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The map label for this gene is dltA [H]

Identifier: 222095105

GI number: 222095105

Start: 1426086

End: 1427600

Strand: Reverse

Name: dltA [H]

Synonym: BCQ_1445

Alternate gene names: 222095105

Gene position: 1427600-1426086 (Counterclockwise)

Preceding gene: 222095106

Following gene: 222095104

Centisome position: 27.38

GC content: 37.16

Gene sequence:

>1515_bases
ATGAAGTTATTAGAACAAATTGAAAAGTGGGCTATTGAAACGCCTGATCAAACTGCTTTTGTTTGGCGAGATGCGAAAAT
TACGTACAAACAATTAAAGGAAGATTCTGATGCGTTAGCACATTGGATTTCTTCTGAGTATCCAGATGATCGTTCACCAA
TTATGGTGTATGGCCATATGCAACCTGAAATGATTATTAACTTTTTAGGATGTGTAAAAGCTGGACATGCTTATATTCCT
GTAGATTTATCTATCCCAGCTGATCGTGTACAACGTATCGCTGAAAATTCTGGTGCGAAACTACTTTTATCAGGAACTGA
AGTAACTGTAACTGATTTACCAGTTCGCATTGTAAGTGAGGACAACTTAAAAGATATTTTCTTTACTCATAAAGGGAAAA
CTCCAAATCCTGAACATGCGGTAAAAGGTGATGAAAACTTCTACATTATTTACACATCAGGAAGCACAGGTAATCCGAAA
GGGGTTCAGATTACTTATAACTGCCTTGTAAGTTTTACAAAATGGGCTGTAGAAGATTTCAACTTACAAACGGGGCAAGT
ATTCTTAAACCAAGCACCTTTCTCATTTGATTTATCTGTCATGGATATTTACCCATCATTAGTAACAGGTGGTACACTTT
GGGCAATTGATAAAGATATGATTGCACGTCCAAAAGACTTGTTTGCTTCTTTAGAGCAATCGGATATACAAGTATGGACT
TCCACACCATCTTTCGCAGAAATGTGTTTAATGGAAGCATCTTTCTCTGAGAGTATGCTACCAAACATGAAAACATTCTT
ATTCTGCGGTGAAGTGTTACCAAATGAAGTAGCTAGAAAATTAATTGAGCGTTTCCCGAAAGCAACAATTATGAATACGT
ACGGTCCAACTGAAGCTACTGTCGCTGTAACAGGTATTCACGTTACAGAAGAAGTGCTTGATCAATACAAATCACTTCCA
GTTGGCTACTGTAAATCAGACTGCCGCCTTCTTATTATGAAAGAAGATGGTACGATTGCGCCTGATGGTGAAAAAGGTGA
AATCGTAATTGTTGGTCCAAGCGTAAGCGTTGGATATTTAGGAAGCCCTGAATTAACAGAAAAAGCATTTACTATGATTG
ACGGTGAGCGCGCCTATAAAACAGGCGATGCTGGCTATGTTGAAAATGGTCTTCTATTCTATAATGGTCGTCTTGATTTC
CAAATTAAGCTGCATGGTTATCGAATGGAATTAGAAGAAATTGAGCATCACCTTCGTGCGTGTTCTTACGTAGAAGGAGC
AGTTATCGTTCCAATTAAAAAAGGTGAGAAATACGATTATTTATTAGCGGTTGTTGTTCCTGGAGAACATTCATTTGAAA
AAGAATTCAAATTAACATCTGCAATCAAAAAAGAACTCAATGAGCGATTACCAAACTACATGATTCCACGTAAATTCATG
TATCAATCTTCTATTCCAATGACACCAAATGGAAAGGTAGATCGCAAAAAATTATTGAGTGAGGTTACAGCATGA

Upstream 100 bases:

>100_bases
TTATTACCTTGCAATTTTATTTGCATTACTTTGGTTGTATGGATTCCATGATACAAACACAAGTACATTTATTTACAATG
AATTCTAGGGTGGGAACGTT

Downstream 100 bases:

>100_bases
CCGCATATGGATCATTTTATTTTTTCGCTATAGTGGGCATTTTATTAATACCTACTATCATAGCTGGATTAAAAGGTAAA
ATGTTGCGTAAATATAATGC

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSEDNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Sequences:

>Translated_504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSEDNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA
>Mature_504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSEDNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=361, Percent_Identity=26.0387811634349, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI187761345, Length=399, Percent_Identity=26.5664160401003, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI187761343, Length=399, Percent_Identity=26.5664160401003, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI157311624, Length=501, Percent_Identity=24.750499001996, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI157311622, Length=501, Percent_Identity=24.750499001996, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI156151445, Length=363, Percent_Identity=25.6198347107438, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI58082049, Length=505, Percent_Identity=24.3564356435644, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=21.9512195121951, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786801, Length=533, Percent_Identity=30.0187617260788, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI145693145, Length=537, Percent_Identity=23.8361266294227, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=24.2774566473988, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI221142682, Length=466, Percent_Identity=22.3175965665236, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=497, Percent_Identity=24.5472837022133, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=481, Percent_Identity=26.8191268191268, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=26.890756302521, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=502, Percent_Identity=23.9043824701195, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=368, Percent_Identity=22.8260869565217, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=376, Percent_Identity=24.7340425531915, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=442, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=362, Percent_Identity=22.9281767955801, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=434, Percent_Identity=24.4239631336406, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=570, Percent_Identity=24.7368421052632, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=358, Percent_Identity=22.0670391061453, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648676, Length=521, Percent_Identity=25.7197696737044, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=22.6765799256506, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355225, Length=532, Percent_Identity=21.6165413533835, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356441, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581924, Length=368, Percent_Identity=22.554347826087, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56595; Mature: 56595

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCEEEEEECCEEEECC
DNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWAVEDF
CCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEEHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSGTEVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCEEEEEECCEEEECC
DNLKDIFFTHKGKTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWAVEDF
CCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEEHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA