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The map label for this gene is comEC [H]

Identifier: 220932240

GI number: 220932240

Start: 1492632

End: 1493852

Strand: Direct

Name: comEC [H]

Synonym: Hore_14040

Alternate gene names: 220932240

Gene position: 1492632-1493852 (Clockwise)

Preceding gene: 220932226

Following gene: 220932241

Centisome position: 57.9

GC content: 34.97

Gene sequence:

>1221_bases
ATGGGAAAGAATAAATTAACCTTAAAAACAGTTATATATTTAATGTTATTCATTTTTATAGCCTATAGTATGTATCTATA
TTTAACCCCGGAAACACCGGAAAAAAACCAGCTCGAAATCCACTTTATCAGTGTAGGCCAGGGTGATGCTGTCCTGATTA
AATTACCTGACACCAAAAACATGCTGATTGATGCTGGAAGCAATAAATACAGCAACAAAGTTATCAACTACATCAGACAT
CAGGGAATAAATCAACTTGATTATGTAATTGCTACCCACCCCCACGAAGACCATATAGGCGGTCTGGACAGGGTTATATC
TACTTTTAGAATCGGTAAGATATTTATGCCTGATGTTATTCACCCCACCAGGTCTTTTGAGGATGTTTTAACTATAATTA
AGAAAAAGAAATTGAGAATTACACCGGCAAAAAAAGATCTTGTTATCATTAACAACAATAAAAAGGATTTAAAAGCAGTG
ATTATATCACCTGAAGACAAAAAATATGATAAGATTAATAATTATTCAGTCGTTTTAAAGTTAACTTATCATAAAACCTC
ATTCTTATTTACCGGTGACATCGAAAAAGAGATTGAGTCAAAACTGGTTAATTCTAAATACAACCTCAGATCCAATTTAA
TAAAAATTCCCCATCATGGGAGTGCAACATCGTCTTCTACTCCATTTCTTAAAGAAGTATCACCCGGTTATGCTGTTATA
TCTGTTGGGAGGGATAATGATTATAACCACCCTTCACCCATAACCCTGGAAAAATTAAAAGAAATGAAAGTAAAAATCTT
TAGAACCGATAAACAGGGCACAATAATAGTAATGAGTGATGGCTCCAGGTTGTCCTTTAATTTGCAACCATTAGAGATTT
CTTACCAAAAGAAAAATAACAACAAGAATAAAGCAGTTAAAATTATTAGCCTGGACCTTAAAAATGAAGTAGTGGTTATT
AAAAATACCGGAAATGAGACAATAAACCTGGCAGGCTGGAAACTGGTTAGTCTTAAGGGTAATCAACAATTCAATTTCCC
TGACAACACAGTCTTAAAACCGGGACAATCCTTTAAAATACTGAGCGGCCCCTCTGCCCTGAATAAGCCTGATAATATCA
TCTGGACCAGATCTAACATATGGAATAACAGTGGTGATGGGGCCCTCTTGACTGATTCTAACGGAGAGATAATTGACAGG
TTATTAAGGGAGGAAGACTAA

Upstream 100 bases:

>100_bases
ATTATTTAAAAAAAGGCTTATCCCCTTTTTTCTCGAATTATATGTTTACAACCTGACTAAATACACCAAAAAACTTTGTC
ATAACAGGAGGTATAACATT

Downstream 100 bases:

>100_bases
ATAATAAGGAGGGAAAATAATGATAATCATCGATCGTTTTGAGGGGGAAAAAGTCATTCTGGAATATAGCAATAATCAGG
GAAAAATTATAACCTTTGCG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MGKNKLTLKTVIYLMLFIFIAYSMYLYLTPETPEKNQLEIHFISVGQGDAVLIKLPDTKNMLIDAGSNKYSNKVINYIRH
QGINQLDYVIATHPHEDHIGGLDRVISTFRIGKIFMPDVIHPTRSFEDVLTIIKKKKLRITPAKKDLVIINNNKKDLKAV
IISPEDKKYDKINNYSVVLKLTYHKTSFLFTGDIEKEIESKLVNSKYNLRSNLIKIPHHGSATSSSTPFLKEVSPGYAVI
SVGRDNDYNHPSPITLEKLKEMKVKIFRTDKQGTIIVMSDGSRLSFNLQPLEISYQKKNNNKNKAVKIISLDLKNEVVVI
KNTGNETINLAGWKLVSLKGNQQFNFPDNTVLKPGQSFKILSGPSALNKPDNIIWTRSNIWNNSGDGALLTDSNGEIIDR
LLREED

Sequences:

>Translated_406_residues
MGKNKLTLKTVIYLMLFIFIAYSMYLYLTPETPEKNQLEIHFISVGQGDAVLIKLPDTKNMLIDAGSNKYSNKVINYIRH
QGINQLDYVIATHPHEDHIGGLDRVISTFRIGKIFMPDVIHPTRSFEDVLTIIKKKKLRITPAKKDLVIINNNKKDLKAV
IISPEDKKYDKINNYSVVLKLTYHKTSFLFTGDIEKEIESKLVNSKYNLRSNLIKIPHHGSATSSSTPFLKEVSPGYAVI
SVGRDNDYNHPSPITLEKLKEMKVKIFRTDKQGTIIVMSDGSRLSFNLQPLEISYQKKNNNKNKAVKIISLDLKNEVVVI
KNTGNETINLAGWKLVSLKGNQQFNFPDNTVLKPGQSFKILSGPSALNKPDNIIWTRSNIWNNSGDGALLTDSNGEIIDR
LLREED
>Mature_405_residues
GKNKLTLKTVIYLMLFIFIAYSMYLYLTPETPEKNQLEIHFISVGQGDAVLIKLPDTKNMLIDAGSNKYSNKVINYIRHQ
GINQLDYVIATHPHEDHIGGLDRVISTFRIGKIFMPDVIHPTRSFEDVLTIIKKKKLRITPAKKDLVIINNNKKDLKAVI
ISPEDKKYDKINNYSVVLKLTYHKTSFLFTGDIEKEIESKLVNSKYNLRSNLIKIPHHGSATSSSTPFLKEVSPGYAVIS
VGRDNDYNHPSPITLEKLKEMKVKIFRTDKQGTIIVMSDGSRLSFNLQPLEISYQKKNNNKNKAVKIISLDLKNEVVVIK
NTGNETINLAGWKLVSLKGNQQFNFPDNTVLKPGQSFKILSGPSALNKPDNIIWTRSNIWNNSGDGALLTDSNGEIIDRL
LREED

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=263, Percent_Identity=25.8555133079848, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 45981; Mature: 45850

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNKLTLKTVIYLMLFIFIAYSMYLYLTPETPEKNQLEIHFISVGQGDAVLIKLPDTKN
CCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCC
MLIDAGSNKYSNKVINYIRHQGINQLDYVIATHPHEDHIGGLDRVISTFRIGKIFMPDVI
EEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCHHHHHHHHHCCCEECCCCC
HPTRSFEDVLTIIKKKKLRITPAKKDLVIINNNKKDLKAVIISPEDKKYDKINNYSVVLK
CCCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEE
LTYHKTSFLFTGDIEKEIESKLVNSKYNLRSNLIKIPHHGSATSSSTPFLKEVSPGYAVI
EEEECEEEEEECCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCEEEE
SVGRDNDYNHPSPITLEKLKEMKVKIFRTDKQGTIIVMSDGSRLSFNLQPLEISYQKKNN
EECCCCCCCCCCCCHHHHHHCCEEEEEEECCCCEEEEEECCCEEEEEEEEEEEEEEECCC
NKNKAVKIISLDLKNEVVVIKNTGNETINLAGWKLVSLKGNQQFNFPDNTVLKPGQSFKI
CCCEEEEEEEEECCCCEEEEECCCCCEEEEEEEEEEEEECCCEECCCCCCEECCCCCEEE
LSGPSALNKPDNIIWTRSNIWNNSGDGALLTDSNGEIIDRLLREED
EECCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure 
GKNKLTLKTVIYLMLFIFIAYSMYLYLTPETPEKNQLEIHFISVGQGDAVLIKLPDTKN
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCC
MLIDAGSNKYSNKVINYIRHQGINQLDYVIATHPHEDHIGGLDRVISTFRIGKIFMPDVI
EEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHCCCHHHHHHHHHCCCEECCCCC
HPTRSFEDVLTIIKKKKLRITPAKKDLVIINNNKKDLKAVIISPEDKKYDKINNYSVVLK
CCCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEE
LTYHKTSFLFTGDIEKEIESKLVNSKYNLRSNLIKIPHHGSATSSSTPFLKEVSPGYAVI
EEEECEEEEEECCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCEEEE
SVGRDNDYNHPSPITLEKLKEMKVKIFRTDKQGTIIVMSDGSRLSFNLQPLEISYQKKNN
EECCCCCCCCCCCCHHHHHHCCEEEEEEECCCCEEEEEECCCEEEEEEEEEEEEEEECCC
NKNKAVKIISLDLKNEVVVIKNTGNETINLAGWKLVSLKGNQQFNFPDNTVLKPGQSFKI
CCCEEEEEEEEECCCCEEEEECCCCCEEEEEEEEEEEEECCCEECCCCCCEECCCCCEEE
LSGPSALNKPDNIIWTRSNIWNNSGDGALLTDSNGEIIDRLLREED
EECCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]