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The map label for this gene is ethR [H]

Identifier: 221230001

GI number: 221230001

Start: 1234677

End: 1235330

Strand: Direct

Name: ethR [H]

Synonym: MLBr_01070

Alternate gene names: 221230001

Gene position: 1234677-1235330 (Clockwise)

Preceding gene: 221230000

Following gene: 221230003

Centisome position: 37.78

GC content: 59.48

Gene sequence:

>654_bases
ATGATCGTGGTTGGTAATTTTACGCAGAGCAATTACGTGCCTGCGTCGCGAGGCCGTCGGTCGTCGCAGCTCTCCGGCGA
CGACCGAGAACAGGCAATCCTGGCCGTTGCTGAACGGCTCCTGGCGGAGCGGCCACTGGGTGACTTTTCCGTCGATGAAC
TAGCCAAAGGCGCCGGAATCTCGCGCCCAACCTTTTATTTCTACTTCCCGTCAAAGAACGCGGTGTTGTTGTCGCTGCTT
GATGATCTGAATATGAAGTCACGCTCGGCGGTTGAAGCACTCGCTGAACAGCTGCCCGCGGACCCCGCCGCGGTCTGGCG
GTCCGCAATCACGGCGTTCTTCGAGGTGTGCGGGACTCACCGAGCGGTGGCTGTTGCTGGTGCCGCGGCCAAAGCCACTA
GCCCTGAGGTACGCCGGCTGTGGTCCACAGTCATGCAGCAGTGGATCGACTACAACACAGCTGCGATTCAGGCTGAGCGC
AAGTGCGGCGTAGCCCCCGACACCATTCCCGCCGAGGATCTGGCTGTGGCGCTGCAATTAATGACCGAACGCGTGATGGC
CGCGACATTCTCCGACGAAAAGCCGTTGATCCCCGATAAGAAAGTTATCGACACGCTCGTGCATATCTGGTTGGCCAGCA
TTTACGGCAGTTGA

Upstream 100 bases:

>100_bases
GTGGTCGGCAAGGGTGTGTGGATTTAGCTCGGTGCTAGCTAGGCCAGTTGTTGAGCTGTGTCGACATGTTTGTCGAAGCC
TATCGACACTTGGGTAAGCT

Downstream 100 bases:

>100_bases
CCGCGCACCATACGTAAGGCGCCAGCCGATAGCGCACCTGCTGTGTGTATTGGCGGTATCCGCTCAATTCTTGGGTAAAG
CTACCTTCTCCTCGTCGCGG

Product: putative TetR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLL
DDLNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAER
KCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS

Sequences:

>Translated_217_residues
MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLL
DDLNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAER
KCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS
>Mature_217_residues
MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLL
DDLNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAER
KCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23615; Mature: 23615

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFSVDELAKGAGI
CEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
SRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTH
CCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
RAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQL
HHHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
MTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFSVDELAKGAGI
CEEECCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
SRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLPADPAAVWRSAITAFFEVCGTH
CCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
RAVAVAGAAAKATSPEVRRLWSTVMQQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQL
HHHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
MTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]