Click here to switch to the map view.

The map label for this gene is hyuA [H]

Identifier: 220933077

GI number: 220933077

Start: 2446721

End: 2448460

Strand: Direct

Name: hyuA [H]

Synonym: Hore_22450

Alternate gene names: 220933077

Gene position: 2446721-2448460 (Clockwise)

Preceding gene: 220933074

Following gene: 220933078

Centisome position: 94.9

GC content: 46.78

Gene sequence:

>1740_bases
ATGATTATCGGAATTGATGTCGGTGGAACACACACTGATGGGGTTTTACTTGTTCTGGATTCAGACAATCCCCCGGTCTA
TAAAGTCCATAAAACCTGCAAAATGGAAACTGATCATCAGGAACTGGAAGGTTCCATTTTAAAGGTCCTCGATTATCTAA
CTGAAGGGGTCAACAGAAAAGATATAACCCGGATTGTTTTAAGTACTACTCTGAGTACCAATACAATCATAGAACATAAT
CATGACCCGGTGGGGTTAATTATCATCCCCGGCCCGGGTTTAAACCCCGGACTATTATTAATCGGTGAAGAAAATGCCAG
CCTCAATGGGTATATAAACCACCGGGGGCAAGAAGAAAAACCACTGGTTGAGTCAGAAATCAGCAAAGCCCTGAAAAGGT
TTCAAGAAAAAGGGATAACTAATCTGGCTATAGTTGGTAAGTTCTCACCCCGCAACCCCGGTCATGAACTTAAGATTAAA
GACTATATCATGGAACAGGGATATAATTTCAAACACATCACCCTGGGGCATGAACTCTCCGGAACTTTAAATTTCCCGAG
ACGGGTAGCTACTGCCTATTACAATGCTGCTATTTCTTCAGTCCACCATAATTTTATAACTTCTATAAAAAAGGCTCTCA
GTCTCAGGAATATTAAGGCTGAGGTGGTGCTTCTTAAATGTGATGGTGGAACCCTTACCCTAGCACAGGCAGCCCGGCGG
CCTGTTGCTACCGTTAAATCAGGCCCGGCCGCCAGTCTTATGGGAAACCTGGCTTTTATCAGGGACAAACTCACCTCCAT
TGCCCTGGATATTGGCGGGACTACTACCGATATCGGACTATTTATTGATGGGGTACCCGCCTTTGTTCCCGGTGGTATAA
AAGTGGGGGGCTTACCTACCCTGGTCCGGGGCCTCTTCTCCCGGTCCATCCCCTGTGGTGGGGATAGTGAAGTCAGGGTT
GTTAAAGGCCAGCTTACAATCGGCCCACGGCGCCGGGGAATACCAGCCTCAAAAGGAGGCCCGTCCCCGACCCCGACCGA
TGCCCTGGTTGCCCTGGGGCTTATAGAAGACAGCAAACACTTTAATTATGAACTGGCTGTAAAAAGCTTGTCTCCCCTCT
ATGACCTGGTAAAAAACGGTCTAATAAAAAAAGATAATAATGAAAAAACTGAAAAACCCGTTTTCAGAGCTAAAAAAGTA
GCCCGTCTCATTATTGACAGGATGAGTCATATAATCGAACAGGAAATTAATAATATCCTGACAACCCTGGAAAACCAGCC
AGTCTATACCATCAGGGAGTTGCTGGAAAATTTCTCTATTAACCCCCGACTCATTACTGGAATGGGGGGACCGGCCCGGG
CACTCATCCCCCGGCTTGCTTCAAAAATGGGTTATGACTATATAATTACACCCCATTCAGGAGTGGCCAATGCTATCGGA
GCCGGGGCAGCCCGGCCAACGGTCGAAGTTACTGTCAGGGCCGATACCGCAACCGGACAATTAACCGTTCCGGAAACAGG
TTTACATAAAAGAATAAACCGGGACCTCAGGTTAAATCAGGTTGAAGAAGTAGCCCGGAAAGAGCTTGAAAAACTCAATC
CTAATCCCCATCCTGAAAGCCCTGTTGAAATAACCCAGCGGGAAAGCTTTAATGTAATCAGGGGTTTCAGAACTCTGGGA
AGGATTATAGAAGTAAAGGCCCAGGTCAAACCCGGCCTGATAGCCCGGATCAGGCCCTGA

Upstream 100 bases:

>100_bases
AATATCTTTTATATTTATTACCCGGGACTTAAGGCAAATTTTAATTTGCTTTAAATATTTACTGTAGGTAAATAAATTAC
GATTTACAGGAGGCTTTATT

Downstream 100 bases:

>100_bases
TAACAGGACACGCAATAATTTAATGTTAAATAAATGTTAAACAAAAGGTAGATTTAACCCCTTTCCAGAATTAAATAATA
GATAATATTATATTCCGGGG

Product: N-methylhydantoinase

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MIIGIDVGGTHTDGVLLVLDSDNPPVYKVHKTCKMETDHQELEGSILKVLDYLTEGVNRKDITRIVLSTTLSTNTIIEHN
HDPVGLIIIPGPGLNPGLLLIGEENASLNGYINHRGQEEKPLVESEISKALKRFQEKGITNLAIVGKFSPRNPGHELKIK
DYIMEQGYNFKHITLGHELSGTLNFPRRVATAYYNAAISSVHHNFITSIKKALSLRNIKAEVVLLKCDGGTLTLAQAARR
PVATVKSGPAASLMGNLAFIRDKLTSIALDIGGTTTDIGLFIDGVPAFVPGGIKVGGLPTLVRGLFSRSIPCGGDSEVRV
VKGQLTIGPRRRGIPASKGGPSPTPTDALVALGLIEDSKHFNYELAVKSLSPLYDLVKNGLIKKDNNEKTEKPVFRAKKV
ARLIIDRMSHIIEQEINNILTTLENQPVYTIRELLENFSINPRLITGMGGPARALIPRLASKMGYDYIITPHSGVANAIG
AGAARPTVEVTVRADTATGQLTVPETGLHKRINRDLRLNQVEEVARKELEKLNPNPHPESPVEITQRESFNVIRGFRTLG
RIIEVKAQVKPGLIARIRP

Sequences:

>Translated_579_residues
MIIGIDVGGTHTDGVLLVLDSDNPPVYKVHKTCKMETDHQELEGSILKVLDYLTEGVNRKDITRIVLSTTLSTNTIIEHN
HDPVGLIIIPGPGLNPGLLLIGEENASLNGYINHRGQEEKPLVESEISKALKRFQEKGITNLAIVGKFSPRNPGHELKIK
DYIMEQGYNFKHITLGHELSGTLNFPRRVATAYYNAAISSVHHNFITSIKKALSLRNIKAEVVLLKCDGGTLTLAQAARR
PVATVKSGPAASLMGNLAFIRDKLTSIALDIGGTTTDIGLFIDGVPAFVPGGIKVGGLPTLVRGLFSRSIPCGGDSEVRV
VKGQLTIGPRRRGIPASKGGPSPTPTDALVALGLIEDSKHFNYELAVKSLSPLYDLVKNGLIKKDNNEKTEKPVFRAKKV
ARLIIDRMSHIIEQEINNILTTLENQPVYTIRELLENFSINPRLITGMGGPARALIPRLASKMGYDYIITPHSGVANAIG
AGAARPTVEVTVRADTATGQLTVPETGLHKRINRDLRLNQVEEVARKELEKLNPNPHPESPVEITQRESFNVIRGFRTLG
RIIEVKAQVKPGLIARIRP
>Mature_579_residues
MIIGIDVGGTHTDGVLLVLDSDNPPVYKVHKTCKMETDHQELEGSILKVLDYLTEGVNRKDITRIVLSTTLSTNTIIEHN
HDPVGLIIIPGPGLNPGLLLIGEENASLNGYINHRGQEEKPLVESEISKALKRFQEKGITNLAIVGKFSPRNPGHELKIK
DYIMEQGYNFKHITLGHELSGTLNFPRRVATAYYNAAISSVHHNFITSIKKALSLRNIKAEVVLLKCDGGTLTLAQAARR
PVATVKSGPAASLMGNLAFIRDKLTSIALDIGGTTTDIGLFIDGVPAFVPGGIKVGGLPTLVRGLFSRSIPCGGDSEVRV
VKGQLTIGPRRRGIPASKGGPSPTPTDALVALGLIEDSKHFNYELAVKSLSPLYDLVKNGLIKKDNNEKTEKPVFRAKKV
ARLIIDRMSHIIEQEINNILTTLENQPVYTIRELLENFSINPRLITGMGGPARALIPRLASKMGYDYIITPHSGVANAIG
AGAARPTVEVTVRADTATGQLTVPETGLHKRINRDLRLNQVEEVARKELEKLNPNPHPESPVEITQRESFNVIRGFRTLG
RIIEVKAQVKPGLIARIRP

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322634, Length=325, Percent_Identity=25.2307692307692, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550492, Length=459, Percent_Identity=24.1830065359477, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 63079; Mature: 63079

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGIDVGGTHTDGVLLVLDSDNPPVYKVHKTCKMETDHQELEGSILKVLDYLTEGVNRK
CEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
DITRIVLSTTLSTNTIIEHNHDPVGLIIIPGPGLNPGLLLIGEENASLNGYINHRGQEEK
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEECCCCCCCC
PLVESEISKALKRFQEKGITNLAIVGKFSPRNPGHELKIKDYIMEQGYNFKHITLGHELS
CHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHHHCCCCEEEEEECCCCC
GTLNFPRRVATAYYNAAISSVHHNFITSIKKALSLRNIKAEVVLLKCDGGTLTLAQAARR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEHHHHHHCC
PVATVKSGPAASLMGNLAFIRDKLTSIALDIGGTTTDIGLFIDGVPAFVPGGIKVGGLPT
CCHHCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCHHHCCCCEEECCHHH
LVRGLFSRSIPCGGDSEVRVVKGQLTIGPRRRGIPASKGGPSPTPTDALVALGLIEDSKH
HHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCC
FNYELAVKSLSPLYDLVKNGLIKKDNNEKTEKPVFRAKKVARLIIDRMSHIIEQEINNIL
CCEEEEHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLENQPVYTIRELLENFSINPRLITGMGGPARALIPRLASKMGYDYIITPHSGVANAIG
HHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHC
AGAARPTVEVTVRADTATGQLTVPETGLHKRINRDLRLNQVEEVARKELEKLNPNPHPES
CCCCCCEEEEEEEECCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
PVEITQRESFNVIRGFRTLGRIIEVKAQVKPGLIARIRP
CCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MIIGIDVGGTHTDGVLLVLDSDNPPVYKVHKTCKMETDHQELEGSILKVLDYLTEGVNRK
CEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
DITRIVLSTTLSTNTIIEHNHDPVGLIIIPGPGLNPGLLLIGEENASLNGYINHRGQEEK
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEECCCCCCCC
PLVESEISKALKRFQEKGITNLAIVGKFSPRNPGHELKIKDYIMEQGYNFKHITLGHELS
CHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHHHCCCCEEEEEECCCCC
GTLNFPRRVATAYYNAAISSVHHNFITSIKKALSLRNIKAEVVLLKCDGGTLTLAQAARR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEHHHHHHCC
PVATVKSGPAASLMGNLAFIRDKLTSIALDIGGTTTDIGLFIDGVPAFVPGGIKVGGLPT
CCHHCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCHHHCCCCEEECCHHH
LVRGLFSRSIPCGGDSEVRVVKGQLTIGPRRRGIPASKGGPSPTPTDALVALGLIEDSKH
HHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCC
FNYELAVKSLSPLYDLVKNGLIKKDNNEKTEKPVFRAKKVARLIIDRMSHIIEQEINNIL
CCEEEEHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLENQPVYTIRELLENFSINPRLITGMGGPARALIPRLASKMGYDYIITPHSGVANAIG
HHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHC
AGAARPTVEVTVRADTATGQLTVPETGLHKRINRDLRLNQVEEVARKELEKLNPNPHPES
CCCCCCEEEEEEEECCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
PVEITQRESFNVIRGFRTLGRIIEVKAQVKPGLIARIRP
CCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]