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The map label for this gene is penA [H]

Identifier: 221232410

GI number: 221232410

Start: 1612429

End: 1614471

Strand: Reverse

Name: penA [H]

Synonym: SPN23F_16740

Alternate gene names: 221232410

Gene position: 1614471-1612429 (Counterclockwise)

Preceding gene: 221232412

Following gene: 221232409

Centisome position: 72.68

GC content: 41.65

Gene sequence:

>2043_bases
ATGAGAAAATTTAACAGCCATTCGATTCCGATTCGGCTTAATTTATTGTTTTCAATCGTCATTTTACTCTTTATGACCAT
TATTGGTCGTTTGTTGTATATGCAGGTTTTGAACAAGGATTTTTATGAAAAAAAGCTAGCCTCAGCTAGTCAGACCAAGG
TCACAACCAGTTCTGCTCGTGGGGAAATCTATGATGCTAGTGGAAAACCTTTGGTAGAAAATACGTTAAAGCAGGTTGTT
TCCTTTACGCGTAGCAATAAAATGACGGCTACAGACTTAAAAGAAATAGCTAAAAAGTTACTGACTTATGTGAGCATCAG
TTCGCCAAATTTGACAGAACGCCAGCTGGCTGATTACTATTTGGCTGATCCTGAAATCTATAAAAAAACAGTGGAAGCTC
TCCCAAGTGAGAAACGCTTGGATTCAGATGGCAATCGCCTATCCGAATCAGAACTGTATAACAATGCTGTCGATAGTGTC
CCAACAAGTCAACTAAACTATACAGAGGATGAAAAGAAAGAAATCTATCTTTTTAGTCAGTTAAATGCTGTTGGAAACTT
TGCGACAGGAACCATTGTGACAGATCCTCTAAATGATTCTCAGGTGGCTGTTATTGCCTCTATTTCAAAGGAGATGCCTG
GCATTAGTATTTCTACTTCTTGGGATCGAAAGGTTTTGGAAACTTCCCTTTCTTCTATAGTAGGGAGTGTATCCAGTGAA
AAAGCTGGTCTCCCAGCGGAAGAAGCAGAATCCTATCTTAAAAAAGGCTATTCTCTAAATGACCGTGTTGGAACCTCCTA
TTTGGAAAAGCAATATGAAGAGACCTTACAAGGAAAACGCTCGGTAAAAGAAATCCATCTGGATAAATATGGCAATATGG
AAAGCGTGGACACAATTGAGGAAGGTAGTAAGGGAAACAATATCAAACTGACCATTGATTTGGCCTTCCAAGATAGCGTG
GATGCTTTGCTGAAAAGTTATTTCAATTCCGAGCTAGGAAATGGTGGAGCTAAATATTCTGAAGGTGTCTATGCAGTCGC
CCTTAACCCAAAAACAGGTGCTGTTTTATCCATGTCAGGGATCAAACATGACCTGAAAACGGGAGAGTTGACTCCTGATT
CCTTGGGAACGGTAACCAATGTCTTTGTCCCAGGTTCGGTTGTCAAGGCTGCGACCATCAGCTCAGGTTGGGAAAATGGT
GTTTTATCAGGAAACCAAACCTTAACAGATCAGCCTATTGTTTTCCAAGGTTCAGCTCCAATTTATTCTTGGTATAAATT
GGCATATGGATCTTTTCCTATTACAGCTGTGGAAGCCTTGGAGTATTCATCCAATGCTTACATGGTTCAAACCGCTCTTG
GAATCATGGGCCAGACCTATCAACCAAATATGTTTGTTGGAACCAGCAATTTGGAAACAGCTATGGGAAAACTTCGTGCG
ACCTTTGGCGAATATGGCTTGGGGGCTGCGACCGGAATTGACCTACCAGATGAATCTACTGGATTTGTTCCCAAAGAGTA
TAGCTTTGCTAATTACATCACCAATTCCTTTGGGCAGTTTGATAACTATACGCCCATGCAGTTGGCTCAGTATGTAGCAA
CTATTGCAAATAATGGTGTTCGTGTGGCTCCTCGTATTGTTGAAGGCATTTATGGTAATAATGATAAGGGAGGACTGGGT
GACTTGATTCAGCAACTGCAACCGACAGAGATGAATAAGGTCAATATATCCGACTCCGATATGAGCATCTTGCACCAAGG
TTTTTATCAGGTTGCCCATGGTACTAGTGGATTGACAACTGGACGTGCCTTTTCAAATGGTGCCTTGGTATCCATTAGCG
GAAAAACAGGTACAGCCGAAAGCTATGTGGCAGATGGTCAGCAAGCAACCAATACCAATGCGGTGGCCTATGCCCCATCT
GATAATCCCCAAATCGCTGTCGCAGTGGTCTTTCCTCATAATACCAATCTAACAAATGGTGTAGGACCTTCCATTGCGCG
TGACATTATCAATCTGTATCAAAAATACCATCCAATGAACTAG

Upstream 100 bases:

>100_bases
TGTAAAAACGAAAAAAAGCTTCTTTCTTTTCCATAATTTTCTGCTCAAATTGTGGTACAATTAAGAGTAAGATTTTAAGT
TAGAAATGAGACTGATTTGT

Downstream 100 bases:

>100_bases
AAAGGAAATTATGCTTTATCCAACACCTATTGCCAAGTTGATTGACAGTTATTCTAAGTTACCAGGTATCGGGATTAAGA
CGGCTACGCGTCTGGCCTTT

Product: penicillin-binding protein 2b

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVV
SFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSV
PTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIVTDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
KAGLPAEEAESYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSV
DALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENG
VLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRA
TFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNSFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLG
DLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPS
DNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN

Sequences:

>Translated_680_residues
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVV
SFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSV
PTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIVTDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
KAGLPAEEAESYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSV
DALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENG
VLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRA
TFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNSFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLG
DLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPS
DNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN
>Mature_680_residues
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVV
SFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSV
PTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIVTDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
KAGLPAEEAESYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSV
DALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENG
VLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRA
TFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNSFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLG
DLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPS
DNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=629, Percent_Identity=24.8012718600954, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786272, Length=311, Percent_Identity=27.3311897106109, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73769; Mature: 73769

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSAR
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYY
CCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
LADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSVPTSQLNYTEDEKKEIYLFSQ
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEH
LNAVGNFATGTIVTDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
HHHHCCCCCCCEEECCCCCCCEEEEEEHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCC
KAGLPAEEAESYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSG
CCCCCCEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEECC
IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQPIVFQGSAP
CCHHCCCCCCCCCHHCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
IYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRA
HHHHHHHHHCCCCHHHHHHHHHCCCCEEHEEHHHHHCCCCCCCEEEECCHHHHHHHHHHH
TFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNSFGQFDNYTPMQLAQYVATIANNGV
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCE
RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT
EECHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCC
GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG
CCEECCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCC
VGPSIARDIINLYQKYHPMN
CCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKVTTSSAR
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEIAKKLLTYVSISSPNLTERQLADYY
CCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
LADPEIYKKTVEALPSEKRLDSDGNRLSESELYNNAVDSVPTSQLNYTEDEKKEIYLFSQ
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEH
LNAVGNFATGTIVTDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
HHHHCCCCCCCEEECCCCCCCEEEEEEHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCC
KAGLPAEEAESYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELGNGGAKYSEGVYAVALNPKTGAVLSMSG
CCCCCCEEEEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEECC
IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQPIVFQGSAP
CCHHCCCCCCCCCHHCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
IYSWYKLAYGSFPITAVEALEYSSNAYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRA
HHHHHHHHHCCCCHHHHHHHHHCCCCEEHEEHHHHHCCCCCCCEEEECCHHHHHHHHHHH
TFGEYGLGAATGIDLPDESTGFVPKEYSFANYITNSFGQFDNYTPMQLAQYVATIANNGV
HHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCE
RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT
EECHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCC
GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG
CCEECCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCC
VGPSIARDIINLYQKYHPMN
CCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]