Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 220918231

GI number: 220918231

Start: 3462211

End: 3464319

Strand: Direct

Name: luxQ [H]

Synonym: A2cp1_3134

Alternate gene names: 220918231

Gene position: 3462211-3464319 (Clockwise)

Preceding gene: 220918230

Following gene: 220918236

Centisome position: 68.84

GC content: 76.86

Gene sequence:

>2109_bases
ATGCGTAGGCCGGACCTCTCCATCGGGACCTGGGTGTCGCTCGGGTTCGCGATCGCCGGCGCGCTCCTGGCCGGCGTCGT
GGTGCTGGCGGTCACGCTCCAGGGGCGGATCGCGGCCAGCGCCGACGCGCAGCTCGAGGTCATCGGCCCGCGCGCGGCCG
CGGCGGCGTCGCTCGAGAGCGCGGTGCTGCACCTCAGCCTGACCGCGCGCGCGTACGCGCTCGCGCCCGAGCCCGCGCGG
ATGGACGCGCTGCAGGCGGCGCTGCGCCGGCTGGAGGGGGCGGCGGCGCGCTTCGCGGCGGTGCCGAAGCAGGGCGAGGG
GACGGCCCTGGCGGACCGGATCCTGGCGGCGGTCCCGCCGTTCGAGAAGGCGGCGGTCGCCCTCGGCACGGTCGTGGCGA
CCGGCGGCGACGACGCCGCGATCCGCGCGCGCGAGGCGACCCTGCCGCCGATGCGCGAGGAGCTGCTGGAGCTGCTCCGG
GGCTTCTCCGCGATCCAGCAGCGGCACGACGCGGGCGCGAGCCACACCATCCTCGCGTACCAGCGCGACACCGTCCGCAC
CCTGGTGCTCGCCTTCGCCGCCGTGGCCCTGCTCCTGGCGGTGACCGCCTGGGTGGTCGTCACGGAGGTGCGCCGCCCGG
CGAAGCGGCTGGTGGACGCGGCCCGGCGGCTCGCCGCGGGCGACTACTCGGCCGTGGCGGGCCTGGAGGCACGGACCGCG
GCCAGGGGGCCGCGCAGCGAGCTGGCCGAGCTGGCGCGGGCGTTCGCGGCGATGGCGGCGGAGCTGCGCGATCGCGAGGA
GCGGCTCGCCGCGCAGAACGAGGAGCTCCAGGCCCAGAACGAGGAGCTCCAGTCGAAGGAGGAGGAGCTCCACGGCCAGA
ACGAGGAGCTCCAGGTCCAGCAGGAGGAGCTGCAGGCCCAGAACGAGGAGCTCCAGTCGCAGGGCGAGGCGCTCCGGGCC
AGCGACGCGCGCCTCACGCAGCTCGTGGAGGCGCTGTCGCAGGCGGACCGCCGCAAGAACGAGTTCCTGGCGGTGCTGTC
GCACGAGCTGCGCAACCCGCTGGCGCCGGTGCTGAACGCGCTCACCGTCCTCGATCGCGGCGACCCCTCGGGCGAGCAGG
GCCGGCACGCGCGCCAGGTCATCGCGCGCCAGGTGGCGCACCTGGCCCGGCTGGTGGACGACCTGCTCGACGTCGCCCGC
ATCACGCAGGGGAAGATCCAGCTCCGCCGGACGCACCTGGAGCTGGGGACGGCGGTGCGGCAGGCCGCCGAGGACCTGGG
CTCGCTGCTCGAGGCGCGCGGCCTCCGGCTGGCGCTCGACGTGCCCGAGCGCGAGCTGTGGGTCCACGCCGACGCGGCGC
GCATCGCGCAGGTCGTGGGCAACCTGGTGCAGAACGCGGCCAAGTTCACCGACGGCGGCGGGACCGTGACGGTCGCCGTG
GACGCCACGCCGGACGGGCGAGCCCGGATCCGGGTGCGCGACGACGGCATCGGGATGCCACCGGAGGTGCTGGAGCGGCT
GTTCCAGCCGTTCGTGCAGGCCGAGGGGACGCTGGCGCGGACCCGCGGCGGCCTGGGGCTGGGGCTCGCGCTGGTGAAGG
GGCTGGTCGAGCTGCACGGCGGCACGGTCGGCGCCGCGAGCGCCGGGGCTGGGCGCGGGGCGACGTTCACGGTGGAGCTG
CCGCTCGACGGCGTGCCGGTCCGCGCCGCCGACGCCGCAGCGCCACGCCCGGCCGCGCCGCGCCGGGTGCTCGTGGTCGA
GGACAACCCGGACTCCGCCGAGACGCTGCGCGACCTGCTCGAGCTGGCCGGCCACCACGCCGACATCGCGCTCGACGGAC
GGCAGGCGCTGGAGCGCTGCCGCACGGCGCGCCCGGACGCGATCGTGTGCGACCTGGGGCTGCCCGACATGGACGGCTAC
GAGCTGGCGCGCACGCTGCGCGCCGACCCGGAGCTGTCGTCCGTGCTGCTCGTCGCCCTCTCCGGCTACGCCCTGCCCGA
CGACCTGGCCCGCTCGGCGCAGGCCGGCTTCGACGCGCACCTCGCCAAGCCGGCGCGCTTCGAGGCCATCGAGGCGCTGC
TGGCGGGGGCGCACCGGCAGCGCGGCTGA

Upstream 100 bases:

>100_bases
TGGCTGGGGCCGGCGGAGTGGCCGGCGGGGCTGGGCGGCGGGAGGCTCGAGGTCCTCGACCGCCGCGCCCGCCTGTTCCG
CGCGATCGGAGGGAGCGCCG

Downstream 100 bases:

>100_bases
GCGGGGCCGCAGGGCCGCTCACGCGTCCGGCGGCGGCCGCTCGACGGCACGGCGGAGCGCCTCGATCTCGACCGGCTTCG
TCAGGTGCACGTCGAACCCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MRRPDLSIGTWVSLGFAIAGALLAGVVVLAVTLQGRIAASADAQLEVIGPRAAAAASLESAVLHLSLTARAYALAPEPAR
MDALQAALRRLEGAAARFAAVPKQGEGTALADRILAAVPPFEKAAVALGTVVATGGDDAAIRAREATLPPMREELLELLR
GFSAIQQRHDAGASHTILAYQRDTVRTLVLAFAAVALLLAVTAWVVVTEVRRPAKRLVDAARRLAAGDYSAVAGLEARTA
ARGPRSELAELARAFAAMAAELRDREERLAAQNEELQAQNEELQSKEEELHGQNEELQVQQEELQAQNEELQSQGEALRA
SDARLTQLVEALSQADRRKNEFLAVLSHELRNPLAPVLNALTVLDRGDPSGEQGRHARQVIARQVAHLARLVDDLLDVAR
ITQGKIQLRRTHLELGTAVRQAAEDLGSLLEARGLRLALDVPERELWVHADAARIAQVVGNLVQNAAKFTDGGGTVTVAV
DATPDGRARIRVRDDGIGMPPEVLERLFQPFVQAEGTLARTRGGLGLGLALVKGLVELHGGTVGAASAGAGRGATFTVEL
PLDGVPVRAADAAAPRPAAPRRVLVVEDNPDSAETLRDLLELAGHHADIALDGRQALERCRTARPDAIVCDLGLPDMDGY
ELARTLRADPELSSVLLVALSGYALPDDLARSAQAGFDAHLAKPARFEAIEALLAGAHRQRG

Sequences:

>Translated_702_residues
MRRPDLSIGTWVSLGFAIAGALLAGVVVLAVTLQGRIAASADAQLEVIGPRAAAAASLESAVLHLSLTARAYALAPEPAR
MDALQAALRRLEGAAARFAAVPKQGEGTALADRILAAVPPFEKAAVALGTVVATGGDDAAIRAREATLPPMREELLELLR
GFSAIQQRHDAGASHTILAYQRDTVRTLVLAFAAVALLLAVTAWVVVTEVRRPAKRLVDAARRLAAGDYSAVAGLEARTA
ARGPRSELAELARAFAAMAAELRDREERLAAQNEELQAQNEELQSKEEELHGQNEELQVQQEELQAQNEELQSQGEALRA
SDARLTQLVEALSQADRRKNEFLAVLSHELRNPLAPVLNALTVLDRGDPSGEQGRHARQVIARQVAHLARLVDDLLDVAR
ITQGKIQLRRTHLELGTAVRQAAEDLGSLLEARGLRLALDVPERELWVHADAARIAQVVGNLVQNAAKFTDGGGTVTVAV
DATPDGRARIRVRDDGIGMPPEVLERLFQPFVQAEGTLARTRGGLGLGLALVKGLVELHGGTVGAASAGAGRGATFTVEL
PLDGVPVRAADAAAPRPAAPRRVLVVEDNPDSAETLRDLLELAGHHADIALDGRQALERCRTARPDAIVCDLGLPDMDGY
ELARTLRADPELSSVLLVALSGYALPDDLARSAQAGFDAHLAKPARFEAIEALLAGAHRQRG
>Mature_702_residues
MRRPDLSIGTWVSLGFAIAGALLAGVVVLAVTLQGRIAASADAQLEVIGPRAAAAASLESAVLHLSLTARAYALAPEPAR
MDALQAALRRLEGAAARFAAVPKQGEGTALADRILAAVPPFEKAAVALGTVVATGGDDAAIRAREATLPPMREELLELLR
GFSAIQQRHDAGASHTILAYQRDTVRTLVLAFAAVALLLAVTAWVVVTEVRRPAKRLVDAARRLAAGDYSAVAGLEARTA
ARGPRSELAELARAFAAMAAELRDREERLAAQNEELQAQNEELQSKEEELHGQNEELQVQQEELQAQNEELQSQGEALRA
SDARLTQLVEALSQADRRKNEFLAVLSHELRNPLAPVLNALTVLDRGDPSGEQGRHARQVIARQVAHLARLVDDLLDVAR
ITQGKIQLRRTHLELGTAVRQAAEDLGSLLEARGLRLALDVPERELWVHADAARIAQVVGNLVQNAAKFTDGGGTVTVAV
DATPDGRARIRVRDDGIGMPPEVLERLFQPFVQAEGTLARTRGGLGLGLALVKGLVELHGGTVGAASAGAGRGATFTVEL
PLDGVPVRAADAAAPRPAAPRRVLVVEDNPDSAETLRDLLELAGHHADIALDGRQALERCRTARPDAIVCDLGLPDMDGY
ELARTLRADPELSSVLLVALSGYALPDDLARSAQAGFDAHLAKPARFEAIEALLAGAHRQRG

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=370, Percent_Identity=29.7297297297297, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI48994928, Length=376, Percent_Identity=30.8510638297872, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081816, Length=546, Percent_Identity=28.7545787545788, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789149, Length=430, Percent_Identity=28.3720930232558, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=34.5991561181435, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=30.5785123966942, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=29.7872340425532, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1790346, Length=256, Percent_Identity=29.6875, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=26.7782426778243, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=256, Percent_Identity=25.390625, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=27.4678111587983, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=30.9623430962343, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=29.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=25.2100840336134, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=263, Percent_Identity=25.0950570342205, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74500; Mature: 74500

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50885 HAMP ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPDLSIGTWVSLGFAIAGALLAGVVVLAVTLQGRIAASADAQLEVIGPRAAAAASLES
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHH
AVLHLSLTARAYALAPEPARMDALQAALRRLEGAAARFAAVPKQGEGTALADRILAAVPP
HHHHEEEHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
FEKAAVALGTVVATGGDDAAIRAREATLPPMREELLELLRGFSAIQQRHDAGASHTILAY
HHHHHHHHHHHEECCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
QRDTVRTLVLAFAAVALLLAVTAWVVVTEVRRPAKRLVDAARRLAAGDYSAVAGLEARTA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
ARGPRSELAELARAFAAMAAELRDREERLAAQNEELQAQNEELQSKEEELHGQNEELQVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
QEELQAQNEELQSQGEALRASDARLTQLVEALSQADRRKNEFLAVLSHELRNPLAPVLNA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LTVLDRGDPSGEQGRHARQVIARQVAHLARLVDDLLDVARITQGKIQLRRTHLELGTAVR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAAEDLGSLLEARGLRLALDVPERELWVHADAARIAQVVGNLVQNAAKFTDGGGTVTVAV
HHHHHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
DATPDGRARIRVRDDGIGMPPEVLERLFQPFVQAEGTLARTRGGLGLGLALVKGLVELHG
ECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCC
GTVGAASAGAGRGATFTVELPLDGVPVRAADAAAPRPAAPRRVLVVEDNPDSAETLRDLL
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
ELAGHHADIALDGRQALERCRTARPDAIVCDLGLPDMDGYELARTLRADPELSSVLLVAL
HHCCCCCCEEECHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHH
SGYALPDDLARSAQAGFDAHLAKPARFEAIEALLAGAHRQRG
CCCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRPDLSIGTWVSLGFAIAGALLAGVVVLAVTLQGRIAASADAQLEVIGPRAAAAASLES
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHH
AVLHLSLTARAYALAPEPARMDALQAALRRLEGAAARFAAVPKQGEGTALADRILAAVPP
HHHHEEEHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
FEKAAVALGTVVATGGDDAAIRAREATLPPMREELLELLRGFSAIQQRHDAGASHTILAY
HHHHHHHHHHHEECCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
QRDTVRTLVLAFAAVALLLAVTAWVVVTEVRRPAKRLVDAARRLAAGDYSAVAGLEARTA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
ARGPRSELAELARAFAAMAAELRDREERLAAQNEELQAQNEELQSKEEELHGQNEELQVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
QEELQAQNEELQSQGEALRASDARLTQLVEALSQADRRKNEFLAVLSHELRNPLAPVLNA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LTVLDRGDPSGEQGRHARQVIARQVAHLARLVDDLLDVARITQGKIQLRRTHLELGTAVR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAAEDLGSLLEARGLRLALDVPERELWVHADAARIAQVVGNLVQNAAKFTDGGGTVTVAV
HHHHHHHHHHHHCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
DATPDGRARIRVRDDGIGMPPEVLERLFQPFVQAEGTLARTRGGLGLGLALVKGLVELHG
ECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCC
GTVGAASAGAGRGATFTVELPLDGVPVRAADAAAPRPAAPRRVLVVEDNPDSAETLRDLL
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
ELAGHHADIALDGRQALERCRTARPDAIVCDLGLPDMDGYELARTLRADPELSSVLLVAL
HHCCCCCCEEECHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHH
SGYALPDDLARSAQAGFDAHLAKPARFEAIEALLAGAHRQRG
CCCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]