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The map label for this gene is tesB [H]

Identifier: 221230137

GI number: 221230137

Start: 1521290

End: 1522183

Strand: Direct

Name: tesB [H]

Synonym: MLBr_01278

Alternate gene names: 221230137

Gene position: 1521290-1522183 (Clockwise)

Preceding gene: 221230136

Following gene: 221230138

Centisome position: 46.55

GC content: 55.82

Gene sequence:

>894_bases
GTGAAAAGACTCTGGGAAAAAAAGACTATGTCTGACTTCGAGGAACTGCTTGCGGTATTAGATCTCAACCGCGTCGCCGA
TGACCTATTCATCGGATCCCATCCCAGCAAGAACCCGCTGCGGACATTCGGCGGGCAGCTCGTGGCGCAGTCCTTTGTGG
CTAGTAGCCGCACGCTGATCCGAGACGACCTGCCGCCCAGCGCATTTTCAGTGCACTTTATCAATGGTGGTGATACAGCC
AAGGAAATCGAGTTTCACGTTGTACGGCTGCGTGACGAGCGGCGCTTCGCCAACCGTCGTGTCGATGCGATTCAGGACGG
CATGTTGTTGTCCTCAGCGATGGCTTCCTACATGTCTGGCGGGTGTGGGCTTGAGCATGCTGTCGAGCCGCCGGAGGCGG
CCGAACCTCATACCCGGCCGCCGATAGGCGAGCTGTTACGCGGCTACGAGCAGATTGTGCAGCATTTCGTCAATGCGTTG
CAACCGGTCGAGTGGCGCTACGTCAATGACCCGTCTTGGGTTATGCGTAACAAAGGCCAACGGCTTGCCTACAATCGGGT
CTGGGTAAAGGCGTTGGGGGCACTGCCCAACGATCCTACCTTGCACACCGCGGCGATGCTGTATTCTACTGACACCACCG
TGTTGGATTCAGTTATAACTACTCATGGGCTGTCGTGGGGCTTCGACCGTATTTTTGCTGTTTCCGCTAACCATTCGGTG
TGGTTTCACCGACAGGTGAACTTCGATGACTGGGTGTTGTATTCGACGTCGTCTCCGGTAGCTGCAGATTCGCGCGGACT
GGGTACTGGGCATTTGTTTGATCGCTCGGGGCAACTAATTGCCACGGTGGTCCAAGAAGGGGTATTGAAATACTTTCCTG
CCTCCCATCGATAG

Upstream 100 bases:

>100_bases
CGTCTCGGCAACGATGCGGGCCGGGTAGCGGCCCGACGAAGAGCTGGGCAATCAGTCTGAGGAGAGCCCGTCCGTGTCGG
TTTGGCGATGAGCCGAATGC

Downstream 100 bases:

>100_bases
ACCATAGCTCGATACGCAAATCGACCTCACGATTTCGGCTCAGCACCATTCTGGTCGAGCGCCCCGTTTCTTTAGGTGGT
ATTTTATTTGCGTCGTGGGA

Product: acyl CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTA
KEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSGGCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNAL
QPVEWRYVNDPSWVMRNKGQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGFDRIFAVSANHSV
WFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQEGVLKYFPASHR

Sequences:

>Translated_297_residues
MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTA
KEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSGGCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNAL
QPVEWRYVNDPSWVMRNKGQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGFDRIFAVSANHSV
WFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQEGVLKYFPASHR
>Mature_297_residues
MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGGQLVAQSFVASSRTLIRDDLPPSAFSVHFINGGDTA
KEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSGGCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNAL
QPVEWRYVNDPSWVMRNKGQRLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGFDRIFAVSANHSV
WFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQEGVLKYFPASHR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=297, Percent_Identity=31.6498316498317, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786657, Length=277, Percent_Identity=31.7689530685921, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=29.2096219931272, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17558508, Length=304, Percent_Identity=27.6315789473684, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115532456, Length=311, Percent_Identity=25.4019292604502, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17531889, Length=311, Percent_Identity=25.4019292604502, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17531885, Length=311, Percent_Identity=25.4019292604502, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982224, Length=308, Percent_Identity=23.7012987012987, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33303; Mature: 33303

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGGQLVAQSFVASSRTLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHH
RDDLPPSAFSVHFINGGDTAKEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSG
HCCCCCCCEEEEEECCCCCHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVMRNKGQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCC
RLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGFDRIFAVSANHSV
CHHHHHHHHHHHCCCCCCCCHHHHHEEEECCHHHHHHHHHHCCCCCCCCEEEEEECCCEE
WFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQEGVLKYFPASHR
EEEEECCCCCEEEEECCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRLWEKKTMSDFEELLAVLDLNRVADDLFIGSHPSKNPLRTFGGQLVAQSFVASSRTLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHH
RDDLPPSAFSVHFINGGDTAKEIEFHVVRLRDERRFANRRVDAIQDGMLLSSAMASYMSG
HCCCCCCCEEEEEECCCCCHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCGLEHAVEPPEAAEPHTRPPIGELLRGYEQIVQHFVNALQPVEWRYVNDPSWVMRNKGQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCC
RLAYNRVWVKALGALPNDPTLHTAAMLYSTDTTVLDSVITTHGLSWGFDRIFAVSANHSV
CHHHHHHHHHHHCCCCCCCCHHHHHEEEECCHHHHHHHHHHCCCCCCCCEEEEEECCCEE
WFHRQVNFDDWVLYSTSSPVAADSRGLGTGHLFDRSGQLIATVVQEGVLKYFPASHR
EEEEECCCCCEEEEECCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]