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The map label for this gene is trmH [C]

Identifier: 221230819

GI number: 221230819

Start: 2959327

End: 2959875

Strand: Reverse

Name: trmH [C]

Synonym: MLBr_02485

Alternate gene names: 221230819

Gene position: 2959875-2959327 (Counterclockwise)

Preceding gene: 221230820

Following gene: 221230818

Centisome position: 90.57

GC content: 61.38

Gene sequence:

>549_bases
TTGTTGCGGGACGGCGATACTCGCAATGTTGTCGATGCCTACCGTTATTGGACTCGAGAAGCGATCATTGTCGATATCGA
TAGGCGCCGTCACCCCTTTCATGTGGCGATCGAGAACTTCGGTCACGACGCCAACATCGGCTCGGTAGTGCGTACCGCCA
ACGCGTTCGCGGTTGACACCATGCATATTGTTGGGCGTCGGCGCTGGAACCGCCGGGGTGCCATGGTGACGGATCGCTAT
CAGCGGTTGTGTCATCATGACAGTACTGCTTCAATGCTCGACTTCGCGGCGGGTGCTGGCTTGACTGTCGTCGCGGTAGA
CAACATTCCGGGGGCGGCGCGTCTGGAACAGACCACGTTGCCGCGGCAGTGTCTATTGGTGTTCGGTCAGGAAGGTCCCG
GCATCACCGACGAGGCCCGGACCGGCGCGGCGATGATCGTGTCAATCGCCCAGTTCGGCTCGACCCGCAGCATCAACGCT
GGTGTTGCCGCCGGGATCGCGATGCATGCCTGGATCAGGCAGCACGCGGACATGTCCCGCGCCTGGTAG

Upstream 100 bases:

>100_bases
TCCGATGAGTGAACTCGGCCCTACTGAATGGGGGACATCGTCCGGCAGTGTCGGCCCCTGGTCCGGTGACGTCCCGGATG
ACCCGCGGTATGACCCAGTC

Downstream 100 bases:

>100_bases
CCAAAGCGCCCGGACACCCATGGGCCAGCACAATTTTTCAACTTGATATCGCATGCGGTATCAAGTTGCTGACCGCACCC
CTTGGTTTCGCAGGGTGACA

Product: putative RNA methyltransferase

Products: S-adenosyl-L-homocysteine; tRNATyr Containing 2'-O-methylguanosine [C]

Alternate protein names: RNA Methyltransferase; rRNA Methylase; TRNA/RRNA MethyltransferaU; RNA Methyltransferase TrmH Family; 23S RRNA Methyltransferase; TrmH Family RNA Methyltransferase; RNA Methylase Family Protein; Spou RRNA Methylase Family Protein; Methyltransferase; SPOU RRNA Methylase Family Protein

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MLRDGDTRNVVDAYRYWTREAIIVDIDRRRHPFHVAIENFGHDANIGSVVRTANAFAVDTMHIVGRRRWNRRGAMVTDRY
QRLCHHDSTASMLDFAAGAGLTVVAVDNIPGAARLEQTTLPRQCLLVFGQEGPGITDEARTGAAMIVSIAQFGSTRSINA
GVAAGIAMHAWIRQHADMSRAW

Sequences:

>Translated_182_residues
MLRDGDTRNVVDAYRYWTREAIIVDIDRRRHPFHVAIENFGHDANIGSVVRTANAFAVDTMHIVGRRRWNRRGAMVTDRY
QRLCHHDSTASMLDFAAGAGLTVVAVDNIPGAARLEQTTLPRQCLLVFGQEGPGITDEARTGAAMIVSIAQFGSTRSINA
GVAAGIAMHAWIRQHADMSRAW
>Mature_182_residues
MLRDGDTRNVVDAYRYWTREAIIVDIDRRRHPFHVAIENFGHDANIGSVVRTANAFAVDTMHIVGRRRWNRRGAMVTDRY
QRLCHHDSTASMLDFAAGAGLTVVAVDNIPGAARLEQTTLPRQCLLVFGQEGPGITDEARTGAAMIVSIAQFGSTRSINA
GVAAGIAMHAWIRQHADMSRAW

Specific function: Specifically Methylates Guanosine-18 In Various tRNAs. [C]

COG id: COG0566

COG function: function code J; rRNA methylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.34 [C]

Molecular weight: Translated: 20125; Mature: 20125

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRDGDTRNVVDAYRYWTREAIIVDIDRRRHPFHVAIENFGHDANIGSVVRTANAFAVDT
CCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHH
MHIVGRRRWNRRGAMVTDRYQRLCHHDSTASMLDFAAGAGLTVVAVDNIPGAARLEQTTL
HHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCC
PRQCLLVFGQEGPGITDEARTGAAMIVSIAQFGSTRSINAGVAAGIAMHAWIRQHADMSR
CCEEEEEECCCCCCCCCCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
AW
CC
>Mature Secondary Structure
MLRDGDTRNVVDAYRYWTREAIIVDIDRRRHPFHVAIENFGHDANIGSVVRTANAFAVDT
CCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHH
MHIVGRRRWNRRGAMVTDRYQRLCHHDSTASMLDFAAGAGLTVVAVDNIPGAARLEQTTL
HHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCC
PRQCLLVFGQEGPGITDEARTGAAMIVSIAQFGSTRSINAGVAAGIAMHAWIRQHADMSR
CCEEEEEECCCCCCCCCCHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
AW
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; tRNATyr [C]

Specific reaction: S-Adenosyl-L-methionine + tRNATyr = S-adenosyl-L-homocysteine + tRNATyr Containing 2'-O-methylguanosine [C]

General reaction: Methyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA