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The map label for this gene is apt

Identifier: 221232338

GI number: 221232338

Start: 1538060

End: 1538572

Strand: Reverse

Name: apt

Synonym: SPN23F_15940

Alternate gene names: 221232338

Gene position: 1538572-1538060 (Counterclockwise)

Preceding gene: 221232339

Following gene: 221232337

Centisome position: 69.26

GC content: 42.11

Gene sequence:

>513_bases
ATGAATTTAAAAGATTACATTGCAACAATTGAAAATTATCCAAAGGAAGGCATTACCTTCCGTGATATTAGTCCTTTGAT
GGCTGATGGAAATGCTTATAGCTACGCTGTTCGTGAAATCGTTCAGTATGCTACTGACAAGAAAGTCGACATGATCGTGG
GACCTGAAGCTCGTGGATTTATCGTGGGTTGTCCAGTTGCCTTTGAGTTGGGAATTGGTTTTGCGCCTGTTCGTAAGCCA
GGTAAATTGCCACGCGAAGTTATTTCTGCTGACTATGAAAAAGAGTACGGTGTCGATACCTTGACTATGCACGCGGATGC
CATTAAGCCAGGTCAACGTGTTCTTATTGTAGATGACCTTTTGGCGACAGGTGGAACTGTTAAGGCAACTATCGAGATGA
TTGAAAAACTTGGTGGTGTTATGGCAGGTTGTGCCTTCCTTGTTGAATTGGATGAATTGAACGGCCGTGAAAAAATCGGT
GACTACGACTACAAAGTTCTTATGCATTATTAA

Upstream 100 bases:

>100_bases
GTCAAAACGTTAGATAATTATTGAAGTTAACTTTTCCTTTTTTCTTTCTTAAAAAATATGCTATAATAGAGAGTAAAAAA
CTTTGAAAGAAAGAAAAAAG

Downstream 100 bases:

>100_bases
TGAAAACAGTCCCTAGGGCTGTTTTCTCTACACTAGGATATAAAAATAGACTATAACTAGTTAGAGAAAAACTATAATTG
AAAACTATATCTTCTTGCAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
DYDYKVLMHY

Sequences:

>Translated_170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
DYDYKVLMHY
>Mature_170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
DYDYKVLMHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=40.3508771929825, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=42.9752066115703, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=52.2292993630573, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=42.1052631578947, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=40.7407407407407, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=32.9411764705882, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=44.6540880503145, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_STRP2 (Q04JH1)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816867.1
- ProteinModelPortal:   Q04JH1
- SMR:   Q04JH1
- STRING:   Q04JH1
- EnsemblBacteria:   EBSTRT00000018920
- GeneID:   4441767
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1407
- eggNOG:   COG0503
- GeneTree:   EBGT00050000026782
- HOGENOM:   HBG703830
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18729; Mature: 18729

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGF
CCHHHHHHHHHCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCE
IVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDL
EEECCEEEECCCCCCCCCCCCCCCHHHHHCCCCHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGF
CCHHHHHHHHHCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCE
IVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDL
EEECCEEEECCCCCCCCCCCCCCCHHHHHCCCCHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA