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The map label for this gene is 220933080

Identifier: 220933080

GI number: 220933080

Start: 2450822

End: 2452264

Strand: Direct

Name: 220933080

Synonym: Hore_22480

Alternate gene names: NA

Gene position: 2450822-2452264 (Clockwise)

Preceding gene: 220933078

Following gene: 220933099

Centisome position: 95.06

GC content: 45.18

Gene sequence:

>1443_bases
ATGGTCACATTTATTCTCTACCCAGTTTATGGTATAATTAAAAATAAAAAAAATCAACCGGCAGGTGATATAATGCCAGA
TTCAATTAAAAATATTAAGGCAAAAAATAAACTGGGCCTTATTTTCTTCCCGGCCTTTGACTGGGCTATCTCCCCCACCC
ATCCGGAGCGGGAAGAACGCCTCCTCTATACCAGGGACCAGGTCTTTGAGGAGGGGCTTATGGATATTGATGGTATTAAG
GAATTTAACCCCGGAATCGCGGAGGAAAAAGATGTCCAGAAGGTTCATATCTGTGTCCCTGAAGTAAAGAAAGTAACCAC
TCCATCCCACCTTATATCAGCCGGGGGAGCCATTAAAGCCGCCGGGCTTGTTTTAAATAAAGAAGTTGACAAGGCTTTTG
CCATCGTCAGACCACCAGGCCACCACGCCTTCCGGGTAGTTCACGGAGCCAGAGGATTTTGTAATATCAATAATGAGGCC
ATCATGGTTGAAGCCATCCGGTCAAAATACCCGGATCTGAAAATAGCCTTTGTAGATACTGATGCCCATCATGCCGATGG
TACCCAGGAAATATTTTATCATGACCCCCATGTCTTACATATATCACTTCATCAGAATGGGAGAACCCTCTTTCCGGGAT
CCGGTTTTACAAACGAAGTGGGAGGGCCCGGGGCCTATGCCAGAACCCTCAACATACCCCTCCCCCCCTACACTACTGAC
GAAGGCCTGCATTACGTCCTGGATAACCTGGTATTACCGGTTTTAGAAGATTTTAAGCCTGACCTCATCATTAACGCAGC
CGGCCAGGATAATCACTATTCTGACCCCTTAACCAATATGAAAATATCAGCCCGGGGATATGCCGAATTAAATGCCAGAC
TCAACCCCGATATTGCCATTCTTCAGGGTGGTTATTCTATAGAAAGTGCCCTTCCCTATATCAATGTTGGGCTCATCCTG
GCCATGGCCGGCCTTGATTATAGTAATGTCAGGGAACCAGATTTTGACAGCCGGAACCTGACTCAGGACCCGGTCATAAC
AGATAATATCAAAAATACGGTTGCTGTCCTGAGGGAAATCTGGGAAAACCGGAATAACCAGGCACCAGTCCCTGATACAG
GTGAATTTACTATTAAGAACAATTTCTATGAAAGGGAAAAACACATCTTTTATGATACTGACGGTATAAATGAACTCCAG
CGAGAGCGGGTAAAAGCCTGTCCCGACTGCCCTGGATATATTATTATCGACTCCAGGGCTGAAAAGGGCTTTAGAAATAC
CCGTATCAAAGCCATAAGTATCCCCTTAAAGGCCTGCAAGAATTGTCACGAAGAGGCACACCTCAAATTTGAGGAGGCAA
AAAAAGAGGCAGGTAATAAGTATGATTACCTCTACCTGCAGGATGTAAAGGGAGAAGAATTTGTAACCTATCCTTCTCCC
TGA

Upstream 100 bases:

>100_bases
TCCAGAAATCAGGCATAATTATTCCTCCTATCCAGACTGTGTCCATATTTATTTTTTATATGATTGTAGTTATAATACAA
GACCCGAAATCACATGGATT

Downstream 100 bases:

>100_bases
TTTTCTCTTTTTAAACAATTAATTTACTTTTAAAGTTTAAACAAATACTCTCCTTTTATTCTACTTTTTCAAACTGATCT
TTCCCAACACCACAGACCGG

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MVTFILYPVYGIIKNKKNQPAGDIMPDSIKNIKAKNKLGLIFFPAFDWAISPTHPEREERLLYTRDQVFEEGLMDIDGIK
EFNPGIAEEKDVQKVHICVPEVKKVTTPSHLISAGGAIKAAGLVLNKEVDKAFAIVRPPGHHAFRVVHGARGFCNINNEA
IMVEAIRSKYPDLKIAFVDTDAHHADGTQEIFYHDPHVLHISLHQNGRTLFPGSGFTNEVGGPGAYARTLNIPLPPYTTD
EGLHYVLDNLVLPVLEDFKPDLIINAAGQDNHYSDPLTNMKISARGYAELNARLNPDIAILQGGYSIESALPYINVGLIL
AMAGLDYSNVREPDFDSRNLTQDPVITDNIKNTVAVLREIWENRNNQAPVPDTGEFTIKNNFYEREKHIFYDTDGINELQ
RERVKACPDCPGYIIIDSRAEKGFRNTRIKAISIPLKACKNCHEEAHLKFEEAKKEAGNKYDYLYLQDVKGEEFVTYPSP

Sequences:

>Translated_480_residues
MVTFILYPVYGIIKNKKNQPAGDIMPDSIKNIKAKNKLGLIFFPAFDWAISPTHPEREERLLYTRDQVFEEGLMDIDGIK
EFNPGIAEEKDVQKVHICVPEVKKVTTPSHLISAGGAIKAAGLVLNKEVDKAFAIVRPPGHHAFRVVHGARGFCNINNEA
IMVEAIRSKYPDLKIAFVDTDAHHADGTQEIFYHDPHVLHISLHQNGRTLFPGSGFTNEVGGPGAYARTLNIPLPPYTTD
EGLHYVLDNLVLPVLEDFKPDLIINAAGQDNHYSDPLTNMKISARGYAELNARLNPDIAILQGGYSIESALPYINVGLIL
AMAGLDYSNVREPDFDSRNLTQDPVITDNIKNTVAVLREIWENRNNQAPVPDTGEFTIKNNFYEREKHIFYDTDGINELQ
RERVKACPDCPGYIIIDSRAEKGFRNTRIKAISIPLKACKNCHEEAHLKFEEAKKEAGNKYDYLYLQDVKGEEFVTYPSP
>Mature_480_residues
MVTFILYPVYGIIKNKKNQPAGDIMPDSIKNIKAKNKLGLIFFPAFDWAISPTHPEREERLLYTRDQVFEEGLMDIDGIK
EFNPGIAEEKDVQKVHICVPEVKKVTTPSHLISAGGAIKAAGLVLNKEVDKAFAIVRPPGHHAFRVVHGARGFCNINNEA
IMVEAIRSKYPDLKIAFVDTDAHHADGTQEIFYHDPHVLHISLHQNGRTLFPGSGFTNEVGGPGAYARTLNIPLPPYTTD
EGLHYVLDNLVLPVLEDFKPDLIINAAGQDNHYSDPLTNMKISARGYAELNARLNPDIAILQGGYSIESALPYINVGLIL
AMAGLDYSNVREPDFDSRNLTQDPVITDNIKNTVAVLREIWENRNNQAPVPDTGEFTIKNNFYEREKHIFYDTDGINELQ
RERVKACPDCPGYIIIDSRAEKGFRNTRIKAISIPLKACKNCHEEAHLKFEEAKKEAGNKYDYLYLQDVKGEEFVTYPSP

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI17158039, Length=256, Percent_Identity=34.765625, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI30795204, Length=256, Percent_Identity=34.765625, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI30795202, Length=256, Percent_Identity=34.765625, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148539870, Length=276, Percent_Identity=31.1594202898551, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI169234807, Length=276, Percent_Identity=31.1594202898551, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI13128864, Length=232, Percent_Identity=33.6206896551724, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI153085395, Length=200, Percent_Identity=36.5, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI62750347, Length=266, Percent_Identity=33.0827067669173, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI62750349, Length=266, Percent_Identity=33.0827067669173, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI20070354, Length=208, Percent_Identity=33.6538461538462, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI13128862, Length=202, Percent_Identity=29.2079207920792, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI13128860, Length=204, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI8923769, Length=198, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI262073088, Length=163, Percent_Identity=29.4478527607362, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI293336691, Length=182, Percent_Identity=27.4725274725275, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI226529806, Length=125, Percent_Identity=36.8, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209491, Length=292, Percent_Identity=30.1369863013699, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540334, Length=208, Percent_Identity=28.8461538461538, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193206283, Length=208, Percent_Identity=28.8461538461538, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17540332, Length=208, Percent_Identity=28.8461538461538, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI25154020, Length=208, Percent_Identity=31.7307692307692, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25154022, Length=208, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537347, Length=231, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534739, Length=220, Percent_Identity=28.6363636363636, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=200, Percent_Identity=28, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508561, Length=203, Percent_Identity=27.0935960591133, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=212, Percent_Identity=31.6037735849057, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321244, Length=200, Percent_Identity=28, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323999, Length=204, Percent_Identity=26.4705882352941, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325325, Length=150, Percent_Identity=29.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24642146, Length=267, Percent_Identity=31.4606741573034, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642142, Length=267, Percent_Identity=31.4606741573034, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642144, Length=267, Percent_Identity=31.4606741573034, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281360899, Length=267, Percent_Identity=31.4606741573034, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281360799, Length=263, Percent_Identity=28.5171102661597, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24641720, Length=211, Percent_Identity=31.2796208530806, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281360801, Length=209, Percent_Identity=31.5789473684211, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644244, Length=173, Percent_Identity=28.9017341040462, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657891, Length=203, Percent_Identity=29.064039408867, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 53850; Mature: 53850

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFILYPVYGIIKNKKNQPAGDIMPDSIKNIKAKNKLGLIFFPAFDWAISPTHPEREER
CEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCEECCCCCCHHHH
LLYTRDQVFEEGLMDIDGIKEFNPGIAEEKDVQKVHICVPEVKKVTTPSHLISAGGAIKA
EEHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEEEECCCHHHCCCCHHHHHCCCCEEE
AGLVLNKEVDKAFAIVRPPGHHAFRVVHGARGFCNINNEAIMVEAIRSKYPDLKIAFVDT
EEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCCCEEEEEEHHHCCCCEEEEEEEC
DAHHADGTQEIFYHDPHVLHISLHQNGRTLFPGSGFTNEVGGPGAYARTLNIPLPPYTTD
CCCCCCCCCEEEECCCEEEEEEEECCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCC
EGLHYVLDNLVLPVLEDFKPDLIINAAGQDNHYSDPLTNMKISARGYAELNARLNPDIAI
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEECCCCEEECCCCCCCEEE
LQGGYSIESALPYINVGLILAMAGLDYSNVREPDFDSRNLTQDPVITDNIKNTVAVLREI
EECCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WENRNNQAPVPDTGEFTIKNNFYEREKHIFYDTDGINELQRERVKACPDCPGYIIIDSRA
HHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCC
EKGFRNTRIKAISIPLKACKNCHEEAHLKFEEAKKEAGNKYDYLYLQDVKGEEFVTYPSP
CCCCCCCEEEEEECCHHHHHCCHHHHCCCHHHHHHHCCCCEEEEEEEECCCCEEEECCCC
>Mature Secondary Structure
MVTFILYPVYGIIKNKKNQPAGDIMPDSIKNIKAKNKLGLIFFPAFDWAISPTHPEREER
CEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCEECCCCCCHHHH
LLYTRDQVFEEGLMDIDGIKEFNPGIAEEKDVQKVHICVPEVKKVTTPSHLISAGGAIKA
EEHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEEEECCCHHHCCCCHHHHHCCCCEEE
AGLVLNKEVDKAFAIVRPPGHHAFRVVHGARGFCNINNEAIMVEAIRSKYPDLKIAFVDT
EEEEEECCCCCEEEEECCCCCCEEEEEECCCCEEECCCCEEEEEEHHHCCCCEEEEEEEC
DAHHADGTQEIFYHDPHVLHISLHQNGRTLFPGSGFTNEVGGPGAYARTLNIPLPPYTTD
CCCCCCCCCEEEECCCEEEEEEEECCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCC
EGLHYVLDNLVLPVLEDFKPDLIINAAGQDNHYSDPLTNMKISARGYAELNARLNPDIAI
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEECCCCEEECCCCCCCEEE
LQGGYSIESALPYINVGLILAMAGLDYSNVREPDFDSRNLTQDPVITDNIKNTVAVLREI
EECCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WENRNNQAPVPDTGEFTIKNNFYEREKHIFYDTDGINELQRERVKACPDCPGYIIIDSRA
HHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCC
EKGFRNTRIKAISIPLKACKNCHEEAHLKFEEAKKEAGNKYDYLYLQDVKGEEFVTYPSP
CCCCCCCEEEEEECCHHHHHCCHHHHCCCHHHHHHHCCCCEEEEEEEECCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]