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The map label for this gene is zraR [H]

Identifier: 220918381

GI number: 220918381

Start: 3656257

End: 3657627

Strand: Direct

Name: zraR [H]

Synonym: A2cp1_3285

Alternate gene names: 220918381

Gene position: 3656257-3657627 (Clockwise)

Preceding gene: 220918379

Following gene: 220918382

Centisome position: 72.7

GC content: 77.32

Gene sequence:

>1371_bases
GTGCCCCCGCCCAGCGCCGCCCCCCTCCCGTTCCTCGGCCTCGGCAGCGAGGACGCGCTCCGCGCCGTCGCCGACGCGCT
CCCGGACGGCCTGTTCACCACCGACGCCGCGGGGCGCATCACGTTCTGGAACCGCGCCGCGGCGCGGATCACCGGGTGGT
CCTCCGGCGACGCGGTCGGGCGCGACTGCTCGCTGCTCGCCGGCGACCCGGTGCATGGCTGTGCGTGCGGCGCCGGGCCC
ATCCGCTGCGGCATGGCCGAGCGCGAGCGCACCTCCAAGACCTGCTCGGTGCGCACGCGCGACGACCGCCTGCTGGTGAT
CGTGAAGAGCGCCGTGCCCCTGCTCGCGCCCGACGGCACCGCGGTCGGGGCGCTCGAGTCCTTCAGCCCGGTGGACCCGG
TGCCCGGCGGGCGGCGGCAGGACGCGTGCGCGCGGCCCCAGGCGTCCGGCCTGCTCGGCCGCGGGCCGGCCATGGAGGAG
CTGCGCCGGATGATCGCGCTGGTGGCGCGCTCCGACGCCACGGTGATGCTGCACGGCGAGAGCGGCTCCGGCAAGGAGCG
CGTCGCCGAGGCCATCCACGCCGGCAGCGCGCGGGCGGCGGGCCCGTTCGTGCGCGTGAACTGCTCCGCGCTGAACGAGA
ACCTGCTGGAGAGCGAGCTGTTCGGGCACGTGCGCGGCGCGTTCACCGGCGCCCTGCGCGATCGGCGCGGGCGCTTCCAG
GACGCGGACGGCGGCACCTTGCTGCTGGACGAGATCGGCGACATCTCGCCGGTGGTGCAGGTGAAGCTGCTGCGGGTCAT
CGAGCAGCGCCAGATCGAGCGCGTGGGCGACTCCGCGCCGGTCCCGGTGGACGTGCGCATCGTGTGCGCCACCCACCGCG
ACCTGCGCGCGCTGGTCGACGCGGGTCGGTTCCGCGCGGACCTGTACTTCCGCCTGGCGGTGTTCCCGCTGCGCGTCCCC
CCGCTGCGCGAGCACGTCGAGGACCTCCCCGAGATCGCCACCGCGTTCCTGGAGCGCCACGCGCCGGCCCCCGGGGGGCG
GCCGCGCGCCCTCTCCGCCGCCGCGATCGCGGCGCTGTCCGCCTGCACCTGGCCCGGCAACGTGCGCGAGCTCCAGAACG
TGCTCGAGTTCGCGGCGCTGCAGGCGGGGGACGGTGACCTCGGGATCGAGCACCTCCCCGCCGAGCTGCGCGGCGCCTGC
GCCCCGCTGCCCCGCCGCCCGGGTGCGATGCCGGGGCCGGAGGAGATCCGGTCCGCGCTGGAGGCCTGCGGCGGGCGCCG
GGCCGAGGCCGCGCGGCGGCTCGGCATCTCGCGGGGTACCCTCTGGAAGCGGATGCGGGCGCTCGCGCCGGGCTCGTCCG
ATCCGGGCTAG

Upstream 100 bases:

>100_bases
CTCGGAAACCGGCCATGCGGCGATCCGCCGCAGCGCCGCGCGGAACCTTCGCCAGGGCGTGCGGCTCCGATCCGGCGTTC
ACGTGAACGCCGGAGGAGAC

Downstream 100 bases:

>100_bases
GCCGCCGCGGTCCCTCCGGCATCCGCCGCCTGCTGGCGGGCAAGTGCCCGATCTCGCACGGCGCCAGGCCATGCGTCATG
CGCCGGATGGCGCGTCCGCG

Product: PAS modulated Fis family sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPPPSAAPLPFLGLGSEDALRAVADALPDGLFTTDAAGRITFWNRAAARITGWSSGDAVGRDCSLLAGDPVHGCACGAGP
IRCGMAERERTSKTCSVRTRDDRLLVIVKSAVPLLAPDGTAVGALESFSPVDPVPGGRRQDACARPQASGLLGRGPAMEE
LRRMIALVARSDATVMLHGESGSGKERVAEAIHAGSARAAGPFVRVNCSALNENLLESELFGHVRGAFTGALRDRRGRFQ
DADGGTLLLDEIGDISPVVQVKLLRVIEQRQIERVGDSAPVPVDVRIVCATHRDLRALVDAGRFRADLYFRLAVFPLRVP
PLREHVEDLPEIATAFLERHAPAPGGRPRALSAAAIAALSACTWPGNVRELQNVLEFAALQAGDGDLGIEHLPAELRGAC
APLPRRPGAMPGPEEIRSALEACGGRRAEAARRLGISRGTLWKRMRALAPGSSDPG

Sequences:

>Translated_456_residues
MPPPSAAPLPFLGLGSEDALRAVADALPDGLFTTDAAGRITFWNRAAARITGWSSGDAVGRDCSLLAGDPVHGCACGAGP
IRCGMAERERTSKTCSVRTRDDRLLVIVKSAVPLLAPDGTAVGALESFSPVDPVPGGRRQDACARPQASGLLGRGPAMEE
LRRMIALVARSDATVMLHGESGSGKERVAEAIHAGSARAAGPFVRVNCSALNENLLESELFGHVRGAFTGALRDRRGRFQ
DADGGTLLLDEIGDISPVVQVKLLRVIEQRQIERVGDSAPVPVDVRIVCATHRDLRALVDAGRFRADLYFRLAVFPLRVP
PLREHVEDLPEIATAFLERHAPAPGGRPRALSAAAIAALSACTWPGNVRELQNVLEFAALQAGDGDLGIEHLPAELRGAC
APLPRRPGAMPGPEEIRSALEACGGRRAEAARRLGISRGTLWKRMRALAPGSSDPG
>Mature_455_residues
PPPSAAPLPFLGLGSEDALRAVADALPDGLFTTDAAGRITFWNRAAARITGWSSGDAVGRDCSLLAGDPVHGCACGAGPI
RCGMAERERTSKTCSVRTRDDRLLVIVKSAVPLLAPDGTAVGALESFSPVDPVPGGRRQDACARPQASGLLGRGPAMEEL
RRMIALVARSDATVMLHGESGSGKERVAEAIHAGSARAAGPFVRVNCSALNENLLESELFGHVRGAFTGALRDRRGRFQD
ADGGTLLLDEIGDISPVVQVKLLRVIEQRQIERVGDSAPVPVDVRIVCATHRDLRALVDAGRFRADLYFRLAVFPLRVPP
LREHVEDLPEIATAFLERHAPAPGGRPRALSAAAIAALSACTWPGNVRELQNVLEFAALQAGDGDLGIEHLPAELRGACA
PLPRRPGAMPGPEEIRSALEACGGRRAEAARRLGISRGTLWKRMRALAPGSSDPG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=300, Percent_Identity=50.6666666666667, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI87082117, Length=318, Percent_Identity=44.3396226415094, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1788550, Length=314, Percent_Identity=42.9936305732484, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1790299, Length=330, Percent_Identity=41.8181818181818, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786524, Length=317, Percent_Identity=42.2712933753943, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788905, Length=300, Percent_Identity=43.3333333333333, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=42.9936305732484, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=50.8474576271186, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789233, Length=360, Percent_Identity=34.4444444444444, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87081872, Length=264, Percent_Identity=45.0757575757576, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=34.7692307692308, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87081858, Length=443, Percent_Identity=29.7968397291196, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789828, Length=257, Percent_Identity=36.1867704280156, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48149; Mature: 48017

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPSAAPLPFLGLGSEDALRAVADALPDGLFTTDAAGRITFWNRAAARITGWSSGDAVG
CCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEECCCCCEEEEECCCHHEEECCCCCCCCC
RDCSLLAGDPVHGCACGAGPIRCGMAERERTSKTCSVRTRDDRLLVIVKSAVPLLAPDGT
CCCCEEECCCCCCCCCCCCCHHCCCHHHHHCCCCEEEEECCCCEEEEEECCCCEECCCCC
AVGALESFSPVDPVPGGRRQDACARPQASGLLGRGPAMEELRRMIALVARSDATVMLHGE
HHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGSGKERVAEAIHAGSARAAGPFVRVNCSALNENLLESELFGHVRGAFTGALRDRRGRFQ
CCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DADGGTLLLDEIGDISPVVQVKLLRVIEQRQIERVGDSAPVPVDVRIVCATHRDLRALVD
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHH
AGRFRADLYFRLAVFPLRVPPLREHVEDLPEIATAFLERHAPAPGGRPRALSAAAIAALS
HHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ACTWPGNVRELQNVLEFAALQAGDGDLGIEHLPAELRGACAPLPRRPGAMPGPEEIRSAL
HCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHH
EACGGRRAEAARRLGISRGTLWKRMRALAPGSSDPG
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PPPSAAPLPFLGLGSEDALRAVADALPDGLFTTDAAGRITFWNRAAARITGWSSGDAVG
CCCCCCCCCEECCCCHHHHHHHHHHCCCCCEECCCCCEEEEECCCHHEEECCCCCCCCC
RDCSLLAGDPVHGCACGAGPIRCGMAERERTSKTCSVRTRDDRLLVIVKSAVPLLAPDGT
CCCCEEECCCCCCCCCCCCCHHCCCHHHHHCCCCEEEEECCCCEEEEEECCCCEECCCCC
AVGALESFSPVDPVPGGRRQDACARPQASGLLGRGPAMEELRRMIALVARSDATVMLHGE
HHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGSGKERVAEAIHAGSARAAGPFVRVNCSALNENLLESELFGHVRGAFTGALRDRRGRFQ
CCCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DADGGTLLLDEIGDISPVVQVKLLRVIEQRQIERVGDSAPVPVDVRIVCATHRDLRALVD
CCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHH
AGRFRADLYFRLAVFPLRVPPLREHVEDLPEIATAFLERHAPAPGGRPRALSAAAIAALS
HHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ACTWPGNVRELQNVLEFAALQAGDGDLGIEHLPAELRGACAPLPRRPGAMPGPEEIRSAL
HCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHH
EACGGRRAEAARRLGISRGTLWKRMRALAPGSSDPG
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]