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The map label for this gene is dcp [H]

Identifier: 220918398

GI number: 220918398

Start: 3675715

End: 3677868

Strand: Direct

Name: dcp [H]

Synonym: A2cp1_3302

Alternate gene names: 220918398

Gene position: 3675715-3677868 (Clockwise)

Preceding gene: 220918391

Following gene: 220918401

Centisome position: 73.09

GC content: 72.52

Gene sequence:

>2154_bases
ATGTCGGCACTCGTCGCGAGCGCGCTCGCACAGCTCGTCCTGCTCTCCAGCCCGCCCGCGGCCCCCGCGCGCGCGGAGGT
CCCCGTGAACAACCCGCTGCTCGCCCCGTGGGCGGGCCCGCACGGCGGCGTCCCGCCGTTCGACGTGGCGCGCGTCGATC
AGCTCGCCCCGGCCATCGAGGCCGGCATGGCCGCGAAGCTCGCCGCCGTCGAGGCGATCGCCGCCGACCCGGCCGCGCCC
ACCTTCGACAACACGCTGGCCGCGATGGAGCGCTCCGGCCGGGCGCTCGACCGCGCCATGACGGTCTTCGGGGTGTTCTC
CACCTCGATGAGCACGCCGGAGTTCCAGGCGGTGGAGCGCGAGCTGGCGCCGAAGCTGGCCGCGTTCGACGACCGGATCA
CGCAGAACGAGAAGCTGTTCGCGCGCATCGCCGCCGTCTACGATGCGCGCGAGACCTCCTGCAGGACGCCCGAGCAGAAG
CGGCTCGCCTGGCTCTATTACACGACGTTCGTCCGCGCCGGCGCGAAGCTCGACCCGGCCGCGAAGCAGCGCGTCGCCGC
GATCAACGAGCGGCTCGCCACGCTGTACACGAAGTTCGCGCAGGACGTGCTGGCCGACGAGTCCGGCTACACCCTGGTCC
TCGAGGACGAGGCGGCGCTGGCGGGCCTGCCGGCGAGCGTGCGCGCCGGCATGGCGGCCGCGGCCGCGACCCGCGGGAAG
GCCGGCAAGTGGGCGGTGCTCAACACGCGCTCCAGCGTCGAGCCGTTCCTGGCCTACTCGGAGCGGCGCGACCTCCGCGA
GCGGGTCTGGCGCGACTTCACCAGCCGCGGCGATCACGGCGACGCGCACGACACCAAGGCGGCCATCACCGAGATCCTGA
AGCTGCGCGCCGAGCGCGCGAAGCTGCTCGGGTACCCGACGCACGCGCACTGGCGGCTCGAGGACTCGATGGCGAAGACG
CCCGGGCGCGCCATGGCGCTCATGGAGGCGGTCTGGCCGGCGGCGGTGGCGCGGGTCCGCGAGGAGGTCGCCGACATGCA
GGCGGTGGCCGACCGCGAGGGCGCGGGCATCACCATCGAGCCGTGGGACTACCGCTTCTACGCGGAGAAGGTCCGCAAGG
CGAAGTACGACCTCGACGAGAACGAGGTGAAGCCGTACCTCCAGCTCGAGAAGCTGCGCGAGGCGATGTTCTGGGTGGCC
GGCCGCCTGTTCGACCTGCACTTCACGCCGGCGAAGGGCGTGCCGGTGTACCACCCCGACGTGCGCGTCTGGGAGGTGAA
GGACGGCAAGGGCCGGCACGTGGGCCGCTGGTACTTCGACCCGTACGCGCGCGACGGGAAGCGCTCGGGCGCGTGGATGA
ACGCGTACCGCGCGCAGGAGCGGTTCGACGGCGAGATCCCGACCATCGTCTCGAACAACGCGAACTTCGTGAAGGGGAAG
CCGGGCGAGCCGGTGCTGGTGAGCTGGACCGACGCCGAGACCCTGTTCCACGAGTTCGGGCACGCGCTGCACGGCCTCGC
CTCCAGCGTCGGGTACCCGTCGCTCTCCGGCACCGCGGTGGCGCGCGACTACGTGGAGTTCCCGTCGCAGCTCCTGGAGC
GCTGGCTCGAGACGCCGGAGGTGCTGGACCGCTTCGCGCGCCACGTGAAGACCGGCAAGCCGCTGCCGCGGGCGCTGGTG
GCGAAGATCCAGAAGGCGTCCACCTTCAACCAGGGCTTCGGGACGGTGGAGTACCTCTCGGCCGCGCTGGTGGATCTGAA
GATGCACCTCGCCGGCTCGACCGAGATCGACCCCGCCGCGTTCGAGAAGGACACGCTCGCCGCGCTGGGCATGCCGCGCG
AGGTGGTGATGCGCCACCGGCCGCCGCACTTCCTCCACGTGTTCTCCGGCGACGGCTACTCCGCCGGCTACTACAGCTAC
CTCTGGGCCGACACCCTCAGCACCGACGCGTACGAGGCGTTCACCGAGGCGAAGGGACCCTACGATCGGGCGGTCGCCGC
CCGCCTGCGCGAGCACGTGTTCTCCGCCGGGAACACCGTCGACCCCGCCGACGCGTACCGCGCGTTCCGCGGGCGCGACC
CCGGCATCGGCGCGCTCATGCGCAAGCGCGGCTTCCCGGTGCCGGCGGCGGAGCCGGGCGCGGCGCCGCGGTAA

Upstream 100 bases:

>100_bases
TCGCACCGCGACGCGCACGTGATCCGGCGCGACGAGGGACTTGACCCGCTCGCGGCCCCGCGCGAGAGAACCGGGAGCCC
ATTCGGCGCGGAGGTCGTAC

Downstream 100 bases:

>100_bases
GCGCGCGCGGCACGCGATCCGCGATCCGGTCCCGGGATCGCGGATCGCGCCGACCAGGCCCTGCGCCCGGCGGCGTCCCG
GCTACGGCCCGGGCGCGGCG

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MSALVASALAQLVLLSSPPAAPARAEVPVNNPLLAPWAGPHGGVPPFDVARVDQLAPAIEAGMAAKLAAVEAIAADPAAP
TFDNTLAAMERSGRALDRAMTVFGVFSTSMSTPEFQAVERELAPKLAAFDDRITQNEKLFARIAAVYDARETSCRTPEQK
RLAWLYYTTFVRAGAKLDPAAKQRVAAINERLATLYTKFAQDVLADESGYTLVLEDEAALAGLPASVRAGMAAAAATRGK
AGKWAVLNTRSSVEPFLAYSERRDLRERVWRDFTSRGDHGDAHDTKAAITEILKLRAERAKLLGYPTHAHWRLEDSMAKT
PGRAMALMEAVWPAAVARVREEVADMQAVADREGAGITIEPWDYRFYAEKVRKAKYDLDENEVKPYLQLEKLREAMFWVA
GRLFDLHFTPAKGVPVYHPDVRVWEVKDGKGRHVGRWYFDPYARDGKRSGAWMNAYRAQERFDGEIPTIVSNNANFVKGK
PGEPVLVSWTDAETLFHEFGHALHGLASSVGYPSLSGTAVARDYVEFPSQLLERWLETPEVLDRFARHVKTGKPLPRALV
AKIQKASTFNQGFGTVEYLSAALVDLKMHLAGSTEIDPAAFEKDTLAALGMPREVVMRHRPPHFLHVFSGDGYSAGYYSY
LWADTLSTDAYEAFTEAKGPYDRAVAARLREHVFSAGNTVDPADAYRAFRGRDPGIGALMRKRGFPVPAAEPGAAPR

Sequences:

>Translated_717_residues
MSALVASALAQLVLLSSPPAAPARAEVPVNNPLLAPWAGPHGGVPPFDVARVDQLAPAIEAGMAAKLAAVEAIAADPAAP
TFDNTLAAMERSGRALDRAMTVFGVFSTSMSTPEFQAVERELAPKLAAFDDRITQNEKLFARIAAVYDARETSCRTPEQK
RLAWLYYTTFVRAGAKLDPAAKQRVAAINERLATLYTKFAQDVLADESGYTLVLEDEAALAGLPASVRAGMAAAAATRGK
AGKWAVLNTRSSVEPFLAYSERRDLRERVWRDFTSRGDHGDAHDTKAAITEILKLRAERAKLLGYPTHAHWRLEDSMAKT
PGRAMALMEAVWPAAVARVREEVADMQAVADREGAGITIEPWDYRFYAEKVRKAKYDLDENEVKPYLQLEKLREAMFWVA
GRLFDLHFTPAKGVPVYHPDVRVWEVKDGKGRHVGRWYFDPYARDGKRSGAWMNAYRAQERFDGEIPTIVSNNANFVKGK
PGEPVLVSWTDAETLFHEFGHALHGLASSVGYPSLSGTAVARDYVEFPSQLLERWLETPEVLDRFARHVKTGKPLPRALV
AKIQKASTFNQGFGTVEYLSAALVDLKMHLAGSTEIDPAAFEKDTLAALGMPREVVMRHRPPHFLHVFSGDGYSAGYYSY
LWADTLSTDAYEAFTEAKGPYDRAVAARLREHVFSAGNTVDPADAYRAFRGRDPGIGALMRKRGFPVPAAEPGAAPR
>Mature_716_residues
SALVASALAQLVLLSSPPAAPARAEVPVNNPLLAPWAGPHGGVPPFDVARVDQLAPAIEAGMAAKLAAVEAIAADPAAPT
FDNTLAAMERSGRALDRAMTVFGVFSTSMSTPEFQAVERELAPKLAAFDDRITQNEKLFARIAAVYDARETSCRTPEQKR
LAWLYYTTFVRAGAKLDPAAKQRVAAINERLATLYTKFAQDVLADESGYTLVLEDEAALAGLPASVRAGMAAAAATRGKA
GKWAVLNTRSSVEPFLAYSERRDLRERVWRDFTSRGDHGDAHDTKAAITEILKLRAERAKLLGYPTHAHWRLEDSMAKTP
GRAMALMEAVWPAAVARVREEVADMQAVADREGAGITIEPWDYRFYAEKVRKAKYDLDENEVKPYLQLEKLREAMFWVAG
RLFDLHFTPAKGVPVYHPDVRVWEVKDGKGRHVGRWYFDPYARDGKRSGAWMNAYRAQERFDGEIPTIVSNNANFVKGKP
GEPVLVSWTDAETLFHEFGHALHGLASSVGYPSLSGTAVARDYVEFPSQLLERWLETPEVLDRFARHVKTGKPLPRALVA
KIQKASTFNQGFGTVEYLSAALVDLKMHLAGSTEIDPAAFEKDTLAALGMPREVVMRHRPPHFLHVFSGDGYSAGYYSYL
WADTLSTDAYEAFTEAKGPYDRAVAARLREHVFSAGNTVDPADAYRAFRGRDPGIGALMRKRGFPVPAAEPGAAPR

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=598, Percent_Identity=28.7625418060201, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI14149738, Length=645, Percent_Identity=25.4263565891473, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI156105687, Length=640, Percent_Identity=22.96875, Blast_Score=145, Evalue=2e-34,
Organism=Escherichia coli, GI1787819, Length=681, Percent_Identity=39.9412628487518, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789913, Length=688, Percent_Identity=30.6686046511628, Blast_Score=320, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71999758, Length=331, Percent_Identity=25.6797583081571, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32565901, Length=569, Percent_Identity=20.2108963093146, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319793, Length=696, Percent_Identity=23.9942528735632, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322715, Length=640, Percent_Identity=19.6875, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356111, Length=703, Percent_Identity=22.475106685633, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129717, Length=394, Percent_Identity=25.1269035532995, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 78845; Mature: 78714

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALVASALAQLVLLSSPPAAPARAEVPVNNPLLAPWAGPHGGVPPFDVARVDQLAPAIE
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHH
AGMAAKLAAVEAIAADPAAPTFDNTLAAMERSGRALDRAMTVFGVFSTSMSTPEFQAVER
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELAPKLAAFDDRITQNEKLFARIAAVYDARETSCRTPEQKRLAWLYYTTFVRAGAKLDPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
AKQRVAAINERLATLYTKFAQDVLADESGYTLVLEDEAALAGLPASVRAGMAAAAATRGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHCCC
AGKWAVLNTRSSVEPFLAYSERRDLRERVWRDFTSRGDHGDAHDTKAAITEILKLRAERA
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KLLGYPTHAHWRLEDSMAKTPGRAMALMEAVWPAAVARVREEVADMQAVADREGAGITIE
HHHCCCCCCCEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
PWDYRFYAEKVRKAKYDLDENEVKPYLQLEKLREAMFWVAGRLFDLHFTPAKGVPVYHPD
CCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCC
VRVWEVKDGKGRHVGRWYFDPYARDGKRSGAWMNAYRAQERFDGEIPTIVSNNANFVKGK
CEEEEECCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCC
PGEPVLVSWTDAETLFHEFGHALHGLASSVGYPSLSGTAVARDYVEFPSQLLERWLETPE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
VLDRFARHVKTGKPLPRALVAKIQKASTFNQGFGTVEYLSAALVDLKMHLAGSTEIDPAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
FEKDTLAALGMPREVVMRHRPPHFLHVFSGDGYSAGYYSYLWADTLSTDAYEAFTEAKGP
CCHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCC
YDRAVAARLREHVFSAGNTVDPADAYRAFRGRDPGIGALMRKRGFPVPAAEPGAAPR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SALVASALAQLVLLSSPPAAPARAEVPVNNPLLAPWAGPHGGVPPFDVARVDQLAPAIE
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHH
AGMAAKLAAVEAIAADPAAPTFDNTLAAMERSGRALDRAMTVFGVFSTSMSTPEFQAVER
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELAPKLAAFDDRITQNEKLFARIAAVYDARETSCRTPEQKRLAWLYYTTFVRAGAKLDPA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
AKQRVAAINERLATLYTKFAQDVLADESGYTLVLEDEAALAGLPASVRAGMAAAAATRGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHCCC
AGKWAVLNTRSSVEPFLAYSERRDLRERVWRDFTSRGDHGDAHDTKAAITEILKLRAERA
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KLLGYPTHAHWRLEDSMAKTPGRAMALMEAVWPAAVARVREEVADMQAVADREGAGITIE
HHHCCCCCCCEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
PWDYRFYAEKVRKAKYDLDENEVKPYLQLEKLREAMFWVAGRLFDLHFTPAKGVPVYHPD
CCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEECCC
VRVWEVKDGKGRHVGRWYFDPYARDGKRSGAWMNAYRAQERFDGEIPTIVSNNANFVKGK
CEEEEECCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCC
PGEPVLVSWTDAETLFHEFGHALHGLASSVGYPSLSGTAVARDYVEFPSQLLERWLETPE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
VLDRFARHVKTGKPLPRALVAKIQKASTFNQGFGTVEYLSAALVDLKMHLAGSTEIDPAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
FEKDTLAALGMPREVVMRHRPPHFLHVFSGDGYSAGYYSYLWADTLSTDAYEAFTEAKGP
CCHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCC
YDRAVAARLREHVFSAGNTVDPADAYRAFRGRDPGIGALMRKRGFPVPAAEPGAAPR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]