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The map label for this gene is ptpA [H]

Identifier: 221232746

GI number: 221232746

Start: 1991641

End: 1992069

Strand: Reverse

Name: ptpA [H]

Synonym: SPN23F_20490

Alternate gene names: 221232746

Gene position: 1992069-1991641 (Counterclockwise)

Preceding gene: 221232747

Following gene: 221232745

Centisome position: 89.68

GC content: 38.46

Gene sequence:

>429_bases
ATGAAAAAATTAGTCTTTGTCTGTCTGGGAAATATTTGCCGTAGCCCTATGGCCGAGTTTGTTATGAAATCAATGACAGA
TAACTACGAAATCCAAAGTCGAGCAACTTCCTCTTGGGAACATGGCAATCCGATTCATAAGGGGACTCAGGGAATTTTTC
AAGAGTATGAGATTCCTTATGACAAGAACAAGACATCGCTTCAGATTAGTAAGGAAGATTTTGAAGCCTTTGATTATATT
ATCGGAATGGACGCTTCAAATATTTCTGACTTATGTCAGATGTGTCCAGTAGACTGTCAAGATAAGATTTACTCATTTTC
ATCTGAAAGTGTTCCAGACCCTTGGTATACAGGAGATTTTGAAGAAACCTATCGACGTGTTCAAGAGGGCTGTCAAGCTT
GGTTAGAACGTTTAGAAAAGGAGAGTTAA

Upstream 100 bases:

>100_bases
ACAGTATTACCGCTGAAAGAAACAGCTTCACTAGAAGGCGCAATTGAAAAATAAGACGGGATCACGAACTCCCGTTTTTC
TATAAAAGAAAGGAAATGGG

Downstream 100 bases:

>100_bases
GGTGGAAAATCTTACGAATTTTTACGAAAAGTATCGTGTCTATCTGACTCGTCCACGTTTAGAGCTTTTGGCAGTAGTTA
CCATTGTTTTTTGTGCTGTA

Product: phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: Phosphotyrosine phosphatase A; PTPase A [H]

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNPIHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYI
IGMDASNISDLCQMCPVDCQDKIYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES

Sequences:

>Translated_142_residues
MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNPIHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYI
IGMDASNISDLCQMCPVDCQDKIYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES
>Mature_142_residues
MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNPIHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYI
IGMDASNISDLCQMCPVDCQDKIYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES

Specific function: Dephosphorylates the phosphotyrosine-containing proteins [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=152, Percent_Identity=38.1578947368421, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI6005988, Length=152, Percent_Identity=35.5263157894737, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325330, Length=152, Percent_Identity=29.6052631578947, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706766, Length=156, Percent_Identity=32.0512820512821, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78706768, Length=156, Percent_Identity=32.0512820512821, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78706770, Length=150, Percent_Identity=28.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI78706772, Length=150, Percent_Identity=28.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI78706764, Length=132, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78711846, Length=154, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16487; Mature: 16487

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNPIHKGTQGIFQEYEIPY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
DKNKTSLQISKEDFEAFDYIIGMDASNISDLCQMCPVDCQDKIYSFSSESVPDPWYTGDF
CCCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCH
EETYRRVQEGCQAWLERLEKES
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNPIHKGTQGIFQEYEIPY
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
DKNKTSLQISKEDFEAFDYIIGMDASNISDLCQMCPVDCQDKIYSFSSESVPDPWYTGDF
CCCCCEEEECHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCH
EETYRRVQEGCQAWLERLEKES
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA