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The map label for this gene is htrA [H]

Identifier: 221230910

GI number: 221230910

Start: 3181943

End: 3183007

Strand: Reverse

Name: htrA [H]

Synonym: MLBr_02659

Alternate gene names: 221230910

Gene position: 3183007-3181943 (Counterclockwise)

Preceding gene: 221230911

Following gene: 221230906

Centisome position: 97.4

GC content: 61.03

Gene sequence:

>1065_bases
ATGAGCAGACAACCCCACCGTTCACTCTGGCGGTCATGGCTGGTAAGTACATTAGCTGCGCTAGGTCTGAGTCTAGCCGT
GGTTCCAGGGTCAGCCACACCGTCTGGACCGTCCACTTTGGCGCTCGATCGGTTCAGCAACCGGCCACCCCTGCCGCTCA
ATCCCGCCGCGATGGTTGCGCCTCAGGTGGTCAATATCAGCACTAGATTAGGCTACAACAGCGCGGTGGGAGCCGGGACG
GGAATCGTTATCGATTCCAGCGGTGTCGTGCTGACCAATAATCACGTGATCTCGGGTGCTACCGATATCAGTGCGTTCGA
TGTCGGAAATGGCAAAACTTACGGCGTCGACGTGGTTGGTTACGACCGTACCCAGGACGTCGCGGTGCTCCAGCTTCGTG
GCGCGAGTAACCTGCCTACCGCAGTAATCGGTGGTGACGTGGCGATCGGCGAACCGATTGTGGCTCTGGGCAACACGGGC
GGCCAGGGTGGACTTCCCAGCGTGTTGCCGGGTCGTGTCGTAGCACTTAACCAGACCGTCCAAGCGTCTGAACCCCTGAC
CGGCGCCCAAGAGACGTTGTCCGGACTAATCCAGGTCGACGCCCCGATCAAACCCGGCGATTCGGGCGGGCCCGTCGTCA
ACAGCCGAGGTCAGGTGGTCGGCATGAACACTGCTGCTACCGATAACTACAAGATGTTGGGTGGGCAGGGCTTCGCCATT
CCGATTGGTCAGGCGATGGAGGTCGTCGGTGCCATCCGGTCCGGGGCTGGGTCAAACACCGTACACATAGGCCCGACGGC
CTTCTTTGGCCTGGGCGTTTTAGACAACAACGGCAACGGCGCACGGGTTGCCCGTGTGGTCGCGACGGGTCCAGCCGCGA
TGGCTGGGATTTCGGTAGGTGACATCATCACGTCGGTCGACGGTGTACCCATCAGCGAGGCCACCGCTATGACGAATGTG
CTCGTGCCGCATCATCCTGGGGAAACCGTTGCGGTGAACTATCGCTCTGCTGGCGGCGGTGACCTCACCGCGAATGTGAC
GTTAGCGGAGGGACCTCCAGCTTGA

Upstream 100 bases:

>100_bases
CGACAGCAATTTGCACTAGCTTGATATACACAAAGTCATGCCACCCAGAACCGAAGGTTGGAACAATTCTAGTTCTTAGC
TGGATGCGGGAGATTACGGG

Downstream 100 bases:

>100_bases
CATCCGGTCGGATAGTGGCGCGGCCTGCCGGCCAGCCAATTCGCTTGGAGCGATGCTTGATCTCAGGCCTGATCCCAGGG
TGTCTTGCCTCGGGTATCTG

Product: putative secreted serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSRQPHRSLWRSWLVSTLAALGLSLAVVPGSATPSGPSTLALDRFSNRPPLPLNPAAMVAPQVVNISTRLGYNSAVGAGT
GIVIDSSGVVLTNNHVISGATDISAFDVGNGKTYGVDVVGYDRTQDVAVLQLRGASNLPTAVIGGDVAIGEPIVALGNTG
GQGGLPSVLPGRVVALNQTVQASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNSRGQVVGMNTAATDNYKMLGGQGFAI
PIGQAMEVVGAIRSGAGSNTVHIGPTAFFGLGVLDNNGNGARVARVVATGPAAMAGISVGDIITSVDGVPISEATAMTNV
LVPHHPGETVAVNYRSAGGGDLTANVTLAEGPPA

Sequences:

>Translated_354_residues
MSRQPHRSLWRSWLVSTLAALGLSLAVVPGSATPSGPSTLALDRFSNRPPLPLNPAAMVAPQVVNISTRLGYNSAVGAGT
GIVIDSSGVVLTNNHVISGATDISAFDVGNGKTYGVDVVGYDRTQDVAVLQLRGASNLPTAVIGGDVAIGEPIVALGNTG
GQGGLPSVLPGRVVALNQTVQASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNSRGQVVGMNTAATDNYKMLGGQGFAI
PIGQAMEVVGAIRSGAGSNTVHIGPTAFFGLGVLDNNGNGARVARVVATGPAAMAGISVGDIITSVDGVPISEATAMTNV
LVPHHPGETVAVNYRSAGGGDLTANVTLAEGPPA
>Mature_353_residues
SRQPHRSLWRSWLVSTLAALGLSLAVVPGSATPSGPSTLALDRFSNRPPLPLNPAAMVAPQVVNISTRLGYNSAVGAGTG
IVIDSSGVVLTNNHVISGATDISAFDVGNGKTYGVDVVGYDRTQDVAVLQLRGASNLPTAVIGGDVAIGEPIVALGNTGG
QGGLPSVLPGRVVALNQTVQASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNSRGQVVGMNTAATDNYKMLGGQGFAIP
IGQAMEVVGAIRSGAGSNTVHIGPTAFFGLGVLDNNGNGARVARVVATGPAAMAGISVGDIITSVDGVPISEATAMTNVL
VPHHPGETVAVNYRSAGGGDLTANVTLAEGPPA

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=335, Percent_Identity=26.5671641791045, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI24308541, Length=288, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4506141, Length=288, Percent_Identity=25.3472222222222, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI7019477, Length=270, Percent_Identity=27.4074074074074, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786356, Length=259, Percent_Identity=34.3629343629344, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789630, Length=318, Percent_Identity=34.2767295597484, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789629, Length=285, Percent_Identity=32.280701754386, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646839, Length=269, Percent_Identity=27.8810408921933, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35265; Mature: 35134

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQPHRSLWRSWLVSTLAALGLSLAVVPGSATPSGPSTLALDRFSNRPPLPLNPAAMVA
CCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHC
PQVVNISTRLGYNSAVGAGTGIVIDSSGVVLTNNHVISGATDISAFDVGNGKTYGVDVVG
CEEEEEEECCCCCCCCCCCCEEEECCCCEEEECCEEEECCCCCEEEECCCCCEEEEEEEE
YDRTQDVAVLQLRGASNLPTAVIGGDVAIGEPIVALGNTGGQGGLPSVLPGRVVALNQTV
CCCCCCEEEEEEECCCCCCEEEECCCEECCCCEEEECCCCCCCCCCCCCCCEEEEEECCC
QASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNSRGQVVGMNTAATDNYKMLGGQGFAI
CCCCCCCCHHHHHHEEEEECCCCCCCCCCCCEECCCCCEEEECCCCCCCEEEECCCEEEE
PIGQAMEVVGAIRSGAGSNTVHIGPTAFFGLGVLDNNGNGARVARVVATGPAAMAGISVG
EHHHHHHHHHHHHCCCCCCEEEECCHHEEEEEEEECCCCCEEEEEEEECCCHHHHCCCHH
DIITSVDGVPISEATAMTNVLVPHHPGETVAVNYRSAGGGDLTANVTLAEGPPA
HHHHHCCCCCCCHHHHHHEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SRQPHRSLWRSWLVSTLAALGLSLAVVPGSATPSGPSTLALDRFSNRPPLPLNPAAMVA
CCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEHHCCCCCCCCCCCHHHHC
PQVVNISTRLGYNSAVGAGTGIVIDSSGVVLTNNHVISGATDISAFDVGNGKTYGVDVVG
CEEEEEEECCCCCCCCCCCCEEEECCCCEEEECCEEEECCCCCEEEECCCCCEEEEEEEE
YDRTQDVAVLQLRGASNLPTAVIGGDVAIGEPIVALGNTGGQGGLPSVLPGRVVALNQTV
CCCCCCEEEEEEECCCCCCEEEECCCEECCCCEEEECCCCCCCCCCCCCCCEEEEEECCC
QASEPLTGAQETLSGLIQVDAPIKPGDSGGPVVNSRGQVVGMNTAATDNYKMLGGQGFAI
CCCCCCCCHHHHHHEEEEECCCCCCCCCCCCEECCCCCEEEECCCCCCCEEEECCCEEEE
PIGQAMEVVGAIRSGAGSNTVHIGPTAFFGLGVLDNNGNGARVARVVATGPAAMAGISVG
EHHHHHHHHHHHHCCCCCCEEEECCHHEEEEEEEECCCCCEEEEEEEECCCHHHHCCCHH
DIITSVDGVPISEATAMTNVLVPHHPGETVAVNYRSAGGGDLTANVTLAEGPPA
HHHHHCCCCCCCHHHHHHEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9829922 [H]