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The map label for this gene is wecA [H]

Identifier: 221230045

GI number: 221230045

Start: 1328540

End: 1329739

Strand: Direct

Name: wecA [H]

Synonym: MLBr_01137

Alternate gene names: 221230045

Gene position: 1328540-1329739 (Clockwise)

Preceding gene: 221230044

Following gene: 221230046

Centisome position: 40.65

GC content: 58.67

Gene sequence:

>1200_bases
TTGGTGCAGTACGTTCGCGAGATGTCCAGCGACCTAGCCACCTTTGCCAGTGGTTTGCTCGCCTTGTTTGAGCGTAGTGC
TGGTGTCCCGCTGCGCGAGCTTGCATTGGTCGGACTGACCGCCGCGATCATCACTTACTTCGCAACTGGGCTGGTAGGGG
TGTTAGCCAACCGCTTGGAAGCGGTCGCTTATCCTCGCGAACGCGATGTTCATGTGACGCCAACCCCACGGATGGGTGGG
CTGGCCATGTATCTCGGCGTTTTGGCTGCTGTCTTTCTGGCTTCTCAGCTTCCGGCGCTTACCCGCGGGTTCGTCTATTC
CTCGGGCATGCCCGCGGTATTGGTGGCTGGTGCGGTGATCACGGGTATCGGACTGATCGACGACCGCTGGGGTCTGGACG
CACTGACGAAGTTTGCGGGTCAGATCACCGCAGCCAGCGTGCTGGTCACCATGGGAGTTGCTTGGAGTGTCCTCTATATC
CCGCTGGGTGGCGTCGGCACTATCGTGTTGGACCAGACCTCCTCGATTTTGCTTACCTTGGCGTTGACCGTGTCGATCGT
TAACGCGATTAACTTCGTCGACGGACTCGACGGACTGGCCGCCGGGTTGGGGCTCATTACCGCGATGGCAATCTGCATAT
TCTCGGTTGGCTTGCTTCGTGACCATGATGGTGACGTGTTGTTTTATCCGCCGGCGGTGATTTCGGTGGTACTTGCGGGA
TCCTGTCTGGGTTTCCTGCCGCACAACTTTCACCGGGCCAAGATCTTCATGGGTGATTCCGGGTCGATGTTGGTAGGCTT
AATGCTTGCGGCGGCCTCTACGACCGCTGCTGGACCGATCTCGCAGAACGCTTACGGCACTCGCGATGTGTTTGCTCTGC
TGTCACCGTTCCTGCTGGTGGTGGCGGTCATGTTTGTGCCTATGCTCGACTTGCTGCTAGCGATCGTGCGTCGTATTCGC
GCGGGTCGTAGCGCCTTTAGCCCCGACAAGATGCATTTGCACCATCGGCTGCTGCAGATCGGACACTCGCATCGTCGTGT
GGTGCTGCTGATCTACCTTTGGGTGGGCATCGTCGCATTCGGTGCGGCAAGCACGATTTTCTTCAACCCGCGTAACACCG
GAGCGGTCATGTTGGGCGCAATTGTGATCACTGGCATGGCGACGGTGATCCCGCTGTTGCGCCGTCGCGACAACTATTAG

Upstream 100 bases:

>100_bases
AGCCGGCCCAGTGAGCGTTGCGCGGATCGCGGAGGTGCTAGGGGTGGTTCCCGCGAGTCTGATCGCCTAAACTGGCCAGC
GCGGTTAGGCGGGTCTCAGG

Downstream 100 bases:

>100_bases
GACCATGCCTAGGAGGCTTTTACTACCGATAGTAGTAGTGATGTCTATTAGTGTGGTACACTGCTGCCAGAGCCCCGAAA
TAAATTTCTCGGGTTCCCGT

Product: putative glycosyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGG
LAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYI
PLGGVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAG
SCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIR
AGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY

Sequences:

>Translated_399_residues
MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGG
LAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYI
PLGGVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAG
SCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIR
AGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY
>Mature_399_residues
MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGG
LAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYI
PLGGVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAG
SCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIR
AGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=311, Percent_Identity=28.6173633440514, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42189; Mature: 42189

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAYPRERDVHVTPTPRMGGLAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVI
HHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHH
TGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPLGGVGTIVLDQTSSILLTL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHH
ALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
SCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLV
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAVMFVPMLDLLLAIVRRIRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAYPRERDVHVTPTPRMGGLAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVI
HHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHH
TGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPLGGVGTIVLDQTSSILLTL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHH
ALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHH
SCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLV
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAVMFVPMLDLLLAIVRRIRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]