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The map label for this gene is cadA [H]

Identifier: 222094347

GI number: 222094347

Start: 655466

End: 657832

Strand: Direct

Name: cadA [H]

Synonym: BCQ_0661

Alternate gene names: 222094347

Gene position: 655466-657832 (Clockwise)

Preceding gene: 222094346

Following gene: 222094349

Centisome position: 12.57

GC content: 36.38

Gene sequence:

>2367_bases
ATGGCTGAAGCATTAGTGAAAAAGAAACTGATGTTAGAAGGTTTAGATTGTGCGAACTGTGCAATGAAAATCGAAAAAGG
TGTTGGAAATATAGAAGGAGTAAATTCTTGCTCTGTAAATTTTGCAACAAAAACAATGGTTTTAGAGACAGAACAAAATA
AAGAAAACGAAGTTGTTACAGAAGCAAAACAACTCGTTACAAAATTAGAACCGCACATTAAAGTGCAAGAAGAAAAAAGC
ACAAAAGTAGCAAAAGAAGTATTTATATTAGAAGGTTTAGATTGCGCAAATTGTGCGATGAAGATTGAAAATAAAGTGAA
AGAAATGCCGACTGTTTCAACAGCAACTGTTGATTTCGTATCAAAGAAATTACGAGTTGAGGTAGCGAATAAAAGAGAAT
TAGAAGCGACTGTAGCCAATATAACAAATGTCGTTCAAAAGTTAGAACCAGATGTGAAAGTTCTTCGTGAAGAAAAGGGT
GGTCATGACCATGGACATAGTCATGATCATGGTGAAGCAAATGTGAAAAAGATGGTAGGACGATTAGTGGTCGGCGGAAT
TTTGACAGCAATTGCTGCATTAGCTAGCTTACCACAAATGATCACAATTCCGTTATTCGTCCTTGCGTATGTATTAATCG
GTGGAGATATTGTTTGGAGAGCGGTAAGAAACATAACTCGTGGCCAAGTATTTGATGAGAACTTCTTAATGGCAATTGCC
ACACTAGGAGCTTTCGCGATTCAACAATACCCAGAAGCGGTTGCAGTAATGTTATTCTATCAAGTAGGGGAACTATTCCA
AAGTATTGCGGTAAACCGTTCTCGAAAATCAATTACTTCATTAATGGATATTCGTCCTGATTACGCGAATGTAAAGGTTG
GTAATGAAACGAAACAAGTATCACCAGAAGATGTACAAATCGGCGATTATATTATCGTGAAACCTGGTGAGAAAGTACCA
TTAGACGGAAAAGTAGTTGAAGGAACATCAATGGTAGATACTTCAGCATTGACTGGTGAATCTGTACCACGTGAAGTTGA
AGTTGGAAATGATGTACTAAGTGGTTTTGTGAACCAAAATGGTGTATTAACAATTGAGGTTACAAAAGAATTTGGTGAAT
CAACCGTATCAAAAATTTTAGATTTAGTTCAAAATGCAAGCAGTAAAAAAGCGCCAACAGAAAACTTTATTACGAAGTTC
GCGCGTTACTACACTCCAGTTGTAGTAATTACAGCAGCGATCATGGCGTTTATTCCACCACTTATTTTAGAAGGAGCTAC
ATTCTCTGATTGGATTTATAGAGCGTTAGTGTTCCTAGTAATCTCTTGTCCATGTGCGTTAGTTGTATCTATTCCTCTTG
GATTCTTTGGAGGTATCGGTGGTGCATCTAAAAGTGGTGTGTTAGTAAAAGGAAGTAACTATTTAGAAGCTTTAAATGAT
GTGAAATATATTGTTTTTGATAAAACAGGCACATTAACAAAAGGTGTCTTCAAAGTTACAAAAATGGAACCGAGCGAAGG
TATTACAAATGAAGAATTATTAGAGTATGCAGCATTTGCTGAAGTATATTCTAACCATCCAATTGCACAATCGATTCGAA
ATGCATATGGAAAATCAGTTGATGAAAAAATGATCGATGATTATAACGAAATTTCTGGTCACGGTACAGTCGTAAAAGTA
CAAGGAAAAGAAATTTTTGCAGGTAATGCTAAATTAATGAGAAAAGAGAACATTACATTTAAGCAACCAGAAACGGTAGG
TACATTAGTTCACGTTGCTGTAGATGGAAAATATGCAGGTTATATTGTTATCTCTGATGAGGTAAAAGAAGATTCAAAAC
AAGCAATTCAAAAGTTAAAAGAACTAGGTATTAAGAAGACAGTCATGTTAACTGGTGATGCAAAATCAGTTGGTGAAGCT
GTTGGTAAGGAATTAGGTTTAGATGAAGTTCACGCAGAACTATTACCGCAACAAAAAGTAGAAGAGATTGAAAAAATTGA
TGCAGCGAAGCATGGAAAAGAAAAAGTCGCTTTCGTTGGTGATGGTATTAATGATACACCGGTATTAGCGAGAGCCGATG
TTGGTATTGCGATGGGTGGTTTAGGATCAGATGCAGCAATTGAAGCGGCAGATATTGTTATTATGACTGATGAGCCATCA
AAAATTGCAACAGCTGTAAACATTGCAAAACGTACACGACGTATTGTGTGGCAAAATATTATCTTTGCATTAGGGGTAAA
AGGATTAGTTTTACTACTTGGTGCTTTCGGTATTGCAACAATGTGGGAAGCTGTTTTCTCAGATGTTGGTGTGACACTAC
TGGCAGTGTTAAATGCAATGCGTGTACTACGAGTGAAAGATTTATAA

Upstream 100 bases:

>100_bases
TTTATTATTCGTTAGCTGACCAGCACGTAATTCATATCTTCGAGCAAGCGTTTGAACACGTAAACGAGGAAGAATAAAAA
GAACGCGAGGAGGGAGAACG

Downstream 100 bases:

>100_bases
AAAAAGAGGGCGCAACCTGCGTCCTCTTTTTTAGGTTATTCTGTTGAAATTGACTCAATAAAATAATAACAAATATTATT
TTGTAAATAAATAACTTAAT

Product: heavy metal-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 787

Protein sequence:

>788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETEQNKENEVVTEAKQLVTKLEPHIKVQEEKS
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSTATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVLREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALASLPQMITIPLFVLAYVLIGGDIVWRAVRNITRGQVFDENFLMAIA
TLGAFAIQQYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYGKSVDEKMIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKSVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVNIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Sequences:

>Translated_788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETEQNKENEVVTEAKQLVTKLEPHIKVQEEKS
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSTATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVLREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALASLPQMITIPLFVLAYVLIGGDIVWRAVRNITRGQVFDENFLMAIA
TLGAFAIQQYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYGKSVDEKMIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKSVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVNIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL
>Mature_787_residues
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETEQNKENEVVTEAKQLVTKLEPHIKVQEEKST
KVAKEVFILEGLDCANCAMKIENKVKEMPTVSTATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVLREEKGG
HDHGHSHDHGEANVKKMVGRLVVGGILTAIAALASLPQMITIPLFVLAYVLIGGDIVWRAVRNITRGQVFDENFLMAIAT
LGAFAIQQYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVPL
DGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFA
RYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALNDV
KYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYGKSVDEKMIDDYNEISGHGTVVKVQ
GKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKSVGEAV
GKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSK
IATAVNIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=869, Percent_Identity=25.3164556962025, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI55743073, Length=543, Percent_Identity=28.5451197053407, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI115529486, Length=649, Percent_Identity=24.653312788906, Blast_Score=163, Evalue=7e-40,
Organism=Homo sapiens, GI118498343, Length=212, Percent_Identity=28.7735849056604, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789879, Length=705, Percent_Identity=34.3262411347518, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1786691, Length=853, Percent_Identity=27.3153575615475, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1786914, Length=475, Percent_Identity=29.2631578947368, Blast_Score=152, Evalue=1e-37,
Organism=Escherichia coli, GI2367363, Length=592, Percent_Identity=24.4932432432432, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=575, Percent_Identity=31.4782608695652, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI71997275, Length=212, Percent_Identity=26.4150943396226, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71997262, Length=212, Percent_Identity=26.4150943396226, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=560, Percent_Identity=30.7142857142857, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6319772, Length=635, Percent_Identity=24.8818897637795, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6325221, Length=563, Percent_Identity=22.7353463587922, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321430, Length=569, Percent_Identity=22.4956063268893, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321271, Length=220, Percent_Identity=26.8181818181818, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329854, Length=606, Percent_Identity=26.4026402640264, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24668704, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668708, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366617, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24668696, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161085803, Length=153, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366676, Length=293, Percent_Identity=25.938566552901, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 85332; Mature: 85201

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETEQNKENEVVT
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHH
EAKQLVTKLEPHIKVQEEKSTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSTATVDFV
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVLREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALASLPQMITIPLFVLAYVLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TLGAFAIQQYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYGKSV
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
DEKMIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCCCCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKSVGEAVGKELGLDEVHAELLPQQKV
EEEEEHHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVNIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC
>Mature Secondary Structure 
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETEQNKENEVVT
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHH
EAKQLVTKLEPHIKVQEEKSTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSTATVDFV
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVLREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALASLPQMITIPLFVLAYVLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TLGAFAIQQYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVVEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGITNEELLEYAAFAEVYSNHPIAQSIRNAYGKSV
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
DEKMIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGKYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCCCCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKSVGEAVGKELGLDEVHAELLPQQKV
EEEEEHHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVNIAKRTRRIVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]