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The map label for this gene is serA [H]

Identifier: 220918253

GI number: 220918253

Start: 3487602

End: 3488801

Strand: Direct

Name: serA [H]

Synonym: A2cp1_3156

Alternate gene names: 220918253

Gene position: 3487602-3488801 (Clockwise)

Preceding gene: 220918250

Following gene: 220918254

Centisome position: 69.35

GC content: 75.5

Gene sequence:

>1200_bases
GTGAAGATCCTCGTCGCCGATGCCTTCCCCGCCGACCGGCTGAAGGACCTCGCCGCGCTCGGGCTCGAGGTGGAGCTGCG
CGCCGACGTGCCGGCGAAGGACCTGCCCGCCGCCGTCGCCGGCGCGTCCATCCTCGTGGTGCGGTCGAAGCAGGTGAGCG
CGGAGGTGTTCGAGCGCGCGCCGGGGCTGTCGCTGGTGGTCCGCGCCGGCGCGGGGGTGAACACGATCGACGTGGCGGCC
GCCTCCCGGCGCGGCGTGTACGTCACCAACTGCCCCGGCCAGAACTCCATCGCCGTCGCCGAGCTCGCCATCGGCCTGCT
CGTCGCGCTGGACCGGCGCATCCCGGACAACGTGGCCGCGCTGCGCGCCGGCCGCTGGGACAAGAAGCGCTTCTCCGAGG
CGGAGGGGCTCTTCGGCCGCACGCTGGGGATCGCGGGCGTGGGCGCCATCGGGCGCGAGGTGGCGGCCCGGGCCCGCGCG
CTCGGGATGCGGGTGGTGGCGTGGTCGCGCTCGCTCGACGACGCGCGGGCGCGGGCGCTCGGGGTGGAGCGCGCGCCGGA
CCTCCTCGCGCTGGCGCGGGCCAGCGACGCGCTCTCGCTGCACCTGCCGCTCGCGCGCGAGACGCGCGGCGTGATCTCGC
GGGACGTCCTGGAGGCGCTCCGCCCCGGCGCGCTGCTGGTGAACACCGCGCGCGCCGAGCTGGTCGATCAGGACGCGCTG
CTCGAGCTCGCCACCGCGGGCCGCCTCCGGGTCGGCGCGGACGTGTTCGCGGGCGAGCCGGAGAAGGGGCAGGCCGAGTT
CGACAGCCCGCTCGCGAAGCTGCCCGGCGTGTACGGCACGCACCACATCGGCGCCTCCACCGCCCAGGCGCAGGACGCCA
TCGCGCGCGAGACGGTGCGGATCGTCGAGGCGTTCGTGCGCAGCGGACAGGTGCCGAGCTGCGTGAACGTGGCGCGGAAG
ACCCCGGCGCGCGCGCGGCTGGTGGTGCGGCACGTGGACCGCGTCGGCGTGATCGCGAACGTGATGGCGCTCATCCGCGA
GGCGGGCATCAACGCCCAGGAGATCCGGAACACCGTGTTCGACGAGGCGGTGGCGGCGAGCTGCGCCATCGACCTCGACG
AGCGGCCGCCGGAGGCCGTCGTGGAGCGCATCCGCGCCCGCGTCGACGAGATCCTGTTCGTCGGCTGCTTCGACCTCTGA

Upstream 100 bases:

>100_bases
CCGGGGCACGCCCCGGCAGGCGCGCACGCGCCGGGGCGCCGCCGCGGTAATGAGGCGCCCACGCAGGGCGCGCGCCCGCG
CCCGGAACCGGAGGCCACCC

Downstream 100 bases:

>100_bases
TCCCTGCCGGCGGGGCGCCGGGCGGTCCGGCGGGACGTCCGGCGCCTCCCCCACGGCGGGGTCCCCGCGGCGGCGGGTTG
ACGCGCGCGCGCACGTCCGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKILVADAFPADRLKDLAALGLEVELRADVPAKDLPAAVAGASILVVRSKQVSAEVFERAPGLSLVVRAGAGVNTIDVAA
ASRRGVYVTNCPGQNSIAVAELAIGLLVALDRRIPDNVAALRAGRWDKKRFSEAEGLFGRTLGIAGVGAIGREVAARARA
LGMRVVAWSRSLDDARARALGVERAPDLLALARASDALSLHLPLARETRGVISRDVLEALRPGALLVNTARAELVDQDAL
LELATAGRLRVGADVFAGEPEKGQAEFDSPLAKLPGVYGTHHIGASTAQAQDAIARETVRIVEAFVRSGQVPSCVNVARK
TPARARLVVRHVDRVGVIANVMALIREAGINAQEIRNTVFDEAVAASCAIDLDERPPEAVVERIRARVDEILFVGCFDL

Sequences:

>Translated_399_residues
MKILVADAFPADRLKDLAALGLEVELRADVPAKDLPAAVAGASILVVRSKQVSAEVFERAPGLSLVVRAGAGVNTIDVAA
ASRRGVYVTNCPGQNSIAVAELAIGLLVALDRRIPDNVAALRAGRWDKKRFSEAEGLFGRTLGIAGVGAIGREVAARARA
LGMRVVAWSRSLDDARARALGVERAPDLLALARASDALSLHLPLARETRGVISRDVLEALRPGALLVNTARAELVDQDAL
LELATAGRLRVGADVFAGEPEKGQAEFDSPLAKLPGVYGTHHIGASTAQAQDAIARETVRIVEAFVRSGQVPSCVNVARK
TPARARLVVRHVDRVGVIANVMALIREAGINAQEIRNTVFDEAVAASCAIDLDERPPEAVVERIRARVDEILFVGCFDL
>Mature_399_residues
MKILVADAFPADRLKDLAALGLEVELRADVPAKDLPAAVAGASILVVRSKQVSAEVFERAPGLSLVVRAGAGVNTIDVAA
ASRRGVYVTNCPGQNSIAVAELAIGLLVALDRRIPDNVAALRAGRWDKKRFSEAEGLFGRTLGIAGVGAIGREVAARARA
LGMRVVAWSRSLDDARARALGVERAPDLLALARASDALSLHLPLARETRGVISRDVLEALRPGALLVNTARAELVDQDAL
LELATAGRLRVGADVFAGEPEKGQAEFDSPLAKLPGVYGTHHIGASTAQAQDAIARETVRIVEAFVRSGQVPSCVNVARK
TPARARLVVRHVDRVGVIANVMALIREAGINAQEIRNTVFDEAVAASCAIDLDERPPEAVVERIRARVDEILFVGCFDL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=298, Percent_Identity=34.8993288590604, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI61743967, Length=322, Percent_Identity=31.3664596273292, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4557497, Length=322, Percent_Identity=31.3664596273292, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI145580578, Length=320, Percent_Identity=31.875, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557499, Length=320, Percent_Identity=31.875, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI145580575, Length=320, Percent_Identity=31.875, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI6912396, Length=326, Percent_Identity=27.9141104294479, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789279, Length=362, Percent_Identity=31.767955801105, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787645, Length=265, Percent_Identity=28.6792452830189, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082289, Length=286, Percent_Identity=28.3216783216783, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788660, Length=313, Percent_Identity=31.3099041533546, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081824, Length=220, Percent_Identity=30.4545454545455, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=35.0993377483444, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=286, Percent_Identity=29.020979020979, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=375, Percent_Identity=29.8666666666667, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=375, Percent_Identity=29.6, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=255, Percent_Identity=25.8823529411765, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=26.5917602996255, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=35.5140186915888, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646446, Length=322, Percent_Identity=32.2981366459627, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646448, Length=322, Percent_Identity=32.2981366459627, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646452, Length=322, Percent_Identity=32.2981366459627, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646450, Length=322, Percent_Identity=32.2981366459627, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI62472511, Length=322, Percent_Identity=32.2981366459627, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574286, Length=243, Percent_Identity=30.0411522633745, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28571528, Length=277, Percent_Identity=32.4909747292419, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552429, Length=246, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24585514, Length=246, Percent_Identity=28.0487804878049, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=246, Percent_Identity=28.0487804878049, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=246, Percent_Identity=28.0487804878049, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574284, Length=246, Percent_Identity=28.0487804878049, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=25.4125412541254, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 42221; Mature: 42221

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVADAFPADRLKDLAALGLEVELRADVPAKDLPAAVAGASILVVRSKQVSAEVFERA
CEEEEECCCCHHHHHHHHHHCCEEEEECCCCCHHCCHHHCCCEEEEEECCHHHHHHHHHC
PGLSLVVRAGAGVNTIDVAAASRRGVYVTNCPGQNSIAVAELAIGLLVALDRRIPDNVAA
CCCEEEEECCCCCCEEEEHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
LRAGRWDKKRFSEAEGLFGRTLGIAGVGAIGREVAARARALGMRVVAWSRSLDDARARAL
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
GVERAPDLLALARASDALSLHLPLARETRGVISRDVLEALRPGALLVNTARAELVDQDAL
CCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCHHHH
LELATAGRLRVGADVFAGEPEKGQAEFDSPLAKLPGVYGTHHIGASTAQAQDAIARETVR
HHHHHCCCEEECCHHHCCCCCCCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
IVEAFVRSGQVPSCVNVARKTPARARLVVRHVDRVGVIANVMALIREAGINAQEIRNTVF
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEAVAASCAIDLDERPPEAVVERIRARVDEILFVGCFDL
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure
MKILVADAFPADRLKDLAALGLEVELRADVPAKDLPAAVAGASILVVRSKQVSAEVFERA
CEEEEECCCCHHHHHHHHHHCCEEEEECCCCCHHCCHHHCCCEEEEEECCHHHHHHHHHC
PGLSLVVRAGAGVNTIDVAAASRRGVYVTNCPGQNSIAVAELAIGLLVALDRRIPDNVAA
CCCEEEEECCCCCCEEEEHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
LRAGRWDKKRFSEAEGLFGRTLGIAGVGAIGREVAARARALGMRVVAWSRSLDDARARAL
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
GVERAPDLLALARASDALSLHLPLARETRGVISRDVLEALRPGALLVNTARAELVDQDAL
CCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCHHHH
LELATAGRLRVGADVFAGEPEKGQAEFDSPLAKLPGVYGTHHIGASTAQAQDAIARETVR
HHHHHCCCEEECCHHHCCCCCCCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
IVEAFVRSGQVPSCVNVARKTPARARLVVRHVDRVGVIANVMALIREAGINAQEIRNTVF
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DEAVAASCAIDLDERPPEAVVERIRARVDEILFVGCFDL
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]