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The map label for this gene is glcD [H]

Identifier: 220918144

GI number: 220918144

Start: 3370396

End: 3371862

Strand: Reverse

Name: glcD [H]

Synonym: A2cp1_3047

Alternate gene names: 220918144

Gene position: 3371862-3370396 (Counterclockwise)

Preceding gene: 220918154

Following gene: 220918143

Centisome position: 67.04

GC content: 75.66

Gene sequence:

>1467_bases
GTGACCCGAGCTCCCGCCGTGAGCAGCGCCCTCGCCCGACGCCTCGCCGCCGCGCTCGGCCCGGCGCACGTGATCGCGGA
CCCGGCGGAGCTGCGCGTCTACGCGTGCGACGGGATCACCCACGGTCGAACGACCCCGGCGCTGGTGGCGCTGCCGGGCT
CGACCGAGGAGGTGGTCGAGGTGGTGAACGCGGCGCGCGAGGCGGGCGTGCCGCTCGTGCCGCGCGGCGCGGGCACCGGG
CTCTCGGGCGGCGCGCGCCCGTCGCCGGGCTCGATCGTGGTCTCGCTCGCGCGCATGCGGCGCATCCTCGAGCTGGACCT
CGAGAACGGCTGGGCGCGCGTCGAGCCGGGCGTCATCAACCTGGACGTCTCGCGCGCGGTGGCGGCGGCGGGCTGGTACT
ACGCGCCGGACCCGTCGTCGCAGGGGGTGTGCTCGATCGGCGGCAACGTGGCCGAGAACTCGGGCGGCGCGCACTGCCTC
AAGTACGGGTTCACCACGAACCACGTGCTCGCGGCGCGGGTGGTCCTCTCCGACGGCAGCGTGGTGGACCTGGGCGGCCC
GGCCGCCGACGCGCCCGGCTACGACCTGCTCGCGGCGATGGTGGGCAGCGAGGGGCTGCTGGGCATCGCCACCGAGGCGA
CGCTGCGGCTGCTGCGCAAGCCCGAGGTGACGCGGACCTTCTTCGCCACCTTCCCGTCCACCGACGAGGCGGGCGCGGCG
GTCTCGGGCATCATCGCCGCGGGCATCCTGCCCGCCGCGATCGAGATGATGGACCGGCTCGCCATCGTGGCCGCGAAGGC
TGCGACGGGCCTCGACTGGCCGGACGTGGGCGCGGCGCTGCTCATGGACGCGGACGGCTGCCGGGCCGAGGTGGAGCACG
TCGCGGCGCGCGCCATCGAGATCACCCGCGCCGCCGGCGCGCTGGAGATCCGCGTGCCGCGCGACGAGGCCGAGCGCCAG
CTCATGTGGAAGGGGCGCAAGAGCGCCTTCGCGGCGGTGGGCCGCATCAGCCCGAACTACCTGGTGGAGGACGGCGTCAT
CCCGCGTTCGGAGATCGCGCGCGTGCTGCGCGAGATCGAGCGCATGGCCGCCGAGGCGGGCCTGCGCGTCGCGAACGTGT
TCCACGCCGGCGACGGCAACCTCCACCCGCTGGTGCTCTACGACGCGCGCAACCCCGGCGAGGAGGCGCGCGCCGCGGCG
CTGGGAGGCGAGATCCTGCGGCTGTGCATCCGCAGCGGCGGCTCGATCACCGGCGAGCACGGGGTGGGCGCGGAGAAGGC
CGCGTACATGGCGGAGCAGTTCGCCCCGGAGGACCTCGAGACGATGCAGCGCGTCCGCTGCGCCTTCGACGGCGCGGCCC
TCATGAACCCGGGCAAGGTGTTCCCGACGCCGCGCCTGTGCGGCGAGCGGCCCGGACCCTACCGCCCCCACCCCGCCGAG
GTGGCCGGGCTCGCGGAGCGCTGGTGA

Upstream 100 bases:

>100_bases
CCGTCCCCGCGCGCCCCCGATCGATGCACCCCGTCGAAGGTTGACCGGACGGAGCGGTCCCGGAACATTCAACCACCACC
TCGCAACCGAAGGAGCCCGC

Downstream 100 bases:

>100_bases
GCGCCGCCGCCCGTCCCGCGAGCGCCGCCGACGCGGTGGCCGGCGCCGTGCCGCGCCTGGCGATCGAGCCCGCGACGCTC
GACGAGGCCGCCGAGGCGAT

Product: D-lactate dehydrogenase (cytochrome)

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTRAPAVSSALARRLAAALGPAHVIADPAELRVYACDGITHGRTTPALVALPGSTEEVVEVVNAAREAGVPLVPRGAGTG
LSGGARPSPGSIVVSLARMRRILELDLENGWARVEPGVINLDVSRAVAAAGWYYAPDPSSQGVCSIGGNVAENSGGAHCL
KYGFTTNHVLAARVVLSDGSVVDLGGPAADAPGYDLLAAMVGSEGLLGIATEATLRLLRKPEVTRTFFATFPSTDEAGAA
VSGIIAAGILPAAIEMMDRLAIVAAKAATGLDWPDVGAALLMDADGCRAEVEHVAARAIEITRAAGALEIRVPRDEAERQ
LMWKGRKSAFAAVGRISPNYLVEDGVIPRSEIARVLREIERMAAEAGLRVANVFHAGDGNLHPLVLYDARNPGEEARAAA
LGGEILRLCIRSGGSITGEHGVGAEKAAYMAEQFAPEDLETMQRVRCAFDGAALMNPGKVFPTPRLCGERPGPYRPHPAE
VAGLAERW

Sequences:

>Translated_488_residues
MTRAPAVSSALARRLAAALGPAHVIADPAELRVYACDGITHGRTTPALVALPGSTEEVVEVVNAAREAGVPLVPRGAGTG
LSGGARPSPGSIVVSLARMRRILELDLENGWARVEPGVINLDVSRAVAAAGWYYAPDPSSQGVCSIGGNVAENSGGAHCL
KYGFTTNHVLAARVVLSDGSVVDLGGPAADAPGYDLLAAMVGSEGLLGIATEATLRLLRKPEVTRTFFATFPSTDEAGAA
VSGIIAAGILPAAIEMMDRLAIVAAKAATGLDWPDVGAALLMDADGCRAEVEHVAARAIEITRAAGALEIRVPRDEAERQ
LMWKGRKSAFAAVGRISPNYLVEDGVIPRSEIARVLREIERMAAEAGLRVANVFHAGDGNLHPLVLYDARNPGEEARAAA
LGGEILRLCIRSGGSITGEHGVGAEKAAYMAEQFAPEDLETMQRVRCAFDGAALMNPGKVFPTPRLCGERPGPYRPHPAE
VAGLAERW
>Mature_487_residues
TRAPAVSSALARRLAAALGPAHVIADPAELRVYACDGITHGRTTPALVALPGSTEEVVEVVNAAREAGVPLVPRGAGTGL
SGGARPSPGSIVVSLARMRRILELDLENGWARVEPGVINLDVSRAVAAAGWYYAPDPSSQGVCSIGGNVAENSGGAHCLK
YGFTTNHVLAARVVLSDGSVVDLGGPAADAPGYDLLAAMVGSEGLLGIATEATLRLLRKPEVTRTFFATFPSTDEAGAAV
SGIIAAGILPAAIEMMDRLAIVAAKAATGLDWPDVGAALLMDADGCRAEVEHVAARAIEITRAAGALEIRVPRDEAERQL
MWKGRKSAFAAVGRISPNYLVEDGVIPRSEIARVLREIERMAAEAGLRVANVFHAGDGNLHPLVLYDARNPGEEARAAAL
GGEILRLCIRSGGSITGEHGVGAEKAAYMAEQFAPEDLETMQRVRCAFDGAALMNPGKVFPTPRLCGERPGPYRPHPAEV
AGLAERW

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=453, Percent_Identity=30.6843267108168, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI37595754, Length=476, Percent_Identity=29.2016806722689, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI119964728, Length=449, Percent_Identity=27.8396436525612, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4501993, Length=248, Percent_Identity=27.8225806451613, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789351, Length=447, Percent_Identity=50.3355704697987, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787977, Length=495, Percent_Identity=26.6666666666667, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI48994907, Length=490, Percent_Identity=23.469387755102, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=423, Percent_Identity=27.8959810874704, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71992381, Length=423, Percent_Identity=26.241134751773, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71992392, Length=355, Percent_Identity=27.3239436619718, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17534361, Length=426, Percent_Identity=26.5258215962441, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17556096, Length=284, Percent_Identity=24.6478873239437, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320027, Length=435, Percent_Identity=27.816091954023, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320023, Length=490, Percent_Identity=25.5102040816327, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320764, Length=455, Percent_Identity=25.0549450549451, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI18921117, Length=451, Percent_Identity=27.2727272727273, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639277, Length=451, Percent_Identity=27.2727272727273, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639275, Length=451, Percent_Identity=27.2727272727273, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653753, Length=229, Percent_Identity=28.3842794759825, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50821; Mature: 50689

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAPAVSSALARRLAAALGPAHVIADPAELRVYACDGITHGRTTPALVALPGSTEEVVE
CCCCCHHHHHHHHHHHHHHCCHHHEECHHHEEEEEECCCCCCCCCCEEEECCCCHHHHHH
VVNAAREAGVPLVPRGAGTGLSGGARPSPGSIVVSLARMRRILELDLENGWARVEPGVIN
HHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEE
LDVSRAVAAAGWYYAPDPSSQGVCSIGGNVAENSGGAHCLKYGFTTNHVLAARVVLSDGS
EEHHHHHHHCCCEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCC
VVDLGGPAADAPGYDLLAAMVGSEGLLGIATEATLRLLRKPEVTRTFFATFPSTDEAGAA
EEECCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHEEEEEECCCCCCCCHH
VSGIIAAGILPAAIEMMDRLAIVAAKAATGLDWPDVGAALLMDADGCRAEVEHVAARAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
ITRAAGALEIRVPRDEAERQLMWKGRKSAFAAVGRISPNYLVEDGVIPRSEIARVLREIE
HHHCCCEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
RMAAEAGLRVANVFHAGDGNLHPLVLYDARNPGEEARAAALGGEILRLCIRSGGSITGEH
HHHHHCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVGAEKAAYMAEQFAPEDLETMQRVRCAFDGAALMNPGKVFPTPRLCGERPGPYRPHPAE
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHCCCCCCCCCCCHHH
VAGLAERW
HHHHHHCC
>Mature Secondary Structure 
TRAPAVSSALARRLAAALGPAHVIADPAELRVYACDGITHGRTTPALVALPGSTEEVVE
CCCCHHHHHHHHHHHHHHCCHHHEECHHHEEEEEECCCCCCCCCCEEEECCCCHHHHHH
VVNAAREAGVPLVPRGAGTGLSGGARPSPGSIVVSLARMRRILELDLENGWARVEPGVIN
HHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEE
LDVSRAVAAAGWYYAPDPSSQGVCSIGGNVAENSGGAHCLKYGFTTNHVLAARVVLSDGS
EEHHHHHHHCCCEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCC
VVDLGGPAADAPGYDLLAAMVGSEGLLGIATEATLRLLRKPEVTRTFFATFPSTDEAGAA
EEECCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHEEEEEECCCCCCCCHH
VSGIIAAGILPAAIEMMDRLAIVAAKAATGLDWPDVGAALLMDADGCRAEVEHVAARAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
ITRAAGALEIRVPRDEAERQLMWKGRKSAFAAVGRISPNYLVEDGVIPRSEIARVLREIE
HHHCCCEEEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
RMAAEAGLRVANVFHAGDGNLHPLVLYDARNPGEEARAAALGGEILRLCIRSGGSITGEH
HHHHHCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVGAEKAAYMAEQFAPEDLETMQRVRCAFDGAALMNPGKVFPTPRLCGERPGPYRPHPAE
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHCCCCCCCCCCCHHH
VAGLAERW
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]