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The map label for this gene is yrhP [H]

Identifier: 222524021

GI number: 222524021

Start: 920929

End: 921549

Strand: Reverse

Name: yrhP [H]

Synonym: Chy400_0736

Alternate gene names: 222524021

Gene position: 921549-920929 (Counterclockwise)

Preceding gene: 222524023

Following gene: 222524010

Centisome position: 17.49

GC content: 57.81

Gene sequence:

>621_bases
ATGGTTCCCGAACGCCTGATCGCCTACACGATTGCGGTTGCCATCCTGACTCTCATCCCCGGTGCTGACACCATGCTGGT
GCTGCGCAATGCCCTGGCTCGCGGGCGCCTCGCCGGTATTGCAACTGCCTTTGGTATCGGGAGTGGTCTGTTCGTGCAGG
CAACGCTCTCCGGTTTGGGGTTAGCCGCGATTGTGCTCCAGTCGGCACAGCTCTACCACGCGCTCAAACTGGCCGGTGCC
TGCTATCTGGCCGGGTTAGGTCTGTGGACGATTATTACCACCTGGCGACAACGATCAACGGAGGAACCGCATCTGCCCGT
CGGTCAAGAGCGCCATGCCTTTGTCGAAGGTTTATTGAGCAATGTCCTCAATCCAAAAGTTGCGGTGTTTTATCTGGCAT
TTTTGCCGCAGTTTATCGATCCAGGTGATCCGGTTTTGTGGTCGGCACTCGCGCTCACGACCATCCACTTCATGTTCAGC
ATTCTCTGGTTTTCAACCCTAACCTTTGTTGTCGCCGGGGTCAGTGTCTGGCTGCGCCGCAGTGACGTGCGTCGTCGGCT
CAACTATGCCACGGGAGCGGTACTGGCCGGTTTGGGAGTACGGTTGGCGGTTGAGGCGTAA

Upstream 100 bases:

>100_bases
TTCATCATCGCAGGTAGTCTTTCGTGGCCTGCTCACAGTGTAGGTGGCAACTTGGGTTATCATAGTCTGAATAATGCTTG
TTGATGCTTACGGAGTTGCT

Downstream 100 bases:

>100_bases
TTCAAATGCAACTGACCGTTCTTGTGTGGGATGGGTACCCATCATGTTCACGAGATGACAGGTGCTTGTGTCAAATCTTG
AGTGATGCTGTGCATTAGTC

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MVPERLIAYTIAVAILTLIPGADTMLVLRNALARGRLAGIATAFGIGSGLFVQATLSGLGLAAIVLQSAQLYHALKLAGA
CYLAGLGLWTIITTWRQRSTEEPHLPVGQERHAFVEGLLSNVLNPKVAVFYLAFLPQFIDPGDPVLWSALALTTIHFMFS
ILWFSTLTFVVAGVSVWLRRSDVRRRLNYATGAVLAGLGVRLAVEA

Sequences:

>Translated_206_residues
MVPERLIAYTIAVAILTLIPGADTMLVLRNALARGRLAGIATAFGIGSGLFVQATLSGLGLAAIVLQSAQLYHALKLAGA
CYLAGLGLWTIITTWRQRSTEEPHLPVGQERHAFVEGLLSNVLNPKVAVFYLAFLPQFIDPGDPVLWSALALTTIHFMFS
ILWFSTLTFVVAGVSVWLRRSDVRRRLNYATGAVLAGLGVRLAVEA
>Mature_206_residues
MVPERLIAYTIAVAILTLIPGADTMLVLRNALARGRLAGIATAFGIGSGLFVQATLSGLGLAAIVLQSAQLYHALKLAGA
CYLAGLGLWTIITTWRQRSTEEPHLPVGQERHAFVEGLLSNVLNPKVAVFYLAFLPQFIDPGDPVLWSALALTTIHFMFS
ILWFSTLTFVVAGVSVWLRRSDVRRRLNYATGAVLAGLGVRLAVEA

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=205, Percent_Identity=28.780487804878, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788099, Length=203, Percent_Identity=26.6009852216749, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI48994978, Length=192, Percent_Identity=25.5208333333333, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786522, Length=210, Percent_Identity=24.2857142857143, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22199; Mature: 22199

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPERLIAYTIAVAILTLIPGADTMLVLRNALARGRLAGIATAFGIGSGLFVQATLSGLG
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LAAIVLQSAQLYHALKLAGACYLAGLGLWTIITTWRQRSTEEPHLPVGQERHAFVEGLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
NVLNPKVAVFYLAFLPQFIDPGDPVLWSALALTTIHFMFSILWFSTLTFVVAGVSVWLRR
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVRRRLNYATGAVLAGLGVRLAVEA
HHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MVPERLIAYTIAVAILTLIPGADTMLVLRNALARGRLAGIATAFGIGSGLFVQATLSGLG
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LAAIVLQSAQLYHALKLAGACYLAGLGLWTIITTWRQRSTEEPHLPVGQERHAFVEGLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
NVLNPKVAVFYLAFLPQFIDPGDPVLWSALALTTIHFMFSILWFSTLTFVVAGVSVWLRR
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVRRRLNYATGAVLAGLGVRLAVEA
HHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]