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The map label for this gene is opuE [H]

Identifier: 222094960

GI number: 222094960

Start: 1286378

End: 1287856

Strand: Reverse

Name: opuE [H]

Synonym: BCQ_1298

Alternate gene names: 222094960

Gene position: 1287856-1286378 (Counterclockwise)

Preceding gene: 222094971

Following gene: 222094959

Centisome position: 24.7

GC content: 37.39

Gene sequence:

>1479_bases
ATGAGTACGCAGATGTTAACTTTAACTTCTATCTCTATTTACATGCTCGGGATGTTAGTGATTGGCTATTTCGCCTATAA
ACGAACATCCAACTTAACAGATTATATGCTTGGCGGGCGTACACTAGGCCCCGCAGTAACAGCATTAAGTGCTGGAGCAT
CCGATATGAGTGGTTGGCTTTTAATGGGCTTACCGGGTGCAATGTTTAGCGTTGGATTAAGTAGTAGTTGGATTGCGATC
GGCCTAACACTAGGCGCATACGCAAACTGGCTATATGTCGCTCCTCGCTTACGTACCTACTCAGAAATTGCAAACAACTC
TATTACTATCCCAGAATTTTTGGAACACCGATTCCAAGACAAATCCCATATGCTACGCTTAGTATCTGGACTTGTTATTA
TGATTTTCTTTACTTTTTATGTAGCTTCAGGATTAGTTTCAGGCGCTGTATTATTTGAAAATTCATTTGGTATGAACTAC
CATGTTGGATTATTCATTGTTGCAGGCGTTGTTGTTGCTTACACGTTATTTGGTGGTTTCTTGGCAGTAAGTTGGACAGA
CTTCGTGCAAGGAATCATTATGGTAATTGCTCTTATTCTTGTTCCTACTGTTACAATTATGAATGTAAATGGGCTTGGTC
CAGCATTTAGCACAATTAAATCAATTGATCCAACATTATTAGACATTTTTAAAGGCACTTCTGTATTAGGTATTATTTCA
TTATTCGCATGGGGCCTTGGTTATGTTGGACAACCACATATTATCGTACGATTTATGGCAATTTCTTCTGTAAAAGAAAT
TAAAAGTGCAAGACGAATTGGTATGAGCTGGATGATTTTCTCTGTTGTTGGAGCTATGTTTACTGGTCTTATCGGTATTG
CATACTACTCAGACAAAGGATTAAAGCTATCCAATCCAGAGACAATTTTCCTTGAACTGGGAAAAATTTTATTCCACCCG
CTTATTACTGGATTTTTATTAGCCGCTATTTTAGCAGCAATTATGAGTACAATCTCATCTCAGTTACTCGTTACTTCTAG
TGCCATAACTGAAGACTTATATCGTACTTTCTTTAAACGTTCTGCTTCTGATAAAGAGCTTGTATTTGTCGGCCGTATGG
CTGTTCTTGTTATTGCATTAGTTGGATGTGCATTAGCGTTTAAACAAAATGATACGATTTTAGCTCTTGTTGGATACGCT
TGGGCTGGATTTGGCTCTTCATTCGGACCTGCTATTTTATTAAGCTTATACTGGAAACGTATGACGAAGTGGGGCGCACT
TGCTGGTATGATTTCTGGTGCCGCTACAGTCATTATTTGGACTCAATTCAAATTCTTAAAAGAATTCTTATATGAAATGA
TTCCTGGTTTCACTATTAGTTTACTAGTAATCGTAATTGTTAGTTTACTAACACAGCCTTCAAAAGAAATTGAAGAGCAA
TTTGAGAATTTCGAAAAACAACATAGTGATAATCTATAA

Upstream 100 bases:

>100_bases
CCTTGCCCAGCCGATTTTAAGGTGGGAGTTTTACTGCCCGTTAATGCGGGATAAATATGCATAACGCATCAAAAGACATG
ACAAAAGGAAGGGGAACTAC

Downstream 100 bases:

>100_bases
AGGAAAAGCTCTGCTGTTATGATAGCAGAGCTTTCTTTTTATCCCGCTATTTGTTGGCAATAAGACTCACACCTCAAAAT
TCGGCGAATACGAAGGAGCT

Product: sodium/proline symporter; osmoregulated proline transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKEFLYEMIPGFTISLLVIVIVSLLTQPSKEIEEQ
FENFEKQHSDNL

Sequences:

>Translated_492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKEFLYEMIPGFTISLLVIVIVSLLTQPSKEIEEQ
FENFEKQHSDNL
>Mature_491_residues
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAIG
LTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYH
VGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIISL
FAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHPL
ITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYAW
AGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKEFLYEMIPGFTISLLVIVIVSLLTQPSKEIEEQF
ENFEKQHSDNL

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=491, Percent_Identity=54.3788187372709, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI110835708, Length=553, Percent_Identity=24.0506329113924, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI206597483, Length=438, Percent_Identity=25.1141552511416, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI206597487, Length=438, Percent_Identity=25.1141552511416, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI109659836, Length=448, Percent_Identity=22.5446428571429, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4507031, Length=493, Percent_Identity=22.1095334685598, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI109659839, Length=466, Percent_Identity=22.5321888412017, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI14140236, Length=555, Percent_Identity=22.7027027027027, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507035, Length=364, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI11141885, Length=451, Percent_Identity=24.390243902439, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4507033, Length=410, Percent_Identity=24.8780487804878, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1787251, Length=493, Percent_Identity=54.5638945233266, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87082237, Length=442, Percent_Identity=28.2805429864253, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790503, Length=501, Percent_Identity=25.748502994012, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1790113, Length=481, Percent_Identity=23.4927234927235, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=387, Percent_Identity=24.2894056847545, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=474, Percent_Identity=22.5738396624473, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24645928, Length=383, Percent_Identity=26.8929503916449, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221459584, Length=373, Percent_Identity=22.7882037533512, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221459588, Length=398, Percent_Identity=25.1256281407035, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.4545454545455, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640370, Length=368, Percent_Identity=24.1847826086957, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650192, Length=379, Percent_Identity=22.6912928759894, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221459582, Length=372, Percent_Identity=24.4623655913978, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651739, Length=349, Percent_Identity=25.214899713467, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573698, Length=408, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362918, Length=289, Percent_Identity=25.9515570934256, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651741, Length=183, Percent_Identity=31.6939890710383, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19920916, Length=402, Percent_Identity=24.6268656716418, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53703; Mature: 53572

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAMFSVGLSSSWIAIGLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQD
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHHHHHHHCC
KSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYHVGLFIVAGVVVAYTLFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHH
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
LKLSNPETIFLELGKILFHPLITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYAWAGFGSSFGPAILLSLYWKR
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHH
MTKWGALAGMISGAATVIIWTQFKFLKEFLYEMIPGFTISLLVIVIVSLLTQPSKEIEEQ
HHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHH
FENFEKQHSDNL
HHHHHHHCCCCC
>Mature Secondary Structure 
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAMFSVGLSSSWIAIGLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQD
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHHHHHHHCC
KSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYHVGLFIVAGVVVAYTLFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHH
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
LKLSNPETIFLELGKILFHPLITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYAWAGFGSSFGPAILLSLYWKR
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHH
MTKWGALAGMISGAATVIIWTQFKFLKEFLYEMIPGFTISLLVIVIVSLLTQPSKEIEEQ
HHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHH
FENFEKQHSDNL
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]