTCTCTGATGACGATATTCAGGCGCAGGTGCTGGCCGTCTTTCGCGCAGAACAGGCCGAGCATCGTCAAACCATCAT
CGATATTCTGCTCGATCTGGAGCGGACACCAGATCACCCTCGCCGTCGTGATCTGGTTGATCACCTGTTTCGAGCCGCTC
ACAGTCTGAAAGGTGGGGCACGCGCTGCTGGTGTCAAAAGCGTTGAGCAGATCGCTCATCACATTGAGCATATCTTTGCG
GCCCTGCGCCAGAACCAGCTTACGCTCACCGCCGATATCTGTGATGTGATTTATCAGGCGCTTGATGTTATTGGCGCGTT
GATGGAACAGGCGGTGCCGGGGCAAATAGACGATCAGGACGCATTGGATGACTTACTCGCTCATCTGATGGCAATCGGCC
AGAACATGCGCGACGGCGACGCAACCAGTCTATCACCATCTTCATTTACGCCAGAAGATCACACCCGGCAGTCGGCGCCA
TCGCTGGCCGCCGAAACAAGTGTCCGGGTTGATGTGGCTGTTCTCGACAATTTGATGAGCGAAATGGGGGAGTTGTTAAC
AAGTACGCTGCGTACCCGTCAGCTTGCCCGTGATCTGCAAGAACTGGCCCGGCTGCCTGAGCGCTGGCAGCGCGCCTGGC
GGCGAACTGCACCGTTCCTGCGCCACGGATCGTCGTTGCATGCCAATGGTCAGCTCATTCCGCAAAGTCAACAACAGATT
GTCATCGACATGCTCAGGCAGGCAAATGACGTTATCAGTGCACTCGGTACAAGATTGTCTCAGCTTGCCTATCAGGCCCG
CGATAATCACGATCTCCTGGCCGATATTAGCACGCGGATGCAGGCCCAGGTGCAGCGTACTCGTATGTCGCCCCTGAGTA
GAATTGTCGGTTCATTACGCCTGCACGTGCGCGATTTGGCTCGTAGCGCCGGCAAAGAAGTGACATTTGTCGTCGAAGAC
TCTGGGGCAGAAGCTGATCGCCAGGTCCTTGATCAGGTGTATGAGATTTGTCTGCATTTGCTCCGCAATGCAGTGGATCA
TGGGATTGAACCCCCTGAGGTGCGTAAGGCCAGGGGGAAACCACCTACCGGTCTGATCCGCCTGACGGCGAACGCCAGCA
GTGACCGCCTCAATCTTGTGATTAGTGACGATGGCGCCGGGATTGATCGAGAAGATATCAAACGGCATGCGCTTCAGCTC
GGTCTGTTGAGTCAACATGACAGTGAGCATGCTGACGATGCGATGGTTCTCGATCTCATCTTTACTCCAGGGTTCTCGAC
CAAATCGCATGTCAGTGAGTTGTCGGGACGGGGGGTTGGCCTTGATGTCGTGCGAACGACTGTCGAGCGGATGGGAGGGA
GCGTGACGGTAATGAGTGTTCCCGGTCAGGGCACAACGTTCACTCTGGCTCTCCCGCTCACCCTCATGCGCACGCGCGGT
CTGCTGATGTATGTGAATAATCAAGTCTTTGCCTTACCCGTTGATAGTCTACGCCGCGTGGTGCAGGTTAATCGTACCCA
ACTTCATACCCTGGAAGGTCGTCCGGTTGTGCTTGTTGATGGACGGCCATTACAACTGATTTCCATGGCCCGGCTCATCG
GTTTTTCATCAGAAACAGTGATCGATTTCCCTGGTCCCAAGCCGGCATTATTGATCGGGAGTAATGAACGACAAATTGCC
TGTATTGTTGATTCTATCGGCGAAGAGATCGATCTCGTCGTTCACCGGCTGCCACCACCATTACAACGGGTTCGCTTTGT
CAGTGGCGCGGCAATTCTCGCTGATGGCAGCGTAGCCCCGATCCTTGATGCGGTCGATCTGTTACGAGCAGCCCTGACGG
TTGAGCATGCGGTGATGTTACCGACTGCCAATCCTACCCCTGCTCATTCGCCGACGATCCTCGTGGTTGATGACTCAATC
ACGACCCGTACATTGGAAAAGAACATCCTGGAAGCCGCCGGTTATCGGGTTGTGCTGGCAACTGATGGTCAGGAGGCACT
GGAACGATTGCACAACTTGCAAAATCAGGGTGGATGTCAGCTTGTCCTGAGTGATATTGATATGCCACGTTTGAATGGCT
TCGATCTGACTCGTCAGATTCGCACCGATCCTGCCTTCCGTCACTTGCCGGTGGTACTCGTTACCTCGCTCGATAGTCCA
GCCGACCGCGAACGTGGCCTGGCTGCGGGTGCCGATGCCTATATCGTTAAACGTGCCTTTGATCAGCAAGCACTGCTGGA
AACTATCGCACGGTTGCTATGA

Upstream 100 bases:

>100_bases
TTCACTATGGGTGACCGGGTGGAAGTATCTGCGTCAGCGAGCGCGGGACTGTTTTCACTACCGGCTTGCGACCTTACGCT
CATCTAACTAAGAGGTTTAT

Downstream 100 bases:

>100_bases
GATAGTACTATGAAACACATCCAGACCCAAAAAATCACGGTCAGCAATGATGCTGATCTGATACTGCTTCGCCAGATACT
GCGCCAGAGTACGCGAACGA

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MLSDDDIQAQVLAVFRAEQAEHRQTIIDILLDLERTPDHPRRRDLVDHLFRAAHSLKGGARAAGVKSVEQIAHHIEHIFA
ALRQNQLTLTADICDVIYQALDVIGALMEQAVPGQIDDQDALDDLLAHLMAIGQNMRDGDATSLSPSSFTPEDHTRQSAP
SLAAETSVRVDVAVLDNLMSEMGELLTSTLRTRQLARDLQELARLPERWQRAWRRTAPFLRHGSSLHANGQLIPQSQQQI
VIDMLRQANDVISALGTRLSQLAYQARDNHDLLADISTRMQAQVQRTRMSPLSRIVGSLRLHVRDLARSAGKEVTFVVED
SGAEADRQVLDQVYEICLHLLRNAVDHGIEPPEVRKARGKPPTGLIRLTANASSDRLNLVISDDGAGIDREDIKRHALQL
GLLSQHDSEHADDAMVLDLIFTPGFSTKSHVSELSGRGVGLDVVRTTVERMGGSVTVMSVPGQGTTFTLALPLTLMRTRG
LLMYVNNQVFALPVDSLRRVVQVNRTQLHTLEGRPVVLVDGRPLQLISMARLIGFSSETVIDFPGPKPALLIGSNERQIA
CIVDSIGEEIDLVVHRLPPPLQRVRFVSGAAILADGSVAPILDAVDLLRAALTVEHAVMLPTANPTPAHSPTILVVDDSI
TTRTLEKNILEAAGYRVVLATDGQEALERLHNLQNQGGCQLVLSDIDMPRLNGFDLTRQIRTDPAFRHLPVVLVTSLDSP
ADRERGLAAGADAYIVKRAFDQQALLETIARLL

Sequences:

>Translated_753_residues
MLSDDDIQAQVLAVFRAEQAEHRQTIIDILLDLERTPDHPRRRDLVDHLFRAAHSLKGGARAAGVKSVEQIAHHIEHIFA
ALRQNQLTLTADICDVIYQALDVIGALMEQAVPGQIDDQDALDDLLAHLMAIGQNMRDGDATSLSPSSFTPEDHTRQSAP
SLAAETSVRVDVAVLDNLMSEMGELLTSTLRTRQLARDLQELARLPERWQRAWRRTAPFLRHGSSLHANGQLIPQSQQQI
VIDMLRQANDVISALGTRLSQLAYQARDNHDLLADISTRMQAQVQRTRMSPLSRIVGSLRLHVRDLARSAGKEVTFVVED
SGAEADRQVLDQVYEICLHLLRNAVDHGIEPPEVRKARGKPPTGLIRLTANASSDRLNLVISDDGAGIDREDIKRHALQL
GLLSQHDSEHADDAMVLDLIFTPGFSTKSHVSELSGRGVGLDVVRTTVERMGGSVTVMSVPGQGTTFTLALPLTLMRTRG
LLMYVNNQVFALPVDSLRRVVQVNRTQLHTLEGRPVVLVDGRPLQLISMARLIGFSSETVIDFPGPKPALLIGSNERQIA
CIVDSIGEEIDLVVHRLPPPLQRVRFVSGAAILADGSVAPILDAVDLLRAALTVEHAVMLPTANPTPAHSPTILVVDDSI
TTRTLEKNILEAAGYRVVLATDGQEALERLHNLQNQGGCQLVLSDIDMPRLNGFDLTRQIRTDPAFRHLPVVLVTSLDSP
ADRERGLAAGADAYIVKRAFDQQALLETIARLL
>Mature_753_residues
MLSDDDIQAQVLAVFRAEQAEHRQTIIDILLDLERTPDHPRRRDLVDHLFRAAHSLKGGARAAGVKSVEQIAHHIEHIFA
ALRQNQLTLTADICDVIYQALDVIGALMEQAVPGQIDDQDALDDLLAHLMAIGQNMRDGDATSLSPSSFTPEDHTRQSAP
SLAAETSVRVDVAVLDNLMSEMGELLTSTLRTRQLARDLQELARLPERWQRAWRRTAPFLRHGSSLHANGQLIPQSQQQI
VIDMLRQANDVISALGTRLSQLAYQARDNHDLLADISTRMQAQVQRTRMSPLSRIVGSLRLHVRDLARSAGKEVTFVVED
SGAEADRQVLDQVYEICLHLLRNAVDHGIEPPEVRKARGKPPTGLIRLTANASSDRLNLVISDDGAGIDREDIKRHALQL
GLLSQHDSEHADDAMVLDLIFTPGFSTKSHVSELSGRGVGLDVVRTTVERMGGSVTVMSVPGQGTTFTLALPLTLMRTRG
LLMYVNNQVFALPVDSLRRVVQVNRTQLHTLEGRPVVLVDGRPLQLISMARLIGFSSETVIDFPGPKPALLIGSNERQIA
CIVDSIGEEIDLVVHRLPPPLQRVRFVSGAAILADGSVAPILDAVDLLRAALTVEHAVMLPTANPTPAHSPTILVVDDSI
TTRTLEKNILEAAGYRVVLATDGQEALERLHNLQNQGGCQLVLSDIDMPRLNGFDLTRQIRTDPAFRHLPVVLVTSLDSP
ADRERGLAAGADAYIVKRAFDQQALLETIARLL

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=644, Percent_Identity=28.5714285714286, Blast_Score=207, Evalue=3e-54,
Organism=Escherichia coli, GI1790863, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=147, Percent_Identity=31.2925170068027, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 82626; Mature: 82626

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDDDIQAQVLAVFRAEQAEHRQTIIDILLDLERTPDHPRRRDLVDHLFRAAHSLKGGA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
RAAGVKSVEQIAHHIEHIFAALRQNQLTLTADICDVIYQALDVIGALMEQAVPGQIDDQD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ALDDLLAHLMAIGQNMRDGDATSLSPSSFTPEDHTRQSAPSLAAETSVRVDVAVLDNLMS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCCCEEHHHHHHHHHH
EMGELLTSTLRTRQLARDLQELARLPERWQRAWRRTAPFLRHGSSLHANGQLIPQSQQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHH
VIDMLRQANDVISALGTRLSQLAYQARDNHDLLADISTRMQAQVQRTRMSPLSRIVGSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHVRDLARSAGKEVTFVVEDSGAEADRQVLDQVYEICLHLLRNAVDHGIEPPEVRKARGK
HHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
PPTGLIRLTANASSDRLNLVISDDGAGIDREDIKRHALQLGLLSQHDSEHADDAMVLDLI
CCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
FTPGFSTKSHVSELSGRGVGLDVVRTTVERMGGSVTVMSVPGQGTTFTLALPLTLMRTRG
ECCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHHCC
LLMYVNNQVFALPVDSLRRVVQVNRTQLHTLEGRPVVLVDGRPLQLISMARLIGFSSETV
EEEEECCEEEEECHHHHHHHHHHCHHHEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCE
IDFPGPKPALLIGSNERQIACIVDSIGEEIDLVVHRLPPPLQRVRFVSGAAILADGSVAP
EECCCCCCEEEECCCCCEEEEEHHHHCHHHHHHHHCCCCHHHHHHHHCCCEEEECCCHHH
ILDAVDLLRAALTVEHAVMLPTANPTPAHSPTILVVDDSITTRTLEKNILEAAGYRVVLA
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEE
TDGQEALERLHNLQNQGGCQLVLSDIDMPRLNGFDLTRQIRTDPAFRHLPVVLVTSLDSP
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHCCCCHHHCCEEEEECCCCC
ADRERGLAAGADAYIVKRAFDQQALLETIARLL
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLSDDDIQAQVLAVFRAEQAEHRQTIIDILLDLERTPDHPRRRDLVDHLFRAAHSLKGGA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
RAAGVKSVEQIAHHIEHIFAALRQNQLTLTADICDVIYQALDVIGALMEQAVPGQIDDQD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ALDDLLAHLMAIGQNMRDGDATSLSPSSFTPEDHTRQSAPSLAAETSVRVDVAVLDNLMS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHCCCEEHHHHHHHHHH
EMGELLTSTLRTRQLARDLQELARLPERWQRAWRRTAPFLRHGSSLHANGQLIPQSQQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHH
VIDMLRQANDVISALGTRLSQLAYQARDNHDLLADISTRMQAQVQRTRMSPLSRIVGSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHVRDLARSAGKEVTFVVEDSGAEADRQVLDQVYEICLHLLRNAVDHGIEPPEVRKARGK
HHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
PPTGLIRLTANASSDRLNLVISDDGAGIDREDIKRHALQLGLLSQHDSEHADDAMVLDLI
CCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
FTPGFSTKSHVSELSGRGVGLDVVRTTVERMGGSVTVMSVPGQGTTFTLALPLTLMRTRG
ECCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHHCC
LLMYVNNQVFALPVDSLRRVVQVNRTQLHTLEGRPVVLVDGRPLQLISMARLIGFSSETV
EEEEECCEEEEECHHHHHHHHHHCHHHEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCE
IDFPGPKPALLIGSNERQIACIVDSIGEEIDLVVHRLPPPLQRVRFVSGAAILADGSVAP
EECCCCCCEEEECCCCCEEEEEHHHHCHHHHHHHHCCCCHHHHHHHHCCCEEEECCCHHH
ILDAVDLLRAALTVEHAVMLPTANPTPAHSPTILVVDDSITTRTLEKNILEAAGYRVVLA
HHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEE
TDGQEALERLHNLQNQGGCQLVLSDIDMPRLNGFDLTRQIRTDPAFRHLPVVLVTSLDSP
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHCCCCHHHCCEEEEECCCCC
ADRERGLAAGADAYIVKRAFDQQALLETIARLL
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]