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The map label for this gene is lexA [H]

Identifier: 220932927

GI number: 220932927

Start: 2271436

End: 2272038

Strand: Direct

Name: lexA [H]

Synonym: Hore_20950

Alternate gene names: 220932927

Gene position: 2271436-2272038 (Clockwise)

Preceding gene: 220932924

Following gene: 220932928

Centisome position: 88.1

GC content: 34.16

Gene sequence:

>603_bases
ATGGAAAAGTTCGGTCAGAAACTGAGGAAATTAAGGAAAGAAAAAAATTTAACCTTACGGGAATTGGGTAATAAACTGAA
CTTATCTTTTTCATTACTGGCTATGTATGAAAGGGGAGAAAGAACACCATCACTGGATAAACTACTATTAATTGCAGATT
TTTTCAACGTATCAACTGACTATCTTCTGGACCATTCGCCCCTGGAAGATCTGAATAGAAAACTGGGTATAATCCCCTAT
CTTGATAACAATAACTTTAATGGGGATGACAACTCGATAATTTGTGAGGAAAAACTCATCAATTATTATTCCAGAAACTC
AATTAACCAGAAATATTTTTATCTTAAGGTTGAAAAAGATGACATGGTCAACAGCAGAATCCATCCAGGGGATCTGGTAC
TAATACGAAGGCAAAAACACCTTAAAGATGGAGCTGTCGGAGTGGCAATATATAAAGATGAGCTATACATAAGGCGGGTA
TATAAAAATGATAATTTATATATACTCCAGGCTGATAATCCCGACTATACTCCACTGTTTGCAAGTCAAAAAGAACTTGA
CATAATCGGTCAAATAATTATGGTAATTTTCAAAGTAAATTAA

Upstream 100 bases:

>100_bases
TTTTTACAAATATTATTTATTTATGTATATATTTGCACTATTTGTTTACACAATGGGTATTATAAATATGGTATAATAAC
CCTGGGCTAGGGGGGACTTT

Downstream 100 bases:

>100_bases
AAGGAGGATTTATACTATGACCCTGATTTTTATCGGTCTGGGCGGTTTTTTAGGAGCCCTGGCCCGTTATGGAATTACCA
GATGGGCAGAAACCAAATGG

Product: putative prophage repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MEKFGQKLRKLRKEKNLTLRELGNKLNLSFSLLAMYERGERTPSLDKLLLIADFFNVSTDYLLDHSPLEDLNRKLGIIPY
LDNNNFNGDDNSIICEEKLINYYSRNSINQKYFYLKVEKDDMVNSRIHPGDLVLIRRQKHLKDGAVGVAIYKDELYIRRV
YKNDNLYILQADNPDYTPLFASQKELDIIGQIIMVIFKVN

Sequences:

>Translated_200_residues
MEKFGQKLRKLRKEKNLTLRELGNKLNLSFSLLAMYERGERTPSLDKLLLIADFFNVSTDYLLDHSPLEDLNRKLGIIPY
LDNNNFNGDDNSIICEEKLINYYSRNSINQKYFYLKVEKDDMVNSRIHPGDLVLIRRQKHLKDGAVGVAIYKDELYIRRV
YKNDNLYILQADNPDYTPLFASQKELDIIGQIIMVIFKVN
>Mature_200_residues
MEKFGQKLRKLRKEKNLTLRELGNKLNLSFSLLAMYERGERTPSLDKLLLIADFFNVSTDYLLDHSPLEDLNRKLGIIPY
LDNNNFNGDDNSIICEEKLINYYSRNSINQKYFYLKVEKDDMVNSRIHPGDLVLIRRQKHLKDGAVGVAIYKDELYIRRV
YKNDNLYILQADNPDYTPLFASQKELDIIGQIIMVIFKVN

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1396

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23469; Mature: 23469

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFGQKLRKLRKEKNLTLRELGNKLNLSFSLLAMYERGERTPSLDKLLLIADFFNVSTD
CCHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEEEECCCCCCCCHHHEEEEEHHHCCCCC
YLLDHSPLEDLNRKLGIIPYLDNNNFNGDDNSIICEEKLINYYSRNSINQKYFYLKVEKD
EEECCCCHHHHHHHCCEEEEECCCCCCCCCCCEEEHHHHHHHHHCCCCCCEEEEEEECCC
DMVNSRIHPGDLVLIRRQKHLKDGAVGVAIYKDELYIRRVYKNDNLYILQADNPDYTPLF
CHHCCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEEEEEEECCCEEEEECCCCCCCCCC
ASQKELDIIGQIIMVIFKVN
CCCCHHHHHHHHHHEEEECC
>Mature Secondary Structure
MEKFGQKLRKLRKEKNLTLRELGNKLNLSFSLLAMYERGERTPSLDKLLLIADFFNVSTD
CCHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEEEEECCCCCCCCHHHEEEEEHHHCCCCC
YLLDHSPLEDLNRKLGIIPYLDNNNFNGDDNSIICEEKLINYYSRNSINQKYFYLKVEKD
EEECCCCHHHHHHHCCEEEEECCCCCCCCCCCEEEHHHHHHHHHCCCCCCEEEEEEECCC
DMVNSRIHPGDLVLIRRQKHLKDGAVGVAIYKDELYIRRVYKNDNLYILQADNPDYTPLF
CHHCCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEEEEEEECCCEEEEECCCCCCCCCC
ASQKELDIIGQIIMVIFKVN
CCCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA