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The map label for this gene is mrdA [H]

Identifier: 222523417

GI number: 222523417

Start: 148408

End: 150705

Strand: Reverse

Name: mrdA [H]

Synonym: Chy400_0120

Alternate gene names: 222523417

Gene position: 150705-148408 (Counterclockwise)

Preceding gene: 222523418

Following gene: 222523415

Centisome position: 2.86

GC content: 56.96

Gene sequence:

>2298_bases
ATGGCACGACTGATTGCTCTGCGCAGTATCCTGTTACTGGTTGTGGTGGTGCTGGTATCCCGGCTGGCCCAACTACAACT
GATTGAGACTGATACGCAGCGATTCGGTGCCGACATCGAAGTTACCACCCGTCGTTACCTCACCAATCAGCCACGGCGGG
GAGAAATTTTCGATGCCCGTGGTGTGCTGTTGGCCGAGAGTGTGCCGATTTATAACCTGGCCGTTATTCCCGGTCAACTG
CCTTCCTCCAGCGCTGCACCAGAACAGCGGGCACTAACGCTGGCGCGGCTGGCGCAGATTGCCGAATTACCGGCGACACT
GGTGATTGATCCTGGTACTGCGATTGACACCACACCCGGCTTGCGCAGCGATCTCAGGTCATTTGGCAGCTTGCCGACGG
CAAGTGATGTTGTGACCATGACTATCGCACCATCTGATGTCCTGCGGGCGCTAGATGTGAGTCAAAAGTACCGCGATGTG
GCAACGCTGGTCAACCCGATTGAACAGCTTCTCACGCAGGCGAATGTGCGTAGCTACCAGCCCATTGTGATCAAGGAAGA
CATTTCACCGGAACTGGCACTGGCACTACGCGAAAATGCCAATTATCTGCCCGGTGCCCGTGTCGTTGAAGGTTTTCGCC
GGCGCTACCCGTTAAGTGGTGAGATACCTTCATTATCGCACCTGCTGGGATATGTCGGACGGATCAATGCATGTGAGCTG
GTAGCGGTCAATCCGGCAAGTTCCTGGTTGCGGGCATTGACTGACATCACTGCCAACGCGCCAACCTGTGGCCTGATGGC
AAAATCGATTGAACCGACCAGCGTTGGTTTACCGCCCTATTTGTCGAGTGATCAAATTGGCAAAGATGGCCTGGAAGGTG
CTTACGAGTCGGTGTTGCGCGGCCAGATGGGGATTGACTCGCTCCTGGTCGATGCGTTGCAGCGTCCGGTCAGCGGGGTC
ACCACCCTGCGGGCAGTGGCTAACGGGCATGATCTGATCTTAACCATCGATACCCGGTTTCAGGCCGAGGTCGAACGCAT
CCTCCAGCGCTGGATCAATGTCGGTGAAGAGCGCCGGTTAGCAGCACGGGAAGCGCATAAACGGGCGTATGAACCGATAG
TCGCCGGCGTAGCAGTCGCGCTCGATCCACGTGATGGGCGCATCCTGGCCATGGTCAGTCTCCCCGACTACGATAACAAC
ATCTGGGTAGACCCGGCGCGGATCGCTGAGTTGCAGGCTCTGCTGGCACCACCTGATGCCGAGACCCAACAGACATTGCA
ACGTCTGGCACCATTCACCAACCGAGCGATTGCCGGTCTATACCCACCCGGCTCGACAGTCAAGCAATTTGTTGGTGCAG
TTGCGCTTCAACAGGGCATTATCGCGGCAGATACCCAACTCCGTGATCCCGGTTTGCTGCGGTTGATCGAGCGCAGTGGT
GCTGAGTTCATCTTGCCCAACTCGGTGCGTAATCGTGATAATGGGCTGATCAACGTTCGTGATGCCTTGCGGCTCTCTTC
AAATGTCTTTTTTGCCAGTATAGCGGGCGGGAACGATCAGGCGATCAACCTGGATCAGCGAGCATTACGGATTACCGGTC
TCGGTATCGACCAACTGGTGGAAGGGCTGTCGTGGTTCAATTTTGGCCGTCCAACCGGGGTTGATCTGGTTGGCGAAGCC
AGTGGACGGGTGCCAACCCAGGCATGGAAAGCCCAGGTTCTACGTGAAGCCTGGACGACCGGTGACACCTATAACACAGC
GATTGGTCAGGGTTATCTGGAAGTAACACCGCTCCAGTTGGCAGTAGCAGCGGGGGCTGTCGCAACAGATGGTACTCTGT
ACCGACCGCATCTGGTTGATCGAATTGTCGATGAGAATGGTCAGCTTATTCAGCAAATGCAGCCAGAGGCCATTGGGCAG
GTGCCGATTGACCCCCGACACCTGGCAGCGATCCGTGAGGGATTGTTTGCGTCGATCACCGATGGTCTGGGTGTTGCAGC
CCGTGAAGTCTGTTCAGGCTTACGCATTGCCGGCAAAACCGGAACAGCAGAGTTTGGCCCACTCTTGACGACGGCGGATG
GGCGGTTAGTGCGGCAAAGCCACGCCTGGTTTGTCGGGTTTGCCCCCTACGAAAACCCGGAGATTGTGGTGGCTGTGCTG
GTTGAGGGTGTTGGTGACCTGAACGATGGCTCGTCAACGATTGCTGTGCCGGCGGTAACGCAGATTATGCAGGCCTATTT
CGGGATCACGCCACCGGCTAACCGACCGGCGATCTGTCCGGTGTTGCCAGGGGAGTGA

Upstream 100 bases:

>100_bases
CCTGCCGGTAGTGGCCATAGTGCATCGACTGGTGCGCAATACCGAATATCAATGATGGCGTTCTATGCAGACGATTGCCT
GGAAAGCGTGATGAACGGCC

Downstream 100 bases:

>100_bases
TCTCGTCGGCATTCTGCATGTGTGCCAGTGTAACCGGATGATCAAAATGGGCAAAAAATGTGATTGATAGCTGTTGCGTA
ATTCATCATCTGATAATGTC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MARLIALRSILLLVVVVLVSRLAQLQLIETDTQRFGADIEVTTRRYLTNQPRRGEIFDARGVLLAESVPIYNLAVIPGQL
PSSSAAPEQRALTLARLAQIAELPATLVIDPGTAIDTTPGLRSDLRSFGSLPTASDVVTMTIAPSDVLRALDVSQKYRDV
ATLVNPIEQLLTQANVRSYQPIVIKEDISPELALALRENANYLPGARVVEGFRRRYPLSGEIPSLSHLLGYVGRINACEL
VAVNPASSWLRALTDITANAPTCGLMAKSIEPTSVGLPPYLSSDQIGKDGLEGAYESVLRGQMGIDSLLVDALQRPVSGV
TTLRAVANGHDLILTIDTRFQAEVERILQRWINVGEERRLAAREAHKRAYEPIVAGVAVALDPRDGRILAMVSLPDYDNN
IWVDPARIAELQALLAPPDAETQQTLQRLAPFTNRAIAGLYPPGSTVKQFVGAVALQQGIIAADTQLRDPGLLRLIERSG
AEFILPNSVRNRDNGLINVRDALRLSSNVFFASIAGGNDQAINLDQRALRITGLGIDQLVEGLSWFNFGRPTGVDLVGEA
SGRVPTQAWKAQVLREAWTTGDTYNTAIGQGYLEVTPLQLAVAAGAVATDGTLYRPHLVDRIVDENGQLIQQMQPEAIGQ
VPIDPRHLAAIREGLFASITDGLGVAAREVCSGLRIAGKTGTAEFGPLLTTADGRLVRQSHAWFVGFAPYENPEIVVAVL
VEGVGDLNDGSSTIAVPAVTQIMQAYFGITPPANRPAICPVLPGE

Sequences:

>Translated_765_residues
MARLIALRSILLLVVVVLVSRLAQLQLIETDTQRFGADIEVTTRRYLTNQPRRGEIFDARGVLLAESVPIYNLAVIPGQL
PSSSAAPEQRALTLARLAQIAELPATLVIDPGTAIDTTPGLRSDLRSFGSLPTASDVVTMTIAPSDVLRALDVSQKYRDV
ATLVNPIEQLLTQANVRSYQPIVIKEDISPELALALRENANYLPGARVVEGFRRRYPLSGEIPSLSHLLGYVGRINACEL
VAVNPASSWLRALTDITANAPTCGLMAKSIEPTSVGLPPYLSSDQIGKDGLEGAYESVLRGQMGIDSLLVDALQRPVSGV
TTLRAVANGHDLILTIDTRFQAEVERILQRWINVGEERRLAAREAHKRAYEPIVAGVAVALDPRDGRILAMVSLPDYDNN
IWVDPARIAELQALLAPPDAETQQTLQRLAPFTNRAIAGLYPPGSTVKQFVGAVALQQGIIAADTQLRDPGLLRLIERSG
AEFILPNSVRNRDNGLINVRDALRLSSNVFFASIAGGNDQAINLDQRALRITGLGIDQLVEGLSWFNFGRPTGVDLVGEA
SGRVPTQAWKAQVLREAWTTGDTYNTAIGQGYLEVTPLQLAVAAGAVATDGTLYRPHLVDRIVDENGQLIQQMQPEAIGQ
VPIDPRHLAAIREGLFASITDGLGVAAREVCSGLRIAGKTGTAEFGPLLTTADGRLVRQSHAWFVGFAPYENPEIVVAVL
VEGVGDLNDGSSTIAVPAVTQIMQAYFGITPPANRPAICPVLPGE
>Mature_764_residues
ARLIALRSILLLVVVVLVSRLAQLQLIETDTQRFGADIEVTTRRYLTNQPRRGEIFDARGVLLAESVPIYNLAVIPGQLP
SSSAAPEQRALTLARLAQIAELPATLVIDPGTAIDTTPGLRSDLRSFGSLPTASDVVTMTIAPSDVLRALDVSQKYRDVA
TLVNPIEQLLTQANVRSYQPIVIKEDISPELALALRENANYLPGARVVEGFRRRYPLSGEIPSLSHLLGYVGRINACELV
AVNPASSWLRALTDITANAPTCGLMAKSIEPTSVGLPPYLSSDQIGKDGLEGAYESVLRGQMGIDSLLVDALQRPVSGVT
TLRAVANGHDLILTIDTRFQAEVERILQRWINVGEERRLAAREAHKRAYEPIVAGVAVALDPRDGRILAMVSLPDYDNNI
WVDPARIAELQALLAPPDAETQQTLQRLAPFTNRAIAGLYPPGSTVKQFVGAVALQQGIIAADTQLRDPGLLRLIERSGA
EFILPNSVRNRDNGLINVRDALRLSSNVFFASIAGGNDQAINLDQRALRITGLGIDQLVEGLSWFNFGRPTGVDLVGEAS
GRVPTQAWKAQVLREAWTTGDTYNTAIGQGYLEVTPLQLAVAAGAVATDGTLYRPHLVDRIVDENGQLIQQMQPEAIGQV
PIDPRHLAAIREGLFASITDGLGVAAREVCSGLRIAGKTGTAEFGPLLTTADGRLVRQSHAWFVGFAPYENPEIVVAVLV
EGVGDLNDGSSTIAVPAVTQIMQAYFGITPPANRPAICPVLPGE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=598, Percent_Identity=29.5986622073579, Blast_Score=219, Evalue=8e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 82262; Mature: 82131

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLIALRSILLLVVVVLVSRLAQLQLIETDTQRFGADIEVTTRRYLTNQPRRGEIFDAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHCCCEEEEHHHHHCCCCCCCCEECCC
GVLLAESVPIYNLAVIPGQLPSSSAAPEQRALTLARLAQIAELPATLVIDPGTAIDTTPG
CEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
LRSDLRSFGSLPTASDVVTMTIAPSDVLRALDVSQKYRDVATLVNPIEQLLTQANVRSYQ
HHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PIVIKEDISPELALALRENANYLPGARVVEGFRRRYPLSGEIPSLSHLLGYVGRINACEL
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEE
VAVNPASSWLRALTDITANAPTCGLMAKSIEPTSVGLPPYLSSDQIGKDGLEGAYESVLR
EEECCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GQMGIDSLLVDALQRPVSGVTTLRAVANGHDLILTIDTRFQAEVERILQRWINVGEERRL
HHCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHH
AAREAHKRAYEPIVAGVAVALDPRDGRILAMVSLPDYDNNIWVDPARIAELQALLAPPDA
HHHHHHHHHHHHHHHCEEEEECCCCCEEEEEEECCCCCCCEEECHHHHHHHHHHHCCCCC
ETQQTLQRLAPFTNRAIAGLYPPGSTVKQFVGAVALQQGIIAADTQLRDPGLLRLIERSG
HHHHHHHHHCCHHCCCEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCC
AEFILPNSVRNRDNGLINVRDALRLSSNVFFASIAGGNDQAINLDQRALRITGLGIDQLV
CCEECCCCCCCCCCCEEEEHHHHHHCCCEEEEEEECCCCCEECCCCCEEEEECCCHHHHH
EGLSWFNFGRPTGVDLVGEASGRVPTQAWKAQVLREAWTTGDTYNTAIGQGYLEVTPLQL
HHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCEEECHHHH
AVAAGAVATDGTLYRPHLVDRIVDENGQLIQQMQPEAIGQVPIDPRHLAAIREGLFASIT
HHHHCCEECCCCEECHHHHHHHHCCCCHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHH
DGLGVAAREVCSGLRIAGKTGTAEFGPLLTTADGRLVRQSHAWFVGFAPYENPEIVVAVL
CCCHHHHHHHHCCCEEECCCCCCCCCCEEECCCCCEEEECCCEEEEECCCCCCCEEEEEE
VEGVGDLNDGSSTIAVPAVTQIMQAYFGITPPANRPAICPVLPGE
ECCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
ARLIALRSILLLVVVVLVSRLAQLQLIETDTQRFGADIEVTTRRYLTNQPRRGEIFDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHCCCEEEEHHHHHCCCCCCCCEECCC
GVLLAESVPIYNLAVIPGQLPSSSAAPEQRALTLARLAQIAELPATLVIDPGTAIDTTPG
CEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
LRSDLRSFGSLPTASDVVTMTIAPSDVLRALDVSQKYRDVATLVNPIEQLLTQANVRSYQ
HHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PIVIKEDISPELALALRENANYLPGARVVEGFRRRYPLSGEIPSLSHLLGYVGRINACEL
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEE
VAVNPASSWLRALTDITANAPTCGLMAKSIEPTSVGLPPYLSSDQIGKDGLEGAYESVLR
EEECCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GQMGIDSLLVDALQRPVSGVTTLRAVANGHDLILTIDTRFQAEVERILQRWINVGEERRL
HHCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHH
AAREAHKRAYEPIVAGVAVALDPRDGRILAMVSLPDYDNNIWVDPARIAELQALLAPPDA
HHHHHHHHHHHHHHHCEEEEECCCCCEEEEEEECCCCCCCEEECHHHHHHHHHHHCCCCC
ETQQTLQRLAPFTNRAIAGLYPPGSTVKQFVGAVALQQGIIAADTQLRDPGLLRLIERSG
HHHHHHHHHCCHHCCCEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCC
AEFILPNSVRNRDNGLINVRDALRLSSNVFFASIAGGNDQAINLDQRALRITGLGIDQLV
CCEECCCCCCCCCCCEEEEHHHHHHCCCEEEEEEECCCCCEECCCCCEEEEECCCHHHHH
EGLSWFNFGRPTGVDLVGEASGRVPTQAWKAQVLREAWTTGDTYNTAIGQGYLEVTPLQL
HHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCEEECHHHH
AVAAGAVATDGTLYRPHLVDRIVDENGQLIQQMQPEAIGQVPIDPRHLAAIREGLFASIT
HHHHCCEECCCCEECHHHHHHHHCCCCHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHH
DGLGVAAREVCSGLRIAGKTGTAEFGPLLTTADGRLVRQSHAWFVGFAPYENPEIVVAVL
CCCHHHHHHHHCCCEEECCCCCCCCCCEEECCCCCEEEECCCEEEEECCCCCCCEEEEEE
VEGVGDLNDGSSTIAVPAVTQIMQAYFGITPPANRPAICPVLPGE
ECCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]