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The map label for this gene is uvrB [H]

Identifier: 221230200

GI number: 221230200

Start: 1661598

End: 1663694

Strand: Direct

Name: uvrB [H]

Synonym: MLBr_01387

Alternate gene names: 221230200

Gene position: 1661598-1663694 (Clockwise)

Preceding gene: 221230199

Following gene: 221230202

Centisome position: 50.84

GC content: 60.52

Gene sequence:

>2097_bases
GTGCGCGTCGGTGGCCGCTTCGAGGTGATCAGCCCGCACGAACCGGCTGGTGACCAGCCAGCGGCTATTGATGAGTTGCA
GCGACGGATCCTGGCGGGGGAGCGTGACGTAGTGTTACTTGGTGCCACCGGTACCGGAAAGTCAGCAACCACCGCCTGGC
TTATCGAACGGTTGCAGCGACCTACTTTGGTGATGGCGCCGAATAAGACGCTGGCAGCTCAACTTGCGAACGAACTGCGT
GGGATGTTGCCGCACAACGCGGTCGAGTACTTCGTATCATACTATGATTACTATCAGCCAGAAGCGTACATCGCACAGAC
CGACACCTATATCGAAAAAGACAGCTCCATCAACGACGACGTGGAGCGGCTGCGGCACTCCGCCACGTCGTCGCTGCTGT
CGCGGCGCGATGTGGTAGTGGTGGCTTCGGTGTCATGCATTTACGGCCTAGGTACTCCACAGTCCTACCTGGACCGCTCT
GTCGAGCTAGCGGTTAGCAACGAGGTGCCTCGCGACGGCCTATTGCGGCTGCTGGTCGACGTGCAATACACCCGCAATGA
TCTGTCCTTCACCCGCGGCTCCTTCCGGGTGCGCGGCGACACTGTGGAGATCATTCCGTCCTACGAGGAGCTGGCGGTTC
GTATCGAGTTCTTCGGCGACGAGATCGAGGCGTTGTACTACCTACACCCCCTCACCGGCGAGGTGATTCGTCAGGTCGAC
TCGCTACGGATCTTCCCCGCCACCCACTATGTAGCCGGTCCCGAGCGGATGGCGCAGGCAATCTCAGCCATCGAGGAAGA
ACTTGCCGAGCGGCTCGCCGAATTCGAACGCCAGGGCAAGCTGCTGGAGGCGCAGCGGCTGCGGATGCGGACCAACTACG
ACATCGAAATGATGCGGCAGGTCGGGTTCTGCTCAGGTATAGAGAATTACTCCCGCCATATCGACGGCAGGGGGCCGGGC
ACGCCGCCGGCAACGTTGCTCGATTACTTCCCGGAGGACTTTTTGCTCGTCATCGACGAGTCGCATGTCACCGTCCCGCA
AATCGGCGGCATGTACGAAGGTGACATGTCGCGGAAGCGTAACCTCGTCGAATATGGGTTTCGGCTGCCGTCAGCGTGTG
ACAACCGCCCGCTGACCTGGGAGGAATTCGCCGATCGGATCGGGCAAACGGTGTACCTATCGGCCACCCCGGGACCGTAT
GAGCTCAGCCAGTCCGGTGGTGAGTTCGTCGAGCAGGTGATCCGACCGACCGGTTTGGTCGACCCGAAAGTGGTAGTCAA
GCCAACCAAGGGGCAAATCGACGACCTGATTGGCGAAATCCGCAAACGCGCCAACGCCGACCAACGGGTCTTGGTAACGA
CGCTGACCAAGAAAATGGCCGAAGACCTCACCGACTACTTGCTAGAGATGGGTATCCGGGTGCGCTACCTGCACTCCGAG
GTCGACACCTTGCGGCGGGTAGAACTGCTGCGTCAACTGCGGCTTGGCGACTATGACGTGTTGGTCGGCATTAACCTGTT
GCGCGAAGGCCTCGACCTGCCCGAGGTGTCGCTGGTGGCGATCCTGGACGCCGACAAGGAAGGCTTCCTGCGGTCGGCGC
GCAGCCTAATCCAGACCATAGGCCGGGCAGCCCGCAACGTCTCCGGTGAAGTACATATGTATGCCGACACGATCACTGAT
TCGATGACCGAAGCCATCGATGAAACCGAACGGCGACGGGCAAAGCAGATCGCCTACAACAATGCCAATGGTATCGACCC
ACAGCCGCTGCGCAAGAAGATCGCCGACATCCTCGACCAGGTCTATCGCGAGGCCGACGACACCGACACCGTTCAAGTGG
GTGGATCGGGACGTAACGTGTCCCGCGGTCGGCGCGCCCAGAGTGAACCTGTTCGCTCGGTCAGCGTCGGAGTGTTCGAG
GGTCGCGACACCGCTGGTATGCCGCGTGCAGAACTGGCTGACCTGATCAAAGATCTTACCGCCCAAATGATGGCCGCCGC
AAGTGACTTGCAATTCGAGCTGGCCGCGCGCTTCCGTGACGAGATCGCAGACCTCAAAAAGGAACTGCGTGGGATGGACG
CGGCGGGCCTCAAATGA

Upstream 100 bases:

>100_bases
CAGCCAACCTCTTGGTGCCTGGCCTTACGCTGAGGGCATGGCTTTCGCCACCGAGCACCCGATAATAACGCATTCGGAAT
ATCGCGCTGTCAAGGAGATT

Downstream 100 bases:

>100_bases
ATGTCAACCGCGTGTGCACTCCTACGGTGTATGGCGTGACGGATACGGAAAGCAATACTGGCAGTTAGCATGAGCTGCTG
GGCCACAGCATCTCGGAACG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
GMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELAVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITD
SMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFE
GRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK

Sequences:

>Translated_698_residues
MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
GMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELAVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITD
SMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFE
GRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK
>Mature_698_residues
MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
GMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELAVSNEVPRDGLLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITD
SMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQVYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFE
GRDTAGMPRAELADLIKDLTAQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=688, Percent_Identity=55.3779069767442, Blast_Score=730, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78160; Mature: 78160

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQR
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PTLVMAPNKTLAAQLANELRGMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD
CCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHH
VERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVELAVSNEVPRDGLLRLLVD
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHH
VQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
HHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHH
SLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQ
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKR
HHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHH
NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLV
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHCCHHHHHHHHHCCCCCC
DPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
CCCEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
GRAARNVSGEVHMYADTITDSMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQ
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFEGRDTAGMPRAELADLIKDLT
HHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
AQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRVGGRFEVISPHEPAGDQPAAIDELQRRILAGERDVVLLGATGTGKSATTAWLIERLQR
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PTLVMAPNKTLAAQLANELRGMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD
CCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHH
VERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQSYLDRSVELAVSNEVPRDGLLRLLVD
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHH
VQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
HHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHH
SLRIFPATHYVAGPERMAQAISAIEEELAERLAEFERQGKLLEAQRLRMRTNYDIEMMRQ
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKR
HHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHH
NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLV
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHCCHHHHHHHHHCCCCCC
DPKVVVKPTKGQIDDLIGEIRKRANADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
CCCEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSLIQTI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
GRAARNVSGEVHMYADTITDSMTEAIDETERRRAKQIAYNNANGIDPQPLRKKIADILDQ
HHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VYREADDTDTVQVGGSGRNVSRGRRAQSEPVRSVSVGVFEGRDTAGMPRAELADLIKDLT
HHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
AQMMAAASDLQFELAARFRDEIADLKKELRGMDAAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA