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The map label for this gene is lutP [H]

Identifier: 220918269

GI number: 220918269

Start: 3515332

End: 3517005

Strand: Direct

Name: lutP [H]

Synonym: A2cp1_3172

Alternate gene names: 220918269

Gene position: 3515332-3517005 (Clockwise)

Preceding gene: 220918268

Following gene: 220918270

Centisome position: 69.9

GC content: 70.49

Gene sequence:

>1674_bases
ATGAGCTGGACCCAGATCTACACCCCCGTCGCCGGGAGCCTGATCGTCTCGGCGCTCGTCGCCGCCATCCCGGTGGTCGC
GCTGCTCGGCGCGCTCGCCTTCTTCCACGTGAAGGCCCACTGGGCCGCGCTGATCGGCCTGGTGCTGGCGCTCGGCATCG
CGATCGGCGTCTACGGCATGCCGGCGTCGATGGCCGGCGCGGCCGCGCTGAACGGCGCCGCGTTCGGCCTGCTGCCGATC
GGCTGGATCGTGCTGAACGCGATCTTCGTCTACGACATCACCGTCCGGACCGGGAAGTTCGAGGTGGTGAAGGAGACCAT
CGCCGGCCTCGCCTCCGACCGGCGCATCCAGGTGCTGCTCATCGGCTTCTCCTTCGGCGCGTTCATCGAGGGCGCGGCCG
GGTTCGGGACGCCGGTGGCCATCAGCGCCGCCATGCTCATCGGCCTCGGCTTCAAGCCGCTGCCGGCGGCGGGCCTGGCG
CTCATCGGCAACACCGCGCCGGTCGCGTACGGCGCCCTCGGCACCCCCATCATCACGCTCGCCAAGGTGACCGGCCTGAA
CGAGCTCGCGCTGTCCGCCATGACCGGGCGCCAGCTCCCGCTGTTCTCGCTCATCGTGCCGTTCTGGCTCGTGTGGGCGA
TGTCCGGCTTCCGCGGCATGGTCGAGGTCTGGCCGGCCTGCCTGGTGGCCGGCCTGTTCTTCGCGGTCCCGCAGTTCGTG
GTGTCCAACTTCTACGGCCCCTCGCTGGTGGACATCGTGGCCGCCGCGGTGTCGCTCCTCGCGATGTACCTGCTGCTGAA
GGTCTGGCAGCCCCGGACCGTGTGGCGCTTCCACGACGAGCGCGACTCCGACGCGGCCCTGGCGGCCCGGAAGTCGGTCG
GCGCCGCCGCCGCGCACCGGGCGCCCACCGGCGCGGAGGCGCTGGTGGCGTGGCTCCCCTGGATCATCCTCTCGGTGTTC
GTGTTCGCGTGGGGCCTGCCGTCGGTGAAGGCCTGGATGAACGGCATCTTCAACCCGACCTGGGAGGTGCCGTTCCTGCA
CAACCTGGTGCACAAGGCGCCGCCGGTGTCGAAGGCGCTCGCGCCCGAGGCGGCGAAGTACAGCCTGAACCTGCTCTCCG
CCACCGGCACCGGCCTGCTGCTGTCCGGCGTGGTCTCCGGCCTCGTCCTGAAGCTCGGCCCGGGCGCGCTGCTCCGCACC
TACCTCGGCACGCTGAAGCGGGTGCGCTTCTCGCTCGTCACCATCGCGGCCATGCTGGCGCTCGGGTTCACCACGCGCTT
CTCGGGGTCGGACTCGACCATGGGGCTCGCGTTCGCCTCCACCGGCCACCTGTTCCCGTTCTTCTCGCCCCTGCTCGGCT
GGCTGGGCGTGGCGCTCACCGGGTCCGACACGTCGTCGAACGTGCTGTTCGGCAACCTGCAGGTGGTGAGCGCGCAGCAG
ATCGGCATGAACCCGATCCTCGCGGCGGCCTCCAACAGCTCGGGCGGCGTGATGGGCAAGATGATCGACGCGCAGAGCAT
CGTGGTCGCGTCGGTCGCGACCGGCCAGCACGGCCACGAGGGGATCATCCTCCGCTACGTGTTCTGGCACTCGCTCGTGC
TCGCCTGCCTGGTCGGCGTGGTGGTGTTCCTCCAGGCCTACGTGTTCACCGGCATGGTCCCCATCCCGCACTAG

Upstream 100 bases:

>100_bases
CCGCTGGCCTGGCTGGTGGACCGCTGCGCGTCGCCGCGCGCCGGCCGAGACCTCGAGCCCCCCGTCCCCCGCATGCACGC
ACCGTGAAGGAGATCGCCCG

Downstream 100 bases:

>100_bases
CGCAGGCCCGCCCGCATCCCGCTTCACCGCCGGGCGGGATCCGGGCACACTCGCGCCGGAGGTCCCGGTGAAGGTCGCGC
TGTTCGTTCCGTGCTACGTG

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSWTQIYTPVAGSLIVSALVAAIPVVALLGALAFFHVKAHWAALIGLVLALGIAIGVYGMPASMAGAAALNGAAFGLLPI
GWIVLNAIFVYDITVRTGKFEVVKETIAGLASDRRIQVLLIGFSFGAFIEGAAGFGTPVAISAAMLIGLGFKPLPAAGLA
LIGNTAPVAYGALGTPIITLAKVTGLNELALSAMTGRQLPLFSLIVPFWLVWAMSGFRGMVEVWPACLVAGLFFAVPQFV
VSNFYGPSLVDIVAAAVSLLAMYLLLKVWQPRTVWRFHDERDSDAALAARKSVGAAAAHRAPTGAEALVAWLPWIILSVF
VFAWGLPSVKAWMNGIFNPTWEVPFLHNLVHKAPPVSKALAPEAAKYSLNLLSATGTGLLLSGVVSGLVLKLGPGALLRT
YLGTLKRVRFSLVTIAAMLALGFTTRFSGSDSTMGLAFASTGHLFPFFSPLLGWLGVALTGSDTSSNVLFGNLQVVSAQQ
IGMNPILAAASNSSGGVMGKMIDAQSIVVASVATGQHGHEGIILRYVFWHSLVLACLVGVVVFLQAYVFTGMVPIPH

Sequences:

>Translated_557_residues
MSWTQIYTPVAGSLIVSALVAAIPVVALLGALAFFHVKAHWAALIGLVLALGIAIGVYGMPASMAGAAALNGAAFGLLPI
GWIVLNAIFVYDITVRTGKFEVVKETIAGLASDRRIQVLLIGFSFGAFIEGAAGFGTPVAISAAMLIGLGFKPLPAAGLA
LIGNTAPVAYGALGTPIITLAKVTGLNELALSAMTGRQLPLFSLIVPFWLVWAMSGFRGMVEVWPACLVAGLFFAVPQFV
VSNFYGPSLVDIVAAAVSLLAMYLLLKVWQPRTVWRFHDERDSDAALAARKSVGAAAAHRAPTGAEALVAWLPWIILSVF
VFAWGLPSVKAWMNGIFNPTWEVPFLHNLVHKAPPVSKALAPEAAKYSLNLLSATGTGLLLSGVVSGLVLKLGPGALLRT
YLGTLKRVRFSLVTIAAMLALGFTTRFSGSDSTMGLAFASTGHLFPFFSPLLGWLGVALTGSDTSSNVLFGNLQVVSAQQ
IGMNPILAAASNSSGGVMGKMIDAQSIVVASVATGQHGHEGIILRYVFWHSLVLACLVGVVVFLQAYVFTGMVPIPH
>Mature_556_residues
SWTQIYTPVAGSLIVSALVAAIPVVALLGALAFFHVKAHWAALIGLVLALGIAIGVYGMPASMAGAAALNGAAFGLLPIG
WIVLNAIFVYDITVRTGKFEVVKETIAGLASDRRIQVLLIGFSFGAFIEGAAGFGTPVAISAAMLIGLGFKPLPAAGLAL
IGNTAPVAYGALGTPIITLAKVTGLNELALSAMTGRQLPLFSLIVPFWLVWAMSGFRGMVEVWPACLVAGLFFAVPQFVV
SNFYGPSLVDIVAAAVSLLAMYLLLKVWQPRTVWRFHDERDSDAALAARKSVGAAAAHRAPTGAEALVAWLPWIILSVFV
FAWGLPSVKAWMNGIFNPTWEVPFLHNLVHKAPPVSKALAPEAAKYSLNLLSATGTGLLLSGVVSGLVLKLGPGALLRTY
LGTLKRVRFSLVTIAAMLALGFTTRFSGSDSTMGLAFASTGHLFPFFSPLLGWLGVALTGSDTSSNVLFGNLQVVSAQQI
GMNPILAAASNSSGGVMGKMIDAQSIVVASVATGQHGHEGIILRYVFWHSLVLACLVGVVVFLQAYVFTGMVPIPH

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=571, Percent_Identity=45.8844133099825, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1790031, Length=562, Percent_Identity=45.373665480427, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58275; Mature: 58144

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTQIYTPVAGSLIVSALVAAIPVVALLGALAFFHVKAHWAALIGLVLALGIAIGVYGM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PASMAGAAALNGAAFGLLPIGWIVLNAIFVYDITVRTGKFEVVKETIAGLASDRRIQVLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCEEEEEE
IGFSFGAFIEGAAGFGTPVAISAAMLIGLGFKPLPAAGLALIGNTAPVAYGALGTPIITL
EEECHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHEECCCCCHHHCCCCCHHHHH
AKVTGLNELALSAMTGRQLPLFSLIVPFWLVWAMSGFRGMVEVWPACLVAGLFFAVPQFV
HHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VSNFYGPSLVDIVAAAVSLLAMYLLLKVWQPRTVWRFHDERDSDAALAARKSVGAAAAHR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHCC
APTGAEALVAWLPWIILSVFVFAWGLPSVKAWMNGIFNPTWEVPFLHNLVHKAPPVSKAL
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHH
APEAAKYSLNLLSATGTGLLLSGVVSGLVLKLGPGALLRTYLGTLKRVRFSLVTIAAMLA
CCCHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFTTRFSGSDSTMGLAFASTGHLFPFFSPLLGWLGVALTGSDTSSNVLFGNLQVVSAQQ
HHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEEEHHH
IGMNPILAAASNSSGGVMGKMIDAQSIVVASVATGQHGHEGIILRYVFWHSLVLACLVGV
CCCCCEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
VVFLQAYVFTGMVPIPH
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SWTQIYTPVAGSLIVSALVAAIPVVALLGALAFFHVKAHWAALIGLVLALGIAIGVYGM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PASMAGAAALNGAAFGLLPIGWIVLNAIFVYDITVRTGKFEVVKETIAGLASDRRIQVLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCEEEEEE
IGFSFGAFIEGAAGFGTPVAISAAMLIGLGFKPLPAAGLALIGNTAPVAYGALGTPIITL
EEECHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHEECCCCCHHHCCCCCHHHHH
AKVTGLNELALSAMTGRQLPLFSLIVPFWLVWAMSGFRGMVEVWPACLVAGLFFAVPQFV
HHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VSNFYGPSLVDIVAAAVSLLAMYLLLKVWQPRTVWRFHDERDSDAALAARKSVGAAAAHR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHCC
APTGAEALVAWLPWIILSVFVFAWGLPSVKAWMNGIFNPTWEVPFLHNLVHKAPPVSKAL
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHH
APEAAKYSLNLLSATGTGLLLSGVVSGLVLKLGPGALLRTYLGTLKRVRFSLVTIAAMLA
CCCHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFTTRFSGSDSTMGLAFASTGHLFPFFSPLLGWLGVALTGSDTSSNVLFGNLQVVSAQQ
HHHHHEECCCCCCCEEEEECCCCCHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEEEHHH
IGMNPILAAASNSSGGVMGKMIDAQSIVVASVATGQHGHEGIILRYVFWHSLVLACLVGV
CCCCCEEEECCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
VVFLQAYVFTGMVPIPH
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]