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The map label for this gene is lon2 [H]

Identifier: 222523393

GI number: 222523393

Start: 110759

End: 113182

Strand: Reverse

Name: lon2 [H]

Synonym: Chy400_0094

Alternate gene names: 222523393

Gene position: 113182-110759 (Counterclockwise)

Preceding gene: 222523395

Following gene: 222523392

Centisome position: 2.15

GC content: 58.17

Gene sequence:

>2424_bases
ATGACCACAACGCCGGCAAATGAACAGTCACCATCTCCTTCCGGTACCACATTGTATGAGCGACCGGTCTTGCCACTGCT
GGACAGTGTTTTGTTTCCGCAGATGCTGGCCCCGCTGTTTGTCAGTGATGAGCGGGCAATCAATGCGGTTGAGCAGGCAG
TGGCTGAGGATCGCCTGGTGCTGGCGGTGGCGGTGCGCGGCCCGGTTGATGAGCTGACGTTAGGCATTGATGATCTCTAC
CCGGTTGGGGTAGAAGCGACTGTACAGCGTGTGCGCCGACTGCCCGATGGTACACTGAGCGTCGTGTTGGAAGGGCGTCA
GCGCATGCAGATTGTCAGTGTGGTGACTGAACATCCCGCCTTGCGTGTGCTGGCGACGCCGCTTGAAACACCGCCGCTCG
ATGAGGATGCTGCGTTGATGGTCGAGGCATTGAGCCGTACCATCTTGACCACCTTCGAGAAGATCGTTCGCCTCTCGCGC
AATCTTCCCGATGACGCTTACCTGTCGGCGCTCAACAGTGCCGAACCCGGTGAGCTGGCCGATATTATTGCTGCACTGCT
GCCTATCTCAGTTGAAGATCGCCAGCGTATTCTGGCGTTAGCTGATATTCAGCAGCGCCTGCGTCAGTTGGAGATTCTGC
TTGCTAAAGAGTTGGATTTACTAGAGCTGGAAAATCGTATTCATAGTCAGGTGCAGCAAGAGGTTGATCGCAGCCAGCGC
GAACTCTTTCTGCGCGAGCAATTGCGGGCGATTCAGCGTGAACTTGGGCAGGAAGACCCCTCACGGCGCGAGATTATGCT
CTTGCGTGAACGGGCGGCGGCAGCCGGTTTGCCCGCCCATGCGATGGCCCGCTTTGAAGAGGAGCTGGCCCGGCTGGAAC
TCATCTCACCAATGTCGCCTGAACACGGCATGCTGCGCACCTATCTCGACTGGCTGATTTCACTGCCGTGGAGTAATGCC
AGCCCTGAAAACCGTGATCTGCGAGCGGCAGCGGCAGTGCTCGAACGCAACCATTATGGTTTGCGGAAGGTGAAAGATCG
CATCCTCGAATACATTGCAGTGCGCCAACTGGCCGGGCCGTCGCGGCGGGCACCGATCCTCTGCTTTGTCGGCCCACCCG
GCGTTGGCAAGACCAGTCTTGGGCAGAGCATTGCTGAAGCACTGGGTCGGCGCTTTGTACGCCTCAGCCTGGGTGGTGTT
CATGACGAAGCCGAGATTCGTGGTCATCGCCGTACCTACATTGGGGCGATGCCAGGGCGCATCTTGCAACGGATGAAAGT
TGCCGGGACGATCAACCCTGTCTTTATGCTCGACGAGGTTGATAAGCTGGGCAGTGATTTTCGGGGCGATCCTGCGGCAG
CATTGCTAGAGGTTCTTGATCCGGAGCAAAACAGCACCTTCAGCGATCACTATCTCGATCTGCCTTACGATCTCAGTCAA
ACCCTCTTTATCACGACGGCAAATGTTGCTGACGACATTCCCGATCCGTTGCTCGACCGCATGGAGCTGGTTGAGTTGCC
CGGCTACACCGAAGATGAGAAGCTCCATATCGCCCGCCGATTTCTCATTCCCCGCCAGATGACCGACAGCGGTTTGCCGC
CGGCAACCATTCGTTTCGGCGATGCGACCATTCACACAATTATCCGCAACTACACCTACGAAGCCGGTGTGCGTAATCTC
GAACGCGAGATTGGCGCGATCTGCCGCAAAATTGCCCGTCGGATTGCGGAAGGAAGACGTTACCCCCGTCAGATTACACC
GCGTGCGTTGCCGAAGCTGCTGGGGCCACCCCGCTTTGAGATTGGCAAGATTGATCCTCGCGACCAGGTAGGGGTAGCGA
TTGGGATGGTCTACACCAGTGCCGGAGGCGACATCATGCCGGTTGAGGTCGTCTTGATGGATGGCAAAGGCAACCTCCTC
CTCACCGGTCAGCTCGGCGAAGTGATGCAAGAATCGGCGCAGGCAGCGCTCTCGTTTGCGCGGGCGAACGCGAGTCGTTT
GGGGATCGAAATCCGCCATTTCGACAAACTCGATATTCACGTTCACGTCCCCGAAGGCGCTACCCCGAAAGATGGCCCTT
CAGCGGGGGTGACGATTGCGACAGCGCTGATTTCGGCCTTGACCGGGCGAACGGTACGGCACGACATTGCCATGACCGGT
GAAATTACCCTGCATGGGCGTGTATTACCGATTGGCGGGGTAAAAGAAAAGGTGCTCGGTGCGTATCGGGCCGGCATTCG
CCAGATCATTCTGCCGCGGCGCAACGAGCACGATCTGGTTGAGATACCGGTTGCCTTGCGGCGACAACTGACCATTCACC
TGATAGAGCGCATCGAGCAGGCGCTTGAGCTGGTGTTAGGGCCGCCACCGCCGAAAGAGCCGCGCCGGGCGCCACGAGTC
ATTCCACGCCGGGATGAGGATTAG

Upstream 100 bases:

>100_bases
CGCAACATGTCAGTATGTGCTACACTGAACATACTATCATGACAATGCGCAGATGGTTTACCATCGTCTCTCTCGGATGC
ATCTGCGCAGGAGCGAGCAT

Downstream 100 bases:

>100_bases
GCGGGGTGCCACAGTCAGCAGCGACAACGTGCTGTAGCGCACCTTGCCTCTCTGCGATCTCTCCGGGTTATCAGAAGCAG
GGTAAGCGGTCATCAGACAC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MTTTPANEQSPSPSGTTLYERPVLPLLDSVLFPQMLAPLFVSDERAINAVEQAVAEDRLVLAVAVRGPVDELTLGIDDLY
PVGVEATVQRVRRLPDGTLSVVLEGRQRMQIVSVVTEHPALRVLATPLETPPLDEDAALMVEALSRTILTTFEKIVRLSR
NLPDDAYLSALNSAEPGELADIIAALLPISVEDRQRILALADIQQRLRQLEILLAKELDLLELENRIHSQVQQEVDRSQR
ELFLREQLRAIQRELGQEDPSRREIMLLRERAAAAGLPAHAMARFEEELARLELISPMSPEHGMLRTYLDWLISLPWSNA
SPENRDLRAAAAVLERNHYGLRKVKDRILEYIAVRQLAGPSRRAPILCFVGPPGVGKTSLGQSIAEALGRRFVRLSLGGV
HDEAEIRGHRRTYIGAMPGRILQRMKVAGTINPVFMLDEVDKLGSDFRGDPAAALLEVLDPEQNSTFSDHYLDLPYDLSQ
TLFITTANVADDIPDPLLDRMELVELPGYTEDEKLHIARRFLIPRQMTDSGLPPATIRFGDATIHTIIRNYTYEAGVRNL
EREIGAICRKIARRIAEGRRYPRQITPRALPKLLGPPRFEIGKIDPRDQVGVAIGMVYTSAGGDIMPVEVVLMDGKGNLL
LTGQLGEVMQESAQAALSFARANASRLGIEIRHFDKLDIHVHVPEGATPKDGPSAGVTIATALISALTGRTVRHDIAMTG
EITLHGRVLPIGGVKEKVLGAYRAGIRQIILPRRNEHDLVEIPVALRRQLTIHLIERIEQALELVLGPPPPKEPRRAPRV
IPRRDED

Sequences:

>Translated_807_residues
MTTTPANEQSPSPSGTTLYERPVLPLLDSVLFPQMLAPLFVSDERAINAVEQAVAEDRLVLAVAVRGPVDELTLGIDDLY
PVGVEATVQRVRRLPDGTLSVVLEGRQRMQIVSVVTEHPALRVLATPLETPPLDEDAALMVEALSRTILTTFEKIVRLSR
NLPDDAYLSALNSAEPGELADIIAALLPISVEDRQRILALADIQQRLRQLEILLAKELDLLELENRIHSQVQQEVDRSQR
ELFLREQLRAIQRELGQEDPSRREIMLLRERAAAAGLPAHAMARFEEELARLELISPMSPEHGMLRTYLDWLISLPWSNA
SPENRDLRAAAAVLERNHYGLRKVKDRILEYIAVRQLAGPSRRAPILCFVGPPGVGKTSLGQSIAEALGRRFVRLSLGGV
HDEAEIRGHRRTYIGAMPGRILQRMKVAGTINPVFMLDEVDKLGSDFRGDPAAALLEVLDPEQNSTFSDHYLDLPYDLSQ
TLFITTANVADDIPDPLLDRMELVELPGYTEDEKLHIARRFLIPRQMTDSGLPPATIRFGDATIHTIIRNYTYEAGVRNL
EREIGAICRKIARRIAEGRRYPRQITPRALPKLLGPPRFEIGKIDPRDQVGVAIGMVYTSAGGDIMPVEVVLMDGKGNLL
LTGQLGEVMQESAQAALSFARANASRLGIEIRHFDKLDIHVHVPEGATPKDGPSAGVTIATALISALTGRTVRHDIAMTG
EITLHGRVLPIGGVKEKVLGAYRAGIRQIILPRRNEHDLVEIPVALRRQLTIHLIERIEQALELVLGPPPPKEPRRAPRV
IPRRDED
>Mature_806_residues
TTTPANEQSPSPSGTTLYERPVLPLLDSVLFPQMLAPLFVSDERAINAVEQAVAEDRLVLAVAVRGPVDELTLGIDDLYP
VGVEATVQRVRRLPDGTLSVVLEGRQRMQIVSVVTEHPALRVLATPLETPPLDEDAALMVEALSRTILTTFEKIVRLSRN
LPDDAYLSALNSAEPGELADIIAALLPISVEDRQRILALADIQQRLRQLEILLAKELDLLELENRIHSQVQQEVDRSQRE
LFLREQLRAIQRELGQEDPSRREIMLLRERAAAAGLPAHAMARFEEELARLELISPMSPEHGMLRTYLDWLISLPWSNAS
PENRDLRAAAAVLERNHYGLRKVKDRILEYIAVRQLAGPSRRAPILCFVGPPGVGKTSLGQSIAEALGRRFVRLSLGGVH
DEAEIRGHRRTYIGAMPGRILQRMKVAGTINPVFMLDEVDKLGSDFRGDPAAALLEVLDPEQNSTFSDHYLDLPYDLSQT
LFITTANVADDIPDPLLDRMELVELPGYTEDEKLHIARRFLIPRQMTDSGLPPATIRFGDATIHTIIRNYTYEAGVRNLE
REIGAICRKIARRIAEGRRYPRQITPRALPKLLGPPRFEIGKIDPRDQVGVAIGMVYTSAGGDIMPVEVVLMDGKGNLLL
TGQLGEVMQESAQAALSFARANASRLGIEIRHFDKLDIHVHVPEGATPKDGPSAGVTIATALISALTGRTVRHDIAMTGE
ITLHGRVLPIGGVKEKVLGAYRAGIRQIILPRRNEHDLVEIPVALRRQLTIHLIERIEQALELVLGPPPPKEPRRAPRVI
PRRDED

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=754, Percent_Identity=41.9098143236074, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI21396489, Length=661, Percent_Identity=43.5703479576399, Blast_Score=548, Evalue=1e-155,
Organism=Escherichia coli, GI1786643, Length=782, Percent_Identity=48.5933503836317, Blast_Score=744, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=725, Percent_Identity=39.1724137931035, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=42.2794117647059, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319449, Length=459, Percent_Identity=43.3551198257081, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221513036, Length=664, Percent_Identity=43.2228915662651, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=664, Percent_Identity=43.2228915662651, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89554; Mature: 89423

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTPANEQSPSPSGTTLYERPVLPLLDSVLFPQMLAPLFVSDERAINAVEQAVAEDRLV
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
LAVAVRGPVDELTLGIDDLYPVGVEATVQRVRRLPDGTLSVVLEGRQRMQIVSVVTEHPA
EEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCC
LRVLATPLETPPLDEDAALMVEALSRTILTTFEKIVRLSRNLPDDAYLSALNSAEPGELA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
DIIAALLPISVEDRQRILALADIQQRLRQLEILLAKELDLLELENRIHSQVQQEVDRSQR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ELFLREQLRAIQRELGQEDPSRREIMLLRERAAAAGLPAHAMARFEEELARLELISPMSP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
EHGMLRTYLDWLISLPWSNASPENRDLRAAAAVLERNHYGLRKVKDRILEYIAVRQLAGP
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
SRRAPILCFVGPPGVGKTSLGQSIAEALGRRFVRLSLGGVHDEAEIRGHRRTYIGAMPGR
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCCHHEECCCHHH
ILQRMKVAGTINPVFMLDEVDKLGSDFRGDPAAALLEVLDPEQNSTFSDHYLDLPYDLSQ
HHHHHHHHCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TLFITTANVADDIPDPLLDRMELVELPGYTEDEKLHIARRFLIPRQMTDSGLPPATIRFG
EEEEEECCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEC
DATIHTIIRNYTYEAGVRNLEREIGAICRKIARRIAEGRRYPRQITPRALPKLLGPPRFE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
IGKIDPRDQVGVAIGMVYTSAGGDIMPVEVVLMDGKGNLLLTGQLGEVMQESAQAALSFA
CCCCCCCHHHCEEEEEEEECCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHH
RANASRLGIEIRHFDKLDIHVHVPEGATPKDGPSAGVTIATALISALTGRTVRHDIAMTG
HCCHHHHCEEEEECCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCEEEEE
EITLHGRVLPIGGVKEKVLGAYRAGIRQIILPRRNEHDLVEIPVALRRQLTIHLIERIEQ
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHH
ALELVLGPPPPKEPRRAPRVIPRRDED
HHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTTPANEQSPSPSGTTLYERPVLPLLDSVLFPQMLAPLFVSDERAINAVEQAVAEDRLV
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
LAVAVRGPVDELTLGIDDLYPVGVEATVQRVRRLPDGTLSVVLEGRQRMQIVSVVTEHPA
EEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCC
LRVLATPLETPPLDEDAALMVEALSRTILTTFEKIVRLSRNLPDDAYLSALNSAEPGELA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHH
DIIAALLPISVEDRQRILALADIQQRLRQLEILLAKELDLLELENRIHSQVQQEVDRSQR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ELFLREQLRAIQRELGQEDPSRREIMLLRERAAAAGLPAHAMARFEEELARLELISPMSP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
EHGMLRTYLDWLISLPWSNASPENRDLRAAAAVLERNHYGLRKVKDRILEYIAVRQLAGP
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
SRRAPILCFVGPPGVGKTSLGQSIAEALGRRFVRLSLGGVHDEAEIRGHRRTYIGAMPGR
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCCHHEECCCHHH
ILQRMKVAGTINPVFMLDEVDKLGSDFRGDPAAALLEVLDPEQNSTFSDHYLDLPYDLSQ
HHHHHHHHCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TLFITTANVADDIPDPLLDRMELVELPGYTEDEKLHIARRFLIPRQMTDSGLPPATIRFG
EEEEEECCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEC
DATIHTIIRNYTYEAGVRNLEREIGAICRKIARRIAEGRRYPRQITPRALPKLLGPPRFE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
IGKIDPRDQVGVAIGMVYTSAGGDIMPVEVVLMDGKGNLLLTGQLGEVMQESAQAALSFA
CCCCCCCHHHCEEEEEEEECCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHH
RANASRLGIEIRHFDKLDIHVHVPEGATPKDGPSAGVTIATALISALTGRTVRHDIAMTG
HCCHHHHCEEEEECCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCEEEEE
EITLHGRVLPIGGVKEKVLGAYRAGIRQIILPRRNEHDLVEIPVALRRQLTIHLIERIEQ
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHH
ALELVLGPPPPKEPRRAPRVIPRRDED
HHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA