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The map label for this gene is dltA [H]

Identifier: 221232881

GI number: 221232881

Start: 2154993

End: 2156543

Strand: Reverse

Name: dltA [H]

Synonym: SPN23F_22090

Alternate gene names: 221232881

Gene position: 2156543-2154993 (Counterclockwise)

Preceding gene: 221232882

Following gene: 221232880

Centisome position: 97.08

GC content: 44.17

Gene sequence:

>1551_bases
GTGTCAAATAAACCAATAGCAGATATGATTGAAACCATTGAGCATTTTGCTCAGACACAGCCTAGCTATCCTGTCTATAA
TGTTTTGGGGCAGGAACACACTTATGGCGATTTAAAGGCTGATTCGGATAGTTTGGCTGCAGTCATTGACCAACTAGGCT
TGCCTGAGAAGTCTCCTGTGGTTGTTTTTGGTGGCCAAGAATATGAAATGTTGGCAACCTTTGTAGCGCTGACTAAGTCA
GGTCATGCCTACATTCCAATTGATAGCCATTCGGCCTTGGAGCGAGTTTCAGCTATTTTAGAAGTAGCAGAGCCAAGCTT
GATTATTGCCATTTCAGCCTTTCCCTTGGAGCAGGTTTCTACACCAATGATAAATCTAGCTCAGGTTCAAGAAGCCTTTG
CCCAAGGGAACAACTATGAAATCACGCATCCAGTCAAGGGAGATGATAATTACTACATTATCTTTACTTCTGGTACGACT
GGTAAGCCTAAGGGAGTGCAGATTTCACATGATAATCTCCTCAGCTTTACAAACTGGATGATTACGGATAAGGAATTTGC
GACACCGAGTCGTCCGCAAATGCTGGCACAGCCACCTTATTCTTTTGACTTGTCTGTCATGTATTGGGCACCGACCTTGG
CACTTGGTGGTACGCTTTTCACTCTTCCTTCAGTCATCACTCAGGACTTTAAGCAACTCTTTGCGGCTATCTTTTCATTG
CCAATCGCTATCTGGACATCAACACCATCCTTTGCAGATATGGCCATGTTGTCTGAATACTTCAACAGTGAGAAAATGCC
TGGAATCACGCATTTCTACTTTGATGGTGAAGAATTGACGGTCAAAACAGCTCAAAAACTGCGCGAGCGTTTCCCAAATG
CCCGTATCATCAATGCTTACGGCCCAACAGAAGCGACAGTAGCTCTGTCAGCAGTTGCCGTGACAGACGAGATGTTAGCG
ACTCTCAAACGCCTACCAATCGGCTATACCAAGGCTGATTCTCCAACCTTTATCATTGACGAGGAAGGAAATAAACTGCC
AAATGGCGAACAGGGAGAAATCATTGTTTCTGGGCCAGCTGTTTCAAAAGGTTATATGAAAAATCCTGAAAAAACAGCAG
AAGCCTTCTTTGAGTTTGAAGGTCTGCCAGCCTATCACACAGGCGATGTGGGAACCATGACAGATGAGGGCTTGCTTCTC
TACGGCGGACGCATGGACTTCCAGATTAAGTTTAACGGTTACCGCATTGAGTTAGAAGATGTCTCTCAAAACCTCAACAA
GTCTCGCTTTATCGAATCTGCTGTCGCAGTACCGCGCTATAACAAGGACCACAAGGTACAAAATCTATTGGCTTATGTCA
TCTTAAAAGACGGTGTTCGTGAGCAGTTTGAGCGAGATATCGATATTACCAAGGCCATCAAGGAAGACCTGACAGACATC
ATGATGTCCTATATGATGCCATCTAAATTCCTTTACCGAGACAGTTTGCCACTAACTCCAAATGGAAAGATTGACATCAA
AGGATTGATTAACGAGGTGAATAAGAGATGA

Upstream 100 bases:

>100_bases
TTCTTATCTTTCTAGGGCTGCTTTACTTCTTTAGCTATCTTGGTCAGGGTCAAGGAAGCTTTATCTATAATGAATTTTAA
CTTGAAGGAGAATCCCTATT

Downstream 100 bases:

>100_bases
TGGAGTTTTTTCAACAGCTTCCTCATTTAGAGCCATATGGCAATCCTCAGTATTTTGTTTATGTGATTGCTGCAACCTTG
CCCATCTTTATAGGTCTCTT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Sequences:

>Translated_516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
>Mature_515_residues
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSG
HAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTG
KPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLP
IAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLAT
LKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLLY
GGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDIM
MSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI115511026, Length=386, Percent_Identity=28.4974093264249, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI45580730, Length=376, Percent_Identity=25.531914893617, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI42544132, Length=540, Percent_Identity=24.2592592592593, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38505220, Length=389, Percent_Identity=26.7352185089974, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI156151445, Length=554, Percent_Identity=22.9241877256318, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157311624, Length=381, Percent_Identity=26.509186351706, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI157311622, Length=381, Percent_Identity=26.509186351706, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786801, Length=496, Percent_Identity=26.4112903225806, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786810, Length=512, Percent_Identity=22.265625, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693145, Length=408, Percent_Identity=24.5098039215686, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=22.262118491921, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=24.5901639344262, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=489, Percent_Identity=24.1308793456033, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=423, Percent_Identity=26.7139479905437, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=362, Percent_Identity=25.1381215469613, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17556356, Length=463, Percent_Identity=27.2138228941685, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=430, Percent_Identity=25.3488372093023, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=544, Percent_Identity=22.6102941176471, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=544, Percent_Identity=22.6102941176471, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994690, Length=544, Percent_Identity=22.6102941176471, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=412, Percent_Identity=24.2718446601942, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=560, Percent_Identity=25, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=28.4182305630027, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648676, Length=462, Percent_Identity=26.4069264069264, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI18859661, Length=372, Percent_Identity=24.7311827956989, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355181, Length=375, Percent_Identity=23.4666666666667, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356441, Length=412, Percent_Identity=20.3883495145631, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 57384; Mature: 57253

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPV
CCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure 
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPV
CCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA