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The map label for this gene is drrB [H]

Identifier: 222523451

GI number: 222523451

Start: 181864

End: 182619

Strand: Reverse

Name: drrB [H]

Synonym: Chy400_0154

Alternate gene names: 222523451

Gene position: 182619-181864 (Counterclockwise)

Preceding gene: 222523452

Following gene: 222523450

Centisome position: 3.47

GC content: 55.56

Gene sequence:

>756_bases
ATGTACGCAACCTACGTTATCTGGACGCGCCACATGCGCAAGTTCGTTCAGCAGACCGAAGAATTGTTTGGACTGGCGCT
TCAATCGGTGTTGTGGGTGGTGCTCTTCGGGGTTGGGATGCGCGGCATGATCGGTGCGGTTGGCGGCAACGACTATATGT
CGTTTATCCTGCCGGGCATCATTGCGCTGAGCGCACTTGGTGGCGCCGTTGGCGGCGGCATGGTCTTACTCGACGAACGC
CTGCGTGGGATTGTCAAAGAGTATCTGGCAGCGCCAATTCCGCGTCTGAGTATTTTGCTGGGAAGTGCCGCCAGTACTGC
GACTAAAGCCCTCTTCCAGGCTGCTCTGATGCTGGTGGTTGGTTTGTTGATGGGAGCGCGCTTAAGCGTGAATCCTATCG
GTTGGCTGGGCGCACTGGCGTTGCTGGCGGTATTTGCAATTGGTTTCAGTGGCCTGGCTCTCGGTGTTGCGGCTATCTCG
CGCAGTATTGCCGGGTATCACGGGATGATTTTTCTCTTTAACTTACCCCTGTTGTTCGCCTCTAACGCACTCTACCCGCT
CGATGTATTACCGGGCTGGATGCGGGTGATTGTGCTGATCAATCCGGCTACCTACTTCATTGATGCGGTACGGGCACTGG
CATTTGGTACTGCGGCTACCTTACCGCTCTGGCTTAGTGGCCTGATTCTGATCGGCTTTGCTGTCCTAAGCATGATGTTT
GCGCTGACACTCTTTCAGCGCTCATTGCGGGCATAG

Upstream 100 bases:

>100_bases
ACGGCTTTGCGATTGAAGATGTCACCCTGGCGCGACCATCGCTCGGTGATGTCTTTCTGCACTATACCGGCACTGCGTTA
CGTGATTAGGTGAAAGAGAT

Downstream 100 bases:

>100_bases
ATCATCTCGCCTCGTGCAGGCTGTATAACCGCATAGAGCTTGTCTCAAATCTGGTTTAGTGTCAGTCATAACACGCTATT
TACCGTCACCCTGACTCTGT

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MYATYVIWTRHMRKFVQQTEELFGLALQSVLWVVLFGVGMRGMIGAVGGNDYMSFILPGIIALSALGGAVGGGMVLLDER
LRGIVKEYLAAPIPRLSILLGSAASTATKALFQAALMLVVGLLMGARLSVNPIGWLGALALLAVFAIGFSGLALGVAAIS
RSIAGYHGMIFLFNLPLLFASNALYPLDVLPGWMRVIVLINPATYFIDAVRALAFGTAATLPLWLSGLILIGFAVLSMMF
ALTLFQRSLRA

Sequences:

>Translated_251_residues
MYATYVIWTRHMRKFVQQTEELFGLALQSVLWVVLFGVGMRGMIGAVGGNDYMSFILPGIIALSALGGAVGGGMVLLDER
LRGIVKEYLAAPIPRLSILLGSAASTATKALFQAALMLVVGLLMGARLSVNPIGWLGALALLAVFAIGFSGLALGVAAIS
RSIAGYHGMIFLFNLPLLFASNALYPLDVLPGWMRVIVLINPATYFIDAVRALAFGTAATLPLWLSGLILIGFAVLSMMF
ALTLFQRSLRA
>Mature_251_residues
MYATYVIWTRHMRKFVQQTEELFGLALQSVLWVVLFGVGMRGMIGAVGGNDYMSFILPGIIALSALGGAVGGGMVLLDER
LRGIVKEYLAAPIPRLSILLGSAASTATKALFQAALMLVVGLLMGARLSVNPIGWLGALALLAVFAIGFSGLALGVAAIS
RSIAGYHGMIFLFNLPLLFASNALYPLDVLPGWMRVIVLINPATYFIDAVRALAFGTAATLPLWLSGLILIGFAVLSMMF
ALTLFQRSLRA

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1787010, Length=181, Percent_Identity=23.7569060773481, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 26724; Mature: 26724

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]