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The map label for this gene is der

Identifier: 220931895

GI number: 220931895

Start: 1142008

End: 1143324

Strand: Direct

Name: der

Synonym: Hore_10530

Alternate gene names: 220931895

Gene position: 1142008-1143324 (Clockwise)

Preceding gene: 220931894

Following gene: 220931896

Centisome position: 44.3

GC content: 38.5

Gene sequence:

>1317_bases
ATGGCGAAGCCAGTAGTAGCTATTGTGGGACGTCCCAATGTCGGTAAATCAACTCTTTTTAATAGATTGGCCGGTTACAG
GATTTCAATTGTAGAGGGAGAACCCAATGTGACCAGGGATCGTATCTATGCAGATGTAAACTGGCTTGATAGGTCTTTTA
TTATTGTTGATACCGGTGGTATTGATCCCTATGATAGGGACCAGATTAAAAATATGGTTAAGTACCAGGCCCAGATGGCA
ATAGATGAGGCCAGTCTTATACTCTTTGTTGTTGATGGCAGAAATGGACTGACGGCTACAGATGAGGAAGTTGCTGCCTT
TTTGCGGAAAAGTAATAAAAAGGTTATACTTGTTGTTAATAAAGTCGATGATTTTAAAAATATGGAAGAAGACTGTTGGG
AATTTTATACCCTCGGTTTTGACAAACTGATCCCCATTTCAGCAGAACATGGTAAAAATACAGGTGATCTCCTGGATGAA
ATAGTAAATATGTTACCGGAAAAAGGGCCAGAAGATTCCGATGATGATGCAATAGATGTTGCCATAATCGGGAAACCCAA
TGTAGGTAAGTCTTCACTGGTTAATTATATTGTGGGCCAGGAACGGGTTATAGTAAGTGATATTCCGGGGACAACGCGGG
ATGCCATTGATACCCTGGTAGAGAAAAATGGTCACAGGTATAATTTAATTGATACAGCAGGCCTAAGGAAGAAATCACGG
GTAAAAGAAGCTACTGAATATTACAGTGCATTAAGGACAATAAAGGCAATAGACAGGTCTGATGGGGTTATAATGATGAT
TGATGCCCTGGAAGGGGTTACTGAGCAGGATAAAAAAATTGCAGGTTATGCTCATGAAGCCGGAAAGGCTATTGTTCTTG
CTGTTAATAAATGGGATCTTGTTGAAAAAGATACCCATACTATGGAAAATTATAAAGAAGAAATATATTATAATTTAAAG
TTTTTACAGTATGCTCCTGTTACTTTTATTTCAGCCCTTACTGGAAAGAGGGTTCAGGAGCTCTTAAAGCTAATTGAATA
TGTGGTTGATCAGAATTCACGTCGGGTTAAAACCGGATTATTAAATGAAGTGGTTCAGGAATCTATTCAGCTCAGAGAAC
CTCCCACCAGAAAGGGAAAAAAGTTAAAAATATTTTATACTACCCAGGTAGGAATAAAACCTCCGACTTTTGTCTTTTTT
GTTAATAACCCCGGGCTTGTTCACTTTGCCTATCAACGTTATCTGGAAAATTCACTCAGAGATGCTTTTGGATTTGTGGG
GAGCCCAATTAGATTGAAATTTAAACAAAAAACATAG

Upstream 100 bases:

>100_bases
TTCCTTGATAGCCTGTCAATACATGATATATTAAATGAGTTTCCTGATAAAAAAATATACCTTTGTTCCAACATTGATGA
AGTAATGGAGGTGATAGTTA

Downstream 100 bases:

>100_bases
AGGAGGGTATTATGGGTATTATAACGATAGCAATAGGTTATATAATAGGTTCAATTCCTTTTGCCTATATTGTAACCAGG
TTAATCTCTGGTAAAGATGT

Product: small GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MAKPVVAIVGRPNVGKSTLFNRLAGYRISIVEGEPNVTRDRIYADVNWLDRSFIIVDTGGIDPYDRDQIKNMVKYQAQMA
IDEASLILFVVDGRNGLTATDEEVAAFLRKSNKKVILVVNKVDDFKNMEEDCWEFYTLGFDKLIPISAEHGKNTGDLLDE
IVNMLPEKGPEDSDDDAIDVAIIGKPNVGKSSLVNYIVGQERVIVSDIPGTTRDAIDTLVEKNGHRYNLIDTAGLRKKSR
VKEATEYYSALRTIKAIDRSDGVIMMIDALEGVTEQDKKIAGYAHEAGKAIVLAVNKWDLVEKDTHTMENYKEEIYYNLK
FLQYAPVTFISALTGKRVQELLKLIEYVVDQNSRRVKTGLLNEVVQESIQLREPPTRKGKKLKIFYTTQVGIKPPTFVFF
VNNPGLVHFAYQRYLENSLRDAFGFVGSPIRLKFKQKT

Sequences:

>Translated_438_residues
MAKPVVAIVGRPNVGKSTLFNRLAGYRISIVEGEPNVTRDRIYADVNWLDRSFIIVDTGGIDPYDRDQIKNMVKYQAQMA
IDEASLILFVVDGRNGLTATDEEVAAFLRKSNKKVILVVNKVDDFKNMEEDCWEFYTLGFDKLIPISAEHGKNTGDLLDE
IVNMLPEKGPEDSDDDAIDVAIIGKPNVGKSSLVNYIVGQERVIVSDIPGTTRDAIDTLVEKNGHRYNLIDTAGLRKKSR
VKEATEYYSALRTIKAIDRSDGVIMMIDALEGVTEQDKKIAGYAHEAGKAIVLAVNKWDLVEKDTHTMENYKEEIYYNLK
FLQYAPVTFISALTGKRVQELLKLIEYVVDQNSRRVKTGLLNEVVQESIQLREPPTRKGKKLKIFYTTQVGIKPPTFVFF
VNNPGLVHFAYQRYLENSLRDAFGFVGSPIRLKFKQKT
>Mature_437_residues
AKPVVAIVGRPNVGKSTLFNRLAGYRISIVEGEPNVTRDRIYADVNWLDRSFIIVDTGGIDPYDRDQIKNMVKYQAQMAI
DEASLILFVVDGRNGLTATDEEVAAFLRKSNKKVILVVNKVDDFKNMEEDCWEFYTLGFDKLIPISAEHGKNTGDLLDEI
VNMLPEKGPEDSDDDAIDVAIIGKPNVGKSSLVNYIVGQERVIVSDIPGTTRDAIDTLVEKNGHRYNLIDTAGLRKKSRV
KEATEYYSALRTIKAIDRSDGVIMMIDALEGVTEQDKKIAGYAHEAGKAIVLAVNKWDLVEKDTHTMENYKEEIYYNLKF
LQYAPVTFISALTGKRVQELLKLIEYVVDQNSRRVKTGLLNEVVQESIQLREPPTRKGKKLKIFYTTQVGIKPPTFVFFV
NNPGLVHFAYQRYLENSLRDAFGFVGSPIRLKFKQKT

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=464, Percent_Identity=38.5775862068966, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788919, Length=174, Percent_Identity=37.3563218390805, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI2367268, Length=94, Percent_Identity=40.4255319148936, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17507259, Length=120, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323665, Length=197, Percent_Identity=31.9796954314721, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_HALOH (B8CWY9)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508803.1
- ProteinModelPortal:   B8CWY9
- SMR:   B8CWY9
- GeneID:   7314641
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_10530
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49455; Mature: 49324

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPVVAIVGRPNVGKSTLFNRLAGYRISIVEGEPNVTRDRIYADVNWLDRSFIIVDTGG
CCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHEEEEEEECCCEEEEEECCC
IDPYDRDQIKNMVKYQAQMAIDEASLILFVVDGRNGLTATDEEVAAFLRKSNKKVILVVN
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEE
KVDDFKNMEEDCWEFYTLGFDKLIPISAEHGKNTGDLLDEIVNMLPEKGPEDSDDDAIDV
CCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEE
AIIGKPNVGKSSLVNYIVGQERVIVSDIPGTTRDAIDTLVEKNGHRYNLIDTAGLRKKSR
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHH
VKEATEYYSALRTIKAIDRSDGVIMMIDALEGVTEQDKKIAGYAHEAGKAIVLAVNKWDL
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
VEKDTHTMENYKEEIYYNLKFLQYAPVTFISALTGKRVQELLKLIEYVVDQNSRRVKTGL
CCCHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNEVVQESIQLREPPTRKGKKLKIFYTTQVGIKPPTFVFFVNNPGLVHFAYQRYLENSLR
HHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEHHHHHHHHHHHHH
DAFGFVGSPIRLKFKQKT
HHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
AKPVVAIVGRPNVGKSTLFNRLAGYRISIVEGEPNVTRDRIYADVNWLDRSFIIVDTGG
CCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHEEEEEEECCCEEEEEECCC
IDPYDRDQIKNMVKYQAQMAIDEASLILFVVDGRNGLTATDEEVAAFLRKSNKKVILVVN
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEE
KVDDFKNMEEDCWEFYTLGFDKLIPISAEHGKNTGDLLDEIVNMLPEKGPEDSDDDAIDV
CCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEE
AIIGKPNVGKSSLVNYIVGQERVIVSDIPGTTRDAIDTLVEKNGHRYNLIDTAGLRKKSR
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHH
VKEATEYYSALRTIKAIDRSDGVIMMIDALEGVTEQDKKIAGYAHEAGKAIVLAVNKWDL
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
VEKDTHTMENYKEEIYYNLKFLQYAPVTFISALTGKRVQELLKLIEYVVDQNSRRVKTGL
CCCHHHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNEVVQESIQLREPPTRKGKKLKIFYTTQVGIKPPTFVFFVNNPGLVHFAYQRYLENSLR
HHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEHHHHHHHHHHHHH
DAFGFVGSPIRLKFKQKT
HHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA